Synthesis and structure-activity relationships of 6-substituted androst-4-ene analogs as aromatase inhibitors

Journal of Medicinal Chemistry

Volumn 39, Issue 11, 1996, Pages 2245-2252

  Numazawa, Mitsuteru ^a   Kamiyama, Takayuki ^a   Tachibana, Mii ^a   Oshibe, Mariko ^a  

^a TOHOKU PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

6ALPHA METHYL 17 KETOSTEROID ANDROST 4 ENE; 6BETA METHYL 17 KETOSTEROID ANDROST 4 ENE; ANDROSTENEDIONE DERIVATIVE; AROMATASE INHIBITOR; CYTOCHROME P450; TESTOSTERONE; UNCLASSIFIED DRUG;

ARTICLE; COMPETITIVE INHIBITION; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME SYNTHESIS; HYDROPHOBICITY; NONHUMAN; OXYGENATION; RECEPTOR AFFINITY; STEROID METABOLISM; STRUCTURE ACTIVITY RELATION;

ANDROSTENES; AROMATASE INHIBITORS; COMPUTER GRAPHICS; ENZYME INHIBITORS; FEMALE; HUMANS; INDICATORS AND REAGENTS; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; MICROSOMES; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; PLACENTA; PREGNANCY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0029899588     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm960047o     Document Type: Article

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