Expanded therapeutic potential in activity space of next-generation 5-nitroimidazole antimicrobials with broad structural diversity

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 43, 2013, Pages 17564-17569

  Miyamoto, Yukiko ^a   Kalisiak, Jarosław ^b   Korthals, Keith ^b   Lauwaet, Tineke ^a   Cheung, Dae Young ^a   Lozano, Ricardo ^a   Cobo, Eduardo R ^a   Upcroft, Peter ^c   Upcroft, Jacqueline A ^c   Berg, Douglas E ^a   Gillin, Frances D ^a   Fokin, Valery V ^b   Sharpless, K Barry ^b   Eckmann, Lars ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

Author keywords

Antibiotics; Infectious diseases; Medicinal chemistry

Indexed keywords

4 NITROIMIDAZOLE; ANTIINFECTIVE AGENT; ANTIPROTOZOAL AGENT;

ANIMAL EXPERIMENT; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC SENSITIVITY; ANTIMICROBIAL ACTIVITY; ANTIPROTOZOAL ACTIVITY; ARTICLE; BACTEROIDES FRAGILIS; CLICK CHEMISTRY; CLOSTRIDIUM DIFFICILE; COMMENSAL ESCHERICHIA COLI; COMPARATIVE STUDY; CONTROLLED STUDY; CROSS RESISTANCE; CYCLOADDITION; DRUG BIOAVAILABILITY; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG SAFETY; DRUG SCREENING; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; GIARDIA LAMBLIA; GIARDIASIS; HELICOBACTER PYLORI; HUMAN; HUMAN CELL; HYDROPHOBICITY; INTESTINE PERFORATION; MICRONUCLEUS TEST; MOUSE; NONHUMAN; PATHOGENESIS; PERITONITIS; PRIORITY JOURNAL; SEXUALLY TRANSMITTED DISEASE; TRICHOMONAS VAGINALIS;

ANTIBIOTICS; INFECTIOUS DISEASES; MEDICINAL CHEMISTRY;

ANIMALS; ANTI-INFECTIVE AGENTS; BACTEROIDES FRAGILIS; CELL SURVIVAL; CLOSTRIDIUM DIFFICILE; COMBINATORIAL CHEMISTRY TECHNIQUES; GIARDIA LAMBLIA; GIARDIASIS; HELA CELLS; HELICOBACTER PYLORI; HUMANS; MICE; MICE, INBRED C57BL; MOLECULAR STRUCTURE; NITROIMIDAZOLES; STRUCTURE-ACTIVITY RELATIONSHIP; TREATMENT OUTCOME; TRICHOMONAS VAGINALIS;

EID: 84886416314     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1302664110     Document Type: Article

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