Efflux pump overexpression in multiple-antibiotic-resistant mutants of Bacteroides fragilis

Antimicrobial Agents and Chemotherapy

Volumn 50, Issue 9, 2006, Pages 3150-3153

  Pumbwe, Lilian ^a,b   Glass, Daniel ^b   Wexler, Hannah M ^a,b  

^a VA GREATER LOS ANGELES HEALTHCARE SYSTEM   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPICILLIN; ANTIBIOTIC AGENT; CARBONYL CYANIDE CHLOROPHENYLHYDRAZONE; CEFALEXIN; CEFOPERAZONE; CEFOTAXIME; CEFOXITIN; CEFTIZOXIME; CHLORAMPHENICOL; CIPROFLOXACIN; CLINDAMYCIN; DODECYL SULFATE SODIUM; DORIPENEM; ETHIDIUM BROMIDE; FROPENEM; GATIFLOXACIN; IMIPENEM; LEVOFLOXACIN; MEMBRANE PROTEIN; MEROPENEM; METRONIDAZOLE; MOXIFLOXACIN; NORFLOXACIN; PROTEIN BMEA; PROTEIN BMEC; RESERPINE; TETRACYCLINE; TRICLOSAN; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL STRAIN; BACTERIUM MUTANT; BACTEROIDES FRAGILIS; BIOASSAY; CONCENTRATION RESPONSE; DELETION MUTANT; GENE DELETION; GENE OVEREXPRESSION; MINIMUM INHIBITORY CONCENTRATION; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL;

ANTI-BACTERIAL AGENTS; BACTERIAL OUTER MEMBRANE PROTEINS; BACTEROIDES FRAGILIS; DRUG RESISTANCE, BACTERIAL; MEMBRANE TRANSPORT PROTEINS;

EID: 33747889706     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.00141-06     Document Type: Article

References (16)

1. Drlica, K. 2003. The mutant selection window and antimicrobial resistance. J. Antimicrob. Chemother. 52:11-17.
2. Dumus, J. L., C. Van Delden, K. Perron, and T. Kohler. 2006. Analysis of antibiotic resistance gene expression in Pseudomonas aeruginosa by quantitative real-time-PCR. FEMS Microbiol. Lett. 254:217-225.
3. Giraud, E., A. Cloeckaert, D. Kerboeuf, and E. Chaslus-Dancla. 2000. Evidence for active efflux as the primary mechanism of resistance to ciprofloxacin in Salmonella enterica serovar Typhimurium. Antimicrob. Agents Chemother. 44:1223-1228.
4. Kern, W. V., M. Oethinger, A. S. Jellen-Ritter, and S. B. Levy. 2000. Non-target gene mutations in the development of fluoroquinolone resistance in Escherichia coli. Antimicrob. Agents Chemother. 44:814-820.
5. Llanes, C., D. Hocquet, C. Vogne, D. Ali-Baitich, C. Neuwirth, and P. Plesiat. 2004. Clinical strains of Pseudomonas aeruginosa overproducing MexAB-OprM and MexXY efflux pumps simultaneously. Antimicrob. Agents Chemother. 48:1797-1802.
6. Miyamae, S., H. Nikaido, Y. Tanaka, and F. Yoshimura. 1998. Active efflux of norfloxacin by Bacteroides fragilis. Antimicrob. Agents Chemother. 42: 2119-2121.
7. Pumbwe, L., O. Ueda, F. Yoshimura, A. Chang, R. L. Smith, and H. M. Wexler. 2006. Bacteroides fragilis BmeABC efflux systems additively confer intrinsic antimicrobial resistance. J. Antimicrob. Chemother. 58:37-46.
8. 7a.Pumbwe, L., A. Chang, R. L. Smith, and H. M. Wexler. Clinical significance of overexpression of multiple RND efflux pumps in isolates of Bacteroides fragilis. J. Antimicrob. Chemother., in press.
9. Ricci, V., M. L. Peterson, J. C. Rotschafer, H. Wexler, and L. J. Piddock. 2004. Role of topoisomerase mutations and efflux in fluoroquinolone resistance of Bacteroides fragilis clinical isolates and laboratory mutants. Antimicrob. Agents Chemother. 48:1344-1346.
10. Roychoudhury, S., T. L. Twinem, K. M. Makin, M. A. Nieaber, C. Li, T. W. Morris, B. Ledoussai, and C. E. Catrenich. 2001. Staphylococcus aureus mutants isolated via exposure to nonfluorinated quinolones: detection of known and unique mutations. Antimicrob. Agents Chemother. 45:3422-3426.
11. Sanchez, P., E. Moreno, and J. L. Martinez. 2005. The biocide triclosan selects Stenotrophomonas maltophilia mutants that overproduce the SmeDEF multidrug efflux pump. Antimicrob. Agents Chemother. 49:781-782.
12. Sidhu, M. S., S. Langsrud, and A. Holck. 2001. Disinfectant and antibiotic resistance of lactic acid bacteria isolated from the food industry. Microb. Drug Resist. 7:73-83.
13. Stintzi, A., D. Marlow, K. Palyada, H. Panciera, L. Whiteworth, and C. Clarke. 2005. Use of genome-wide expression profiling and mutagenesis to study the intestinal lifestyle of Campylobacter jejuni. Infect. Immun. 73:1797-1810.
14. Ueda, O., H. M. Wexler, K. Hirai, Y. Shibata, F. Yoshimura, and S. Fujimura. 2005. Sixteen homologs of the mex-type multidrug resistance efflux pump in Bacteroides fragilis. Antimicrob. Agents Chemother. 49:2807-2815.
15. Wexler, H. M., E. Molitoris, F. Jashnian, and S. M. Finegold. 1991. Comparison of spiral gradient with conventional agar dilution for susceptibility testing of anaerobic bacteria. Antimicrob. Agents Chemother. 35:1196-1202.
16. Zhao, X., and K. Drlica. 2002. Restricting the selection of antibiotic-resistant mutant bacteria: measurement and potential use of the mutant selection window. J. Infect. Dis. 185:561-565.