Overestimation of flavonoid aglycones as a result of the ex vivo deconjugation of glucuronides by the tissue β-glucuronidase

Journal of Pharmaceutical and Biomedical Analysis

Volumn 88, Issue , 2014, Pages 364-369

  Lu, Qing Yi ^a   Zhang, Lifeng ^a   Eibl, Guido ^a   Go, Vay Liang W ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Glucuronidase inhibitor; Baicalin; D Saccharic acid 1,4 lactone; Glucuronide conjugates; Quercetin

Indexed keywords

AGLYCONE; BAICALEIN; BETA GLUCURONIDASE; FLAVONOID; GLUCURONIDE; QUERCETIN; SACCHAROLACTONE;

ANIMAL TISSUE; ARTICLE; CHEMICAL STRUCTURE; CONJUGATION; DIET SUPPLEMENTATION; DOSE RESPONSE; ENZYME ACTIVITY; EX VIVO STUDY; GLUCURONIDATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SCUTELLARIA BAICALENSIS; TUMOR XENOGRAFT;

BAICALIN; D-SACCHARIC ACID 1,4-LACTONE; GLUCURONIDE CONJUGATES; QUERCETIN; Β-GLUCURONIDASE INHIBITOR;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIETARY SUPPLEMENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; FLAVANONES; FLAVONOIDS; GLUCARIC ACID; GLUCURONIDASE; GLUCURONIDES; GLYCOPROTEINS; HUMANS; LACTONES; LIVER; LIVER NEOPLASMS; METHYLATION; MICE; PANCREAS; QUERCETIN; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84886395989     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2013.09.013     Document Type: Article

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