메뉴 건너뛰기




Volumn 41, Issue 4, 2012, Pages 571-576

Detection of baicalin metabolites baicalein and oroxylin-a in mouse pancreas and pancreatic xenografts

Author keywords

baicalein; baicalin; in vivo; oroxylin A; pancreatic cancer; Scutelleria baicalensis

Indexed keywords

AGLYCONE; BAICALIN; GLUCURONIDE; OROXYLIN A; SCUTELLARIA BAICALENSIS EXTRACT; WOGONIN;

EID: 84859990178     PISSN: 08853177     EISSN: 15364828     Source Type: Journal    
DOI: 10.1097/MPA.0b013e318232e130     Document Type: Article
Times cited : (36)

References (26)
  • 1
    • 78650250846 scopus 로고    scopus 로고
    • Identification and quantification of baicalein, wogonin, oroxylin A and their major glucuronide conjugated metabolites in rat plasma after oral administration of Radix scutellariae product
    • Li C, Zhang L, Lin G, Zuo Z. Identification and quantification of baicalein, wogonin, oroxylin A and their major glucuronide conjugated metabolites in rat plasma after oral administration of Radix scutellariae product. J Pharm Biomed Anal. 2011;54:750-758.
    • (2011) J Pharm Biomed Anal. , vol.54 , pp. 750-758
    • Li, C.1    Zhang, L.2    Lin, G.3    Zuo, Z.4
  • 2
    • 33846948642 scopus 로고    scopus 로고
    • Experimental study of therapeutic efficacy of baicalin in rats with severe acute pancreatitis
    • Zhang XP, Zhang L, He JX, et al. Experimental study of therapeutic efficacy of baicalin in rats with severe acute pancreatitis. World J Gastroenterol. 2007;13:717-724.
    • (2007) World J Gastroenterol , vol.13 , pp. 717-724
    • Zhang, X.P.1    Zhang, L.2    He, J.X.3
  • 3
    • 70350437658 scopus 로고    scopus 로고
    • Antiobesity effect of baicalin involves the modulations of proadipogenic and antiadipogenic regulators of the adipogenesis pathway
    • Lee H, Kang R, Hahn Y, et al. Antiobesity effect of baicalin involves the modulations of proadipogenic and antiadipogenic regulators of the adipogenesis pathway. Phytother Res. 2009;23:1615-1623.
    • (2009) Phytother Res , vol.23 , pp. 1615-1623
    • Lee, H.1    Kang, R.2    Hahn, Y.3
  • 4
    • 70449370069 scopus 로고    scopus 로고
    • Long-term baicalin administration ameliorates metabolic disorders and hepatic steatosis in rats given a high-fat diet
    • Guo HX, Liu DH, Ma Y, et al. Long-term baicalin administration ameliorates metabolic disorders and hepatic steatosis in rats given a high-fat diet. Acta Pharmacol Sin. 2009;30:1505-1512.
    • (2009) Acta Pharmacol Sin , vol.30 , pp. 1505-1512
    • Guo, H.X.1    Liu, D.H.2    Ma, Y.3
  • 6
    • 18844437520 scopus 로고    scopus 로고
    • Characterization of chemical constituents in Scutellaria baicalensis with antiandrogenic and growth-inhibitory activities toward prostate carcinoma
    • DOI 10.1158/1078-0432.CCR-04-1974
    • Bonham M, Posakony J, Coleman I, et al. Characterization of chemical constituents in Scutellaria baicalensis with antiandrogenic and growth-inhibitory activities toward prostate carcinoma. Clin Cancer Res. 2005;11:3905-3914. (Pubitemid 40685612)
    • (2005) Clinical Cancer Research , vol.11 , Issue.10 , pp. 3905-3914
    • Bonham, M.1    Posakony, J.2    Coleman, I.3    Montgomery, B.4    Simon, J.5    Nelson, P.S.6
  • 8
    • 79953029008 scopus 로고    scopus 로고
    • Flavonoid pharmacokinetics and tissue distribution after repeated dosing of the roots of Scutellaria baicalensis in rats
    • Hou YC, Lin SP, Tsai SY, et al. Flavonoid pharmacokinetics and tissue distribution after repeated dosing of the roots of Scutellaria baicalensis in rats. Planta Med. 2011;77:455-460.
    • (2011) Planta Med. , vol.77 , pp. 455-460
    • Hou, Y.C.1    Lin, S.P.2    Tsai, S.Y.3
  • 9
    • 0344642935 scopus 로고    scopus 로고
    • Comparison of metabolic pharmacokinetics of baicalin and baicalein in rats
    • Lai MY, Hsiu SL, Tsai SY, et al. Comparison of metabolic pharmacokinetics of baicalin and baicalein in rats. J Pharm Pharmacol. 2003;55:205-209.
    • (2003) J Pharm Pharmacol , vol.55 , pp. 205-209
    • Lai, M.Y.1    Hsiu, S.L.2    Tsai, S.Y.3
  • 10
    • 33847790184 scopus 로고    scopus 로고
    • Comparative pharmacokinetics of baicalin after oral administration of pure baicalin, Radix scutellariae extract and Huang-Lian-Jie-Du-Tang to rats
    • DOI 10.1016/j.jep.2006.09.036, PII S0378874106005137
    • Lu T, Song J, Huang F, et al. Comparative pharmacokinetics of baicalin after oral administration of pure baicalin, Radix scutellariae extract and Huang-Lian-Jie-Du-Tang to rats. J Ethnopharmacol. 2007;110:412-418. (Pubitemid 46389634)
    • (2007) Journal of Ethnopharmacology , vol.110 , Issue.3 , pp. 412-418
    • Lu, T.1    Song, J.2    Huang, F.3    Deng, Y.4    Xie, L.5    Wang, G.6    Liu, X.7
  • 11
    • 0034534704 scopus 로고    scopus 로고
    • Baicalin, the predominant flavone glucuronide of scutellariae radix, is absorbed from the rat gastrointestinal tract as the aglycone and restored to its original form
    • DOI 10.1211/0022357001777621
    • Akao T, Kawabata K, Yanagisawa E, et al. Baicalin, the predominant flavone glucuronide of Scutellariae radix, is absorbed from the rat gastrointestinal tract as the aglycone and restored to its original form. J Pharm Pharmacol. 2000;52:1563-1568. (Pubitemid 32058657)
    • (2000) Journal of Pharmacy and Pharmacology , vol.52 , Issue.12 , pp. 1563-1568
    • Akao, T.1    Kawabata, K.2    Yanagisawa, E.3    Ishihara, K.4    Mizuhara, Y.5    Wakui, Y.6    Sakashita, Y.7    Kobashi, K.8
  • 12
    • 27644442245 scopus 로고    scopus 로고
    • Absorption and enterohepatic circulation of baicalin in rats
    • DOI 10.1016/j.lfs.2005.04.072, PII S0024320505007356
    • Xing J, Chen X, Zhong D. Absorption and enterohepatic circulation of baicalin in rats. Life Sci. 2005;78:140-146. (Pubitemid 41560966)
    • (2005) Life Sciences , vol.78 , Issue.2 , pp. 140-146
    • Xing, J.1    Chen, X.2    Zhong, D.3
  • 14
    • 51349086819 scopus 로고    scopus 로고
    • Transport and metabolism of flavonoids from Chinese herbal remedy Xiaochaihu-tang across human intestinal Caco-2 cell monolayers
    • Dai JY, Yang JL, Li C. Transport and metabolism of flavonoids from Chinese herbal remedy Xiaochaihu-tang across human intestinal Caco-2 cell monolayers. Acta Pharmacol Sin. 2008;29:1086-1093.
    • (2008) Acta Pharmacol Sin , vol.29 , pp. 1086-1093
    • Dai, J.Y.1    Yang, J.L.2    Li, C.3
  • 15
    • 33947164202 scopus 로고    scopus 로고
    • Pharmacokinetics of baicalein, baicalin and wogonin after oral administration of a standardized extract of Scutellaria baicalensis, PF-2405 in rats
    • Kim YH, Jeong DW, Kim YC, et al. Pharmacokinetics of baicalein, baicalin and wogonin after oral administration of a standardized extract of Scutellaria baicalensis, PF-2405 in rats. Arch Pharm Res. 2007;30:260-265.
    • (2007) Arch Pharm Res , vol.30 , pp. 260-265
    • Kim, Y.H.1    Jeong, D.W.2    Kim, Y.C.3
  • 16
    • 84859986401 scopus 로고    scopus 로고
    • Down-regulation of Mcl-1 by baicalein induces apoptosis through the mitochondrial pathway in human pancreatic cancer cells
    • Chicago, IL. Pancreas. 2010 November 3-6
    • Takahashi H, Chen MC, Harris DM, et al. Down-regulation of Mcl-1 by baicalein induces apoptosis through the mitochondrial pathway in human pancreatic cancer cells. 41st Annual Meeting of the American Pancreatic Association, November 3-6, 2010, Chicago, IL. Pancreas. 2010;39:1350.
    • (2010) 41st Annual Meeting of the American Pancreatic Association , vol.39 , pp. 1350
    • Takahashi, H.1    Chen, M.C.2    Harris, D.M.3
  • 17
    • 25844482543 scopus 로고    scopus 로고
    • A xenograft nude mouse model for perineural invasion and recurrence in pancreatic cancer
    • DOI 10.1097/01.mpa.0000175176.40045.0f
    • Eibl G, Reber HA. A xenograft nude mouse model for perineural invasion and recurrence in pancreatic cancer. Pancreas. 2005;31:258-262. (Pubitemid 41400484)
    • (2005) Pancreas , vol.31 , Issue.3 , pp. 258-262
    • Eibl, G.1    Reber, H.A.2
  • 18
    • 23944446872 scopus 로고    scopus 로고
    • Stability of baicalin in biological fluids in vitro
    • DOI 10.1016/j.jpba.2005.03.034, PII S0731708505002670
    • Xing J, Chen X, Zhong D. Stability of baicalin in biological fluids in vitro. J Pharm Biomed Anal. 2005;39:593-600. (Pubitemid 41196068)
    • (2005) Journal of Pharmaceutical and Biomedical Analysis , vol.39 , Issue.3-4 , pp. 593-600
    • Xing, J.1    Chen, X.2    Zhong, D.3
  • 19
    • 0032566518 scopus 로고    scopus 로고
    • Deglycosylation of flavonoid and isoflavonoid glycosides by human small intestine and liver β-glucosidase activity
    • DOI 10.1016/S0014-5793(98)01101-6, PII S0014579398011016
    • Day AJ, DuPont MS, Ridley S, et al. Deglycosylation of flavonoid and isoflavonoid glycosides by human small intestine and liver beta-glucosidase activity. FEBS Lett. 1998;436:71-75. (Pubitemid 28454609)
    • (1998) FEBS Letters , vol.436 , Issue.1 , pp. 71-75
    • Day, A.J.1    Dupont, M.S.2    Ridley, S.3    Rhodes, M.4    Rhodes, M.J.C.5    Morgan, M.R.A.6    Williamson, G.7
  • 21
    • 58749114381 scopus 로고    scopus 로고
    • New therapeutic aspects of flavones: The anticancer properties of Scutellaria and its main active constituents wogonin, baicalein and baicalin
    • Li-Weber M. New therapeutic aspects of flavones: the anticancer properties of Scutellaria and its main active constituents wogonin, baicalein and baicalin. Cancer Treat Rev. 2009;35:57-68.
    • (2009) Cancer Treat Rev , vol.35 , pp. 57-68
    • Li-Weber, M.1
  • 22
    • 77950850484 scopus 로고    scopus 로고
    • Baicalin, an emerging multi-therapeutic agent: Pharmacodynamics, pharmacokinetics, and considerations from drug development perspectives
    • Srinivas NR. Baicalin, an emerging multi-therapeutic agent: pharmacodynamics, pharmacokinetics, and considerations from drug development perspectives. Xenobiotica. 2010;40:357-367.
    • (2010) Xenobiotica. , vol.40 , pp. 357-367
    • Srinivas, N.R.1
  • 23
    • 33748916241 scopus 로고    scopus 로고
    • Methylated flavonoids have greatly improved intestinal absorption and metabolic stability
    • DOI 10.1124/dmd.106.011122
    • Wen X, Walle T. Methylated flavonoids have greatly improved intestinal absorption and metabolic stability. Drug Metab Dispos. 2006;34:1786-1792. (Pubitemid 44427483)
    • (2006) Drug Metabolism and Disposition , vol.34 , Issue.10 , pp. 1786-1792
    • Wen, X.1    Walle, T.2
  • 24
    • 30144432225 scopus 로고    scopus 로고
    • Glucuronidase deconjugation in inflammation
    • DOI 10.1016/S0076-6879(05)00015-7, PII S0076687905000157, 15, Phase II Conjugation Enzymes and Transport Systems
    • Shimoi K, Nakayama T. Glucuronidase deconjugation in inflammation. Methods Enzymol. 2005;400:263-272. (Pubitemid 43052426)
    • (2005) Methods in Enzymology , vol.400 , pp. 263-272
    • Shimoi, K.1    Nakayama, T.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.