New evidence for the cerebellar involvement in personality traits

Frontiers in Behavioral Neuroscience

Volumn , Issue OCT, 2013, Pages

  Picerni, Eleonora ^a,b   Petrosini, Laura ^a,b   Piras, Fabrizio ^a   Laricchiuta, Daniela ^a,b   Cutuli, Debora ^a,b   Chiapponi, Chiara ^a   Fagioli, Sabrina ^a   Girardi, Paolo ^b   Caltagirone, Carlo ^a,c   Spalletta, Gianfranco ^a  

^a IRCCS FONDAZIONE SANTA LUCIA   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c UNIVERSITY OF ROME TOR VERGATA   (Italy)

Author keywords

Fractional anisotropy; Individual differences; Mean diffusivity; Novelty seeking; Temperamental traits; Voxel based morphometry

Indexed keywords

ADULT; ARTICLE; BRAIN SIZE; CEREBELLUM; DIFFUSION TENSOR IMAGING; FEMALE; FRACTIONAL ANISOTROPY; GRAY MATTER; HUMAN; MALE; MEAN DIFFUSIVITY; NORMAL HUMAN; PERSONALITY; PERSONALITY TEST; PHYSICAL PARAMETERS; TEMPERAMENT; TEMPERAMENT AND CHARACTER INVENTORY; WHITE MATTER;

EID: 84886301142     PISSN: 16625153     EISSN: None     Source Type: Journal    
DOI: 10.3389/fnbeh.2013.00133     Document Type: Article

References (90)

1. Anderson, C. M., Maas, L. C., Frederick, B., Bendor, J. T., Spencer, T. J., Livni, E., et al. (2006). Cerebellar vermis involve ment in cocaine-related behaviors. Neuropsychopharmacology 31, 1318-1326. doi: 10.1038/sj.npp. 1300937
2. Andersson, J., Jenkinson, M., and Smith, S. (2007). "Non-linear registration, aka Spatial normalization," in FMRIB Technical Report TR07JA2. Available online at: www.fmrib.ox.ac.uk/analysis/techrep
3. Ashburner, J. (2007). A fast diffeo-morphic image registration algorithm. Neuroimage 38, 95-113. doi: 10.1016/j.neuroimage.2007.07.007
4. Ashburner, J., and Friston, K. J. (2005). Unified segmentation. Neuroimage 26, 839-851. doi: 10.1016/j.neuroimage.2005.02.018
5. Baldaçara, L., Borgio, J. G., Moraes, W. A., Lacerda, A. L., Montaño, M. B., Tufik, S., et al. (2011). Cerebellar volume in patients with dementia. Rev. Bras. Psiquiatr. 33, 122-129.
6. Bardo, M. T., Donohew, R. L., and Harrington, N. G. (1996). Psychobiology of novelty seeking and drug seeking behavior. Behav. Brain Res. 77, 23-43. doi: 10.1016/0166-4328(95)00203-0
7. Basser, P. J., and Pierpaoli, C. (1996). Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI. J. Magn. Reson. B 111, 209-219. doi: 10.1006/jmrb.1996.0086
8. Bostan, A. C., Dum, R. P., and Strick, P. L. (2010). The basal ganglia communicate with the cerebellum. Proc. Natl. Acad. Sci. U.S.A. 107, 8452-8456. doi: 10.1073/pnas.1000496107
9. Bunzeck, N., and Düzel, E. (2006). Absolute coding of stimulus novelty in the human substantia nigra/VTA. Neuron 51, 369-379. doi: 10.1016/j.neuron.2006.06.021
10. Carlesimo, G., Caltagirone, C., and Gainotti, G. (1996). The mental deterioration battery: normative data, diagnostic reliability and qualitative analyses of cognitive impairment. the group for the standardization of the mental deterioration battery. Eur. Neurol. 36, 378-384. doi: 10.1159/000117297
11. Caston, J., Chianale, C., Delhaye-Bouchaud, N., and Mariani, J. (1998). Role of the cerebellum in exploration behavior. Brain Res. 808, 232-237. doi: 10.1016/S0006-8993(98)00847-6
12. Cloninger, C. R. (1986). A unified biosocial theory of personality and its role in the development of anxiety states. Psychiatr. Dev. 3, 167-226.
13. Cloninger, C. R. (1987). A systematic method for clinical description and classification of personality variants. Arch. Gen. Psychiatry 44, 573-588. doi: 10.1001/arch-psyc.1987.01800180093014
14. Cloninger, C. R., Svrakic, D. M., and Przybeck, T. R. (1993). A psychobi-ological model of temperament and character. Arch. Gen. Psychiatry 50, 975-990. doi: 10.1001/arch-psyc.1993.01820240059008
15. Cutuli, D., Rossi, S., Burello, L., Laricchiuta, D., De Chiara, V., Foti, F., et al. (2011). Before or after does it matter? Different protocols of environmental enrichment differently influence motor, synaptic and structural deficits of cerebellar origin. Neurobiol. Dis. 42, 9-20. doi: 10.1016/j.nbd.2010. 12.007
16. Dalwani, M., Sakai, J. T., Mikulich-Gilbertson, S. K., Tanabe, J., Raymond, K., McWilliams, S. K., et al. (2011). Reduced cortical gray matter volume in male adolescents with substance and conduct problems. Drug Alcohol Depend. 118, 295-305. doi: 10.1016/j.drugalcdep.2011.04.006
17. D'Angelo, E., and Casali, S. (2012). Seeking a unified framework for cerebellar function and dysfunction: from circuit operations to cognition. Front. Neural Circuits 6:116. doi: 10.3389/fncir.2012.00116
18. De Bellis, M. D., and Kuchibhatla, M. (2006). Cerebellar volumes in pediatric maltreatment-related posttraumatic stress disorder. Biol. Psychiatry 60, 697-703. doi: 10.1016/j.biopsych.2006.04.035
19. De Smet, H. J., Paquier, P., Verhoeven, J., and Mariën, P. (2013). The cerebellum: its role in language and related cognitive and affective functions. Brain Lang. doi: 10.1016/j.bandl.2012.11.001. [Epub ahead of print].
20. Diedrichsen, J., Balster, J. H., Flavell, J., Cussans, E., and Ramnani, N. (2009). A probabilistic MR atlas of the human cerebellum. Neuroimage 46, 39-46. doi: 10.1016/j.neuroimage.2009.01.045
21. Durston, S., van Belle, J., and De Zeeuw, P. (2011). Differentiating frontos-triatal and fronto-cerebellar circuits in attention-deficit/hyperactivity disorder. Biol. Psychiatry 69, 1178-1184. doi: 10.1016/j.biopsych. 2010.07.037
22. Ende, G., Hubrich, P., Walter, S., Weber-Fahr, W., Kammerer, N., Braus, D. F., et al. (2005). Further evidence for altered cerebellar neu-ronal integrity in schizophrenia. Am. J. Psychiatry 162, 790-792. doi: 10.1176/appi.ajp.162.4.790
23. Eysenck, H. J. (1967). The Biological Basis of Personality. Springfield, IL: Thomas. doi: 10.1038/1991031a0
24. Eysenck, H. J. (1981). "General features of the model," in A Model for Personality, ed H. J. Eysenck (Berlin: Springer-Verlag), 1-37. doi: 10.1007/978-3-642-67783-0_1
25. First, M. B., Gibbon, M., Spitzer, R. L., Williams, J. B., and Benjamin, L. S. (1997). Structured Clinical Interview for DSM-IV Axis II Personality Disorders (SCID-II). Washington, DC: American Psychiatric Press.
26. First, M. B., Spitzer, R. L., Gibbon, M., and Williams, J. B. W. (2002). Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version, Non Patient Edition (SCID-I/NP). New York, NY: Biometrics Research; New York State Psychiatric Institute.
27. Fitzgerald, P. B., Laird, A. R., Maller, J., and Daskalakis, Z. J. (2008). A meta-analytic study of changes in brain activation in depression. Hum. Brain Mapp. 29, 683-695. doi: 10.1002/hbm.20426
28. Folstein, M., Folstein, S., and McHugh, P. (1975). "Mini-mental state." A practical method for grading the cognitive state of patients for the clinician. J. Psychiatr. Res. 12, 189-198. doi: 10.1016/0022-3956(75)90026-6.
29. Fossati, A., Donati, D., Donini, M., Novella, L., Bagnato, M., and Maffei, C. (2001). Temperament, character, and attachment patterns in borderline personality disorder. J. Pers. Disord. 15, 390-402. doi: 10.1521/pedi.15.5.390.19197
30. Foti, F., Petrosini, L., Cutuli, D., Menghini, D., Chiarotti, F., Vicari, S., et al. (2011). Explorative function in Williams syndrome analyzed through a large-scale task with multiple rewards. Res. Dev. Disabil. 32, 972-985. doi: 10.1016/j.ridd.2011.02.001
31. Fransen, E., D'Hooge, R., Van Camp, G., Verhoye, M., Sijbers, J., Reyniers, E., et al. (1998). L1 knockout mice show dilated ventricles, vermis hypoplasia and impaired exploration patterns. Hum. Mol. Genet. 7, 999-1009. doi: 10.1093/hmg/7.6.999
32. Fresán, A., Apiquian, R., Nicolini, H., and Cervantes, J. J. (2007). Temperament and character in violent schizophrenic patients. Schizophr. Res. 94, 74-80. doi: 10.1016/j.schres.2007.04.005
33. Ito, M. (2008). Control of mental activities by internal models in the cerebellum. Nat. Rev. Neurosci. 9, 304-313. doi: 10.1038/nrn2332
34. Ivry, R. B., and Spencer, R. M. (2004). The neural representation of time. Curr. Opin. Neurobiol. 14, 225-232. doi: 10.1016/j.conb.2004.03.013
35. Kantarci, K., Senjem, M. L., Avula, R., Zhang, B., Samikoglu, A. R., Weigand, S. D., et al. (2011). Diffusion tensor imaging and cognitive function in older adults with no dementia. Neurology 77, 26-34. doi: 10.1212/WNL.0b013e31822313dc
36. Kelly, R. M., and Strick, P. L. (2003). Cerebellar loops with motor cortex and prefrontal cortex of a non-human primate. J. Neurosci. 23, 8432-8444.
37. Knutson, B., and Cooper, J. C. (2006). The lure of the unknown. Neuron 51, 280-282. doi: 10.1016/j.neuron.2006.07.017
38. Koziol, L. F., Budding, D. E., and Chidekel, D. (2010). Adaptation, expertise, and giftedness: towards an understanding of cortical, subcortical, and cerebellar network contributions. Cerebellum 9, 499-529. doi: 10.1007/s12311-010-0192-7
39. Kunisato, Y., Okamoto, Y., Okada, G., Aoyama, S., Nishiyama, Y., Onoda, K., et al. (2011). Personality traits and the amplitude of spontaneous low-frequency oscillations during resting state. Neurosci. Lett. 492, 109-113. doi: 10.1016/j.neulet.2011.01.067
40. Laricchiuta, D., Petrosini, L., Piras, F., Cutuli, D., Macci, E., Picerni, E., et al. (2013). Linking novelty seeking and harm avoidance personality traits to basal ganglia: vol-umetry and mean diffusivity. Brain Struct. Funct. doi: 10.1007/s00429-013-0535-5. [Epub ahead of print].
41. Laricchiuta, D., Petrosini, L., Piras, F., Macci, E., Cutuli, D., Chiapponi, C., et al. (2012). Linking novelty seeking and harm avoidance personality traits to cerebellar volumes. Hum. Brain. Mapp. doi: 10.1002/hbm.22174. [Epub ahead of print].
42. Le Bihan, D. (2007). The 'wet mind': water and functional neuro- imaging. Phys. Med. Biol. 52, R57-R90. doi: 10.1088/0031-9155/52/7/R02
43. Lisman, J. E., and Grace, A. A. (2005). The hippocampal-VTA loop: controlling the entry of information into long-term memory. Neuron 46, 703-713. doi: 10.1016/j.neuron.2005.05.002
44. Loftus, S. T., Garno, J. L., Jaeger, J., and Malhotra, A. K. (2008). Temperament and character dimensions in bipolar I disorder: a comparison to healthy controls. J. Psychiatr. Res. 42, 1131-1136. doi: 10.1016/j.jpsychires.2007.11.005
45. Mandolesi, L., Leggio, M. G., Spirito, F., and Petrosini, L. (2003). Cerebellar contribution to spatial event processing: do spatial procedures contribute to formation of spatial declarative knowledge? Eur. J. Neurosci. 18, 2618-2626. doi: 10.1046/j.1460-9568.2003.02990.x
46. Martinotti, G., Andreoli, S., Giametta, E., Poli, V., Bria, P., and Janiri, L. (2006). The dimensional assessment of personality in pathologic and social gamblers: the role of novelty seeking and self-transcendence. Compr. Psychiatry 47, 350-356. doi: 10.1016/j.comppsych.2005.12.005
47. McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., and Stadlan, E. (1984). Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA work group under the auspices of department of health and human services task force on Alzheimer's Disease. Neurology 34, 939-944. doi: 10.1212/WNL.34.7.939
48. Measso, G., Zappalà, G., Cavarzeran, F., Crook, T. H., Romani, L., Pirozzolo, F. J., et al. (1993). Raven's colored progressive matrices: a normative study of a random sample of healthy adults. Acta Neurol. Scand. 88, 70-74. doi: 10.1111/j.1600-0404.1993.tb04190.x
49. Menghini, D., Di Paola, M., Federico, F., Vicari, S., Petrosini, L., Caltagirone, C., et al. (2011). Relationship between brain abnormalities and cognitive profile in Williams syndrome. Behav. Genet. 41, 394-402. doi: 10.1007/s10519-010-9419-0
50. Merwood, A., Asherson, P., and Larsson, H. (2012). Genetic associa tions between the ADHD symptom dimensions and Cloninger's tem perament dimensions in adult twins. Eur. Neuropsychopharmacol. doi: 10.1016/j.euroneuro.2012.10.003
51. Mesulam, M. M. (1998). From sensation to cognition. Brain 121, 1013-1052. doi: 10.1093/brain/121. 6.1013
52. Middleton, F. A., and Strick, P. L. (2001). Cerebellar projections to the prefrontal cortex of the primate. J. Neurosci. 21, 700-712.
53. Minassian, A., Henry, B. L., Young, J. W., Masten, V., Geyer, M. A., and Perry, W. (2011). Repeated assessment of exploration and novelty seeking in the human behavioral pattern monitor in bipolar disorder patients and healthy individuals. PLoS ONE 6:e24185. doi: 10.1371/journal.pone.0024185
54. Molinari, M., Petrosini, L., Misciagna, S., and Leggio, M. G. (2004). Visuospatial abilities in cerebel-lar disorders. J. Neurol Neurosurg. Psychiatry 75, 235-240.
55. Müller, H. P., Unrath, A., Ludolph, A. C., and Kassubek, J. (2007). Preservation of diffusion tensor properties during spatial normalization by use of tensor imaging and fibre tracking on a normal brain database. Phys. Med. Biol. 52, N99-N109. doi: 10.1088/0031-9155/52/6/N01
56. Naatanen, R., and Michie, P. T. (1979). Early selective-attention effects on the evoked potential: a critical review and reinterpretation. Biol. Psychol. 8, 81-136. doi: 10.1016/0301-0511(79)90053-X
57. Nichols, T., and Hayasaka, S. (2003). Controlling the familywise error rate in functional neuroimag-ing: a comparative review. Stat. Methods Med. Res. 12, 419-446. doi: 10.1191/0962280203sm341ra
58. O'Gorman, R. L., Kumari, V., Williams, S. C. R., Zelaya, F. O., Connor, S. E. J., Alsop, D. C., et al. (2006). Personality factors correlate with regional cerebral perfu-sion. Neuroimage 31, 489-495. doi: 10.1016/j.neuroimage.2005.12.048
59. Oldfield, R. C. (1971). The assessment and analysis of handedness: the Edinburgh inventory. Neuropsychologia 9, 97-113. doi: 10.1016/0028-3932(71)90067-4
60. Paradiso, S., Johnson, D. L., Andreasen, N. C., O'Leary, D. S., Watkins, G. L., Ponto, L. L., et al. (1999). Cerebral blood flow changes associated with attribution of emotional valence to pleasant, unpleasant, and neutral visual stimuli in a PET study of normal subjects. Am. J. Psychiatry 156, 1618-1629.
61. Petrosini, L., Molinari, M., and Dell'Anna, M. E. (1996) Cerebellar contribution to spatial event processing: morris water maze and T-maze. Eur. J. Neurosci. 8, 1882-1896. doi: 10.1111/j.1460-9568.1996.tb01332.x
62. Pierce, K., and Courchesne, E. (2001). Evidence for a cerebellar role in reduced exploration and stereotyped behavior in autism. Biol. Psychiatry 49, 655-664. doi: 10.1016/S0006-3223(00)01008-8
63. Pierpaoli, C., Jezzard, P., Basser, P. J., Barnett, A., and Di Chiro, G. (1996). Diffusion tensor MR imaging of the human brain. Radiology 201, 637-648.
64. Pillay, S. S., Yurgelun-Todd, D. A., Bonello, C. M., Lafer, B., Fava, M., and Renshaw, P. F. (1997). A quantitative magnetic resonance imaging study of cerebral and cerebellar gray matter volume in primary unipolar major depression: relationship to treatment response and clinical severity. Biol. Psychiatry 42, 79-84. doi: 10.1016/S0006-3223 (96)00335-6
65. Piras, F., Caltagirone, C., and Spalletta, G. (2010). Working memory performance and thalamus microstructure in healthy subjects. Neuroscience 171, 496-505. doi: 10.1016/j.neuroscience.2010.09.006
66. Piras, F., Cherubini, A., Caltagirone, C., and Spalletta, G. (2011). Education mediates microstructural changes in bilateral hippocampus. Hum. Brain Mapp. 32, 282-289. doi: 10.1002/hbm.21018
67. Rae, C., Karmiloff-Smith, A., Lee, M. A., Dixon, R. M., Grant, J., Blamire, A. M., et al. (1998). Brain biochemistry in Williams syndrome: evidence for a role of the cerebellum in cognition? Neurology 51, 33-40. doi: 10.1212/WNL.51.1.33
68. Restuccia, D., Della Marca, G., Valeriani, M., Leggio, M. G., and Molinari, M. (2007). Cerebellar damage impairs detection of somatosensory input changes. A somatosensory mismatch-negativity study. Brain 130, 276-287. doi: 10.1093/brain/ awl236
69. Rochefort, C., Arabo, A., André, M., Poucet, B., Save, E., and Rondi-Reig, L. (2011). Cerebellum shapes hippocampal spatial code. Science 334, 385-389. doi: 10.1126/science. 1207403
70. Schmahmann, J. D. (1991). An emerging concept. The cere-bellar contribution to higher function. Arch. Neurol. 48, 1178-1187. doi: 10.1001/arch-neur.1991.00530230086029.
71. Schmahmann, J. D. (1996). From movement to thought: anatomic substrates of the cerebellar contribution to cognitive processing. Hum. Brain Mapp. 4, 174-198. doi: 10.1002/(SICI)1097-0193(1996)4:3<174::AID-HBM3> 3.3.CO;2-W
72. Schmahmann, J. D. (2004). Disorders of the cerebellum: ataxia, dysmetria of thought, and the cerebellar cognitive affective syndrome. J. Neuropsychiatry Clin. Neurosci. 16, 367-378. doi: 10.1176/appi. neuropsych.16.3.367
73. Schmahmann, J. D., and Sherman, J. C. (1998). The cerebellar cognitive affective syndrome. Brain 121, 2202-2205. doi: 10.1093/brain/121. 4.561
74. Schmahmann, J. D., Weilburg, J. B., and Sherman, J. C. (2007). The neuropsychiatry of the cerebellum-insights from the clinic. Cerebellum 6, 254-267. doi: 10.1080/14734220701490995
75. Schmajuk, N., Lam, Y. W., and Gray, J. A. (1996). Latent inhibition: a neural network approach. J. Exp. Psychol. Anim. Behav. Process. 22, 1029-1041. doi: 10.1037//0097-7403.22.3.321
76. Schutter, D. J. L. G., and Van Honk, J. (2009). The cerebellum in emotion regulation: a repetitive transcranial magnetic stimulation study. Cerebellum 8, 28-34. doi: 10.1007/s12311-008-0056-6
77. Schutter, D. J. L. G., Koolschijn, P. C., Peper, J. S., and Crone, E. A. (2012). The cerebellum link to neuroticism: a volumetric MRI association study in healthy volunteers. PLoS ONE 7:e37252. doi: 10.1371/journal.pone.0037252
78. Sim, M. E., Lyoo, I. K., Streeter, C. C., Covell, J., Sarid-Segal, O., Ciraulo, D. A., et al. (2007). Cerebellar gray matter volume correlates with duration of cocaine use in cocaine-dependent subjects. Neuropsycho-pharmacology 32, 2229-2237. doi: 10.1038/sj.npp.1301346
79. Sokolov, E. N. (1963). Higher nervous functions; the orienting reflex. Annu. Rev. Physiol. 25, 545-580. doi: 10.1146/annurev.ph.25.030163. 002553
80. Spalletta, G., Fagioli, S., Caltagirone, C., and Piras, F. (2012). Brain microstructure of subclinical apathy phenomenology in healthy individuals. Hum. Brain Mapp. doi: 10.1002/hbm.22137. [Epub ahead of print].
81. Stoodley, C. J., and Shmahmann, J. D. (2010). Evidence for topographic organization in the cerebellum of motor control versus cognitive and affective processing. Cortex 46, 831-844. doi: 10.1016/j.cortex. 2009.11.008
82. Stoodley, C. J., Valera, E. M., and Schmahmann, J. D. (2012). Functional topography of the cerebellum for motor and cognitive tasks: an fMRI study. Neuroimage 59, 1560-1570. doi: 10.1016/j. neuroimage.2011.08.065
83. Syková, E. (2004). Extrasynaptic volume transmission and diffusion parameters of the extracellular space. Neuroscience 129, 861-876. doi: 10.1016/j.neuroscience.2004. 06.077
84. Sykovà, E., and Nicholson, C. (2008). Diffusion in brain extracellular space. Physiol. Rev. 88, 1277-1340. doi: 10.1152/physrev.00027.2007
85. Timmann, D., and Daum, I. (2007). Cerebellar contributions to cognitive functions: a progress report after two decades of research. Cerebellum 6, 159-162. doi: 10.1080/14734220701496448
86. Torriero, S., Oliveri, M., Koch, G., Lo Gerfo, E., Salerno, S., Petrosini, L., et al. (2007). Cortical networks of procedural learning: evidence from cerebellar damage. Neuropsychologia 45, 1208-1214. doi: 10.1016/j.neuropsychologia. 2006.10.007
87. Tzourio-Mazoyer, N., Landeau, B., Papathanassiou, D., Crivello, F., Etard, O., Delcroix, N., et al. (2002). Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain. Neuroimage 15, 273-289. doi: 10.1006/nimg.2001.0978
88. Wei, L., Duan, X., Yang, Y., Liao, W., Gao, Q., Ding, J. R., et al. (2011). The synchronization of spontaneous BOLD activity predicts extraversion and neuroti-cism. Brain Res. 1419, 68-75. doi: 10.1016/j.brainres.2011.08.060
89. Wiest-Daesslé, N., Prima, S., Coupé, P., Morrissey, S. P., and Barillot, C. (2008). Rician noise removal by non-Local Means filtering for low signal-to-noise ratio MRI: applications to DT-MRI. Med. Image Comput. Assist. Interv. 11, 171-179. doi: 10.1007/978-3-540-85990-1_21
90. Zhu, J. N., Yung, W. H., Kwok-Chong Chow, B., Chan, Y. S., and Wang, J. J. (2006). The cerebellar hypothalamic circuits: potential pathways underlying cerebellar involvement in somatic-visceral integration. Brain Res. Rev. 52, 93-106. doi: 10.1016/j.brainresrev. 2006.01.003