Brain microstructure of subclinical apathy phenomenology in healthy individuals

Human Brain Mapping

Volumn 34, Issue 12, 2013, Pages 3193-3203

  Spalletta, Gianfranco ^a   Fagioli, Sabrina ^a   Caltagirone, Carlo ^a,b   Piras, Fabrizio ^a  

^a IRCCS FONDAZIONE SANTA LUCIA   (Italy)

^b UNIVERSITY OF ROME TOR VERGATA   (Italy)

Author keywords

Apathy; Diffusion tensor imaging; Healthy subjects; Prefrontal cortex; Sex differences; Thalamus

Indexed keywords

ADULT; AGED; APATHY; APATHY RATING SCALE; ARTICLE; CEREBELLUM; CLINICAL ASSESSMENT; CORPUS CALLOSUM; DAILY LIFE ACTIVITY; DEPRESSION; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; DIFFUSION TENSOR IMAGING; FEMALE; FRACTIONAL ANISOTROPY; HUMAN; IMAGE PROCESSING; MAJOR CLINICAL STUDY; MALE; MEDICAL ETHICS; MENTAL DETERIORATION; MENTAL DISEASE; MIDDLE CEREBELLAR PEDUNCLE; MINI MENTAL STATE EXAMINATION; NEUROIMAGING; OCCIPITAL LOBE; PARIETAL LOBE; PARKINSON DISEASE; PHENOMENOLOGY; PHYSIOLOGICAL PROCESS; PRECUNEUS; PREDICTION; PREFRONTAL CORTEX; PRIORITY JOURNAL; RATING SCALE; SIGNAL NOISE RATIO; SUPRAMARGINAL GYRUS; TEMPORAL LOBE; THALAMUS;

APATHY; DIFFUSION TENSOR IMAGING; HEALTHY SUBJECTS; PREFRONTAL CORTEX; SEX DIFFERENCES; THALAMUS;

ADULT; AGED; ANISOTROPY; APATHY; BRAIN; BRAIN MAPPING; DIFFUSION TENSOR IMAGING; FEMALE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MALE; MIDDLE AGED; NERVE FIBERS, MYELINATED; SEX CHARACTERISTICS; YOUNG ADULT;

EID: 84886279805     PISSN: 10659471     EISSN: 10970193     Source Type: Journal    
DOI: 10.1002/hbm.22137     Document Type: Article

References (48)

1. Basser PJ (1995): Inferring microstructural features and the physiological state of tissues from diffusion-weighted images. NMR Biomed 8:333-344.
2. Basser PJ, Pierpaoli C (1996): Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI. J Magn Reson B 111:209-219.
3. Beck AT, Steer RA (1987):Beck Depression Inventory Manual.San Antonio:Psychological Corporation.
4. Beck AT, Steer RA, Garbin MG (1988): Psychometric properties of the Beck Depression Inventory: Twenty-five years of evaluation. Clin Psychol Rev 8:77-100.
5. Benoit M, Clairet S, Koulibaly PM, Darcourt J, Robert PH (2004): Brain perfusion correlates of the apathy inventory dimensions of Alzheimer's disease. Int J Geriatr Psychiatry 19:864-869.
6. Bhatia KP, Marsden CD (1994): The behavioural and motor consequences of focal lesions of the basal ganglia in man. Brain 117:859-876.
7. Boes AD, Tranel D, Anderson SW, Nopoulos P (2008): Right anterior cingulate: A neuroanatomical correlate of aggression and defiance in boys. Behav Neurosci 122:677-684.
8. Cacciari C, Moraschi M, Di Paola M, Cherubini A, Orfei MD, Giove F, Maraviglia B, Caltagirone C, Spalletta G (2010): White matter microstructure and apathy level in amnestic mild cognitive impairment. J Alzheimers Dis 20:501-507.
9. Carlesimo GA, Caltagirone C, Gainotti G (1996): The mental deterioration battery: Normative data, diagnostic reliability and qualitative analyses of cognitive impairment. The Group for the Standardization of the Mental Deterioration Battery. Eur Neurol 36:378-384.
10. Carré JM, Fisher PM, Manuck SB, Hariri AR (2012): Interaction between trait anxiety and trait anger predict amygdala reactivity to angry facial expression in men but not women. Soc Cogn Affect Neurosci 7:213-221.
11. Craufurd D, Thompson JC, Snowden JS (2001): Behavioral changes in Huntington Disease. Neuropsychiatry Neuropsychol Behav Neurol 14:219-226.
12. Deichmann R, Schwarzbauer C, Turner R (2004): Optimisation of the 3D MDEFT sequence for anatomical brain imaging: Technical implications at 1.5 and 3 T. Neuroimage 21:757-767.
13. Domes G, Schulze L, Böttger M, Grossmann A, Hauenstein K, Wirtz PH, Heinrichs M, Herpertz SC (2010): The neural correlates of sex differences in emotional reactivity and emotion regulation. Hum Brain Mapp 31:758-769.
14. Drapier D, Drapier S, Sauleau P, Haegelen C, Raoul S, Biseul I, Peron J, Lallement F, Rivier I, Reymann JM, Edan G, Verin M, Millet B (2006): Does subthalamic nucleus stimulation induce apathy in Parkinson's disease?J Neurol 253:1083-1091.
15. Engelborghs S, Marine P, Pickut BA, Verstraeten S, De Deyn PP (2000): Loss of psychic self-activation after paramedian bithalamic infarction. Stroke 31:1762-1765.
16. Fine JG, Semrud-Clikeman M, Zhu DC (2009): Gender differences in bold activation to face photographs and video vignettes. Behav Brain Res 201:137-146.
17. First MB, Gibbon M, Spitzer RL, Williams JB, Benjamin LS (1997): Structured Clinical Interview for DSM-IV Axis II Personality Disorders (SCID-II). Washington DC: American Psychiatric Press.
18. First MB, Spitzer RL, Gibbon M, Williams JB (2002): Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version, Non Patient Edition (SCID-I/NP). New York: Biometrics Research, New York State Psychiatric Institute.
19. Folstein MF, Folstein SE, McHugh PR (1975): "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12:189-198.
20. Herrero MT, Barcia C, Navarro JM (2002): Functional anatomy of thalamus and basal ganglia. Childs Nerv Syst 18:386-404.
21. Johansen-Berg H, Behrens TE, Sillery E, Ciccarelli O, Thompson AJ, Smith SM, Matthews PM (2005): Functional-anatomical validation and individual variation of diffusion tractography-based segmentation of the human thalamus. Cereb Cortex 15:31-39.
22. Kantarci K, Petersen RC, Boeve BF, Knopman DS, Weigand SD, O'Brien PC, Shiung MM, Smith GE, Ivnik RJ, Tangalos EG, Jack CR Jr. (2005): DWI predicts future progression to Alzheimer disease in amnestic mild cognitive impairment. Neurology 64:902-904.
23. Kessler RC, McGonagle KA, Swartz M, Blazer DG, Nelson CB (1993): Sex and depression in the National Comorbidity Survey. I: Lifetime prevalence, chronicity and recurrence. J Affect Disord 29:85-96.
24. Kret ME, De Gelder B (2012): A review on sex differences in processing emotional signals. Neuropsychologia, doi:10.1016/j.neuropsychologia.2011.12.022.
25. Le Bihan D (2007): The 'wet mind': Water and functional neuroimaging. Phys Med Biol 52:R57-R90.
26. Le Jeune F, Drapier D, Bourguignon A, Peron J, Mesbah H, Drapier S, Sauleau P, Haegelen C, Travers D, Garin E, Malbert CH, Millet B, Vérin M (2009): Subthalamic nucleus stimulation in Parkinson disease induces apathy: A PET study. Neurology 73:1746-1751.
27. Lee TM, Liu HL, Chan CC, Fang SY, Gao JH (2005): Neural activities associated with emotion recognition observed in men and women. Mol Psychiatry 10:450-455.
28. Levy R, Dubois B (2006): Apathy and the functional anatomy of the prefrontal cortex-basal ganglia circuits. Cereb Cortex 16:916-928.
29. Marin RS (1990): Differential diagnosis and classification of apathy. Am J Psychiatry 147:22-30.
30. Marin RS (1991): Apathy: A neuropsychiatric syndrome. J Neuropsychiatry Clin Neurosci 3:243-254.
31. Marin RS, Firinciogullari S, Biedrzycki RC (1993): The sources of convergence between measures of apathy and depression. J Affect Disord 28:117-124.
32. Marshall GA, Fairbanks LA, Tekin S, Vinters HV, Cummings JL (2006): Neuropathological correlates of apathy in Alzheimer's disease. Dement Geriatr Cogn Disord 21:144-147.
33. Mendez MF, Adams NL, Lewandowski KS (1989): Neurobehavioral changes associated with caudate lesions. Neurology 39:349-354.
34. Migneco O, Benoit M, Koulibaly PM, Dygai I, Bertogliati C, Desvignes P, Robert PH, Malandain G, Bussiere F, Darcourt J (2001): Perfusion brain SPECT and statistical parametric mapping analysis indicate that apathy is a cingulate syndrome: A study in Alzheimer's disease and nondemented patients. Neuroimage 13:896-902.
35. Morel A, Magnin M, Jeanmonod D (1997): Multiarchitectonic and stereotactic atlas of the human thalamus. J Comp Neurol 387:588-630.
36. O'Sullivan M, Morris RG, Huckstep B, Jones DK, Williams SC, Markus HS (2004): Diffusion tensor MRI correlates with executive dysfunction in patients with ischaemic leukoaraiosis. J Neurol Neurosurg Psychiatry 75:441-447.
37. Palmer K, Di Iulio F, Varsi AE, Gianni W, Sancesario G, Caltagirone C, Spalletta G (2010): Neuropsychiatric predictors of progression from amnestic-mild cognitive impairment to Alzheimer's disease: The role of depression and apathy. J Alzheimers Dis 20:175-183.
38. Roth RM, Koven NS, Pendergrass JC, Flashman LA, McAllister TW, Saykin AJ (2008): Apathy and the processing of novelty in schizophrenia. Schizophr Res 98:232-238.
39. Starkstein SE (2000): Apathy and withdrawal. Int Psychogeriatr 12:135-138.
40. Starkstein SE, Leentjens AF (2008): The nosological position of apathy in clinical practice. J Neurol Neurosurg Psychiatry 79:1088-1092.
41. Starkstein SE, Mayberg HS, Preziosi TJ, Andrezejewski P, Leiguarda R, Robinson RG (1992): Reliability, validity, and clinical correlates of apathy in Parkinson's disease. J Neuropsychiatry Clin Neurosci 4:134-139.
42. Starkstein SE, Fedoroff JP, Price TR, Leiguarda R, Robinson RG (1993): Apathy following cerebrovascular lesions. Stroke 24:1625-1630.
43. Starkstein SE, Migliorelli R, Manes F, Teson A, Petracca G, Chemerinsky E, Sabe L, Leiguarda R (1995): The prevalence and clinical correlates of apathy and irritability in Alzheimer's disease. Eur J Neurol 2:540-546.
44. Starkstein SE, Jorge R, Mizrahi R, Robinson RG (2006): A prospective longitudinal study of apathy in Alzheimer's disease. J Neurol Neurosurg Psychiatry 77:8-11.
45. Starkstein SE, Merello M, Brockman S, Bruce D, Petracca G, Power BD (2009): Apathy predicts more severe parkinsonism in Alzheimer's disease. Am J Geriatr Psychiatry 17:291-298.
46. Sykova E (2004): Extrasynaptic volume transmission and diffusion parameters of the extracellular space. Neuroscience 129:861-876.
47. Sykova E, Nicholson C (2008): Diffusion in brain extracellular space. Physiol Rev 88:1277-1340.
48. van der Plas EA, Boes AD, Wemmie JA, Tranel D, Nopoulos P (2010): Amygdala volume correlates positively with fearfulness in normal healthy girls. Soc Cogn Affect Neurosci 5:424-431.