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Volumn 14, Issue 2, 2004, Pages 225-232

The neural representation of time

Author keywords

Conditioned response; CR; fMRI; Functional magnetic resonance imaging; Parkinson's disease; PD; SMA; Supplementary motor area

Indexed keywords

BASAL GANGLION; BRAIN FUNCTION; CEREBELLUM CORTEX; CEREBELLUM DISEASE; CONDITIONING; CORPUS STRIATUM; DECISION MAKING; DISCRIMINATIVE STIMULUS; EXTRAPYRAMIDAL SYNDROME; EYELID REFLEX; HUMAN; HYPOTHESIS; INHIBITORY POSTSYNAPTIC POTENTIAL; MODEL; MOTOR COORDINATION; MOTOR PERFORMANCE; NEUROPHYSIOLOGY; NUCLEAR MAGNETIC RESONANCE IMAGING; PARKINSON DISEASE; PERCEPTION; PRIORITY JOURNAL; PUTAMEN; REVIEW; TASK PERFORMANCE; TIME; TRANSCRANIAL MAGNETIC STIMULATION;

EID: 1842785708     PISSN: 09594388     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.conb.2004.03.013     Document Type: Review
Times cited : (650)

References (73)
  • 2
    • 0042845807 scopus 로고    scopus 로고
    • Brain activation patterns during measurement of sub- and supra-second intervals
    • The authors present a study in which fMRI was used to identify brain systems engaged during a duration discrimination task. The control task required judgments of stimulus length. Three aspects of this study are noteworthy. First, the psychophysical methods ensured that experimental and control tasks were of comparable difficulty and, unlike many similar studies, participants had to attend to the stimulus for its entire duration in both conditions. Second, primary analyses focus on direct comparison of the two conditions rather than a comparison of each to a resting baseline. Third, scanning parameters ensured excellent coverage of cortex and cerebellum.
    • Lewis P.A., Miall R.C. Brain activation patterns during measurement of sub- and supra-second intervals. Neuropsychologia. 41:2003;1583-1592 The authors present a study in which fMRI was used to identify brain systems engaged during a duration discrimination task. The control task required judgments of stimulus length. Three aspects of this study are noteworthy. First, the psychophysical methods ensured that experimental and control tasks were of comparable difficulty and, unlike many similar studies, participants had to attend to the stimulus for its entire duration in both conditions. Second, primary analyses focus on direct comparison of the two conditions rather than a comparison of each to a resting baseline. Third, scanning parameters ensured excellent coverage of cortex and cerebellum.
    • (2003) Neuropsychologia , vol.41 , pp. 1583-1592
    • Lewis, P.A.1    Miall, R.C.2
  • 3
    • 0038396144 scopus 로고    scopus 로고
    • Distinct systems for automatic and cognitively controlled time measurement: Evidence from neuroimaging
    • Lewis P.A., Miall R.C. Distinct systems for automatic and cognitively controlled time measurement: evidence from neuroimaging. Curr Opin Neurobiol. 13:2003;250-255.
    • (2003) Curr Opin Neurobiol , vol.13 , pp. 250-255
    • Lewis, P.A.1    Miall, R.C.2
  • 4
    • 0039405043 scopus 로고    scopus 로고
    • Emergent versus programmed temporal properties of movement sequences
    • Edited by Helfrich H. Seattle, WA: Hogrefe & Huber;
    • Semjen A: Emergent versus programmed temporal properties of movement sequences. In Time and Mind Edited by Helfrich H. Seattle, WA: Hogrefe & Huber; 1996:25-43.
    • (1996) Time and Mind , pp. 25-43
    • Semjen, A.1
  • 5
    • 85131184870 scopus 로고
    • Preliminaries to a theory of action with reference to vision
    • Edited by Bransford R. Hillsdale NJ: Lawerence Erlbaum;
    • Turvey MT: Preliminaries to a theory of action with reference to vision. In Perceiving, Acting and Knowing. Edited by Bransford R. Hillsdale NJ: Lawerence Erlbaum; 1977:211-265.
    • (1977) Perceiving, Acting and Knowing , pp. 211-265
    • Turvey, M.T.1
  • 6
    • 0346991680 scopus 로고    scopus 로고
    • Modeling effects of rhythmic context on perceived duration: A comparison of interval and entrainment approaches to short-interval timing
    • McAuley J.D., Jones M.R. Modeling effects of rhythmic context on perceived duration: a comparison of interval and entrainment approaches to short-interval timing. J Exp Psychol Hum Percept Perform. 29:2003;1102-1125.
    • (2003) J Exp Psychol Hum Percept Perform , vol.29 , pp. 1102-1125
    • McAuley, J.D.1    Jones, M.R.2
  • 8
    • 0037022342 scopus 로고    scopus 로고
    • Cerebellar cortical inhibition and classical eyeblink conditioning
    • Bao S.W., Chen L., Kim J.J., Thompson R.F. Cerebellar cortical inhibition and classical eyeblink conditioning. Proc Natl Acad Sci U S A. 99:2002;1592-1597.
    • (2002) Proc Natl Acad Sci U S a , vol.99 , pp. 1592-1597
    • Bao, S.W.1    Chen, L.2    Kim, J.J.3    Thompson, R.F.4
  • 9
    • 0027456994 scopus 로고
    • Cerebellar cortex lesions disrupt learning-dependent timing of conditioned eyelid responses
    • Perrett S.P., Ruiz B.P., Mauk M.D. Cerebellar cortex lesions disrupt learning-dependent timing of conditioned eyelid responses. J Neurosci. 13:1993;1708-1718.
    • (1993) J Neurosci , vol.13 , pp. 1708-1718
    • Perrett, S.P.1    Ruiz, B.P.2    Mauk, M.D.3
  • 10
    • 0345293114 scopus 로고    scopus 로고
    • Purkinje cell activity during learning a new timing in classical eyeblink conditioning
    • The authors made single unit recordings in the cerebellar lobule HVI of decerebrate guinea pigs during eyeblink conditioning with the initial interval between the conditioned and unconditioned stimuli set to 250 ms, followed by transfer to an interval of 400 ms. The majority of cells showed time-dependent response to the conditioned stimulus, although the pattern could be excitatory, inhibitory, or complex. However, the profile of individual cells was uncorrelated for the two inter-response intervals (ISIs). Their results stand against the hypothesis that the new timing is learned by simple shift of output properties of learning-related cells; rather, learning of new timing required recruitment of different neural populations within the cerebellum.
    • Kotani S., Kawahara S., Kirino Y. Purkinje cell activity during learning a new timing in classical eyeblink conditioning. Brain Res. 994:2003;193-202 The authors made single unit recordings in the cerebellar lobule HVI of decerebrate guinea pigs during eyeblink conditioning with the initial interval between the conditioned and unconditioned stimuli set to 250 ms, followed by transfer to an interval of 400 ms. The majority of cells showed time-dependent response to the conditioned stimulus, although the pattern could be excitatory, inhibitory, or complex. However, the profile of individual cells was uncorrelated for the two inter-response intervals (ISIs). Their results stand against the hypothesis that the new timing is learned by simple shift of output properties of learning-related cells; rather, learning of new timing required recruitment of different neural populations within the cerebellum.
    • (2003) Brain Res , vol.994 , pp. 193-202
    • Kotani, S.1    Kawahara, S.2    Kirino, Y.3
  • 11
    • 0141766906 scopus 로고    scopus 로고
    • Cerebellar LTD and learning-dependent timing of conditioned eyelid responses
    • The authors conducted eyeblink conditioning in transgenic L7-PKCi mice, a knockout species in which LTD at the parallel fiber-Purkinje synapse in cerebellar cortex is impaired by inhibition of protein kinase C. These animals developed conditioned responses over a multi-day training session, although at lower levels compared to wild type littermates. The peak amplitude was much earlier in the mutants and remained maladaptively timed when the interval between the conditioned and the unconditioned stimulus was lengthened.
    • Koekkoek S.K.E., Hulscher H.C., Dortland B.R., Hensbroek R.A., Elgersma Y., Ruigrok T.J.H., DeZeeuw C.I. Cerebellar LTD and learning-dependent timing of conditioned eyelid responses. Science. 301:2003;1736-1739 The authors conducted eyeblink conditioning in transgenic L7-PKCi mice, a knockout species in which LTD at the parallel fiber-Purkinje synapse in cerebellar cortex is impaired by inhibition of protein kinase C. These animals developed conditioned responses over a multi-day training session, although at lower levels compared to wild type littermates. The peak amplitude was much earlier in the mutants and remained maladaptively timed when the interval between the conditioned and the unconditioned stimulus was lengthened.
    • (2003) Science , vol.301 , pp. 1736-1739
    • Koekkoek, S.K.E.1    Hulscher, H.C.2    Dortland, B.R.3    Hensbroek, R.A.4    Elgersma, Y.5    Ruigrok, T.J.H.6    Dezeeuw, C.I.7
  • 12
    • 0032801643 scopus 로고    scopus 로고
    • Failure of cerebellar patients to time finger opening precisely causes ball high-low inaccuracy in overarm throws
    • Timmann D., Watts S., Hore J. Failure of cerebellar patients to time finger opening precisely causes ball high-low inaccuracy in overarm throws. J Neurophysiol. 2:1999;103-114.
    • (1999) J Neurophysiol , vol.2 , pp. 103-114
    • Timmann, D.1    Watts, S.2    Hore, J.3
  • 13
    • 1442286470 scopus 로고    scopus 로고
    • Overarm throwing speed in cerebellar subjects: Effect of timing of ball release
    • McNaughton S., Timmann D., Watts S., Hore J. Overarm throwing speed in cerebellar subjects: effect of timing of ball release. Exp Brain Res. 154:2004;470-478.
    • (2004) Exp Brain Res , vol.154 , pp. 470-478
    • McNaughton, S.1    Timmann, D.2    Watts, S.3    Hore, J.4
  • 14
    • 0032787485 scopus 로고    scopus 로고
    • Internal models for motor control and trajectory planning
    • Kawato M. Internal models for motor control and trajectory planning. Curr Opin Neurobiol. 9:1999;718-727.
    • (1999) Curr Opin Neurobiol , vol.9 , pp. 718-727
    • Kawato, M.1
  • 15
    • 7744224927 scopus 로고    scopus 로고
    • A cognitive neuroscience perspective on bimanual coordination and interference
    • Edited by Swinnen SP, Duyens J. Norwell, MA: Kluwer Academic; in press.
    • Ivry RB, Diedrichsen J, Spencer RMC, Hazeltine E, Semjen A: A cognitive neuroscience perspective on bimanual coordination and interference. In Interlimb Coordination. Edited by Swinnen SP, Duyens J. Norwell, MA: Kluwer Academic; in press.
    • Interlimb Coordination
    • Ivry, R.B.1    Diedrichsen, J.2    Spencer, R.M.C.3    Hazeltine, E.4    Semjen, A.5
  • 17
    • 0038103613 scopus 로고    scopus 로고
    • Disrupted timing of discontinuous movements by cerebellar lesions
    • Previous studies (Zelaznik et al. [73]) had shown that individual differences in timing acuity were not correlated between rhythmic production tasks in which the movements involved discontinuities between successive cycles (slight pause or contact with response surface) and rhythmic production tasks in which the movements were produced in a smooth, continuous manner. As predicted, patients with cerebellar lesions were selectively impaired on the tasks involving discontinuities. The lack of impairment on the continuous tasks is especially striking given that these movements required coordination across multiple joints and involved significant interaction torques.
    • Spencer R.M.C., Zelaznik H.N., Diedrichsen J., Ivry R.B. Disrupted timing of discontinuous movements by cerebellar lesions. Science. 300:2003;1437-1439 Previous studies (Zelaznik et al. [73]) had shown that individual differences in timing acuity were not correlated between rhythmic production tasks in which the movements involved discontinuities between successive cycles (slight pause or contact with response surface) and rhythmic production tasks in which the movements were produced in a smooth, continuous manner. As predicted, patients with cerebellar lesions were selectively impaired on the tasks involving discontinuities. The lack of impairment on the continuous tasks is especially striking given that these movements required coordination across multiple joints and involved significant interaction torques.
    • (2003) Science , vol.300 , pp. 1437-1439
    • Spencer, R.M.C.1    Zelaznik, H.N.2    Diedrichsen, J.3    Ivry, R.B.4
  • 18
    • 1542346218 scopus 로고    scopus 로고
    • Does the representation of time depend on the cerebellum? Effect of cerebellar stroke
    • The authors provide the most thorough attempt to date to specify subregions within the cerebellum that are essential for accurate timing on production and perception tasks. The authors focus on the lack of a consistent impairment in the group of patients, arguing that the results challenge a central role for the cerebellum in temporal processing. However, this acceptance of the null hypothesis is questionable given that patients with lesions in the superior cerebellum exhibited increased variability on a rhythmic tapping task and a marginally significant increase (p = 0.07) on a duration discrimination task. The superior cerebellum was defined as lobules superior to lobulus semilunaris inferior (above Crus II), and the lesions extended into the dentate nucleus in some of the patients.
    • Harrington D.L., Lee R.R., Boyd L.A., Rapcsak S.Z., Knight R.T. Does the representation of time depend on the cerebellum? Effect of cerebellar stroke. Brain. 127:2004;561-574 The authors provide the most thorough attempt to date to specify subregions within the cerebellum that are essential for accurate timing on production and perception tasks. The authors focus on the lack of a consistent impairment in the group of patients, arguing that the results challenge a central role for the cerebellum in temporal processing. However, this acceptance of the null hypothesis is questionable given that patients with lesions in the superior cerebellum exhibited increased variability on a rhythmic tapping task and a marginally significant increase (p = 0.07) on a duration discrimination task. The superior cerebellum was defined as lobules superior to lobulus semilunaris inferior (above Crus II), and the lesions extended into the dentate nucleus in some of the patients.
    • (2004) Brain , vol.127 , pp. 561-574
    • Harrington, D.L.1    Lee, R.R.2    Boyd, L.A.3    Rapcsak, S.Z.4    Knight, R.T.5
  • 19
    • 0036148629 scopus 로고    scopus 로고
    • Dissecting the brain's internal clock: How frontal-striatal circuitry keeps time and shifts attention
    • The authors present a concise review that focuses on hypothesized functions of frontal-striatal circuitry for temporal processing tasks. The article provides an overview of the component operations that constitute the scalar timing model, including timing, attention, and memory processes, and reviews how lesion and imaging studies suggest differential roles for cortical and basal ganglia regions in the instantiation of these processes.
    • Meck W.H., Benson A.M. Dissecting the brain's internal clock: how frontal-striatal circuitry keeps time and shifts attention. Brain Cogn. 48:2002;195-211 The authors present a concise review that focuses on hypothesized functions of frontal-striatal circuitry for temporal processing tasks. The article provides an overview of the component operations that constitute the scalar timing model, including timing, attention, and memory processes, and reviews how lesion and imaging studies suggest differential roles for cortical and basal ganglia regions in the instantiation of these processes.
    • (2002) Brain Cogn , vol.48 , pp. 195-211
    • Meck, W.H.1    Benson, A.M.2
  • 20
    • 0042666924 scopus 로고    scopus 로고
    • Interval timing and the encoding of signal duration by ensembles of cortical and striatal neurons
    • Matell M.S., Meck W.H., Nicolelis M.A.L. Interval timing and the encoding of signal duration by ensembles of cortical and striatal neurons. Behav Neurosci. 117:2003;760-773.
    • (2003) Behav Neurosci , vol.117 , pp. 760-773
    • Matell, M.S.1    Meck, W.H.2    Nicolelis, M.A.L.3
  • 21
    • 0037082990 scopus 로고    scopus 로고
    • Separating storage from retrieval dysfunction of temporal memory in Parkinson's disease
    • Malapani C., Deweer B., Gibbon J. Separating storage from retrieval dysfunction of temporal memory in Parkinson's disease. J Cogn Neurosci. 14:2002;311-322.
    • (2002) J Cogn Neurosci , vol.14 , pp. 311-322
    • Malapani, C.1    Deweer, B.2    Gibbon, J.3
  • 23
    • 0026517853 scopus 로고
    • Temporal discrimination is abnormal in Parkinson's disease
    • Artieda J., Pastor M.A., Lacruz F., Obeso J.A. Temporal discrimination is abnormal in Parkinson's disease. Brain. 115:1992;199-210.
    • (1992) Brain , vol.115 , pp. 199-210
    • Artieda, J.1    Pastor, M.A.2    Lacruz, F.3    Obeso, J.A.4
  • 24
    • 0023794203 scopus 로고
    • Dissociation of the lateral and medial cerebellum in movement timing and movement execution
    • Ivry R.B., Keele S.W., Diener H.C. Dissociation of the lateral and medial cerebellum in movement timing and movement execution. Exp Brain Res. 73:1988;167-180.
    • (1988) Exp Brain Res , vol.73 , pp. 167-180
    • Ivry, R.B.1    Keele, S.W.2    Diener, H.C.3
  • 25
    • 0033175773 scopus 로고    scopus 로고
    • Neuropharmacological evidence for different timing mechanisms in humans
    • Rammsayer T. Neuropharmacological evidence for different timing mechanisms in humans. Q J Exp Psychol. 52:1999;273-286.
    • (1999) Q J Exp Psychol , vol.52 , pp. 273-286
    • Rammsayer, T.1
  • 26
    • 0035990439 scopus 로고    scopus 로고
    • Speech perception deficits in Parkinson's disease: Underestimation of time intervals compromises identification of durational phonetic contrasts
    • Graeber S., Hertrich I., Daum I., Spieker S., Ackermann H. Speech perception deficits in Parkinson's disease: underestimation of time intervals compromises identification of durational phonetic contrasts. Brain Lang. 82:2002;65-74.
    • (2002) Brain Lang , vol.82 , pp. 65-74
    • Graeber, S.1    Hertrich, I.2    Daum, I.3    Spieker, S.4    Ackermann, H.5
  • 28
    • 0024813139 scopus 로고
    • Timing functions of the cerebellum
    • Ivry R.B., Keele S.W. Timing functions of the cerebellum. J Cogn Neurosci. 1:1989;136-152.
    • (1989) J Cogn Neurosci , vol.1 , pp. 136-152
    • Ivry, R.B.1    Keele, S.W.2
  • 29
    • 0030005049 scopus 로고    scopus 로고
    • The accuracy and precision of timing of self-paced, repetitive movements in subjects with Parkinson's disease
    • O'Boyle D.J., Freeman J.S., Cody F.W.J. The accuracy and precision of timing of self-paced, repetitive movements in subjects with Parkinson's disease. Brain. 119:1996;51-70.
    • (1996) Brain , vol.119 , pp. 51-70
    • O'Boyle, D.J.1    Freeman, J.S.2    Cody, F.W.J.3
  • 30
    • 18844406517 scopus 로고    scopus 로고
    • Effects of focal basal ganglia lesions on timing and force control
    • in press.
    • Aparicio PD, Diedrichsen J, Ivry RB: Effects of focal basal ganglia lesions on timing and force control. Brain Cogn in press.
    • Brain Cogn
    • Aparicio, P.D.1    Diedrichsen, J.2    Ivry, R.B.3
  • 31
    • 0036027842 scopus 로고    scopus 로고
    • Cortical involvement in temporal reproduction: Evidence for differential roles of the hemispheres
    • Kagerer F.A., Wittmann M., Szelag E., Von Steinbuchel N. Cortical involvement in temporal reproduction: evidence for differential roles of the hemispheres. Neuropsychologia. 40:2002;357-366.
    • (2002) Neuropsychologia , vol.40 , pp. 357-366
    • Kagerer, F.A.1    Wittmann, M.2    Szelag, E.3    Von Steinbuchel, N.4
  • 33
    • 0034419717 scopus 로고    scopus 로고
    • Hemispheric asymmetries: Attention to visual and auditory primitives
    • Robertson L.C., Ivry R. Hemispheric asymmetries: attention to visual and auditory primitives. Curr Dir Psychol Sci. 9:2000;59-63.
    • (2000) Curr Dir Psychol Sci , vol.9 , pp. 59-63
    • Robertson, L.C.1    Ivry, R.2
  • 34
    • 0038694713 scopus 로고    scopus 로고
    • The analysis of speech in different temporal integration windows: Cerebral lateralization as 'asymmetric sampling time'
    • Poeppel D. The analysis of speech in different temporal integration windows: cerebral lateralization as 'asymmetric sampling time'. Speech Commun. 41:2003;245-255.
    • (2003) Speech Commun , vol.41 , pp. 245-255
    • Poeppel, D.1
  • 35
    • 0031892817 scopus 로고    scopus 로고
    • Cortical networks underlying mechanisms of time perception
    • Harrington D.L., Haaland K.Y., Knight R.T. Cortical networks underlying mechanisms of time perception. J Neurosci. 18:1998;1085-1095.
    • (1998) J Neurosci , vol.18 , pp. 1085-1095
    • Harrington, D.L.1    Haaland, K.Y.2    Knight, R.T.3
  • 36
    • 0037777709 scopus 로고    scopus 로고
    • Underestimation of time perception after repetitive transcranial magnetic stimulation
    • Koch G., Oliveri M., Torriero S., Caltagirone C. Underestimation of time perception after repetitive transcranial magnetic stimulation. Neurology. 60:2003;1844-1846.
    • (2003) Neurology , vol.60 , pp. 1844-1846
    • Koch, G.1    Oliveri, M.2    Torriero, S.3    Caltagirone, C.4
  • 37
    • 0036175335 scopus 로고    scopus 로고
    • Activation of the supplementary motor area and of attentional networks during temporal processing
    • Macar F., Lejeune H., Bonnet M., Ferrara A., Pouthas V., Vidal F., Maquet P. Activation of the supplementary motor area and of attentional networks during temporal processing. Exp Brain Res. 142:2002;475-485.
    • (2002) Exp Brain Res , vol.142 , pp. 475-485
    • MacAr, F.1    Lejeune, H.2    Bonnet, M.3    Ferrara, A.4    Pouthas, V.5    Vidal, F.6    Maquet, P.7
  • 38
  • 39
    • 0141869845 scopus 로고    scopus 로고
    • A right hemispheric frontocerebellar network for time discrimination of several hundreds of milliseconds
    • Smith A., Taylor E., Lidzba K., Rubia K. A right hemispheric frontocerebellar network for time discrimination of several hundreds of milliseconds. Neuroimage. 20:2003;344-350.
    • (2003) Neuroimage , vol.20 , pp. 344-350
    • Smith, A.1    Taylor, E.2    Lidzba, K.3    Rubia, K.4
  • 40
    • 0037219939 scopus 로고    scopus 로고
    • Processing of temporal information in the basal ganglia: New evidence from fMRI
    • Nenadic I., Gaser C., Volz H.-P., Rammsayer T., Hager F., Sauer H. Processing of temporal information in the basal ganglia: new evidence from fMRI. Exp Brain Res. 148:2003;238-246.
    • (2003) Exp Brain Res , vol.148 , pp. 238-246
    • Nenadic, I.1    Gaser, C.2    Volz, H.-P.3    Rammsayer, T.4    Hager, F.5    Sauer, H.6
  • 41
    • 0036891182 scopus 로고    scopus 로고
    • Cortical and subcortical networks underlying syncopated and synchronized coordination revealed using fMRI
    • Mayville J.M., Jantzen K.J., Fuchs A., Steinberg F.L., Kelso J.A.S. Cortical and subcortical networks underlying syncopated and synchronized coordination revealed using fMRI. Hum Brain Mapp. 17:2002;214-229.
    • (2002) Hum Brain Mapp , vol.17 , pp. 214-229
    • Mayville, J.M.1    Jantzen, K.J.2    Fuchs, A.3    Steinberg, F.L.4    Kelso, J.A.S.5
  • 42
    • 0037319244 scopus 로고    scopus 로고
    • Neural networks for the coordination of the hands in time
    • Ullen F., Forssberg H., Ehrsson H.H. Neural networks for the coordination of the hands in time. J Neurophysiol. 89:2003;1126-1135.
    • (2003) J Neurophysiol , vol.89 , pp. 1126-1135
    • Ullen, F.1    Forssberg, H.2    Ehrsson, H.H.3
  • 44
    • 0036796869 scopus 로고    scopus 로고
    • Learning of sequences of finger movements and timing: Frontal lobe and action-oriented representation
    • The authors report an fMRI experiment of motor learning in which two variables were manipulated. First, the sequence of finger movements was either specified or random. Second, the timing of the stimuli specifying the responses was fixed or random. fMRI analyses focused on activation increases and decreases over training sessions associated with the finger sequence alone, the timing sequence alone, or both. Areas activated in the two conditions in which temporal learning was possible were limited to the contralateral inferior parietal lobe and ipsilateral cerebellar hemisphere.
    • Sakai K., Ramnani N., Passingham R.E. Learning of sequences of finger movements and timing: frontal lobe and action-oriented representation. J Neurophysiol. 88:2002;2035-2046 The authors report an fMRI experiment of motor learning in which two variables were manipulated. First, the sequence of finger movements was either specified or random. Second, the timing of the stimuli specifying the responses was fixed or random. fMRI analyses focused on activation increases and decreases over training sessions associated with the finger sequence alone, the timing sequence alone, or both. Areas activated in the two conditions in which temporal learning was possible were limited to the contralateral inferior parietal lobe and ipsilateral cerebellar hemisphere.
    • (2002) J Neurophysiol , vol.88 , pp. 2035-2046
    • Sakai, K.1    Ramnani, N.2    Passingham, R.E.3
  • 45
    • 0041355709 scopus 로고    scopus 로고
    • Coding in auditory space
    • Konishi M. Coding in auditory space. Annu Rev Neurosci. 26:2003;31-55.
    • (2003) Annu Rev Neurosci , vol.26 , pp. 31-55
    • Konishi, M.1
  • 46
    • 0014183876 scopus 로고
    • Is the cerebellar cortex a biological clock in the millisecond range?
    • Braitenberg V. Is the cerebellar cortex a biological clock in the millisecond range? Prog Brain Res. 25:1967;334-346.
    • (1967) Prog Brain Res , vol.25 , pp. 334-346
    • Braitenberg, V.1
  • 48
    • 0344787262 scopus 로고
    • Scalar expectancy theory and Weber's Law in animal timing
    • Gibbon J. Scalar expectancy theory and Weber's Law in animal timing. Psychol Rev. 84:1977;279-325.
    • (1977) Psychol Rev , vol.84 , pp. 279-325
    • Gibbon, J.1
  • 49
    • 0037447234 scopus 로고    scopus 로고
    • Timing of neural responses in cortical organotypic slices
    • Reliably timed action potentials occurring up to 300 ms after stimulus onset are observed in an organotypic cortical slice preparation obtained from rat auditory cortex. The late responses are attributed to the intrinsic dynamics of the neural network, consistent with modeling work in which slow physiological processes are hypothesized to be capable of processing temporal information in the order of hundreds of milliseconds. The authors hypothesize that timing in this range could be a local process, reflected in the dynamics of neurons recruited in a task-specific manner.
    • Buonomano D.V. Timing of neural responses in cortical organotypic slices. Proc Natl Acad Sci U S A. 100:2003;4897-4902 Reliably timed action potentials occurring up to 300 ms after stimulus onset are observed in an organotypic cortical slice preparation obtained from rat auditory cortex. The late responses are attributed to the intrinsic dynamics of the neural network, consistent with modeling work in which slow physiological processes are hypothesized to be capable of processing temporal information in the order of hundreds of milliseconds. The authors hypothesize that timing in this range could be a local process, reflected in the dynamics of neurons recruited in a task-specific manner.
    • (2003) Proc Natl Acad Sci U S a , vol.100 , pp. 4897-4902
    • Buonomano, D.V.1
  • 50
    • 85047681116 scopus 로고    scopus 로고
    • What is a moment? Transient synchrony as a collective mechanism for spatiotemporal integration
    • Hopfield J.J., Brody C.D. What is a moment? Transient synchrony as a collective mechanism for spatiotemporal integration. Proc Natl Acad Sci U S A. 98:2001;1282-1287.
    • (2001) Proc Natl Acad Sci U S a , vol.98 , pp. 1282-1287
    • Hopfield, J.J.1    Brody, C.D.2
  • 51
    • 0038664386 scopus 로고    scopus 로고
    • Representation of time by neurons in the posterior parietal cortex of the macaque
    • Animals were trained to judge the duration of a visual stimulus and indicate their response with an eye movement after an extended delay. Neural activity was time-dependent during the stimulus period, indicating that the cells were not simply recruited at the time of the response. However, it remains plausible that the neural activity reflects the dynamics of decision processes with temporal coding originating upstream.
    • Leon M.I., Shadlen M.N. Representation of time by neurons in the posterior parietal cortex of the macaque. Neuron. 38:2003;317-327 Animals were trained to judge the duration of a visual stimulus and indicate their response with an eye movement after an extended delay. Neural activity was time-dependent during the stimulus period, indicating that the cells were not simply recruited at the time of the response. However, it remains plausible that the neural activity reflects the dynamics of decision processes with temporal coding originating upstream.
    • (2003) Neuron , vol.38 , pp. 317-327
    • Leon, M.I.1    Shadlen, M.N.2
  • 52
    • 0034143330 scopus 로고    scopus 로고
    • Decoding temporal information: A model based on short-term synaptic plasticity
    • Buonomano D.V. Decoding temporal information: a model based on short-term synaptic plasticity. J Neurosci. 20:2000;1129-1141.
    • (2000) J Neurosci , vol.20 , pp. 1129-1141
    • Buonomano, D.V.1
  • 53
    • 0142157650 scopus 로고    scopus 로고
    • Timing and neural encoding of somatosensory parametric working memory in macaque prefrontal cortex
    • Brody C.D., Hernandez A., Antonio Z., Romo R. Timing and neural encoding of somatosensory parametric working memory in macaque prefrontal cortex. Cereb Cortex. 13:2003;1196-1207.
    • (2003) Cereb Cortex , vol.13 , pp. 1196-1207
    • Brody, C.D.1    Hernandez, A.2    Antonio, Z.3    Romo, R.4
  • 54
    • 0041817612 scopus 로고    scopus 로고
    • Context-related representation of timing processes in monkey motor cortex
    • Roux S., Coulmance M., Riehle A. Context-related representation of timing processes in monkey motor cortex. Eur J Neurosci. 18:2003;1011-1016.
    • (2003) Eur J Neurosci , vol.18 , pp. 1011-1016
    • Roux, S.1    Coulmance, M.2    Riehle, A.3
  • 55
    • 0034796381 scopus 로고    scopus 로고
    • Neural basis of a perceptual decision in the parietal cortex (area LIP) of the rhesus monkey
    • Shadlen M.N., Newsome W.T. Neural basis of a perceptual decision in the parietal cortex (area LIP) of the rhesus monkey. J Neurophysiol. 86:2001;1916-1936.
    • (2001) J Neurophysiol , vol.86 , pp. 1916-1936
    • Shadlen, M.N.1    Newsome, W.T.2
  • 56
    • 0037148831 scopus 로고    scopus 로고
    • Numerical representation for action in the parietal cortex of the monkey
    • Sawamura H., Shima K., Tanji J. Numerical representation for action in the parietal cortex of the monkey. Nature. 415:2002;918-922.
    • (2002) Nature , vol.415 , pp. 918-922
    • Sawamura, H.1    Shima, K.2    Tanji, J.3
  • 57
    • 0042166157 scopus 로고    scopus 로고
    • When time is up: CNV time course differentiates the roles of the hemispheres in the discrimination of short tone durations
    • Pfeuty M., Ragot R., Pouthas V. When time is up: CNV time course differentiates the roles of the hemispheres in the discrimination of short tone durations. Exp Brain Res. 151:2003;373-379.
    • (2003) Exp Brain Res , vol.151 , pp. 373-379
    • Pfeuty, M.1    Ragot, R.2    Pouthas, V.3
  • 58
    • 0037254465 scopus 로고    scopus 로고
    • Processes involved in tempo perception: A CNV analysis
    • Pfeuty M., Ragot R., Pouthas V. Processes involved in tempo perception: a CNV analysis. Psychophysiology. 40:2003;69-76.
    • (2003) Psychophysiology , vol.40 , pp. 69-76
    • Pfeuty, M.1    Ragot, R.2    Pouthas, V.3
  • 59
    • 0038548414 scopus 로고    scopus 로고
    • Effects of working memory demands on frontal slow waves in time-interval reproduction tasks in humans
    • Monfort V., Pouthas V. Effects of working memory demands on frontal slow waves in time-interval reproduction tasks in humans. Neurosci Lett. 343:2003;195-199.
    • (2003) Neurosci Lett , vol.343 , pp. 195-199
    • Monfort, V.1    Pouthas, V.2
  • 60
    • 0037383659 scopus 로고    scopus 로고
    • What the cerebellum computes
    • The authors present a computationally oriented review of how eyeblink conditioning provides a model system for understanding feedforward control mechanisms used to support sensorimotor learning. The review emphasizes the importance of error signals in this form of learning, how error signals are used to support associative processes that operate at various levels and how they can shape behavior that is temporally specific.
    • Ohyama T., Nores W.L., Murphy M., Mauk M.D. What the cerebellum computes. Trends Neurosci. 26:2003;222-227 The authors present a computationally oriented review of how eyeblink conditioning provides a model system for understanding feedforward control mechanisms used to support sensorimotor learning. The review emphasizes the importance of error signals in this form of learning, how error signals are used to support associative processes that operate at various levels and how they can shape behavior that is temporally specific.
    • (2003) Trends Neurosci , vol.26 , pp. 222-227
    • Ohyama, T.1    Nores, W.L.2    Murphy, M.3    Mauk, M.D.4
  • 61
    • 0029876036 scopus 로고    scopus 로고
    • Metabotropic glutamate receptor activation in cerebellar Purkinje cells as substrate for adaptive timing of the classically conditioned eye-blink response
    • Fiala J.C., Grossberg S., Bullock D. Metabotropic glutamate receptor activation in cerebellar Purkinje cells as substrate for adaptive timing of the classically conditioned eye-blink response. J Neurosci. 16:1996;3760-3774.
    • (1996) J Neurosci , vol.16 , pp. 3760-3774
    • Fiala, J.C.1    Grossberg, S.2    Bullock, D.3
  • 62
    • 0002538402 scopus 로고
    • Neural network model of the cerebellum: Temporal discrimination and the timing of motor responses
    • Buonomano D.V., Mauk M.D. Neural network model of the cerebellum: temporal discrimination and the timing of motor responses. Neural Comput. 6:1994;38-55.
    • (1994) Neural Comput , vol.6 , pp. 38-55
    • Buonomano, D.V.1    Mauk, M.D.2
  • 63
    • 0036678337 scopus 로고    scopus 로고
    • Cerebellum and speech perception: A functional magnetic resonance imaging study
    • The authors used fMRI to study the neural correlates for processing the phonemic cue of closure duration for stop consonants. Acoustically, this cue can be signaled temporally by the duration of silence or by a combination of spectral and temporal information. Importantly, people might be unaware of this manipulation; thus, the two imaging conditions are essentially identical. Nonetheless, when the cues were purely temporal, activation was restricted to left frontal and right cerebellar foci; by contrast, the inclusion of spectral cues resulted in a shift of activation to left superior temporal lobe.
    • Mathiak K., Hertrich I., Grodd W., Ackermann H. Cerebellum and speech perception: a functional magnetic resonance imaging study. J Cogn Neurosci. 14:2002;902-912 The authors used fMRI to study the neural correlates for processing the phonemic cue of closure duration for stop consonants. Acoustically, this cue can be signaled temporally by the duration of silence or by a combination of spectral and temporal information. Importantly, people might be unaware of this manipulation; thus, the two imaging conditions are essentially identical. Nonetheless, when the cues were purely temporal, activation was restricted to left frontal and right cerebellar foci; by contrast, the inclusion of spectral cues resulted in a shift of activation to left superior temporal lobe.
    • (2002) J Cogn Neurosci , vol.14 , pp. 902-912
    • Mathiak, K.1    Hertrich, I.2    Grodd, W.3    Ackermann, H.4
  • 64
    • 0036428729 scopus 로고    scopus 로고
    • The roles of the cerebellum and basal ganglia in timing and error prediction
    • Both the cerebellum and the basal ganglia have been implicated in similar cognitive operations including timing, error prediction, and the coordination of attentional set. In an attempt to directly evaluate these hypotheses, the authors conducted an fMRI study of task switching in which the timing and order of changes in a task set were manipulated. Cerebellar activation was sensitive to the temporal manipulation. By contrast, striatal activation was sensitive to task order predictability, interpreted as reflecting a role in error prediction. Activation in neither cerebellum nor striatum increased during attention switching compared to a control condition with similar working memory demands.
    • Dreher J.-C., Grafman J. The roles of the cerebellum and basal ganglia in timing and error prediction. Eur J Neurosci. 16:2002;1609-1619 Both the cerebellum and the basal ganglia have been implicated in similar cognitive operations including timing, error prediction, and the coordination of attentional set. In an attempt to directly evaluate these hypotheses, the authors conducted an fMRI study of task switching in which the timing and order of changes in a task set were manipulated. Cerebellar activation was sensitive to the temporal manipulation. By contrast, striatal activation was sensitive to task order predictability, interpreted as reflecting a role in error prediction. Activation in neither cerebellum nor striatum increased during attention switching compared to a control condition with similar working memory demands.
    • (2002) Eur J Neurosci , vol.16 , pp. 1609-1619
    • Dreher, J.-C.1    Grafman, J.2
  • 65
    • 0036823974 scopus 로고    scopus 로고
    • Degeneracy and cognitive anatomy
    • Price C.J., Friston K.J. Degeneracy and cognitive anatomy. Trends Cogn Sci. 6:2002;416-421.
    • (2002) Trends Cogn Sci , vol.6 , pp. 416-421
    • Price, C.J.1    Friston, K.J.2
  • 66
    • 0030464024 scopus 로고    scopus 로고
    • The representation of temporal information in perception and motor control
    • Ivry R.B. The representation of temporal information in perception and motor control. Curr Opin Neurobiol. 6:1996;851-857.
    • (1996) Curr Opin Neurobiol , vol.6 , pp. 851-857
    • Ivry, R.B.1
  • 67
    • 18844370397 scopus 로고    scopus 로고
    • Comparison of patients with Parkinson's disease or cerebellar lesions in the production of periodic movements involving event-based or emergent timing
    • in press.
    • Spencer RMC, Ivry RB: Comparison of patients with Parkinson's disease or cerebellar lesions in the production of periodic movements involving event-based or emergent timing. Brain Cogn in press.
    • Brain Cogn
    • Spencer, R.M.C.1    Ivry, R.B.2
  • 69
    • 0002036011 scopus 로고    scopus 로고
    • How the basal ganglia make decisions
    • Edited by Damasio A, Damasio H, Christen Y: Springer-Verlag;
    • Berns GS, Sejnowski TJ: How the basal ganglia make decisions. In The Neurobiology of Decision Making. Edited by Damasio A, Damasio H, Christen Y: Springer-Verlag; 1996:101-113.
    • (1996) The Neurobiology of Decision Making , pp. 101-113
    • Berns, G.S.1    Sejnowski, T.J.2
  • 70
    • 0346042331 scopus 로고    scopus 로고
    • Prospective and retrospective duration judgments: A meta-analytic review
    • Block R.A., Zakay D. Prospective and retrospective duration judgments: a meta-analytic review. Psychon Bull Rev. 4:1997;184-197.
    • (1997) Psychon Bull Rev , vol.4 , pp. 184-197
    • Block, R.A.1    Zakay, D.2
  • 72
    • 0025321039 scopus 로고
    • Functional architecture of basal ganglia circuits: Neural substrates of parallel processing
    • Alexander G.E., Crutcher M.D. Functional architecture of basal ganglia circuits: neural substrates of parallel processing. Trends Neurosci. 13:1990;266-271.
    • (1990) Trends Neurosci , vol.13 , pp. 266-271
    • Alexander, G.E.1    Crutcher, M.D.2
  • 73
    • 85047671193 scopus 로고    scopus 로고
    • Dissociation of explicit and implicit timing in repetitive tapping and drawing movements
    • Zelaznik HN, Spencer RMC, Ivry RB: Dissociation of explicit and implicit timing in repetitive tapping and drawing movements, J Exp Psychol Hum Percept Perform 28:575-588.
    • J Exp Psychol Hum Percept Perform , vol.28 , pp. 575-588
    • Zelaznik, H.N.1    Spencer, R.M.C.2    Ivry, R.B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.