Conduction properties distinguish unmyelinated sympathetic efferent fibers and unmyelinated primary afferent fibers in the monkey

PLoS ONE

Volumn 5, Issue 2, 2010, Pages

  Ringkamp, Matthias ^a,c   Johanek, Lisa M ^a   Borzan, Jasenka ^a   Hartke, Timothy V ^a   Wu, Gang ^a,d   Pogatzki Zahn, Esther M ^a,e   Campbell, James N ^a   Shim, Beom ^a,f   Schepers, Raf J ^a,g   Meyer, Richard A ^a,b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS UNIVERSITY APPLIED PHYSICS LABORATORY   (United States)

^c MEDTRONIC INC   (United States)

^d PURDUE PHARMA L P   (United States)

^e UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^f Amore Pacific   (South Korea)

^g NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; DORSAL ROOT; ELECTROSTIMULATION; MACACA; NERVE CONDUCTION; NERVE FIBER; NERVE POTENTIAL; NONHUMAN; NONMYELINATED NERVE; PERONEUS NERVE; SENSORY NERVE; SURAL NERVE; SYMPATHETIC NERVE; ACTION POTENTIAL; ADRENERGIC NERVE; ANIMAL; BIOLOGICAL MODEL; EFFERENT NERVE; NERVE TRACT; PHYSIOLOGY; SENSORY NERVE CELL;

ACTION POTENTIALS; ADRENERGIC FIBERS; ANIMALS; ELECTRIC STIMULATION; MACACA FASCICULARIS; MODELS, NEUROLOGICAL; NERVE FIBERS, UNMYELINATED; NEURAL CONDUCTION; NEURAL PATHWAYS; NEURONS, AFFERENT; NEURONS, EFFERENT;

EID: 77949405432     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0009076     Document Type: Article

References (29)

1. Wessberg J, Olausson H, Fernström KW, Vallbo AB (2003) Receptive field properties of unmyelinated tactile afferents in the human skin. J Neurophysiol 89: 1567-1575.
2. Darian-Smith I, Johnson KO, LaMotte C, Shigenaga Y, Kenins P, et al. (1979) Warm fibers innervating palmar and digital skin of the monkey: Responses to thermal stimuli. J Neurophysiol 42: 1297-1315.
3. Schmelz M, Schmidt R, Handwerker HO, Torebjork HE (2000) Encoding of burning pain from capsaicin-treated human skin in two categories of unmyelinated nerve fibres. Brain 123 Pt 3: 560-571.
4. Schmelz M, Schmidt R, Bickel A, Handwerker HO, Torebjörk HE (1997) Specific C-receptors for itch in human skin. J Neurosci 17: 8003-8008.
5. Namer B, Carr R, Johanek LM, Schmelz M, Handwerker HO, et al. (2008) Separate peripheral pathways for pruritus in man. J Neurophysiol.
6. Gee MD, Lynn B, Cotsell B (1996) Activity-dependent slowing of conduction velocity provides a method for identifying different functional classes of C-fibre in the rat saphenous nerve. Neuroscience 73: 667-675.
7. Thalhammer JG, Raymond SA, Popitz-Bergez FA, Strichartz GR (1994) Modality-dependent modulation of conduction by impulse activity in functionally characterized single cutaneous afferents in the rat. Somatosens Mot Res 11: 243-257.
8. Weidner C, Schmelz M, Schmidt R, Hansson B, Handwerker HO, et al. (1999) Functional attributes discriminating mechano-insensitive and mechano- responsive C nociceptors in human skin. J Neurosci 19: 10184-10190.
9. Bostock H, Campero M, Serra J, Ochoa J (2003) Velocity recovery cycles of C fibres innervating human skin. J Physiol 553: 649-663.
10. Campero M, Serra J, Bostock H, Ochoa JL (2001) Slowly conducting afferents activated by innocuous low temperature in human skin. J Physiol 535: 855-865.
11. George A, Serra J, Navarro X, Bostock H (2007) Velocity recovery cycles of single C fibres innervating rat skin. J Physiol 578: 213-232.
12. De Col R, Messlinger K, Carr RW (2008) Conduction velocity is regulated by sodium channel inactivation in unmyelinated axons innervating the rat cranial meninges. J Physiol 586: 1089-1103.
13. Scroggs RS (2008) Evidence of a physiological role for use-dependent inactivation of NaV1.8 sodium channels. J Physiol 586: 923.
14. Weidner C, Schmidt R, Schmelz M, Hilliges M, Handwerker HO, et al. (2000) Time course of post-excitatory effects separates afferent human C fibre classes. J Physiology 527: 185-191.
15. Campbell JN, Meyer RA (1983) Sensitization of unmyelinated nociceptive afferents in the monkey varies with skin type. J Neurophysiol 49: 98-110.
16. Ringkamp M, Eschenfelder S, Grethel EJ, Häbler H-J, Meyer RA, et al. (1999) Lumbar sympathectomy failed to reverse mechanical allodynia- and hyperalgesia-like behavior in rats with L5 spinal nerve injury. Pain 79: 143-153.
17. Serra J, Campero M, Ochoa J, Bostock H (1999) Activity-dependent slowing of conduction differentiates functional subtypes of C fibres innervating human skin [see comments]. Journal of Physiology (London) 515 (Pt 3): 799-811.
18. Meyer RA, Davis KD, Cohen RH, Treede R-D, Campbell JN (1991) Mechanically insensitive afferents (MIAs) in cutaneous nerves of monkey. Brain Res 561: 252-261.
19. Peng YB, Ringkamp M, Campbell JN, Meyer RA (1999) Electrophysiological assessment of the cutaneous arborization of A-delta-fiber nociceptors. J Neurophysiol 82: 1164-1177.
20. Campero M, Serra J, Bostock H, Ochoa JL (2004) Partial reversal of conduction slowing during repetitive stimulation of single sympathetic efferents in human skin. Acta Physiol Scand 182: 305-311.
21. Weidner C, Schmelz M, Schmidt R, Hammarberg B, Ørstavik MH, et al. (2002) Neural signal processing: the underestimated contribution of peripheral human C-fibers. J Neurosci 22: 6704-6712.
22. Raymond SA, Thalhammer JG, Popitz-Bergez F, Strichartz GR (1990) Changes in axonal impulse conduction correlate with sensory modality in primary afferent fibers in the rat. Brain Res 526: 318-321.
23. Serra J, Campero M, Bostock H, Ochoa J (2004) Two types of C nociceptor in human skin and their behavior in areas of capsaicin-induced secondary hyperalgesia. J Neurophysiol 91: 2770-27781.
24. Rush AM, Dib-Hajj SD, Liu S, Cummins TR, Black JA, et al. (2006) A single sodium channel mutation produces hyper- or hypoexcitability in different types of neurons. Proc Natl Acad Sci USA 103: 8245-8250.
25. Leffler A, Reiprich A, Mohapatra DP, Nau C (2007) Use-dependent block by lidocaine but not amitriptyline is more pronounced in tetrodotoxin (TTX)-Resistant Nav1.8 than in TTX-sensitive Na+ channels. J Pharmacol Exp Ther 320: 354-364.
26. Bostock H, Campero M, Serra J, Ochoa J (2003) Velocity recovery cycles of C fibres innervating human skin. J Physiol 553: 649-663.
27. Barrett EF, Barrett JN (1982) Intracellular recording from vertebrate myelinated axons: mechanism of the depolarizing afterpotential. J Physiol 323: 117-144.
28. Armett CJ, Ritchie JM (1963) On the permeability of mammalian non-myelinated fibres to sodium and to lithium ions. J Physiol 165: 130-140.
29. Martinez-Pinna J, McLachlan EM, Gallego R (2000) Distinct mechanisms for activation of Cl- and K+ currents by Ca2+ from different sources in mouse sympathetic neurones. J Physiol 527 Pt 2: 249-264.