Structural and functional differences between neuropathy with and without pain?

Experimental Neurology

Volumn 231, Issue 2, 2011, Pages 199-206

  Kalliomäki, Maija ^a   Kieseritzky, Johanna v ^a   Schmidt, Roland ^b   Hägglöf, Björn ^b   Karlsten, Rolf ^b   Sjögren, Niclas ^b   Albrecht, Phil ^c,d   Gee, Lucy ^c,d   Rice, Frank ^c,d   Wiig, Monica ^a   Schmelz, Martin ^e   Gordh, Torsten ^a  

^a UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^b ASTRAZENECA R AND D   (Sweden)

^c ALBANY MEDICAL COLLEGE   (United States)

^d Integrated Tissue Dynamics LLC   (United States)

^e UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

CGRP; Chronic pain; Nerve fiber density; Nerve injury; Neuropathic pain; Neuropathy

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE;

ADULT; ARTICLE; AXONAL INJURY; CHRONIC PAIN; CLINICAL ARTICLE; COLD INJURY; CONTROLLED STUDY; DISEASE ASSOCIATION; ERYTHEMA; FEMALE; FUNCTIONAL ANATOMY; HEAT INJURY; HUMAN; HUMAN TISSUE; MALE; NERVE INJURY; NEUROPATHIC PAIN; NEUROPATHOLOGY; PAIN THRESHOLD; PRIORITY JOURNAL; SKIN BIOPSY; SKIN INJURY; SKIN NERVE; SKIN STRUCTURE; TEMPERATURE SENSITIVITY; THERMAL INJURY;

EID: 80052523610     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2011.05.019     Document Type: Article

References (33)

1. Aasvang E.K., Brandsborg B., Christensen B., Jensen T.S., Kehlet H. Neurophysiological characterization of postherniotomy pain. Pain 2008, 137:173-181.
2. Albrecht P.J., Hines S., Eisenberg E., Pud D., Finlay D.R., Connolly M.K., Pare M., Davar G., Rice F.L. Pathologic alterations of cutaneous innervation and vasculature in affected limbs from patients with complex regional pain syndrome. Pain 2006, 120:244-266.
3. Attal N., Fermanian C., Fermanian J., Lanteri-Minet M., Alchaar H., Bouhassira D. Neuropathic pain: are there distinct subtypes depending on the aetiology or anatomical lesion?. Pain 2008, 138:343-353.
4. Axelsson H.E., Minde J.K., Sonesson A., Toolanen G., Hogestatt E.D., Zygmunt P.M. Transient receptor potential vanilloid 1, vanilloid 2 and melastatin 8 immunoreactive nerve fibers in human skin from individuals with and without Norrbottnian congenital insensitivity to pain. Neuroscience 2009, 162:1322-1332.
5. Baron R., Binder A., Wasner G. Neuropathic pain: diagnosis, pathophysiological mechanisms, and treatment. Lancet Neurol. 2010, 9:807-819.
6. Bickel A., Kramer H.H., Hilz M.J., Birklein F., Neundorfer B., Schmelz M. Assessment of the neurogenic flare reaction in small-fiber neuropathies. Neurology 2002, 59:917-919.
7. Black J.A., Nikolajsen L., Kroner K., Jensen T.S., Waxman S.G. Multiple sodium channel isoforms and mitogen-activated protein kinases are present in painful human neuromas. Ann. Neurol. 2008, 64:644-653.
8. Cruccu G., Sommer C., Anand P., Attal N., Baron R., Garcia-Larrea L., Haanpaa M., Jensen T.S., Serra J., Treede R.D. EFNS guidelines on neuropathic pain assessment: revised 2009. Eur.J Neurol. 2010, 17:1010-1018.
9. Daut R.L., Cleeland C.S., Flanery R.C. Development of the Wisconsin Brief Pain Questionnaire to assess pain in cancer and other diseases. Pain 1983, 17:197-210.
10. Devigili G., Tugnoli V., Penza P., Camozzi F., Lombardi R., Melli G., Broglio L., Granieri E., Lauria G. The diagnostic criteria for small fibre neuropathy: from symptoms to neuropathology. Brain 2008, 131:1912-1925.
11. Dyck P.J., Dyck P.J., Larson T.S., O'Brien P.C., Velosa J.A. Patterns of quantitative sensation testing of hypoesthesia and hyperalgesia are predictive of diabetic polyneuropathy: a study of three cohorts Nerve growth factor study group. Diabetes Care 2000, 23:510-517.
12. Facer P., Casula M.A., Smith G.D., Benham C.D., Chessell I.P., Bountra C., Sinisi M., Birch R., Anand P. Differential expression of the capsaicin receptor TRPV1 and related novel receptors TRPV3, TRPV4 and TRPM8 in normal human tissues and changes in traumatic and diabetic neuropathy. BMC. Neurol. 2007, 7:11. 11.
13. Finnerup N.B., Jensen T.S. Mechanisms of disease: mechanism-based classification of neuropathic pain-a critical analysis. Nat. Clin. Pract. Neurol. 2006, 2:107-115.
14. Freynhagen R., Rolke R., Baron R., Tolle T.R., Rutjes A.K., Schu S., Treede R.D. Pseudoradicular and radicular low-back pain-a disease continuum rather than different entities? Answers from quantitative sensory testing. Pain 2008, 135:65-74.
15. Gottrup H., Andersen J., Arendt-Nielsen L., Jensen T.S. Psychophysical examination in patients with post-mastectomy pain. Pain 2000, 87:275-284.
16. Ho T.W., Backonja M., Ma J., Leibensperger H., Froman S., Polydefkis M. Efficient assessment of neuropathic pain drugs in patients with small fiber sensory neuropathies 2008, Pain.
17. Jensen T.S., Finnerup N.B. Management of neuropathic pain. Curr. Opin. Support. Palliat. Care. 2007, 1:126-131.
18. Kelly K.G., Cook T., Backonja M.M. Pain ratings at the thresholds are necessary for interpretation of quantitative sensory testing. Muscle Nerve. 2005, 32:179-184.
19. Kleggetveit I.P., Jorum E. Large and small fiber dysfunction in peripheral nerve injuries with or without spontaneous pain. J. Pain 2010, 11:1305-1310.
20. Kramer H.H., Schmelz M., Birklein F., Bickel A. Electrically stimulated axon reflexes are diminished in diabetic small fiber neuropathies. Diabetes 2004, 53:769-774.
21. Landerholm S.H., Ekblom A.G., Hansson P.T. Somatosensory function in patients with and without pain after traumatic peripheral nerve injury. Eur. J. Pain 2010, 14:847-853.
22. Lauria G., Hsieh S.T., Johansson O., Kennedy W.R., Leger J.M., Mellgren S.I., Nolano M., Merkies I.S., Polydefkis M., Smith A.G., Sommer C., Valls-Sole J. European Federation of Neurological Societies/Peripheral Nerve Society Guideline on the use of skin biopsy in the diagnosis of small fiber neuropathy. Report of a joint task force of the European Federation of Neurological Societies and the Peripheral Nerve Society. Eur.J Neurol. 2010, 17:903-909.
23. Leffler A.S., Hansson P. Painful traumatic peripheral partial nerve injury-sensory dysfunction profiles comparing outcomes of bedside examination and quantitative sensory testing. Eur. J. Pain 2008, 12:397-402.
24. McArthur J.C., Stocks E.A., Hauer P., Cornblath D.R., Griffin J.W. Epidermal nerve fiber density: normative reference range and diagnostic efficiency [see comments]. Arch. Neurol. 1998, 55:1513-1520.
25. Novak V., Freimer M.L., Kissel J.T., Sahenk Z., Periquet I.M., Nash S.M., Collins M.P., Mendell J.R. Autonomic impairment in painful neuropathy. Neurology 2001, 56:861-868.
26. Oaklander A.L. The density of remaining nerve endings in human skin with and without postherpetic neuralgia after shingles. Pain 2001, 92:139-145.
27. Oaklander A.L. Mechanisms of pain and itch caused by herpes zoster (shingles). J. Pain 2008, 9:S10-S18.
28. Pare M., Elde R., Mazurkiewicz J.E., Smith A.M., Rice F.L. The Meissner corpuscle revised: a multiafferented mechanoreceptor with nociceptor immunochemical properties. J. Neurosci 2001, 21:7236-7246.
29. Petersen K.L., Rice F.L., Farhadi M., Reda H., Rowbotham M.C. Natural history of cutaneous innervation following herpes zoster. Pain 2010, 150:75-82.
30. Polydefkis M., Yiannoutsos C.T., Cohen B.A., Hollander H., Schifitto G., Clifford D.B., Simpson D.M., Katzenstein D., Shriver S., Hauer P., Brown A., Haidich A.B., Moo L., McArthur J.C. Reduced intraepidermal nerve fiber density in HIV-associated sensory neuropathy. Neurology 2002, 58:115-119.
31. Rolke R., Baron R., Maier C., Tolle T.R., Treede R.D., Beyer A., Binder A., Birbaumer N., Birklein F., Botefur I.C., Braune S., Flor H., Huge V., Klug R., Landwehrmeyer G.B., Magerl W., Maihofner C., Rolko C., Schaub C., Scherens A., Sprenger T., Valet M., Wasserka B. Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS): standardized protocol and reference values. Pain 2006, 123:231-243.
32. Wasner G., Schattschneider J., Binder A., Baron R. Topical menthol-a human model for cold pain by activation and sensitization of C nociceptors. Brain 2004, 127:1159-1171.
33. Zhao P., Barr T.P., Hou Q., Dib-Hajj S.D., Black J.A., Albrecht P.J., Petersen K., Eisenberg E., Wymer J.P., Rice F.L., Waxman S.G. Voltage-gated sodium channel expression in rat and human epidermal keratinocytes: evidence for a role in pain. Pain 2008, 139:90-105.