Activity-dependent slowing of conduction differentiates functional subtypes of C fibres innervating human skin

Journal of Physiology

Volumn 515, Issue 3, 1999, Pages 799-811

  Serra, Jordi ^a   Campero, Mario ^a   Ochoa, José ^a   Bostock, Hugh ^a,b  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACTION POTENTIAL; ADULT; AGED; ARTICLE; COLD; CONTROLLED STUDY; DIABETES MELLITUS; ELECTROSTIMULATION; FEMALE; HUMAN; HUMAN EXPERIMENT; LATENT PERIOD; MALE; MECHANICAL STIMULATION; MICROELECTRODE; NERVE CONDUCTION; NERVE FIBER C; NERVE STIMULATION; NOCICEPTIVE RECEPTOR; PERONEUS NERVE; PRIORITY JOURNAL; SKIN NERVE; SPIKE WAVE; SYMPATHETIC TONE;

EID: 0033559376     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1469-7793.1999.799ab.x     Document Type: Article

References (24)

1. BAKER, M., BOSTOCK, H., GRAFE, P. & MARTIUS, P. (1987). Function and distribution of three types of rectifying channel in rat spinal root myelinated axons. Journal of Physiology 383, 45-67.
2. BERGMANS, J. (1970). The Physiology of Single Human Nerve Fibres. University of Louvain, Vander, Belgium.
3. BOSTOCK, H., CIKUREL, K. & BURKE, D. (1998). Threshold tracking techniques in the study of human peripheral nerve. Muscle and Nerve 21, 137-158.
4. BOSTOCK, H. & GRAFE, P. (1985). Activity-dependent excitability changes in normal and demyelinated rat spinal root axons. Journal of Physiology 365, 229-257.
5. DAVIS, K. D., MEYER, R. A. & CAMPBELL, J. N. (1993). Chemosensitivity and sensitization of nociceptive afferents that innervate the hairy skin of monkey. Journal of Neurophysiology 69, 1071-1081.
6. GASSER, H. S. (1935). Changes in nerve potentials produced by rapidly repeated stimuli and their relation to the responsiveness of nerve to stimulation. American Journal of Physiology 111, 30-50.
7. GEE, M. D., LYNN, B. & COTSELL, B. (1996). Activity-dependent slowing of conduction velocity provides a method for identifying different functional classes of C-fibre in the rat saphenous nerve. Neuroscience 73, 667-675.
8. GRAFE, P., QUASTHOFF, S., GROSSKREUTZ, J. & ALZHEIMER, C. (1997). Function of the hyperpolarization-activated inward rectification in nonmyelinated peripheral rat and human axons. Journal of Neurophysiology 77, 421-426.
9. HALLIN, R. G., EKEDAHL, R. & FRANK, O. (1991). Segregation by modalitv of myelinated and unmyelinated fibres in human sensory nerve, fascicles. Muscle and Nerve 14, 157-165.
10. HALLIN, R. G. & TOREBJÖRK, H. E. (1974). Methods to differentiate electrically induced afferent and sympathetic C units responses in human cutaneous nerves. Acta Physiologica Scandinavica 92, 318-331.
11. LYNN, B. (1994). The fibre composition of cutaneous nerves and the classification and response probities of cutaneous afferents, with particular reference to nociception. Pain Review 1, 172-183.
12. MEYER, R. A., DAVIS, K. D., COHEN, R. H., TREEDE, R.-D. & CAMPBELL, J. N. (1991). Mechanically insensitive afferents (MIAs) in cutaneous nerves of monkey. Brain Research 561, 252-261.
13. NORDIN, M. (1990). Low-threshold mechanoreceptive and nociceptive units with unmyelinated (C) fibres in the human supraorbital nerve. Journal of Physiology 426, 229-240.
14. OCHOA, J. & TOREBJÖRK, H. E. (1989). Sensations evoked by selective intraneural microstimulation of identified C nociceptor fibres in human skin nerves. Journal of Physiology 415, 583-599.
15. PAPE, H. C. (1996). Queer current and pacemaker: the hyperpolarization-activated cation current in neurons. Annual Review of Physiology 58, 299-327.
16. QUASTHOFF, S., GROSSKREUTZ, J., SCHNEIDER, U. & GRAFE, P. (1995). Calcium potentials and tetrodotoxin-resistant sodium potentials in unmyelinated C fibres of biopsied human sural nerve. Neuroscience 69, 955-965.
17. RANG, H. P. & RITCHIE, J. M. (1968). On the electrogenic sodium pump in mammalian non-myelinated nerve fibres and its activation by various external cations. Journal of Physiology 196, 183-221.
18. RITCHIE, J. M. & STRAUB, R. W. (1957). The hyperpolarization which follows activity in mammalian non-medullated fibres. Journal of Physiology 136, 80-97.
19. SCHMELZ, M., FORSTER, C., SCHMIDT, R., RINGKAMP, M., HANDWERKER, H. O. & TOREBJÖRK, H. E. (1995). Delayed responses to electrical stimuli reflect C-fibre responsiveness in human microneurography. Experimental Brain Research 104, 331-336.
20. SCHMIDT, R., SCHMELZ, M., FORSTER, C., RINGKAMP, M., TOREBJÖRK, H. E. & HANDWERKER, H. (1995). Novel classes of responsive and unresponsive C nociceptors in human skin. Journal of Neuroscience 15, 333-341.
21. THALHAMMER, J. G., RAYMOND, S. A., POPITZ-BERGEZ, F. A. & STRICHARTZ, G. R. (1994). Modality-dependent modulation of conduction by impulse activity in functionally characterized single cutaneous afferents in the rat. Somatosensory Motor Research 11, 242-257.
22. TOREBJÖRK, H. E. (1974). Afferent C units responding to mechanical, thermal and chemical stimuli in human non-glabrous skin. Acta Physiologica Scandinavica 92, 374-390.
23. TOREBJÖRK, H. E. & OCHOA, J. L. (1990). New method to identify nociceptor units innervating glabrous skin of the human hand. Experimental Brain Research 81, 509-514.
24. VALLBO, Å. & HAGBARTH, K.-E. (1968). Activity from skin mechanoreceptors recorded percutaneously in awake human subjects. Experimental Neurology 21, 270-289.