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Volumn 8, Issue 10, 2013, Pages

Correction of Chloride Transport and Mislocalization of CFTR Protein by Vardenafil in the Gastrointestinal Tract of Cystic Fibrosis Mice

Author keywords

[No Author keywords available]

Indexed keywords

CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; VARDENAFIL;

EID: 84886248189     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0077314     Document Type: Article
Times cited : (21)

References (55)
  • 1
  • 2
    • 0024424270 scopus 로고
    • Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA
    • Riordan JR, Rommens JM, Kerem B, Alon N, Rozmahel R, et al. (1989) Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA. Science 245: 1066-1073.
    • (1989) Science , vol.245 , pp. 1066-1073
    • Riordan, J.R.1    Rommens, J.M.2    Kerem, B.3    Alon, N.4    Rozmahel, R.5
  • 3
    • 0030970422 scopus 로고    scopus 로고
    • Cystic fibrosis transmembrane conductance regulator inverts protein kinase A-mediated regulation of epithelial sodium channel single channel kinetics
    • Stutts MJ, Rossier BC, Boucher RC, (1997) Cystic fibrosis transmembrane conductance regulator inverts protein kinase A-mediated regulation of epithelial sodium channel single channel kinetics. J Biol Chem 272: 1437-1440.
    • (1997) J Biol Chem , vol.272 , pp. 1437-1440
    • Stutts, M.J.1    Rossier, B.C.2    Boucher, R.C.3
  • 4
    • 0029912194 scopus 로고    scopus 로고
    • Regulation of epithelial sodium channels by the cystic fibrosis transmembrane conductance regulator
    • Ismailov II, Awayda MS, Jovov B, Berdiev BK, Fuller CM, et al. (1996) Regulation of epithelial sodium channels by the cystic fibrosis transmembrane conductance regulator. J Biol Chem 271: 4725-4732.
    • (1996) J Biol Chem , vol.271 , pp. 4725-4732
    • Ismailov, I.I.1    Awayda, M.S.2    Jovov, B.3    Berdiev, B.K.4    Fuller, C.M.5
  • 5
    • 84883448606 scopus 로고    scopus 로고
    • Rescuing mutant CFTR: a multi-task approach to a better outcome in treating Cystic Fibrosis
    • Amaral MD, Farinha CM, (2013) Rescuing mutant CFTR: a multi-task approach to a better outcome in treating Cystic Fibrosis. Curr Pharm Des 19: 3497-3508.
    • (2013) Curr Pharm Des , vol.19 , pp. 3497-3508
    • Amaral, M.D.1    Farinha, C.M.2
  • 6
    • 0028840915 scopus 로고
    • Degradation of CFTR by the ubiquitin-proteasome pathway
    • Ward CL, Omura S, Kopito RR, (1995) Degradation of CFTR by the ubiquitin-proteasome pathway. Cell 83: 121-127.
    • (1995) Cell , vol.83 , pp. 121-127
    • Ward, C.L.1    Omura, S.2    Kopito, R.R.3
  • 7
    • 84855202429 scopus 로고    scopus 로고
    • Results of a phase IIa study of VX-809, an investigational CFTR corrrector compound, in subjects with cystic fibrosis homozygous for the F508del- CFTR mutation
    • Clancy JP, Rowe SM, Accurso FJ, Aitken ML, Amin RS, et al. (2012) Results of a phase IIa study of VX-809, an investigational CFTR corrrector compound, in subjects with cystic fibrosis homozygous for the F508del- CFTR mutation. Thorax 67: 12-18.
    • (2012) Thorax , vol.67 , pp. 12-18
    • Clancy, J.P.1    Rowe, S.M.2    Accurso, F.J.3    Aitken, M.L.4    Amin, R.S.5
  • 8
    • 84879000844 scopus 로고    scopus 로고
    • Cystic fibrosis transmembrane regulator correctors and potentiators
    • Rowe SM, Verkman AS (2013) Cystic fibrosis transmembrane regulator correctors and potentiators. Cold Spring Harb Perspect Med 3.
    • (2013) Cold Spring Harb Perspect Med , vol.3
    • Rowe, S.M.1    Verkman, A.S.2
  • 9
    • 84878827634 scopus 로고    scopus 로고
    • Correctors of the basic trafficking defect of the mutant F508del-CFTR that causes cystic fibrosis
    • Birault V, Solari R, Hanrahan J, Thomas DY, (2013) Correctors of the basic trafficking defect of the mutant F508del-CFTR that causes cystic fibrosis. Curr Opin Chem Biol 17: 353-360.
    • (2013) Curr Opin Chem Biol , vol.17 , pp. 353-360
    • Birault, V.1    Solari, R.2    Hanrahan, J.3    Thomas, D.Y.4
  • 10
    • 84877932776 scopus 로고    scopus 로고
    • Repairing mutated proteins-development of small molecules targeting defects in the cystic fibrosis transmembrane conductance regulator
    • Merk D, Schubert-Zsilavecz M, (2013) Repairing mutated proteins-development of small molecules targeting defects in the cystic fibrosis transmembrane conductance regulator. Expert Opin Drug Discov 8: 691-708.
    • (2013) Expert Opin Drug Discov , vol.8 , pp. 691-708
    • Merk, D.1    Schubert-Zsilavecz, M.2
  • 11
    • 84860605804 scopus 로고    scopus 로고
    • A randomized placebo-controlled trial of miglustat in cystic fibrosis based on nasal potential difference
    • Leonard A, Lebecque P, Dingemanse J, Leal T, (2012) A randomized placebo-controlled trial of miglustat in cystic fibrosis based on nasal potential difference. J Cyst Fibros 11: 231-236.
    • (2012) J Cyst Fibros , vol.11 , pp. 231-236
    • Leonard, A.1    Lebecque, P.2    Dingemanse, J.3    Leal, T.4
  • 12
    • 0026325533 scopus 로고
    • Altered chloride ion channel kinetics associated with the delta F508 cystic fibrosis mutation
    • Dalemans W, Barbry P, Champigny G, Jallat S, Dott K, et al. (1991) Altered chloride ion channel kinetics associated with the delta F508 cystic fibrosis mutation. Nature 354: 526-528.
    • (1991) Nature , vol.354 , pp. 526-528
    • Dalemans, W.1    Barbry, P.2    Champigny, G.3    Jallat, S.4    Dott, K.5
  • 13
    • 0035013543 scopus 로고    scopus 로고
    • The delta F508 mutation shortens the biochemical half-life of plasma membrane CFTR in polarized epithelial cells
    • Heda GD, Tanwani M, Marino CR, (2001) The delta F508 mutation shortens the biochemical half-life of plasma membrane CFTR in polarized epithelial cells. Am J Physiol Cell Physiol 280: 166-174.
    • (2001) Am J Physiol Cell Physiol , vol.280 , pp. 166-174
    • Heda, G.D.1    Tanwani, M.2    Marino, C.R.3
  • 14
    • 33947242252 scopus 로고    scopus 로고
    • Cystic fibrosis is associated with a defect in apical receptor-mediated endocytosis in mouse and human kidney
    • Jouret F, Bernard A, Hermans C, Dom G, Terryn S, et al. (2007) Cystic fibrosis is associated with a defect in apical receptor-mediated endocytosis in mouse and human kidney. J Am Soc Nephrol 18: 707-718.
    • (2007) J Am Soc Nephrol , vol.18 , pp. 707-718
    • Jouret, F.1    Bernard, A.2    Hermans, C.3    Dom, G.4    Terryn, S.5
  • 15
    • 83555168269 scopus 로고    scopus 로고
    • Decreased renal accumulation of aminoglycoside reflects defective receptor-mediated endocytosis in cystic fibrosis and Dent's disease
    • Raggi C, Fujiwara K, Leal T, Jouret F, Devuyst O, et al. (2011) Decreased renal accumulation of aminoglycoside reflects defective receptor-mediated endocytosis in cystic fibrosis and Dent's disease. Pflugers Arch 462: 851-860.
    • (2011) Pflugers Arch , vol.462 , pp. 851-860
    • Raggi, C.1    Fujiwara, K.2    Leal, T.3    Jouret, F.4    Devuyst, O.5
  • 16
    • 27744482654 scopus 로고    scopus 로고
    • The short apical membrane half-life of rescued {Delta}F508-cystic fibrosis transmembrane conductance regulator (CFTR) results from accelerated endocytosis of {Delta}F508-CFTR in polarized human airway epithelial cells
    • Swiatecka-Urban A, Brown A, Moreau-Marquis S, Renuka J, Coutermarsh B, et al. (2005) The short apical membrane half-life of rescued {Delta}F508-cystic fibrosis transmembrane conductance regulator (CFTR) results from accelerated endocytosis of {Delta}F508-CFTR in polarized human airway epithelial cells. J Biol Chem 280: 36762-36772.
    • (2005) J Biol Chem , vol.280 , pp. 36762-36772
    • Swiatecka-Urban, A.1    Brown, A.2    Moreau-Marquis, S.3    Renuka, J.4    Coutermarsh, B.5
  • 17
    • 84874094442 scopus 로고    scopus 로고
    • HGF stimulation of Rac1 signaling enhances pharmacological correction of the most prevalent cystic fibrosis mutant F508del-CFTR
    • Moniz S, Sousa M, Moraes BJ, Mendes AI, Palma M, et al. (2013) HGF stimulation of Rac1 signaling enhances pharmacological correction of the most prevalent cystic fibrosis mutant F508del-CFTR. ACS Chem Biol 8: 432-442.
    • (2013) ACS Chem Biol , vol.8 , pp. 432-442
    • Moniz, S.1    Sousa, M.2    Moraes, B.J.3    Mendes, A.I.4    Palma, M.5
  • 18
    • 77956396747 scopus 로고    scopus 로고
    • Defective CFTR induces aggresome formation and lung inflammation in cystic fibrosis through ROS-mediated autophagy inhibition
    • Luciani A, Villella VR, Esposito S, Brunetti-Pierri N, Medina D, et al. (2010) Defective CFTR induces aggresome formation and lung inflammation in cystic fibrosis through ROS-mediated autophagy inhibition. Nat Cell Biol 12: 863-875.
    • (2010) Nat Cell Biol , vol.12 , pp. 863-875
    • Luciani, A.1    Villella, V.R.2    Esposito, S.3    Brunetti-Pierri, N.4    Medina, D.5
  • 19
    • 84879410121 scopus 로고    scopus 로고
    • Mechanism-based corrector combination restores ΔF508-CFTR folding and function
    • Okiyoneda T, Veit G, Dekkers JF, Bagdany M, Soya N, et al. (2013) Mechanism-based corrector combination restores ΔF508-CFTR folding and function. Nat Chem Biol 9: 444-454.
    • (2013) Nat Chem Biol , vol.9 , pp. 444-454
    • Okiyoneda, T.1    Veit, G.2    Dekkers, J.F.3    Bagdany, M.4    Soya, N.5
  • 20
    • 84864297297 scopus 로고    scopus 로고
    • The challenges and promises of new therapies for cystic fibrosis
    • Pier GB, (2012) The challenges and promises of new therapies for cystic fibrosis. J Exp Med 209: 1235-1239.
    • (2012) J Exp Med , vol.209 , pp. 1235-1239
    • Pier, G.B.1
  • 21
    • 84866137956 scopus 로고    scopus 로고
    • Progress in cystic fibrosis and the CF therapeutics development network
    • Rowe SM, Borowitz DS, Burns JL, Clancy JP, Donaldson SH, et al. (2012) Progress in cystic fibrosis and the CF therapeutics development network. Thorax 67: 882-890.
    • (2012) Thorax , vol.67 , pp. 882-890
    • Rowe, S.M.1    Borowitz, D.S.2    Burns, J.L.3    Clancy, J.P.4    Donaldson, S.H.5
  • 22
    • 0034603709 scopus 로고    scopus 로고
    • Cystic fibrosis transmembrane conductance regulator has an altered structure when its maturation is inhibited
    • Chen EY, Bartlett MC, Clarke DM, (2000) Cystic fibrosis transmembrane conductance regulator has an altered structure when its maturation is inhibited. Biochemistry 39: 3797-3803.
    • (2000) Biochemistry , vol.39 , pp. 3797-3803
    • Chen, E.Y.1    Bartlett, M.C.2    Clarke, D.M.3
  • 23
    • 78549279173 scopus 로고    scopus 로고
    • Effect of VX-770 in persons with cystic fibrosis and the G551D-CFTR mutation
    • Accurso FJ, Rowe SM, Clancy JP, Boyle MP, Dunitz JM, et al. (2010) Effect of VX-770 in persons with cystic fibrosis and the G551D-CFTR mutation. N Engl J Med 363: 1991-2003.
    • (2010) N Engl J Med , vol.363 , pp. 1991-2003
    • Accurso, F.J.1    Rowe, S.M.2    Clancy, J.P.3    Boyle, M.P.4    Dunitz, J.M.5
  • 24
    • 0028020058 scopus 로고
    • Protocols for in vivo measurements of the ion transport defects in cystic fibrosis nasal epithelium
    • Middleton PG, Geddes DM, Alton EWFW, (1994) Protocols for in vivo measurements of the ion transport defects in cystic fibrosis nasal epithelium. Eur Respir J 7: 2050-2056.
    • (1994) Eur Respir J , vol.7 , pp. 2050-2056
    • Middleton, P.G.1    Geddes, D.M.2    Alton, E.W.F.W.3
  • 25
    • 0028991826 scopus 로고
    • In vivo nasal potential difference: techniques and protocols for assessing efficacy of gene transfer in cystic fibrosis
    • Knowles MR, Paradiso AM, Boucher RC, (1995) In vivo nasal potential difference: techniques and protocols for assessing efficacy of gene transfer in cystic fibrosis. Hum Gene Ther 6: 445-455.
    • (1995) Hum Gene Ther , vol.6 , pp. 445-455
    • Knowles, M.R.1    Paradiso, A.M.2    Boucher, R.C.3
  • 26
    • 78349290383 scopus 로고    scopus 로고
    • Ataluren (PTC124) Induces CFTR Protein Expression and Activity in Children with Nonsense Mutation Cystic Fibrosis
    • Sermet-Gaudelus I, De Boeck K, Casimir GJ, Vermeulen F, Leal T, et al. (2010) Ataluren (PTC124) Induces CFTR Protein Expression and Activity in Children with Nonsense Mutation Cystic Fibrosis. Am J Respir Crit Care Med 182: 1262-1272.
    • (2010) Am J Respir Crit Care Med , vol.182 , pp. 1262-1272
    • Sermet-Gaudelus, I.1    De Boeck, K.2    Casimir, G.J.3    Vermeulen, F.4    Leal, T.5
  • 27
    • 34047166052 scopus 로고    scopus 로고
    • Airway surface dehydration in cystic fibrosis: pathogenesis and therapy
    • Boucher RC, (2007) Airway surface dehydration in cystic fibrosis: pathogenesis and therapy. Annu Rev Med 58: 157-170.
    • (2007) Annu Rev Med , vol.58 , pp. 157-170
    • Boucher, R.C.1
  • 28
    • 34547164336 scopus 로고    scopus 로고
    • Patterns of GI disease in adulthood associated with mutations in the CFTR gene
    • Wilschanski M, Durie PR, (2007) Patterns of GI disease in adulthood associated with mutations in the CFTR gene. Gut 56: 1153-1163.
    • (2007) Gut , vol.56 , pp. 1153-1163
    • Wilschanski, M.1    Durie, P.R.2
  • 29
    • 0025863209 scopus 로고
    • Generation of cAMP activated chloride currents by expression of CFTR
    • Anderson MP, Rich DP, Gregory RJ, Smith AE, Welsh MJ, (1991) Generation of cAMP activated chloride currents by expression of CFTR. Science 251: 679-682.
    • (1991) Science , vol.251 , pp. 679-682
    • Anderson, M.P.1    Rich, D.P.2    Gregory, R.J.3    Smith, A.E.4    Welsh, M.J.5
  • 30
    • 0032936619 scopus 로고    scopus 로고
    • Control of CFTR channel gating by phosphorylation and nucleotide hydrolysis
    • Gadsby DC, Nairn AC (1999) Control of CFTR channel gating by phosphorylation and nucleotide hydrolysis. Physiol Rev 79 (1 Suppl): S77-S107.
    • (1999) Physiol Rev , vol.79 , Issue.1 SUPPL.
    • Gadsby, D.C.1    Nairn, A.C.2
  • 31
    • 0020486047 scopus 로고
    • Crypts are the site of intestinal fluid and electrolyte secretion
    • Welsh MJ, Smith PL, Fromm M, Frizzell RA, (1982) Crypts are the site of intestinal fluid and electrolyte secretion. Science 218: 1219-1221.
    • (1982) Science , vol.218 , pp. 1219-1221
    • Welsh, M.J.1    Smith, P.L.2    Fromm, M.3    Frizzell, R.A.4
  • 32
    • 0036717930 scopus 로고    scopus 로고
    • Phosphodiesterase 5 inhibitors: current status and potential applications
    • Rotella DP, (2002) Phosphodiesterase 5 inhibitors: current status and potential applications. Nat Rev Drug Discov 1: 674-682.
    • (2002) Nat Rev Drug Discov , vol.1 , pp. 674-682
    • Rotella, D.P.1
  • 33
    • 11944265976 scopus 로고    scopus 로고
    • Sildenafil (Viagra) corrects DeltaF508-CFTR location in nasal epithelial cells from patients with cystic fibrosis
    • Dormer RL, Harris CM, Clark Z, Pereira MM, Doull IJ, et al. (2005) Sildenafil (Viagra) corrects DeltaF508-CFTR location in nasal epithelial cells from patients with cystic fibrosis. Thorax 60: 55-59.
    • (2005) Thorax , vol.60 , pp. 55-59
    • Dormer, R.L.1    Harris, C.M.2    Clark, Z.3    Pereira, M.M.4    Doull, I.J.5
  • 34
    • 40649117683 scopus 로고    scopus 로고
    • Preclinical evidence that sildenafil and vardenafil activate chloride transport in cystic fibrosis
    • Lubamba B, Lecourt H, Lebacq J, Lebecque P, De Jonge H, et al. (2008) Preclinical evidence that sildenafil and vardenafil activate chloride transport in cystic fibrosis. Am J Respir Crit Care Med 177: 506-515.
    • (2008) Am J Respir Crit Care Med , vol.177 , pp. 506-515
    • Lubamba, B.1    Lecourt, H.2    Lebacq, J.3    Lebecque, P.4    De Jonge, H.5
  • 35
    • 79251582480 scopus 로고    scopus 로고
    • Inhaled phosphodiesterase type 5 inhibitors restore chloride transport in cystic fibrosis mice
    • Lubamba B, Lebacq J, Reychler G, Marbaix E, Wallemacq P, et al. (2011) Inhaled phosphodiesterase type 5 inhibitors restore chloride transport in cystic fibrosis mice. Eur Respir J 37: 72-78.
    • (2011) Eur Respir J , vol.37 , pp. 72-78
    • Lubamba, B.1    Lebacq, J.2    Reychler, G.3    Marbaix, E.4    Wallemacq, P.5
  • 37
    • 84866288704 scopus 로고    scopus 로고
    • Comparative variability of nasal potential difference measurements in human and mice
    • Leonard A, Lubamba B, Dhooghe B, Noel S, Wallemacq P, et al. (2012) Comparative variability of nasal potential difference measurements in human and mice. Open J Respir Dis 2: 43-56.
    • (2012) Open J Respir Dis , vol.2 , pp. 43-56
    • Leonard, A.1    Lubamba, B.2    Dhooghe, B.3    Noel, S.4    Wallemacq, P.5
  • 38
    • 66249120003 scopus 로고    scopus 로고
    • Airway delivery of low-dose miglustat normalizes nasal potential difference in F508del cystic fibrosis mice
    • Lubamba B, Lebacq J, Lebecque P, Vanbever R, Leonard A, et al. (2009) Airway delivery of low-dose miglustat normalizes nasal potential difference in F508del cystic fibrosis mice. Am J Respir Crit Care Med 179: 1022-1028.
    • (2009) Am J Respir Crit Care Med , vol.179 , pp. 1022-1028
    • Lubamba, B.1    Lebacq, J.2    Lebecque, P.3    Vanbever, R.4    Leonard, A.5
  • 39
    • 0742322867 scopus 로고    scopus 로고
    • CFTR localization in native airway cells and cell lines expressing wild-type or F508del-CFTR by a panel of different antibodies
    • Carvalho-Oliveira I, Efthymiadou A, Malhó R, Nogueira P, Tzetis M, et al. (2004) CFTR localization in native airway cells and cell lines expressing wild-type or F508del-CFTR by a panel of different antibodies. J Histochem Cytochem 52: 193-203.
    • (2004) J Histochem Cytochem , vol.52 , pp. 193-203
    • Carvalho-Oliveira, I.1    Efthymiadou, A.2    Malhó, R.3    Nogueira, P.4    Tzetis, M.5
  • 40
    • 84862503933 scopus 로고    scopus 로고
    • Immunomodulatory activity of vardenafil on induced lung inflammation in cystic fibrosis mice
    • Lubamba B, Huaux F, Lebacq J, Marbaix E, Dhooghe B, et al. (2012) Immunomodulatory activity of vardenafil on induced lung inflammation in cystic fibrosis mice. J Cyst Fibros 11: 266-273.
    • (2012) J Cyst Fibros , vol.11 , pp. 266-273
    • Lubamba, B.1    Huaux, F.2    Lebacq, J.3    Marbaix, E.4    Dhooghe, B.5
  • 41
    • 84878464222 scopus 로고    scopus 로고
    • Dysregulated proinflammatory and fibrogenic phenotype of fibroblasts in cystic fibrosis
    • Huaux F, Noel S, Dhooghe B, Panin N, Lo Re S, et al. (2013) Dysregulated proinflammatory and fibrogenic phenotype of fibroblasts in cystic fibrosis. PLoS One 8: e64341.
    • (2013) PLoS One , vol.8
    • Huaux, F.1    Noel, S.2    Dhooghe, B.3    Panin, N.4    Lo Re, S.5
  • 43
    • 37549063954 scopus 로고    scopus 로고
    • Rectal potential difference and the functional expression of CFTR in the gastrointestinal epithelia in cystic fibrosis mouse models
    • Weiner SA, Caputo C, Bruscia E, Ferreira EC, Price JE, et al. (2008) Rectal potential difference and the functional expression of CFTR in the gastrointestinal epithelia in cystic fibrosis mouse models. Pediatr Res 63: 73-78.
    • (2008) Pediatr Res , vol.63 , pp. 73-78
    • Weiner, S.A.1    Caputo, C.2    Bruscia, E.3    Ferreira, E.C.4    Price, J.E.5
  • 44
    • 0030882184 scopus 로고    scopus 로고
    • Intestinal physiology and pathology in gene-targeted mouse models of cystic fibrosis
    • Grubb BR, Gabriel SE, (1997) Intestinal physiology and pathology in gene-targeted mouse models of cystic fibrosis. Am J Physiol 273: G258-G266.
    • (1997) Am J Physiol , vol.273
    • Grubb, B.R.1    Gabriel, S.E.2
  • 45
    • 0028353184 scopus 로고
    • Activation of intestinal CFTR Cl- channel by heat-stable enterotoxin and guanylin via cAMP-dependent protein kinase
    • Chao AC, de Sauvage FJ, Dong YJ, Wagner JA, Goeddel DV, et al. (1994) Activation of intestinal CFTR Cl- channel by heat-stable enterotoxin and guanylin via cAMP-dependent protein kinase. EMBO J 13: 1065-1072.
    • (1994) EMBO J , vol.13 , pp. 1065-1072
    • Chao, A.C.1    de Sauvage, F.J.2    Dong, Y.J.3    Wagner, J.A.4    Goeddel, D.V.5
  • 46
    • 0031799811 scopus 로고    scopus 로고
    • Regulation of amiloride-sensitive sodium absorption in murine airway epithelium by C-type natriuretic peptide
    • Kelley TJ, Cotton CU, Drumm ML, (1998) Regulation of amiloride-sensitive sodium absorption in murine airway epithelium by C-type natriuretic peptide. Am J Physiol 274: L990-L996.
    • (1998) Am J Physiol , vol.274
    • Kelley, T.J.1    Cotton, C.U.2    Drumm, M.L.3
  • 47
    • 0042831329 scopus 로고    scopus 로고
    • Adenosine receptors and phosphodiesterase inhibitors stimulate Cl- secretion in Calu-3 cells
    • Cobb BR, Fan L, Kovacs TE, Sorscher EJ, Clancy JP, (2003) Adenosine receptors and phosphodiesterase inhibitors stimulate Cl- secretion in Calu-3 cells. Am J Respir Cell Mol Biol 29: 410-418.
    • (2003) Am J Respir Cell Mol Biol , vol.29 , pp. 410-418
    • Cobb, B.R.1    Fan, L.2    Kovacs, T.E.3    Sorscher, E.J.4    Clancy, J.P.5
  • 48
    • 0033027269 scopus 로고    scopus 로고
    • Activation of wild-type and deltaF508-CFTR by phosphodiesterase inhibitors through cAMP-dependent and -independent mechanisms
    • Al-Nakkash L, Hwang TC, (1999) Activation of wild-type and deltaF508-CFTR by phosphodiesterase inhibitors through cAMP-dependent and-independent mechanisms. Pflugers Arch 437: 553-561.
    • (1999) Pflugers Arch , vol.437 , pp. 553-561
    • Al-Nakkash, L.1    Hwang, T.C.2
  • 49
    • 0033867234 scopus 로고    scopus 로고
    • Cellular localization of the cystic fibrosis transmembrane conductance regulator in mouse intestinal tract
    • Ameen N, Alexis J, Salas P, (2000) Cellular localization of the cystic fibrosis transmembrane conductance regulator in mouse intestinal tract. Histochem Cell Biol 114: 69-75.
    • (2000) Histochem Cell Biol , vol.114 , pp. 69-75
    • Ameen, N.1    Alexis, J.2    Salas, P.3
  • 50
    • 34548407741 scopus 로고    scopus 로고
    • Pharmacological modulation of cGMP levels by phosphodiesterase 5 inhibitors as a therapeutic strategy for treatment of respiratory pathology in cystic fibrosis
    • Poschet JF, Timmins GS, Taylor-Cousar JL, Ornatowski W, Fazio J, et al. (2007) Pharmacological modulation of cGMP levels by phosphodiesterase 5 inhibitors as a therapeutic strategy for treatment of respiratory pathology in cystic fibrosis. Am J Physiol Lung Cell Mol Physiol 293: L712-L719.
    • (2007) Am J Physiol Lung Cell Mol Physiol , vol.293
    • Poschet, J.F.1    Timmins, G.S.2    Taylor-Cousar, J.L.3    Ornatowski, W.4    Fazio, J.5
  • 51
    • 23944523289 scopus 로고    scopus 로고
    • STa and cGMP stimulate CFTR translocation to the surface of villus enterocytes in rat jejunum and is regulated by protein kinase G
    • Golin-Bisello F, Bradbury N, Ameen N, (2005) STa and cGMP stimulate CFTR translocation to the surface of villus enterocytes in rat jejunum and is regulated by protein kinase G. Am J Physiol Cell Physiol. 289: C708-C716.
    • (2005) Am J Physiol Cell Physiol , vol.289
    • Golin-Bisello, F.1    Bradbury, N.2    Ameen, N.3
  • 52
    • 84861354967 scopus 로고    scopus 로고
    • Sildenafil acts as potentiator and corrector of CFTR but might be not suitable for the treatment of CF lung disease
    • Leier G, Bangel-Ruland N, Sobczak K, Knieper Y, Weber WM, (2012) Sildenafil acts as potentiator and corrector of CFTR but might be not suitable for the treatment of CF lung disease. Cell Physiol Biochem 29: 775-790.
    • (2012) Cell Physiol Biochem , vol.29 , pp. 775-790
    • Leier, G.1    Bangel-Ruland, N.2    Sobczak, K.3    Knieper, Y.4    Weber, W.M.5
  • 53
    • 33751177801 scopus 로고    scopus 로고
    • Azithromycin reduces spontaneous and induced inflammation in DeltaF508 cystic fibrosis mice
    • Legssyer R, Huaux F, Lebacq J, Delos M, Marbaix E, et al. (2006) Azithromycin reduces spontaneous and induced inflammation in DeltaF508 cystic fibrosis mice. Respir Res 7: 134.
    • (2006) Respir Res , vol.7 , pp. 134
    • Legssyer, R.1    Huaux, F.2    Lebacq, J.3    Delos, M.4    Marbaix, E.5
  • 54
    • 19944422399 scopus 로고    scopus 로고
    • Immunohistochemistry of CFTR in native tissues and primary epithelial cell
    • Mendes F, Doucet L, Hinzpeter A, Férec C, Lipecka J, et al. (2004) Immunohistochemistry of CFTR in native tissues and primary epithelial cell. J Cyst Fibros 3Suppl 2: 37-41.
    • (2004) J Cyst Fibros , vol.3 , pp. 37-41
    • Mendes, F.1    Doucet, L.2    Hinzpeter, A.3    Férec, C.4    Lipecka, J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.