Decreased renal accumulation of aminoglycoside reflects defective receptor-mediated endocytosis in cystic fibrosis and Dent's disease

Pflugers Archiv European Journal of Physiology

Volumn 462, Issue 6, 2011, Pages 851-860

  Raggi, Claudia ^a   Fujiwara, Kunio ^b   Leal, Teresinha ^a   Jouret, François ^a   Devuyst, Olivier ^a,c   Terryn, Sara ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^b SOJO UNIVERSITY   (Japan)

^c UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Chloride channel; Endocytosis; Epithelial transport; Kidney; Proximal tubule

Indexed keywords

ABC TRANSPORTER; ALBUMIN; AMINOGLYCOSIDE ANTIBIOTIC AGENT; CHLORIDE ION; CHLORIDE TRANSPORTER; CREATININE; EARLY ENDOSOME ANTIGEN 1; GENTAMICIN; MEGALIN; NITROGEN; PROTON; TRANSMEMBRANE CONDUCTANCE REGULATOR; UNCLASSIFIED DRUG; UREA;

ALBUMINURIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CELLULAR DISTRIBUTION; CHLORIDE TRANSPORT; CONTROLLED STUDY; CREATININE BLOOD LEVEL; CREATININE CLEARANCE; CYSTIC FIBROSIS; DENT DISEASE; DRUG ACCUMULATION; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG PROTEIN BINDING; DRUG TISSUE LEVEL; DRUG UPTAKE; ENDOCYTOSIS; ENDOSOME; IMMUNOREACTIVITY; ION EXCHANGE; KIDNEY CELL; KIDNEY FAILURE; KIDNEY FUNCTION; KIDNEY METABOLISM; KIDNEY PROXIMAL TUBULE; LYSOSOME; MAXIMUM PLASMA CONCENTRATION; MOUSE; NONHUMAN; POLYURIA; PRIORITY JOURNAL; UREA NITROGEN BLOOD LEVEL; URINARY EXCRETION;

AMINOGLYCOSIDES; ANIMALS; ANTI-BACTERIAL AGENTS; CELLS, CULTURED; CHLORIDE CHANNELS; CYSTIC FIBROSIS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; DENT DISEASE; ENDOCYTOSIS; GENTAMICINS; HUMANS; KIDNEY; KIDNEY TUBULES, PROXIMAL; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT;

EID: 83555168269     PISSN: 00316768     EISSN: 14322013     Source Type: Journal    
DOI: 10.1007/s00424-011-1026-2     Document Type: Article

References (33)

1. GB Appel 1990 Aminoglycoside nephrotoxicity Am J Med 88 165 209 10.1016/0002-9343(90)90082-O
2. D Bockenhauer MJ Hug R Kleta 2009 Cystic fibrosis, aminoglycoside treatment and acute renal failure: the not so gentle micin Pediatr Nephrol 24 925 928 19005685 10.1007/s00467-008-1036-2
3. SH Cheng RJ Gregory J Marshall, et al. 1990 Defective intracellular transport and processing of CFTR is the molecular basis of most cystic fibrosis Cell 63 827 834 1699669 10.1016/0092-8674(90)90148-8 1:CAS:528: DyaK3MXnvFKguw%3D%3D (Pubitemid 120035055)
4. EI Christensen H Birn 2002 Megalin and cubilin: multifunctional endocytic receptors Nat Rev Mol Cell Biol 3 256 266 11994745 1:CAS:528: DC%2BD38XjslOnur4%3D (Pubitemid 34619261)
5. EI Christensen O Devuyst G Dom, et al. 2003 Loss of chloride channel ClC-5 impairs endocytosis by defective trafficking of megalin and cubilin in kidney proximal tubules Proc Natl Acad Sci USA 100 8472 8477 12815097 10.1073/pnas.1432873100 1:CAS:528:DC%2BD3sXlsFGntbg%3D (Pubitemid 36842569)
6. EI Christensen PJ Verroust R Nielsen 2009 Receptor-mediated endocytosis in renal proximal tubule Pflugers Arch 458 1039 1048 19499243 10.1007/s00424-009-0685-8 1:CAS:528:DC%2BD1MXhtFensbbJ
7. O Devuyst PT Christie PJ Courtoy, et al. 1999 Intra-renal and subcellular distribution of the human chloride channel, CLC-5, reveals a pathophysiological basis for Dent's disease Hum Mol Genet 8 247 257 9931332 10.1093/hmg/8.2.247 1:CAS:528:DyaK1MXht12itrY%3D (Pubitemid 29054266)
8. O Devuyst RV Thakker 2010 Dent's disease Orphanet J Rare Dis 14 5 28
9. Hawk CT, Leary SL, Morris TH (2005) Formulary for laboratory animals, 3rd edn. Blackwell, Ames
10. K Fujiwara M Shin H Matsunaga, et al. 2009 Light-microscopy immunocytochemistry for gentamicin and its use for studying uptake of the drug in kidney Antimicrob Agents Chemother 53 3302 3307 19451299 10.1128/AAC.01627-08 1:CAS:528:DC%2BD1MXps1yhur0%3D
11. F Jouret A Bernard C Hermans, et al. 2007 Cystic fibrosis is associated with a defect in apical receptor-mediated endocytosis in mouse and human kidney J Am Soc Nephrol 18 707 718 17287432 10.1681/ASN.2006030269 1:CAS:528: DC%2BD2sXjs1Grsrg%3D (Pubitemid 46434488)
12. F Jouret O Devuyst 2009 CFTR and detective endocytosis: new insights in the renal phenotype of cystic fibrosis Pflugers Arch 457 1227 1236 18839205 10.1007/s00424-008-0594-2 1:CAS:528:DC%2BD1MXivFynurg%3D
13. WJ Jusko LL Mosovich LM Gerbracht ME Mattar SJ Yaffe 1975 Enhanced renal excretion of dicloxacillin in patients with cystic fibrosis Pediatrics 56 1038 1044 1196754 1:CAS:528:DyaE28Xotl2ltw%3D%3D
14. JM Lopez-Novoa Y Quiros L Vicente AI Morales FJ Lopez-Hernandez 2011 New insights into the mechanism of aminoglycoside nephrotoxicity: an integrative point of view Kidney Int 79 33 45 20861826 10.1038/ki.2010.337 1:CAS:528:DC%2BC3cXhsFGrur7F
15. SK Moestrup S Cui H Vorum, et al. 1995 Evidence that epithelial glycoprotein 330/megalin mediates uptake of polybasic drugs J Clin Investig 96 1404 1413 7544804 10.1172/JCI118176 1:CAS:528:DyaK2MXnvVGqtLg%3D
16. J Nagai M Takano 2004 Molecular aspects of renal handling of aminoglycosides and strategies for preventing the nephrotoxicity Drug Metab Pharmacokin 19 159 170 10.2133/dmpk.19.159 1:CAS:528:DC%2BD2cXmvFKqs78%3D
17. J Nagai H Tanaka N Nakanishi, et al. 2001 Role of megalin in renal handling of aminoglycosides Am J Physiol Ren Physiol 281 F337 F344 1:CAS:528:DC%2BD3MXmtVCksrk%3D
18. TD Nolin J Himmelfarb 2010 Mechanisms of drug induced nephrotoxicity Handb Exp Pharmacol 196 111 130 20020261 10.1007/978-3-642-00663-0-5 1:CAS:528:DC%2BC3cXnvVynu70%3D
19. A Persu O Devuyst N Lannoy, et al. 2000 CF gene and cystic fibrosis transmembrane conductance regulator expression in autosomal dominant polycystic kidney disease J Am Soc Nephrol 11 2285 2296 11095651 1:CAS:528: DC%2BD3cXptVagsLY%3D
20. - channel disruption impairs endocytosis in a mouse model for Dent's disease Nature 408 369 373 11099045 10.1038/35042597 1:CAS:528: DC%2BD3cXosVertLY%3D
21. AA Reed NY Loh S Terryn, et al. 2010 CLC-5 and KIF3B interact to facilitate CLC-5 plasma membrane expression, endocytosis, and microtubular transport: relevance to pathophysiology of Dent's disease Am J Physiol 298 F365 F380 10.1152/ajprenal.00038.2009 1:CAS:528:DC%2BC3cXhvVykt78%3D
22. SM Rowe S Miller EJ Sorscher 2005 Cystic fibrosis New Eng J Med 352 1992 2001 15888700 10.1056/NEJMra043184 1:CAS:528:DC%2BD2MXjvFyrtLY%3D (Pubitemid 40638370)
23. C Schmitz J Hilpert C Jacobsen, et al. 2002 Megalin deficiency offers protection from renal aminoglycoside accumulation J Biol Chem 277 618 622 11700326 10.1074/jbc.M109959200 1:CAS:528:DC%2BD38XjslGmsA%3D%3D (Pubitemid 34952099)
24. H Servais A Ortiz O Devuyst S Denamur PM Tulkens MP Mingeot-Leclercq 2008 Renal cell apoptosis induced by nephrotoxic drugs: cellular and molecular mechanisms and potential approaches to modulation Apoptosis 13 11 32 17968659 10.1007/s10495-007-0151-z 1:CAS:528:DC%2BD1cXjt12hurk%3D
25. N Soulsby H Greville K Coulthard, et al. 2009 Renal dysfunction in cystic fibrosis: is there cause of concern? Pediatr Pulmonol 44 947 953 19728391 10.1002/ppul.21086
26. M Susanto LZ Benet 2002 Can the enhanced renal clearance of antibiotics in cystic fibrosis patients be explained by P-glycoprotein transport? Pharm Res 19 457 462 12033380 10.1023/A:1015191511817 1:CAS:528:DC%2BD38XjvFejs7w%3D (Pubitemid 34408945)
27. K Tanaka S Terryn L Geffers S Garbay M Pontoglio O Devuyst 2010 The transcription factor HNF1α regulates expression of chloride-proton exchanger ClC-5 in the renal proximal tubule Am J Physiol Ren Physiol 299 F1339 F1347 10.1152/ajprenal.00077.2010 1:CAS:528:DC%2BC3cXhs1elsLfL
28. J Tauris EI Christensen A Nykjaer, et al. 2009 Cubilin and megalin co-localize in the neonatal inner ear Audiol Neurootol 14 267 278 19202329 10.1159/000199446 1:CAS:528:DC%2BD1MXmtlertb0%3D
29. S Terryn F Jouret F Vandenabeele, et al. 2007 A primary culture of mouse proximal tubular cells, established on collagen-coated membranes Am J Physiol 293 F476 F485 10.1152/ajprenal.00363.2006 1:CAS:528:DC%2BD2sXptlyqtLk%3D (Pubitemid 47358117)
30. DJ Touw 1998 Clinical pharmacokinetics of antimicrobial drugs in cystic fibrosis Pharm World Sci 20 149 160 9762727 10.1023/A:1008634911114 1:CAS:528:DyaK1MXltVyltg%3D%3D (Pubitemid 28393870)
31. JH Van Doorninck PJ French E Verbeek, et al. 1995 A mouse model of cystic fibrosis transmembrane conductance regulator results in a temperature-sensitive processing defect in vivo EMBO J 14 4403 4411 7556083
32. SS Wang O Devuyst PJ Courtoy, et al. 2000 Mice lacking renal chloride channel, ClC-5, are a model for Dent's disease, a nephrolithiasis disorder associated with a defective receptor-mediated endocytosis Hum Mol Genet 9 2937 2945 11115837 10.1093/hmg/9.20.2937 1:CAS:528:DC%2BD3MXjt1Sr (Pubitemid 32000767)
33. R Zietse R Zoutendijk EJ Hoorn 2009 Fluid, electrolyte and acid-base disorders associated with antibiotic therapy Nat Rev Nephrol 5 193 202 19322184 10.1038/nrneph.2009.17 1:CAS:528:DC%2BD1MXjs1ynsbc%3D