Dysregulated Proinflammatory and Fibrogenic Phenotype of Fibroblasts in Cystic Fibrosis

PLoS ONE

Volumn 8, Issue 5, 2013, Pages

  Huaux, François ^a   Noel, Sabrina ^a   Dhooghe, Barbara ^a   Panin, Nadtha ^a   Lo Re, Sandra ^a   Lison, Dominique ^a   Wallemacq, Pierre ^a   Marbaix, Etienne ^b   Scholte, Bob J ^c   Lebecque, Patrick ^d   Leal, Teresinha ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^b DE DUVE INSTITUTE   (Belgium)

^c ERASMUS MEDICAL CENTER   (Netherlands)

^d CLINIQUES UNIVERSITAIRES SAINT LUC   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

BLEOMYCIN; GROWTH FACTOR; MESSENGER RNA; VARDENAFIL;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; CYSTIC FIBROSIS; DRUG EFFICACY; DRUG MECHANISM; FEMALE; FIBROBLAST; GENE EXPRESSION; IN VIVO STUDY; INFLAMMATION; LUNG; MACROPHAGE; MOUSE; MYOFIBROBLAST; NONHUMAN; PHENOTYPE; PROTEIN EXPRESSION; SENSITIVITY ANALYSIS; SKIN; UPREGULATION;

ANIMALS; BLEOMYCIN; CELL LINE; CELLS, CULTURED; CYSTIC FIBROSIS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; CYTOKINES; FEMALE; FIBROBLASTS; GENE EXPRESSION; IMIDAZOLES; IMMUNOHISTOCHEMISTRY; INFLAMMATION MEDIATORS; LIPOPOLYSACCHARIDES; LUNG; MICE; MICE, 129 STRAIN; MICE, INBRED C57BL; MICE, INBRED CFTR; PHENOTYPE; PIPERAZINES; PSEUDOMONAS AERUGINOSA; PULMONARY FIBROSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SKIN; SULFONES; TRIAZINES; VASODILATOR AGENTS;

MUS;

EID: 84878464222     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0064341     Document Type: Article

References (30)

1. Andersen DH, (1938) Cystic fibrosis of the pancreas and its relation to celiac disease: a clinical and pathological study. Am J Dis Child 56: 344-399.
2. Hilliard TN, Regamey N, Shute JK, Nicholson AG, Alton EWFW, et al. (2007) Airway remodelling in children with cystic fibrosis. Thorax 62: 1074-1080.
3. Sciaky D, Brazer W, (2000) Center DM, Cruikshank WW, Smith TJ (2000) Cultured human fibroblasts express constitutive IL-16 mRNA: cytokine induction of active IL-16 protein synthesis through a caspase-3-dependent mechanism. J Immunol 164: 3806-3814.
4. Hogaboam CM, Steinhauser ML, Chensue SW, Kunkel SL, (1998) Novel roles for chemokines and fibroblasts in interstitial fibrosis. Kidney Internat 54: 2152-2159.
5. Sweeney SE, Firestein GS, (2004) Rheumatoid arthritis: regulation of synovial inflammation. Int J Biochem Cell Biol 36: 372-378.
6. Smith TJ, (2005) Insights into the role of fibroblasts in human autoimmune diseases. Clin Exp Immunol 141: 388-397.
7. van Doorninck JH, French PJ, Verbeek E, Peters RH, Morreau H, et al. (1995) A mouse model for the cystic fibrosis delta f508 mutation. EMBO J 14: 4403-4411.
8. Lubamba B, Lecourt H, Lebacq J, Lebecque P, De Jonge H, et al. (2008) Preclinical evidence that sildenafil and vardenafil activate chloride transport in cystic fibrosis. Am J Respir Crit Care Med 177: 506-515.
9. Lubamba B, Lebacq J, Reychler G, Marbaix E, Wallemacq P, et al. (2011) Inhaled phosphodiesterase type 5 inhibitors restore chloride transport in cystic fibrosis mice. Eur Respir J 37: 72-78.
10. Lubamba B, Huaux F, Lebacq J, Marbaix E, Dhooghe B, et al. (2012) Immunomodulatory activity of vardenafil on induced lung inflammation in cystic fibrosis mice. J Cyst Fibros 11: 266-273.
11. Nicklas W, Baneux P, Boot R, Decelle T, Deeny AA, et al.; FELASA (Federation of European Laboratory Animal Science Associations Working Group on Health Monitoring of Rodent and Rabbit Colonies) (2002) Recommendations for the health monitoring of rodent and rabbit colonies in breeding and experimental units. Lab Anim 36: 20-42.
12. Gasse P, Mary C, Guenon I, Noulin N, Charron S, et al. (2007) IL-1R1/MyD88 signaling and the inflammasome are essential in pulmonary inflammation and fibrosis in mice. J Clin Invest 117: 3786-3799.
13. Meyer M, Huaux F, Gavilanes X, van den Brûle S, Lebecque P, et al. (2009) Azithromycin reduces exaggerated cytokine production by M1 alveolar macrophages in cystic fibrosis. Am J Respir Cell Mol Biol 41: 590-602.
14. Huaux F, Liu T, McGarry B, Ullenbruch M, Phan SH, (2003) Dual roles of IL-4 in lung injury and fibrosis. J Immunol 170: 2083-92.
15. Di A, Brown ME, Deriy LV, Li C, Szeto FL, et al. (2006) CFTR regulates phagosome acidification in macrophages and alters bactericidal activity. Nat Cell Biol 8: 933-944.
16. Mattes PM, Maloney PC, Littlefield JW, (1987) Altered chloride metabolism in cultured cystic fibrosis skin fibroblasts. Proc Natl Acad Sci USA 84: 3009-3013.
17. Roomans GM, von Euler AM, Muller RM, (1983) Cystic fibrosis - ultrastructural and microanalytical studies. Scan Electron Microsc (Pt2): 697-712.
18. Khalid BA, Gyorki S, Warne GL, Funder JW. Cystic fibrosis, normal fibroblasts have identical glucocorticoid receptor profiles, induced protein responses, (1983) Clin Endocrinol (Oxf). 18: 407-415.
19. Kirkpatrick C, Lecocq R, Lamy F, Defleur V, Dedobeleer G, et al. (1985) Analysis of proteins synthesized by fibroblasts from patients with cystic fibrosis by two-dimensional gel electrophoresis and double label autoradiography. Pediatr Res 19: 1341-1345.
20. Regamey N, Jeffery PK, Alton EW, Bush A, Davies JC, (2011) Airway remodelling and its relationship to inflammation in cystic fibrosis. Thorax 66: 624-629.
21. Piorunek T, Marszalek A, Biczysko W, Gozdzik J, Cofta S, et al. (2008) Correlation between the stage of cystic fibrosis and the level of morphological changes in adult patients. J Physiol Pharmacol 59: 565-572.
22. Harris WT, Muhlenbach MS, Oster RA, Knowles MR, Clancy JP, et al. (2011) Plasma TGF-β1 in pediatric cystic fibrosis: potential biomarker of lung disease and response to therapy. Pediatr Pulmonol 46: 688-695.
23. Dorfman R, Sandford A, Taylor C, Huang B, Frangolias D, et al. (2008) Complex two-gene modulation of lung disease severity in children with cystic fibrosis. J Clin Invest 118: 1040-1049.
24. Hinz B, Celetta G, Tomasek JJ, Gabbiani G, Chaponnier C, (2001) Alpha-smooth muscle actin expression upregulates fibroblast contractile activity. Mol Biol Cell 12: 2730-41.
25. Daguès N, Pawlowski V, Sobry C, Hanton G, Borde F, et al. (2007) Investigation of the molecular mechanisms preceding PDE4 inhibitor-induced vasculopathy in rats: tissue inhibitor of metalloproteinase 1, a potential predictive biomarker. Toxicol Sci 100: 238-247.
26. Hashimoto Y, Shuto T, Mizunoe S, Tomita A, Koga T, et al. (2011) CFTR-deficiency renders mice highly susceptible to cutaneous symptoms during mite infestation. Lab Invest 91: 509-18.
27. Gavilanes X, Huaux F, Meyer M, Lebecque P, Marbaix E, et al. (2009) Azithromycin fails to reduce increased expression of neutrophil-related cytokines in primary-cultured epithelial cells from cystic fibrosis mice. J Cyst Fibros 8: 203-210.
28. Yoshimura K, Nakamura H, Trapnell BC, Chu CS, Dalemans W, et al. (1991) Expression of the cystic fibrosis transmembrane conductance regulator gene in cells of non-epithelial origin. Nucleic Acids Res 19: 5417-5423.
29. Percival JM, Whitehead NP, Adams ME, Adamo CM, Beavo JA, et al. (2012) Sildenafil reduces respiratory muscle weakness and fibrosis in the mdx mouse model of Duchenne muscular dystrophy. J Pathol 228: 77-87.
30. Leier G, Bangel-Ruland N, Sobczak K, Knieper Y, Weber WM, (2012) Sildenafil acts as potentiator and corrector of CFTR but might be not suitable for the treatment of CF lung disease. Cell Physiol Biochem 29: 775-790.