The role of soluble Guanylyl Cyclase in chronic obstructive pulmonary disease

American Journal of Respiratory and Critical Care Medicine

Volumn 188, Issue 7, 2013, Pages 789-799

  Glynos, Constantinos ^a   Dupont, Lisa L ^a   Vassilakopoulos, Theodoros ^b   Papapetropoulos, Andreas ^c   Brouckaert, Peter ^d,e   Giannis, Athanassios ^f   Joos, Guy F ^a   Bracke, Ken R ^a   Brusselle, Guy G ^a  

^a GHENT UNIVERSITY HOSPITAL   (Belgium)

^b UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^c UNIVERSITY OF PATRAS   (Greece)

^d GHENT UNIVERSITY   (Belgium)

^e DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^f UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

Chronic obstructive pulmonary disease; Cigarette smoking; Soluble guanylyl cyclase

Indexed keywords

CINACIGUAT; CYCLIC GMP DEPENDENT PROTEIN KINASE; GUANYLATE CYCLASE; NITRIC OXIDE; SEROTONIN;

ADULT; AIRFLOW; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; HUMAN; IN VIVO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SMOKING;

AGED; ANIMALS; BRONCHOCONSTRICTION; DISEASE MODELS, ANIMAL; DOWN-REGULATION; FEMALE; GUANYLATE CYCLASE; HUMANS; MALE; MICE; MICE, INBRED C57BL; MIDDLE AGED; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RESPIRATORY MUCOSA; SEROTONIN; SMOKING; TOBACCO SMOKE POLLUTION;

EID: 84886247128     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201210-1884OC     Document Type: Article

References (47)

1. Lopez AD, Mathers CD, Ezzati M, Jamison DT, Murray CJ. Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data. Lancet 2006;367:1747-1757. (Pubitemid 43767064)
2. Brusselle GG, Joos GF, Bracke KR. New insights into the immunology of chronic obstructive pulmonary disease. Lancet 2011;378:1015-1026.
3. Oswald DNC, Medvei VC. Chronic bronchitis: the effect of cigarettesmoking. Lancet 1955;269:843-844.
4. Churg A, Cosio M, Wright JL. Mechanisms of cigarette smoke-induced COPD: insights from animal models. Am J Physiol Lung Cell Mol Physiol 2008;294:L612-L631. (Pubitemid 351520094)
5. Tiddens HA, Hofhuis W, Bogaard JM, Hop WC, de Bruin H, Willems LN, de Jongste JC. Compliance, hysteresis, and collapsibility of human small airways. Am J Respir Crit Care Med 1999;160:1110-1118. (Pubitemid 29487447)
6. Mergia E, Russwurm M, Zoidl G, Koesling D. Major occurrence of the new alpha2beta1 isoform of NO-sensitive guanylyl cyclase in brain. Cell Signal 2003;15:189-195. (Pubitemid 35449122)
7. Koesling D, Russwurm M, Mergia E, Mullershausen F, Friebe A. Nitric oxide-sensitive guanylyl cyclase: structure and regulation. Neurochem Int 2004;45:813-819. (Pubitemid 39108053)
8. Mergia E, Friebe A, Dangel O, Russwurm M, Koesling D. Spare guanylyl cyclase NO receptors ensure high NO sensitivity in the vascular system. J Clin Invest 2006;116:1731-1737.
9. Nimmegeers S, Sips P, Buys E, Brouckaert P, Van de Voorde J. Functional role of the soluble guanylyl cyclase alpha(1) subunit in vascular smooth muscle relaxation. Cardiovasc Res 2007;76: 149-159. (Pubitemid 47362046)
10. Friebe A, Koesling D. Regulation of nitric oxide-sensitive guanylyl cyclase. Circ Res 2003;93:96-105. (Pubitemid 36919696)
11. Francis SH, Busch JL, Corbin JD, Sibley D. cGMP-dependent protein kinases and cGMP phosphodiesterases in nitric oxide and cGMP action. Pharmacol Rev 2010;62:525-563.
12. Ansarin K, Chatkin JM, Ferreira IM, Gutierrez C.A., Zamel N, Chapman KR. Exhaled nitric oxide in chronic obstructive pulmonary disease: relationship to pulmonary function. Eur Respir J 2001;17:934-938. (Pubitemid 32600342)
13. Brindicci C, Kharitonov S.A., ItoM, ElliottMW, Hogg JC, Barnes PJ, Ito K. Nitric oxide synthase isoenzyme expression and activity in peripheral lung tissue of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2010;181:21-30.
14. Ichinose M, Sugiura H, Yamagata S, Koarai A, Shirato K. Increase in reactive nitrogen species production in chronic obstructive pulmonary disease airways. Am J Respir Crit Care Med 2000;162:701-706. (Pubitemid 30647222)
15. Papapetropoulos A, Abou-Mohamed G, Marczin N, Murad F, Caldwell RW, Catravas JD. Downregulation of nitrovasodilator-induced cyclic GMP accumulation in cells exposed to endotoxin or interleukin-1 beta. Br J Pharmacol 1996;118:1359-1366. (Pubitemid 26248784)
16. Papapetropoulos A, Go CY, Murad F, Catravas JD. Mechanisms of tolerance to sodium nitroprusside in rat cultured aortic smooth muscle cells. Br J Pharmacol 1996;117:147-155. (Pubitemid 26030264)
17. Gerassimou C, KotanidouA, Zhou Z, SimoesDC, Roussos C, Papapetropoulos A. Regulation of the expression of soluble guanylyl cyclase by reactive oxygen species. Br J Pharmacol 2007;150:1084-1091. (Pubitemid 46625092)
18. Papapetropoulos A, Simoes DC, Xanthou G, Roussos C, Gratziou C. Soluble guanylyl cyclase expression is reduced in allergic asthma. Am J Physiol Lung Cell Mol Physiol 2006;290:L179-L184.
19. Egemnazarov B, Sydykov A, Schermuly RT, Weissmann N, Stasch JP, Sarybaev AS, Seeger W, Grimminger F, Ghofrani HA. Novel soluble guanylyl cyclase stimulator BAY 41-2272 attenuates ischemiareperfusion- induced lung injury. Am J Physiol Lung Cell Mol Physiol 2009;296:L462-L469.
20. Glynos C, Kotanidou A, Orfanos SE, Zhou Z, Simoes DC, Magkou C, Roussos C, Papapetropoulos A. Soluble guanylyl cyclase expression is reduced in LPS-induced lung injury. Am J Physiol Regul Integr Comp Physiol 2007;292:R1448-R1455. (Pubitemid 46557804)
21. Tsai EJ, Liu YC, Koitabashi N, Bedja D, Danner T, Jasmin JF, Lisanti MP, Friebe A, Takimoto E, Kass DA. Pressure-overload-induced subcellular relocalization/oxidation of soluble guanylyl cyclase in the heart modulates enzyme stimulation. Circ Res 2012;110:295-303.
22. Evgenov OV, Pacher P, Schmidt PM, Hasko G, Schmidt HH, Stasch JP. NO-independent stimulators and activators of soluble guanylate cyclase: discovery and therapeutic potential. Nat Rev Drug Discov 2006; 5:755-768. (Pubitemid 44323702)
23. D'hulst AI, Vermaelen KY, Brusselle GG, Joos GF, Pauwels R.A.. Time course of cigarette smoke-induced pulmonary inflammation in mice. Eur Respir J 2005;26:204-213. (Pubitemid 41079063)
24. Pauwels R.A., Buist AS, Calverley PM, Jenkins CR, Hurd SS. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: NHLBI/WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD) Workshop summary. Am J Respir Crit Care Med 2001;163:1256-1276. (Pubitemid 32378468)
25. Buys ES, Sips P, Vermeersch P, Raher MJ, Rogge E, Ichinose F, Dewerchin M, Bloch KD, Janssens S, Brouckaert P. Gender-specific hypertension and responsiveness to nitric oxide in sGCalpha1 knockout mice. Cardiovasc Res 2008;79:179-186. (Pubitemid 351881935)
26. Buys ES, Cauwels A, RaherMJ, Passeri JJ, Hobai I, Cawley SM, Rauwerdink KM, Thibault H, Sips PY, Thoonen R, et al. sGC(alpha)1(beta)1 attenuates cardiac dysfunction and mortality in murine inflammatory shock models. Am J Physiol Heart Circ Physiol 2009;297:H654-H663.
27. Levitt RC, Mitzner W. Autosomal recessive inheritance of airway hyperreactivity to 5-hydroxytryptamine. J Appl Physiol 1989;67:1125-1132. (Pubitemid 19245038)
28. Bracke KR, D'hulst AI, Maes T, Demedts IK, Moerloose KB, Kuziel WA, Joos GF, Brusselle GG. Cigarette smoke-induced pulmonary inflammation, but not airway remodelling, is attenuated in chemokine receptor 5-deficient mice. Clin Exp Allergy 2007;37:1467-1479. (Pubitemid 47460235)
29. Vermaelen K, Pauwels R. Accurate and simple discrimination of mouse pulmonary dendritic cell and macrophage populations by flow cytometry: methodology and new insights. Cytometry A 2004;61:170-177. (Pubitemid 39362291)
30. Coletta C, Papapetropoulos A, Erdelyi K, Olah G, Modis K, Panopoulos P, Asimakopoulou A, Gero D, Sharina I, Martin E, et al. Hydrogen sulfide and nitric oxide are mutually dependent in the regulation of angiogenesis and endothelium-dependent vasorelaxation. Proc Natl Acad Sci US.A. 2012;109:9161-9166.
31. Demoor T, Bracke KR, Dupont LL, Plantinga M, Bondue B, Roy MO, Lannoy V, Lambrecht BN, Brusselle GG, Joos GF. The role of ChemR23 in the induction and resolution of cigarette smoke-induced inflammation. J Immunol 2011;186:5457-5467.
32. Saetta M, Shiner RJ, Angus GE, Kim WD, Wang NS, King M, Ghezzo H, Cosio MG. Destructive index: a measurement of lung parenchymal destruction in smokers. Am Rev Respir Dis 1985;131:764-769. (Pubitemid 15066865)
33. Buechler WA, Nakane M, Murad F. Expression of soluble guanylate cyclase activity requires both enzyme subunits. Biochem Biophys Res Commun 1991;174:351-357.
34. Filippov G, Bloch DB, Bloch KD. Nitric oxide decreases stability of mRNAs encoding soluble guanylate cyclase subunits in rat pulmonary artery smooth muscle cells. J Clin Invest 1997;100:942-948. (Pubitemid 27371713)
35. Kloss S, Srivastava R, Mulsch A. Down-regulation of soluble guanylyl cyclase expression by cyclic AMP is mediated by mRNA-stabilizing protein HuR. Mol Pharmacol 2004;65:1440-1451. (Pubitemid 38668302)
36. Papapetropoulos A, Cziraki A, Rubin JW, Stone CD, Catravas JD. cGMP accumulation and gene expression of soluble guanylate cyclase in human vascular tissue. J Cell Physiol 1996;167:213-221. (Pubitemid 26145854)
37. Feelisch M, Kotsonis P, Siebe J, Clement B, Schmidt HH. The soluble guanylyl cyclase inhibitor 1H-[1,2,4]oxadiazolo[4,3,-a] quinoxalin- 1-one is a nonselective heme protein inhibitor of nitric oxide synthase and other cytochrome P-450 enzymes involved in nitric oxide donor bioactivation. Mol Pharmacol 1999;56:243-253.
38. Wegener JW, Closs EI, Forstermann U, Nawrath H. Failure of 1H-[1,2,4] oxadiazolo[4,3-a]quinoxalin-1-one (ODQ) to inhibit soluble guanylyl cyclase in rat ventricular cardiomyocytes. Br J Pharmacol 1999;127:693-700.
39. Zhao Y, Brandish PE, DiValentin M, Schelvis JP, Babcock GT, Marletta M.A.. Inhibition of soluble guanylate cyclase by ODQ. Biochemistry 2000;39:10848-10854.
40. Buys ES, Raher MJ, Kirby A, Mohd S, Baron DM, Hayton SR, Tainsh LT, Sips PY, Rauwerdink KM, Yan Q, et al. Genetic modifiers of hypertension in soluble guanylate cyclase a1-deficient mice. J Clin Invest 2012;122:2316-2325
41. Chester M, Seedorf G, Tourneux P, Gien J, Tseng N, Grover T, Wright J, Stasch JP, Abman SH. Cinaciguat, a soluble guanylate cyclase activator, augments cGMP after oxidative stress and causes pulmonary vasodilation in neonatal pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol 2011;301:L755-L764.
42. Stasch JP, Schmidt PM, Nedvetsky PI, Nedvetskaya TY, Arun Kumar HS, Meurer S, Deile M, Taye A, Knorr A, Lapp H, et al. Targeting the heme-oxidized nitric oxide receptor for selective vasodilatation of diseased blood vessels. J Clin Invest 2006;116:2552-2561. (Pubitemid 44330154)
43. Geary C.A., Goy M.F., Boucher RC. Synthesis and vectorial export of cGMP in airway epithelium: expression of soluble and CNP-specific guanylate cyclases. Am J Physiol 1993;265:L598-L605.
44. Sager G. Cyclic GMP transporters. Neurochem Int 2004;45:865-873. (Pubitemid 39108059)
45. Mullershausen F, Russwurm M, Thompson WJ, Liu L, Koesling D, Friebe A. Rapid nitric oxide-induced desensitization of the cGMP response is caused by increased activity of phosphodiesterase type 5 paralleled by phosphorylation of the enzyme. J Cell Biol 2001;155:271-278. (Pubitemid 34289302)
46. Hamad AM, Clayton A, Islam B, Knox AJ. Guanylyl cyclases, nitric oxide, natriuretic peptides, and airway smooth muscle function. Am J Physiol Lung Cell Mol Physiol 2003;285:L973-L983. (Pubitemid 37310086)
47. Ahluwalia A, Foster P, Scotland RS, McLean PG, Mathur A, Perretti M, Moncada S, Hobbs AJ. Antiinflammatory activity of soluble guanylate cyclase: cGMP-dependent down-regulation of P-selectin expression and leukocyte recruitment. Proc Natl Acad Sci US.A. 2004;101:1386-1391. (Pubitemid 38182698)