Blockade of islet amyloid polypeptide fibrillation and cytotoxicity by the secretory chaperones 7B2 and proSAAS

FEBS Letters

Volumn 587, Issue 21, 2013, Pages 3406-3411

  Peinado, Juan R ^a   Sami, Furqan ^a   Rajpurohit, Nina ^a   Lindberg, Iris ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

7B2; hIAPP; proSAAS; Type 2 diabetes

Indexed keywords

AMYLIN; CHAPERONE; PROSAAS PROTEIN; SECRETOGRANIN V; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; AMYLOID PLAQUE; AMYLOIDOSIS; ANIMAL CELL; ARTICLE; CELL DEATH; CELL FUNCTION; CELL STRAIN RIN5F; CONTROLLED STUDY; CYTOTOXICITY; IN VITRO STUDY; INSULINOMA; ISLET AMYLOID POLYPEPTIDE FIBRILLATION; MOLECULAR WEIGHT; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; STRUCTURE ACTIVITY RELATION; TUMOR CELL LINE;

7B2; AD; ALZHEIMER'S DISEASE; BOVINE SERUM ALBUMIN; BSA; CA; CARBONIC ANHYDRASE; FBS; FETAL BOVINE SERUM; HIAPP; IAPP; ISLET AMYLOID POLYPEPTIDE; PARKINSON'S DISEASE; PBS; PC1/3; PD; PHOSPHATE-BUFFERED SALINE; PROHORMONE CONVERTASE 1/3; PROSAAS; T2DM; TBS; THIOFLAVIN T; THT; TRIS-BUFFERED SALINE; TYPE 2 DIABETES;

ANIMALS; CELLS, CULTURED; HUMANS; ISLET AMYLOID POLYPEPTIDE; MICE; MOLECULAR CHAPERONES; NERVE TISSUE PROTEINS; NEUROENDOCRINE SECRETORY PROTEIN 7B2; RATS;

EID: 84886233635     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2013.09.006     Document Type: Article

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