Inhibitory Specificity and Potency of proSAAS-derived Peptides toward Proprotein Convertase 1

Journal of Biological Chemistry

Volumn 276, Issue 35, 2001, Pages 32720-32728

  Basak, Ajoy ^a   Koch, Peter ^a   Dupelle, Marcel ^a   Fricker, Lloyd D ^b   Devi, Lakshmi A ^c   Chrétien, Michel ^a   Seidah, Nabil G ^d  

^a OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^c NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; ENZYME INHIBITION; PROTEINS; SUBSTRATES;

ENDOCRINE PRECURSORS;

BIOCHEMISTRY;

ALANINE; ARGININE; CYSTEINE; ENZYME INHIBITOR; FURIN; LEUCINE; LYSINE; PEPTIDE DERIVATIVE; PROLINE DERIVATIVE; PROPROTEIN CONVERTASE 1; UNCLASSIFIED DRUG; VALINE; ENZYME PRECURSOR; NEUROPEPTIDE; PCSK1N PROTEIN, HUMAN; PEPTIDE FRAGMENT; PROPROTEIN CONVERTASE PC7; PROTEIN PRECURSOR; RECOMBINANT PROTEIN; SUBTILISIN;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CIRCULAR DICHROISM; ENZYME INHIBITION; ENZYME SPECIFICITY; ENZYME SUBSTRATE; GENETIC CONSERVATION; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN MOTIF; PROTEIN PROCESSING; ANIMAL; BINDING COMPETITION; CHEMISTRY; DRUG ANTAGONISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; KINETICS; MASS SPECTROMETRY; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; RAT; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

AMINO ACID SEQUENCE; ANIMALS; BINDING, COMPETITIVE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CIRCULAR DICHROISM; CONSERVED SEQUENCE; ENZYME PRECURSORS; HUMANS; KINETICS; MOLECULAR SEQUENCE DATA; NEUROPEPTIDES; PEPTIDE FRAGMENTS; PROTEIN CONFORMATION; PROTEIN PRECURSORS; RATS; RECOMBINANT PROTEINS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; STRUCTURE-ACTIVITY RELATIONSHIP; SUBTILISINS;

EID: 0035980127     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M104064200     Document Type: Article

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