Esters and amides of maslinic acid trigger apoptosis in human tumor cells and alter their mode of action with respect to the substitution pattern at C-28

European Journal of Medicinal Chemistry

Volumn 70, Issue , 2013, Pages 259-272

  Siewert, Bianka ^a   Pianowski, Elke ^a   Csuk, René ^a  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

Antitumor activity; Apoptosis; Maslinic acid; Structure activity relationships

Indexed keywords

(2ALPHA,3BETA) 2,3 DI O ACETYL MASLINIC ACID; (2ALPHA,3BETA) 2,3 DIHYDROXY 28 OXO OLEAN 12 EN 28 AMIDE; (CYLCOHEXYL)METHYL(2ALPHA,3BETA) 2,3 DIHYDROXY OLEAN 12 EN 28 OATE; 2 CHLOROETHYL(2ALPHA,3BETA) 2,3 DIHYDROXY OLEAN 12 EN 28 OATE; 2 HYDROXYETHYL(2ALPHA,3BETA) 2,3 DIHYDROXY OLEAN 12 EN 28 OATE; 2 PROPEN 1 YL(2ALPHA,3BETA) 2,3 DI O ACETYL 28 OXO OLEAN 12 EN 28 AMIDE; 2 PROPEN 1 YL(2ALPHA,3BETA) 2,3 DIHYDROXY OLEAN 12 EN 28 OATE; 2 PROPYN 1 YL(2ALPHA,3BETA) 2,3 DIHYDROXY OLEAN 12 EN 28 OATE; 3 BROMO PROP 1 YL(2ALPHA,3BETA) 2,3 DIHYDROXY OLEAN 12 EN 28 OATE; 3 BUTEN 1 YL (2ALPHA,3BETA) 2,3 DIHYDROXY OLEAN 12 EN 28 OATE; 3 CHLORO PROP 1 YL (2ALPHA,3BETA) 2,3 DIHYDROXY OLEAN 12 EN 28 OATE; 3 HYDROXY PROP 1 YL(2ALPHA,3BETA) 2,3 DIHYDROXY OLEAN 12 EN 28 OATE; 3 IODO PROP 1 YL(2ALPHA,3BETA) 2,3 DIHYDROXY OLEAN 12 EN 28 OATE; 4 BROMO BUT 1 YL(2ALPHA,3BETA) 2,3 DIHYDROXY OLEAN 12 EN 28 OATE; 4 CHLORO BUT 1 YL(2ALPHA,3BETA) 2,3 DIHYDROXY OLEAN 12 EN 28 OATE; 4 CHLOROBUT 2 EN 1 YL(2ALPHA,3BETA) 2,3 DIHYDROXY OLEAN 12 EN 28 OATE; 4 CHLOROBUT 3 YN 1 YL(2ALPHA,3BETA) 2,3 DIHYDROXY OLEAN 12 EN 28 OATE; AMIDE; BUTYL(2ALPHA,3BETA) 2,3 DIHYDROXY OLEAN 12 EN 28 OATE; DODECYL(2ALPHA,3BETA) 2,3 DIHYDROXY OLEAN 12 EN 28 OATE; ESTER DERIVATIVE; ETHYL(2ALPHA,3BETA) 2,3 DI O ACETYL 28 OXO OLEAN 12 EN 28 AMIDE; ETHYL(2ALPHA,3BETA) 2,3 DIHYDROXY OLEAN 12 EN 28 OATE; HEXYL(2ALPHA,3BETA) 2,3 DIHYDROXY OLEAN 12 EN 28 OATE; MASLINIC ACID; METHYL(2ALPHA,3BETA) 2,3 DIHYDROXY OLEAN 12 EN 28 OATE; OCTADECYL(2ALPHA,3BETA) 2,3 DIHYDROXY OLEAN 12 EN 28 OATE; PROPYL(2ALPHA,3BETA) 2,3 DI O ACETYL 28 OXO OLEAN 12 EN 28 AMIDE; PROPYL(2ALPHA,3BETA) 2,3 DIHYDROXY OLEAN 12 EN 28 OATE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL CYCLE; CELL STRAIN HT29; COLON CANCER; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN CELL CULTURE; LIPOPHILICITY; LUNG CANCER; MELANOMA CELL; OVARY CANCER; STRUCTURE ACTIVITY RELATION; THYROID CARCINOMA;

ANTITUMOR ACTIVITY; APOPTOSIS; MASLINIC ACID; STRUCTURE-ACTIVITY RELATIONSHIPS;

AMIDES; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; ESTERS; HT29 CELLS; HUMANS; MCF-7 CELLS; MICE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NIH 3T3 CELLS; STRUCTURE-ACTIVITY RELATIONSHIP; TRITERPENES;

EID: 84886213840     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.10.016     Document Type: Article

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