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Volumn 13, Issue , 2013, Pages

β-sitosterol induces G1 arrest and causes depolarization of mitochondrial membrane potential in breast carcinoma MDA-MB-231 cells

Author keywords

Breast cancer; Cell cycle and apoptosis; Cell death; Cell proliferation; Lung cancer; Skin cancer

Indexed keywords

CYCLIN D1; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE INHIBITOR 1B; LIPOCORTIN 5; MITOGEN ACTIVATED PROTEIN KINASE 1; PROTEIN BAX; PROTEIN BCL 2; SITOSTEROL;

EID: 84886147806     PISSN: None     EISSN: 14726882     Source Type: Journal    
DOI: 10.1186/1472-6882-13-280     Document Type: Article
Times cited : (79)

References (36)
  • 1
    • 78049485263 scopus 로고    scopus 로고
    • Estimates of worldwide burden of cancer in 2008
    • 10.1002/ijc.25516, 21351269
    • Ferlay J, Shin H, Bray F, Forman D, Mathers C, Parkin D. Estimates of worldwide burden of cancer in 2008. Int J Cancer 2010, 127:2893-2917. 10.1002/ijc.25516, 21351269.
    • (2010) Int J Cancer , vol.127 , pp. 2893-2917
    • Ferlay, J.1    Shin, H.2    Bray, F.3    Forman, D.4    Mathers, C.5    Parkin, D.6
  • 2
    • 77955978565 scopus 로고    scopus 로고
    • Atlanta: American Cancer Society, American Cancer Society
    • American Cancer Society Cancer Facts and Figures: 2010 2010, 1-62. Atlanta: American Cancer Society, American Cancer Society.
    • (2010) Cancer Facts and Figures: 2010 , pp. 1-62
  • 5
    • 0027516446 scopus 로고
    • Cancer-protective factors in fruits and vegetables: biochemical and biological background
    • Dragsted L, Strube M, Larsen J. Cancer-protective factors in fruits and vegetables: biochemical and biological background. Pharmacol Toxicol 1993, 72:116-135.
    • (1993) Pharmacol Toxicol , vol.72 , pp. 116-135
    • Dragsted, L.1    Strube, M.2    Larsen, J.3
  • 6
    • 11144234507 scopus 로고    scopus 로고
    • Biologically important thiols in various vegetables and fruits
    • 10.1021/jf040266f, 15612810
    • Demirkol O, Adams C, Ercal N. Biologically important thiols in various vegetables and fruits. J Agric Food Chem 2004, 52:8151-8154. 10.1021/jf040266f, 15612810.
    • (2004) J Agric Food Chem , vol.52 , pp. 8151-8154
    • Demirkol, O.1    Adams, C.2    Ercal, N.3
  • 7
    • 84878091972 scopus 로고    scopus 로고
    • Additive and synergistic effect of phytochemicals in prevention of oral cancer
    • Chandra S, Sah K, Bagewadi A, Keluskar V, Shetty A. Additive and synergistic effect of phytochemicals in prevention of oral cancer. Eur J Gen Dent 2012, 1:142-147.
    • (2012) Eur J Gen Dent , vol.1 , pp. 142-147
    • Chandra, S.1    Sah, K.2    Bagewadi, A.3    Keluskar, V.4    Shetty, A.5
  • 8
    • 6444226213 scopus 로고    scopus 로고
    • Estimation of plant sterol and cholesterol intake in Finland: quality of new values and their effect on intake
    • Valsta L, Lemström A, Ovaskainen M, Lampi A, Toivo J, Korhonen T, Piironen V. Estimation of plant sterol and cholesterol intake in Finland: quality of new values and their effect on intake. Br J Nutr 2007, 92:671-678.
    • (2007) Br J Nutr , vol.92 , pp. 671-678
    • Valsta, L.1    Lemström, A.2    Ovaskainen, M.3    Lampi, A.4    Toivo, J.5    Korhonen, T.6    Piironen, V.7
  • 10
    • 0032977906 scopus 로고    scopus 로고
    • Plant Sterols and Sterolins: A review of their Immune-modulating properties sterols & sterolins
    • Bouic P, Lamprecht J. Plant Sterols and Sterolins: A review of their Immune-modulating properties sterols & sterolins. Altern Med Rev 1999, 4:170-177.
    • (1999) Altern Med Rev , vol.4 , pp. 170-177
    • Bouic, P.1    Lamprecht, J.2
  • 11
    • 35148820279 scopus 로고    scopus 로고
    • Beta-Sitosterol activates Fas signaling in human breast cancer cells
    • 10.1016/j.phymed.2007.01.003, 17350814
    • Awad A, Chinnam M, Fink C, Bradford P. Beta-Sitosterol activates Fas signaling in human breast cancer cells. Phytomedicine 2007, 14:747-754. 10.1016/j.phymed.2007.01.003, 17350814.
    • (2007) Phytomedicine , vol.14 , pp. 747-754
    • Awad, A.1    Chinnam, M.2    Fink, C.3    Bradford, P.4
  • 12
    • 12344278354 scopus 로고    scopus 로고
    • Effect of resveratrol and beta-sitosterol in combination on reactive oxygen species and prostaglandin release by PC-3 cells
    • Awad A, Burr A, Fink C. Effect of resveratrol and beta-sitosterol in combination on reactive oxygen species and prostaglandin release by PC-3 cells. Prostaglandins Leukot Essent Fat Acids 2005, 72:219-226.
    • (2005) Prostaglandins Leukot Essent Fat Acids , vol.72 , pp. 219-226
    • Awad, A.1    Burr, A.2    Fink, C.3
  • 13
    • 0031742610 scopus 로고    scopus 로고
    • Beta-Sitosterol activates the sphingomyelin cycle and induces apoptosis in LNCaP human prostate cancer cells
    • 10.1080/01635589809514709, 9824850
    • Von Holtz R, Fink C, Awad A. Beta-Sitosterol activates the sphingomyelin cycle and induces apoptosis in LNCaP human prostate cancer cells. Nutr Cancer 1998, 32:8-12. 10.1080/01635589809514709, 9824850.
    • (1998) Nutr Cancer , vol.32 , pp. 8-12
    • Von Holtz, R.1    Fink, C.2    Awad, A.3
  • 14
    • 84863071904 scopus 로고    scopus 로고
    • Fisetin inhibits various attributes of angiogenesis in vitro and in vivo-implications for angioprevention
    • Bhat TA, Nambiar D, Pal A, Agarwal R, Singh RP. Fisetin inhibits various attributes of angiogenesis in vitro and in vivo-implications for angioprevention. Carcinog 2012, 33:385-393.
    • (2012) Carcinog , vol.33 , pp. 385-393
    • Bhat, T.A.1    Nambiar, D.2    Pal, A.3    Agarwal, R.4    Singh, R.P.5
  • 15
    • 13444283311 scopus 로고    scopus 로고
    • A novel anticancer agent, decursin, induces G1 arrest and apoptosis in human prostate carcinoma cells
    • Yim D, Singh RP, Agarwal C, Lee S, Chi H. A novel anticancer agent, decursin, induces G1 arrest and apoptosis in human prostate carcinoma cells. Cancer Res 2005, 65:1035-1044.
    • (2005) Cancer Res , vol.65 , pp. 1035-1044
    • Yim, D.1    Singh, R.P.2    Agarwal, C.3    Lee, S.4    Chi, H.5
  • 16
    • 83755182761 scopus 로고    scopus 로고
    • Anticancer effects of imperatorin isolated from Angelica dahurica: induction of apoptosis in HepG2 cells through both death-receptor- and mitochondria-mediated pathways
    • Luo KW, Sun JG, Chan JY, Yang L, Wu SH, et al. Anticancer effects of imperatorin isolated from Angelica dahurica: induction of apoptosis in HepG2 cells through both death-receptor- and mitochondria-mediated pathways. Chemother 2011, 57:449-459.
    • (2011) Chemother , vol.57 , pp. 449-459
    • Luo, K.W.1    Sun, J.G.2    Chan, J.Y.3    Yang, L.4    Wu, S.H.5
  • 17
    • 0344827261 scopus 로고    scopus 로고
    • Silibinin upregulates the expression of cyclin-dependent kinase inhibitors and causes cell cycle arrest and apoptosis in human colon carcinoma HT-29 cells
    • 10.1038/sj.onc.1207158, 14614451
    • Agarwal C, Singh RP, Dhanalakshmi S, Tyagi AK, Tecklenburg M, Sclafani RA, Agarwal R. Silibinin upregulates the expression of cyclin-dependent kinase inhibitors and causes cell cycle arrest and apoptosis in human colon carcinoma HT-29 cells. Oncogene 2003, 22:8271-8282. 10.1038/sj.onc.1207158, 14614451.
    • (2003) Oncogene , vol.22 , pp. 8271-8282
    • Agarwal, C.1    Singh, R.P.2    Dhanalakshmi, S.3    Tyagi, A.K.4    Tecklenburg, M.5    Sclafani, R.A.6    Agarwal, R.7
  • 18
    • 28544439164 scopus 로고    scopus 로고
    • Silibinin efficacy against human hepatocellular carcinoma
    • 10.1158/1078-0432.CCR-05-1646, 16322307
    • Varghese L, Agarwal C, Tyagi A, Singh RP, Agarwal R. Silibinin efficacy against human hepatocellular carcinoma. Clin Cancer Res 2005, 11:8441-8448. 10.1158/1078-0432.CCR-05-1646, 16322307.
    • (2005) Clin Cancer Res , vol.11 , pp. 8441-8448
    • Varghese, L.1    Agarwal, C.2    Tyagi, A.3    Singh, R.P.4    Agarwal, R.5
  • 19
    • 45949088567 scopus 로고    scopus 로고
    • Ethanol extract of Dunaliella salina induces cell cycle arrest and apoptosis in A549 human non-small cell lung cancer cells
    • Sheu MJ, Huang GJ, Wu CH, Chen JS, Chang HY, Chang SJ, Chang JG. Ethanol extract of Dunaliella salina induces cell cycle arrest and apoptosis in A549 human non-small cell lung cancer cells. In Vivo 2004, 212:369-378.
    • (2004) In Vivo , vol.212 , pp. 369-378
    • Sheu, M.J.1    Huang, G.J.2    Wu, C.H.3    Chen, J.S.4    Chang, H.Y.5    Chang, S.J.6    Chang, J.G.7
  • 20
    • 80555129638 scopus 로고    scopus 로고
    • Grape proanthocyanidins induce apoptosis by loss of mitochondrial membrane potential of human non-small cell lung cancer cells in vitro and in vivo
    • 10.1371/journal.pone.0027444, 3210794, 22087318
    • Singh T, Sharma SD, Katiyar SK. Grape proanthocyanidins induce apoptosis by loss of mitochondrial membrane potential of human non-small cell lung cancer cells in vitro and in vivo. PLoS One 2011, 6:e27444. 10.1371/journal.pone.0027444, 3210794, 22087318.
    • (2011) PLoS One , vol.6
    • Singh, T.1    Sharma, S.D.2    Katiyar, S.K.3
  • 21
    • 0642341485 scopus 로고    scopus 로고
    • Chemoprevention of cancer - focusing on clinical trials
    • Kakizoe T. Chemoprevention of cancer - focusing on clinical trials. Japanese J Clin Oncol 2003, 33:421-442.
    • (2003) Japanese J Clin Oncol , vol.33 , pp. 421-442
    • Kakizoe, T.1
  • 22
    • 33244472101 scopus 로고    scopus 로고
    • Silymarin and silibinin cause G1 and G2-M cell cycle arrest via distinct circuitries in human prostate cancer PC3 cells: a comparison of flavanone silibinin with flavanolignan mixture silymarin
    • 10.1038/sj.onc.1209146, 16205633
    • Deep G, Singh RP, Agarwal C, Kroll DJ, Agarwal R. Silymarin and silibinin cause G1 and G2-M cell cycle arrest via distinct circuitries in human prostate cancer PC3 cells: a comparison of flavanone silibinin with flavanolignan mixture silymarin. Oncogene 2006, 25:1053-1069. 10.1038/sj.onc.1209146, 16205633.
    • (2006) Oncogene , vol.25 , pp. 1053-1069
    • Deep, G.1    Singh, R.P.2    Agarwal, C.3    Kroll, D.J.4    Agarwal, R.5
  • 23
    • 0028927179 scopus 로고
    • P53, cell cycle control and apoptosis: implications for cancer
    • 10.1007/BF00690207, 7606818
    • Kastan MB, Canman CE, Leonard CJ. P53, cell cycle control and apoptosis: implications for cancer. Cancer Metastasis Rev 1995, 14:3-15. 10.1007/BF00690207, 7606818.
    • (1995) Cancer Metastasis Rev , vol.14 , pp. 3-15
    • Kastan, M.B.1    Canman, C.E.2    Leonard, C.J.3
  • 24
    • 0036491845 scopus 로고    scopus 로고
    • The restriction point of the cell cycle
    • Blagosklonny MV, Pardee AB. The restriction point of the cell cycle. Cell Cycle 2002, 1:103-110.
    • (2002) Cell Cycle , vol.1 , pp. 103-110
    • Blagosklonny, M.V.1    Pardee, A.B.2
  • 25
    • 0028967830 scopus 로고
    • Cyclin D1 oncoprotein aberrantly accumulates in malignancies of diverse histogenesis
    • Bartkova J, Lukas J, Strauss M, Bartek J. Cyclin D1 oncoprotein aberrantly accumulates in malignancies of diverse histogenesis. Oncogene 1995, 10:775-778.
    • (1995) Oncogene , vol.10 , pp. 775-778
    • Bartkova, J.1    Lukas, J.2    Strauss, M.3    Bartek, J.4
  • 26
    • 0035919922 scopus 로고    scopus 로고
    • Cyclin D1-CDK4 complex, a possible critical factor for cell proliferation and prognosis in laryngeal squamous cell carcinomas
    • 10.1002/1097-0215(20010720)95:4<209::AID-IJC1036>3.0.CO;2-R, 11400112
    • Dong Y, Sui L, Sugimoto K, Tai Y, Tokuda M. Cyclin D1-CDK4 complex, a possible critical factor for cell proliferation and prognosis in laryngeal squamous cell carcinomas. Int J Cancer 2001, 95:209-215. 10.1002/1097-0215(20010720)95:4<209::AID-IJC1036>3.0.CO;2-R, 11400112.
    • (2001) Int J Cancer , vol.95 , pp. 209-215
    • Dong, Y.1    Sui, L.2    Sugimoto, K.3    Tai, Y.4    Tokuda, M.5
  • 28
    • 24144479454 scopus 로고    scopus 로고
    • Cyclin D1 overexpression in thyroid papillary microcarcinoma: its association with tumour size and aberrant beta-catenin expression
    • Lantsov D, Meirmanov S, Nakashima M, Kondo H, Saenko V, Naruke Y, Namba H. Cyclin D1 overexpression in thyroid papillary microcarcinoma: its association with tumour size and aberrant beta-catenin expression. Histopathol 2005, 47:248-256.
    • (2005) Histopathol , vol.47 , pp. 248-256
    • Lantsov, D.1    Meirmanov, S.2    Nakashima, M.3    Kondo, H.4    Saenko, V.5    Naruke, Y.6    Namba, H.7
  • 29
    • 0036670787 scopus 로고    scopus 로고
    • Flavonoid antioxidant silymarin and skin cancer
    • 10.1089/15230860260220166, 12230878
    • Singh RP, Agarwal R. Flavonoid antioxidant silymarin and skin cancer. Antioxid Redox Signal 2002, 4:655-663. 10.1089/15230860260220166, 12230878.
    • (2002) Antioxid Redox Signal , vol.4 , pp. 655-663
    • Singh, R.P.1    Agarwal, R.2
  • 30
    • 0033528830 scopus 로고    scopus 로고
    • P21Waf1/Cip1/Sdi1 induces permanent growth arrest with markers of replicative senescence in human tumor cells lacking functional p53
    • 10.1038/sj.onc.1202615, 10362249
    • Fang L, Igarashi M, Leung J, Sugrue MM, Lee SW, Aaronson SA. p21Waf1/Cip1/Sdi1 induces permanent growth arrest with markers of replicative senescence in human tumor cells lacking functional p53. Oncogene 1999, 18:2789-2797. 10.1038/sj.onc.1202615, 10362249.
    • (1999) Oncogene , vol.18 , pp. 2789-2797
    • Fang, L.1    Igarashi, M.2    Leung, J.3    Sugrue, M.M.4    Lee, S.W.5    Aaronson, S.A.6
  • 31
    • 0028176483 scopus 로고
    • Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals
    • 10.1016/0092-8674(94)90572-X, 8033212
    • Polyak K, Lee MH, Erdjument BH, Koff A, Roberts JM, Tempst P, Massagué J. Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. Cell 1994, 78:59-66. 10.1016/0092-8674(94)90572-X, 8033212.
    • (1994) Cell , vol.78 , pp. 59-66
    • Polyak, K.1    Lee, M.H.2    Erdjument, B.H.3    Koff, A.4    Roberts, J.M.5    Tempst, P.6    Massagué, J.7
  • 32
    • 0032587495 scopus 로고    scopus 로고
    • P27/kip1: A multifunctional cyclin-dependent kinase inhibitor with prognostic significance in human cancers
    • 10.1016/S0002-9440(10)65277-7, 1850003, 10027389
    • Lloyd RV, Erickson LA, Jin L, Kulig E, Qian X, Cheville JC, Scheithauer BW. p27/kip1: A multifunctional cyclin-dependent kinase inhibitor with prognostic significance in human cancers. Am J Pathol 1999, 154:313-323. 10.1016/S0002-9440(10)65277-7, 1850003, 10027389.
    • (1999) Am J Pathol , vol.154 , pp. 313-323
    • Lloyd, R.V.1    Erickson, L.A.2    Jin, L.3    Kulig, E.4    Qian, X.5    Cheville, J.C.6    Scheithauer, B.W.7
  • 33
    • 3542995667 scopus 로고    scopus 로고
    • Oncogenes and tumor suppressor genes in breast cancer: potential diagnostic and therapeutic applications
    • 10.1634/theoncologist.9-4-361, 15266090
    • Osborne C, Wilson P, Tripathy D. Oncogenes and tumor suppressor genes in breast cancer: potential diagnostic and therapeutic applications. Oncologist 2004, 9:361-377. 10.1634/theoncologist.9-4-361, 15266090.
    • (2004) Oncologist , vol.9 , pp. 361-377
    • Osborne, C.1    Wilson, P.2    Tripathy, D.3
  • 34
    • 0037360095 scopus 로고    scopus 로고
    • Inositol hexaphosphate inhibits growth, and induces G1 arrest and apoptotic death of prostate carcinoma DU145 cells: modulation of CDKI-CDK-cyclin and pRb-related protein-E2F complexes
    • Singh RP, Agarwal C, Agarwal R. Inositol hexaphosphate inhibits growth, and induces G1 arrest and apoptotic death of prostate carcinoma DU145 cells: modulation of CDKI-CDK-cyclin and pRb-related protein-E2F complexes. Carcinog 2003, 24:555-563.
    • (2003) Carcinog , vol.24 , pp. 555-563
    • Singh, R.P.1    Agarwal, C.2    Agarwal, R.3
  • 35
    • 0142117313 scopus 로고    scopus 로고
    • The Bcl-2 family: roles in cell survival and oncogenesis
    • 10.1038/sj.onc.1207102, 14634621
    • Cory S, Huang DCS, Adams JM. The Bcl-2 family: roles in cell survival and oncogenesis. Oncogene 2003, 22:8590-8607. 10.1038/sj.onc.1207102, 14634621.
    • (2003) Oncogene , vol.22 , pp. 8590-8607
    • Cory, S.1    Huang, D.C.S.2    Adams, J.M.3
  • 36
    • 14844320063 scopus 로고    scopus 로고
    • Silymarin induces apoptosis primarily through a p53-dependent pathway involving Bcl-2/Bax, cytochrome c release, and caspase activation
    • 10.4161/cbt.4.2.1442, 15713892
    • Katiyar SK, Roy AM, Baliga MS. Silymarin induces apoptosis primarily through a p53-dependent pathway involving Bcl-2/Bax, cytochrome c release, and caspase activation. Mol Cancer Ther 2005, 4:207-216. 10.4161/cbt.4.2.1442, 15713892.
    • (2005) Mol Cancer Ther , vol.4 , pp. 207-216
    • Katiyar, S.K.1    Roy, A.M.2    Baliga, M.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.