메뉴 건너뛰기




Volumn , Issue , 2011, Pages 399-410

Effect of Buffers and Stabilizers on Vaccine Stability and Efficacy

Author keywords

Buffer and stabilizer effect on vaccine stability and efficacy; Excipient effect on vaccine efficacy buffer effects, on protein conformational stability; Polymeric zwitterionic (ZPS) buffers CD4+ T cell responses, positively and negatively charged

Indexed keywords


EID: 84886138088     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9781118023648.ch15     Document Type: Chapter
Times cited : (2)

References (69)
  • 2
    • 0032809028 scopus 로고    scopus 로고
    • Adsorbed protein layers at fluid interfaces: Interactions, structure and surface rheology
    • Dickersen E. Adsorbed protein layers at fluid interfaces: Interactions, structure and surface rheology. Colloids Surfaces B: Biointerfaces 1999;15:161-176.
    • (1999) Colloids Surfaces B: Biointerfaces , vol.15 , pp. 161-176
    • Dickersen, E.1
  • 3
    • 33745359812 scopus 로고    scopus 로고
    • A systematic approach to stabilizing EBA-175 RII-NG for use as malaria vaccine
    • Peek LJ, Brandau DT, Jones LS, Joshi SB, and Middaugh R. A systematic approach to stabilizing EBA-175 RII-NG for use as malaria vaccine. Vaccine 2006;24:5839-5851.
    • (2006) Vaccine , vol.24 , pp. 5839-5851
    • Peek, L.J.1    Brandau, D.T.2    Jones, L.S.3    Joshi, S.B.4    Middaugh, R.5
  • 4
    • 4444368601 scopus 로고    scopus 로고
    • Thermal inactivation of protective antigen of Bacillus anthracis and its prevention by polyol osmolytes
    • Singh S, Singh A, Aziz MA, Waheed SM, Bhat R, and Bhatnagar R. Thermal inactivation of protective antigen of Bacillus anthracis and its prevention by polyol osmolytes. Biochem. Biophys. Res. Commun. 2004;322:1029-1037.
    • (2004) Biochem. Biophys. Res. Commun. , vol.322 , pp. 1029-1037
    • Singh, S.1    Singh, A.2    Aziz, M.A.3    Waheed, S.M.4    Bhat, R.5    Bhatnagar, R.6
  • 5
    • 0142195888 scopus 로고    scopus 로고
    • Comparative efficacy of various chemical stabilizers on the thermostability of live-attenuated peste des petits ruminants (PPR) vaccine
    • Sarkar J, Sreenivasa BP, Singh P, Dhar P, and Bandyopadhyay SK. Comparative efficacy of various chemical stabilizers on the thermostability of live-attenuated peste des petits ruminants (PPR) vaccine. Vaccine 2003;21:4728-4735.
    • (2003) Vaccine , vol.21 , pp. 4728-4735
    • Sarkar, J.1    Sreenivasa, B.P.2    Singh, P.3    Dhar, P.4    Bandyopadhyay, S.K.5
  • 6
    • 33750955290 scopus 로고    scopus 로고
    • Formulation considerations for proteins susceptible to asparagine deamidation and aspartate isomerization
    • Wakankar AA and Borchardt RT. Formulation considerations for proteins susceptible to asparagine deamidation and aspartate isomerization. J. Pharm. Sci . 2006;95:2321-2336.
    • (2006) J. Pharm. Sci. , vol.95 , pp. 2321-2336
    • Wakankar, A.A.1    Borchardt, R.T.2
  • 8
    • 28844507784 scopus 로고    scopus 로고
    • Effects of deamidation on cytotoxi activity of bacillus anthracis protective antigen
    • Zomber G, Reuvenys S, Garti N, Shafferman A, and Elhanany E. Effects of deamidation on cytotoxi activity of bacillus anthracis protective antigen. J. Biol. Chem.280:39897-39906.
    • J. Biol. Chem. , vol.280 , pp. 39897-39906
    • Zomber, G.1    Reuvenys, S.2    Garti, N.3    Shafferman, A.4    Elhanany, E.5
  • 9
    • 0034176272 scopus 로고    scopus 로고
    • The formulation of biopharmaceutical products
    • Parkins DA and Lashmar UT. The formulation of biopharmaceutical products. PSTT 2000;3:129-137.
    • (2000) PSTT , vol.3 , pp. 129-137
    • Parkins, D.A.1    Lashmar, U.T.2
  • 10
    • 0029637161 scopus 로고
    • Chemical instability of protein pharmaceuticals: Mechanisms of oxidation and strategies for stabilization
    • Li S, Schoneich C, and Borchardt RT. Chemical instability of protein pharmaceuticals: Mechanisms of oxidation and strategies for stabilization. Biotechnol. Bioeng. 1995;48:490-500.
    • (1995) Biotechnol. Bioeng. , vol.48 , pp. 490-500
    • Li, S.1    Schoneich, C.2    Borchardt, R.T.3
  • 12
    • 0035961464 scopus 로고    scopus 로고
    • Capsid and RNA stabilization of the oral polio vaccine
    • Verheyden B, Andries K, and Rombaut B. Capsid and RNA stabilization of the oral polio vaccine. Vaccine 2001;19:1899-1905.
    • (2001) Vaccine , vol.19 , pp. 1899-1905
    • Verheyden, B.1    Andries, K.2    Rombaut, B.3
  • 13
    • 0034681288 scopus 로고    scopus 로고
    • Stabilization of poliovirus by capsid-binding antiviral drugs is due to entropic effects
    • Tsang SK, Danthi P, Chow M, and Hogle JM. Stabilization of poliovirus by capsid-binding antiviral drugs is due to entropic effects. J. Mol. Biol . 2000;296:335-340.
    • (2000) J. Mol. Biol. , vol.296 , pp. 335-340
    • Tsang, S.K.1    Danthi, P.2    Chow, M.3    Hogle, J.M.4
  • 14
    • 0342424905 scopus 로고
    • Effect of pH on thermal stabilization of oral poliovaccine by magnesium chloride
    • Melnick JL and Wallis C. Effect of pH on thermal stabilization of oral poliovaccine by magnesium chloride. Proc. Soc. Exp. Biol. Med. 1963;112:894-897.
    • (1963) Proc. Soc. Exp. Biol. Med. , vol.112 , pp. 894-897
    • Melnick, J.L.1    Wallis, C.2
  • 15
    • 0000165635 scopus 로고
    • Cationic stabililzation-a new property of enteroviruses
    • Wallis C and Melnick JL. Cationic stabililzation-a new property of enteroviruses. Virology 1962;16:504-506.
    • (1962) Virology , vol.16 , pp. 504-506
    • Wallis, C.1    Melnick, J.L.2
  • 16
    • 0001356501 scopus 로고
    • The influence of certain salts, amino acids, sugars and proteins on the stability of rickettsiae
    • Bovamick MA, Miller JC, and Snyder JC. The influence of certain salts, amino acids, sugars and proteins on the stability of rickettsiae. J. Bacteriol . 1950;59:509-522.
    • (1950) J. Bacteriol. , vol.59 , pp. 509-522
    • Bovamick, M.A.1    Miller, J.C.2    Snyder, J.C.3
  • 17
    • 0028106297 scopus 로고
    • Thermal inactivation of oral polio vaccine: Contribution of RNA and protein inactivation
    • Rombaut B, Verheyden B, Andries K, and Boeye A. Thermal inactivation of oral polio vaccine: Contribution of RNA and protein inactivation. J. Virol . 1994;68:6454-6457.
    • (1994) J. Virol. , vol.68 , pp. 6454-6457
    • Rombaut, B.1    Verheyden, B.2    Andries, K.3    Boeye, A.4
  • 18
    • 0037500460 scopus 로고
    • Effects of freezing, storage at low temperature, and drying by sublimation in vacuo on the activities of measles
    • Reiff D, Rightsel WA, and Schuler EE. Effects of freezing, storage at low temperature, and drying by sublimation in vacuo on the activities of measles. Nature 1964;202:624-625.
    • (1964) Nature , vol.202 , pp. 624-625
    • Reiff, D.1    Rightsel, W.A.2    Schuler, E.E.3
  • 19
    • 34547603658 scopus 로고    scopus 로고
    • Rational design of an influenze subunit powder with sugar glass technology: Preventing conformational changes of haemagglutinin during freezing and freeze-drying
    • Amorij J-P, Meulenaar J, Hinrichs WLJ, Stegmann T, Huckriede A, Coenen F, and Frijlink HW. Rational design of an influenze subunit powder with sugar glass technology: Preventing conformational changes of haemagglutinin during freezing and freeze-drying. Vaccine 2007;25:6447-6457.
    • (2007) Vaccine , vol.25 , pp. 6447-6457
    • Amorij, J.-P.1    Meulenaar, J.2    Hinrichs, W.L.J.3    Stegmann, T.4    Huckriede, A.5    Coenen, F.6    Frijlink, H.W.7
  • 20
    • 11844249380 scopus 로고    scopus 로고
    • Preservation mechanisms of trehalose in food and biosystems
    • Patist A and Zoerb H. Preservation mechanisms of trehalose in food and biosystems. Colloids Surfaces B: Biointerfaces 2005;40:107-113.
    • (2005) Colloids Surfaces B: Biointerfaces , vol.40 , pp. 107-113
    • Patist, A.1    Zoerb, H.2
  • 21
    • 33748796936 scopus 로고    scopus 로고
    • Lyophilization and sterilization of liposomal vaccines to produce stable and sterile products
    • Mohammed AR, Bramwell VW, Coombes AGA, and Perrie, Y. Lyophilization and sterilization of liposomal vaccines to produce stable and sterile products. Methods 2006;40:30-38.
    • (2006) Methods , vol.40 , pp. 30-38
    • Mohammed, A.R.1    Bramwell, V.W.2    Coombes, A.G.A.3    Perrie, Y.4
  • 22
    • 34547104614 scopus 로고    scopus 로고
    • Inulin sugar glasses preserve the structural integrity and biological activity of influenze virosomes during freeze-drying and storage
    • de Jonge J, Amorij J-P, Hinrichs WLJ, Wilschut J, Huckriede A, and Frijlink HW. Inulin sugar glasses preserve the structural integrity and biological activity of influenze virosomes during freeze-drying and storage. Eur. J. Pharm. Sci . 2007;32:33-44.
    • (2007) Eur. J. Pharm. Sci. , vol.32 , pp. 33-44
    • de Jonge, J.1    Amorij, J.-P.2    Hinrichs, W.L.J.3    Wilschut, J.4    Huckriede, A.5    Frijlink, H.W.6
  • 28
    • 0035816403 scopus 로고    scopus 로고
    • Disulfide bonds stabilize JC virus capsid-like structure by protecting calcium ions from chelation
    • Chen P-L, Wang M, Ou W-C, Lii C-K, Chen L-S, and Chang D. Disulfide bonds stabilize JC virus capsid-like structure by protecting calcium ions from chelation. FEBS Lett . 2001;500:109-113.
    • (2001) FEBS Lett. , vol.500 , pp. 109-113
    • Chen, P.-L.1    Wang, M.2    Ou, W.-C.3    Lii, C.-K.4    Chen, L.-S.5    Chang, D.6
  • 29
    • 0030271221 scopus 로고    scopus 로고
    • Calcium influences the stability and conformation of rotavirus SA11 glycoprotein VP7 expressed in Dixtyostelium discoideum
    • Emslie, KR, Coukell, MB, Birch D, and Williams KL. Calcium influences the stability and conformation of rotavirus SA11 glycoprotein VP7 expressed in Dixtyostelium discoideum. J. Biotechnol. 1996;50:149-159.
    • (1996) J. Biotechnol. , vol.50 , pp. 149-159
    • Emslie, K.R.1    Coukell, M.B.2    Birch, D.3    Williams, K.L.4
  • 30
    • 0015338578 scopus 로고
    • Stabilization of capsid structure and enhancement of immunogenicity of cucumber mosaic virus (Q strain) by formaldehyde
    • Francki RIB and Habili N. Stabilization of capsid structure and enhancement of immunogenicity of cucumber mosaic virus (Q strain) by formaldehyde. Virology 1972;48: 309-315.
    • (1972) Virology , vol.48 , pp. 309-315
    • Francki, R.I.B.1    Habili, N.2
  • 31
    • 0028181355 scopus 로고
    • Toxin inactivation and antigen stabilization: Two different uses of formaldehyde
    • Rappuoli R. Toxin inactivation and antigen stabilization: Two different uses of formaldehyde. Vaccine 1994;12:579-581.
    • (1994) Vaccine , vol.12 , pp. 579-581
    • Rappuoli, R.1
  • 32
    • 1542297708 scopus 로고    scopus 로고
    • The effect of buffers on protein conformational stability
    • Ugwu SO and Apte SP. The effect of buffers on protein conformational stability. Pharm. Tech. 2004:86-113.
    • (2004) Pharm. Tech. , pp. 86-113
    • Ugwu, S.O.1    Apte, S.P.2
  • 36
    • 17144427675 scopus 로고    scopus 로고
    • Effects of adsorption to aluminum salt adjuvants on the structure and stability of protein antigens
    • Jones LS, Peek LJ, Power J, Markham A, Yazzie B, and Middaugh CR. Effects of adsorption to aluminum salt adjuvants on the structure and stability of protein antigens. J. Biol. Chem. 2005;280(14):13406-13414.
    • (2005) J. Biol. Chem. , vol.280 , Issue.14 , pp. 13406-13414
    • Jones, L.S.1    Peek, L.J.2    Power, J.3    Markham, A.4    Yazzie, B.5    Middaugh, C.R.6
  • 37
    • 31544446069 scopus 로고    scopus 로고
    • Citrate mediated disaggregation of rotavirus particles in Rotateq vaccine
    • Peterson SE, Wang S, Ranheim T, and Owen KE. Citrate mediated disaggregation of rotavirus particles in Rotateq vaccine. Antiviral Res. 2006;69:107-115.
    • (2006) Antiviral Res. , vol.69 , pp. 107-115
    • Peterson, S.E.1    Wang, S.2    Ranheim, T.3    Owen, K.E.4
  • 38
    • 0029619776 scopus 로고
    • A novel basis for capsid stabilization by antiviral compounds
    • Phelps DK and Post CB. A novel basis for capsid stabilization by antiviral compounds. J. Mol. Biol . 1995;254:544-551.
    • (1995) J. Mol. Biol. , vol.254 , pp. 544-551
    • Phelps, D.K.1    Post, C.B.2
  • 39
    • 24944552040 scopus 로고    scopus 로고
    • Towards the preparative and large scale precision manufacture of virus like particles
    • Pattenden LK, et.al. Towards the preparative and large scale precision manufacture of virus like particles. Trends Biotechnol. 2005;23(10):523-529.
    • (2005) Trends Biotechnol. , vol.23 , Issue.10 , pp. 523-529
    • Pattenden, L.K.1
  • 40
    • 1542270987 scopus 로고    scopus 로고
    • Effect of microenvironment pH of aluminum hydroxide adjuvant on the chemical stability of adsorbed antigen
    • Wittayanukulluk A, Jiang D, Regnier FE, and Hem SL. Effect of microenvironment pH of aluminum hydroxide adjuvant on the chemical stability of adsorbed antigen. Vaccine 2004;22:1172-1176.
    • (2004) Vaccine , vol.22 , pp. 1172-1176
    • Wittayanukulluk, A.1    Jiang, D.2    Regnier, F.E.3    Hem, S.L.4
  • 41
    • 0030949245 scopus 로고    scopus 로고
    • Comparison of alternative buffers for use with a new live oral Cholera vaccine, Peru-15 in outpatient volunteers
    • Sack DA, Shimko J, Sack RB, Gomes JG, MacLeod K, O'Sullivan D, and Spriggs D. Comparison of alternative buffers for use with a new live oral Cholera vaccine, Peru-15 in outpatient volunteers. Infect. Immun. 1997;65(6):2107-2111.
    • (1997) Infect. Immun. , vol.65 , Issue.6 , pp. 2107-2111
    • Sack, D.A.1    Shimko, J.2    Sack, R.B.3    Gomes, J.G.4    MacLeod, K.5    O'Sullivan, D.6    Spriggs, D.7
  • 42
    • 0034294065 scopus 로고    scopus 로고
    • Amphoteric linear poly(amido-amine)s as endosomolytic polymers: Correlation between physicochemical and biological properties
    • Ferruti P, Manzoni S, Richardson SCW, Pattrick NG, Mendichi R, and Casolaro M. Amphoteric linear poly(amido-amine)s as endosomolytic polymers: Correlation between physicochemical and biological properties. Macromolecules 2000;33:7793-7800.
    • (2000) Macromolecules , vol.33 , pp. 7793-7800
    • Ferruti, P.1    Manzoni, S.2    Richardson, S.C.W.3    Pattrick, N.G.4    Mendichi, R.5    Casolaro, M.6
  • 43
    • 27744574546 scopus 로고    scopus 로고
    • Promoter and strain selective enhancement of gene expression in a mouse skeletal muscle by a polymer excipient Pluronic P85
    • Yang Z, Zhu J, Sriadibhatla S, Gebhart C, Alakhov V, and Kabanov A. Promoter and strain selective enhancement of gene expression in a mouse skeletal muscle by a polymer excipient Pluronic P85. J. Control. Release 2005;108:496-512.
    • (2005) J. Control. Release , vol.108 , pp. 496-512
    • Yang, Z.1    Zhu, J.2    Sriadibhatla, S.3    Gebhart, C.4    Alakhov, V.5    Kabanov, A.6
  • 44
    • 0038148994 scopus 로고    scopus 로고
    • Novel 3-O-Acyl Mesquitol analogues as free radical scavengers and enzyme inhibitors: synthesis, biological evaluation and structure-activity relationship
    • Rao RJ, Tiwari AK, Kumar US, Reddy SV, Ali AZ, and Rao JM. Novel 3-O-Acyl Mesquitol analogues as free radical scavengers and enzyme inhibitors: synthesis, biological evaluation and structure-activity relationship. Bioorg. Med. Chem. Lett . 2003;13:2777-2780.
    • (2003) Bioorg. Med. Chem. Lett. , vol.13 , pp. 2777-2780
    • Rao, R.J.1    Tiwari, A.K.2    Kumar, U.S.3    Reddy, S.V.4    Ali, A.Z.5    Rao, J.M.6
  • 45
    • 3042750605 scopus 로고    scopus 로고
    • Gamma tocopherol upregulates peroxisome proliferator activated receptor (PPAR) gamma expression in SW 480 human colon cancer cell lines
    • Campbell SE, Stone WL, Whaley SG, Qui M, and Krishnan K. Gamma tocopherol upregulates peroxisome proliferator activated receptor (PPAR) gamma expression in SW 480 human colon cancer cell lines. BMC Cancer 2003;3:25.
    • (2003) BMC Cancer , vol.3 , pp. 25
    • Campbell, S.E.1    Stone, W.L.2    Whaley, S.G.3    Qui, M.4    Krishnan, K.5
  • 46
    • 5044234664 scopus 로고    scopus 로고
    • Altered growth in male peroxisome proliferator activated receptor gamma Heterozygous mice: involvement of PPAR-gamma in a negative feedback regulation of growth hormone action
    • Rieusset J, Seydoux J, Anghel SI, Escher P, Michalik L, Tan NS, et al. Altered growth in male peroxisome proliferator activated receptor gamma Heterozygous mice: involvement of PPAR-gamma in a negative feedback regulation of growth hormone action. Mol. Endocrinol. 2004;18(10):2363-2377.
    • (2004) Mol. Endocrinol. , vol.18 , Issue.10 , pp. 2363-2377
    • Rieusset, J.1    Seydoux, J.2    Anghel, S.I.3    Escher, P.4    Michalik, L.5    Tan, N.S.6
  • 47
    • 32044441226 scopus 로고    scopus 로고
    • New approaches to vaccine adjuvants: Inhibiting the inhibitor
    • Graham BS. New approaches to vaccine adjuvants: Inhibiting the inhibitor. PLoS Med. 2006;3(1):e57.
    • (2006) PLoS Med. , vol.3 , Issue.1
    • Graham, B.S.1
  • 48
    • 12844251951 scopus 로고    scopus 로고
    • Immune response to influenza vaccine in healthy adults and the elderly: Association with nutritional status
    • Hara M, Tanaka K, and Hirota Y. Immune response to influenza vaccine in healthy adults and the elderly: Association with nutritional status. Vaccine 2005;23:1457-1463.
    • (2005) Vaccine , vol.23 , pp. 1457-1463
    • Hara, M.1    Tanaka, K.2    Hirota, Y.3
  • 49
    • 0030249914 scopus 로고    scopus 로고
    • Covalent chemical events in immune induction: Fundamental and therapeutic aspects
    • Rhodes J. Covalent chemical events in immune induction: Fundamental and therapeutic aspects. Immunol. Today 1996;17(9):436-441.
    • (1996) Immunol. Today , vol.17 , Issue.9 , pp. 436-441
    • Rhodes, J.1
  • 50
    • 0028800377 scopus 로고
    • Structure/function studies of QS-21 adjuvant: Assessment of triterpene aldehyde and glucuronic acid roles in adjuvant function
    • Soltysik S, Wu JY, Recchia J, Wheeler DA, Newman MJ, Coughlin RT, and Kensil CR. Structure/function studies of QS-21 adjuvant: Assessment of triterpene aldehyde and glucuronic acid roles in adjuvant function. Vaccine 1995;13(15):1403-1410.
    • (1995) Vaccine , vol.13 , Issue.15 , pp. 1403-1410
    • Soltysik, S.1    Wu, J.Y.2    Recchia, J.3    Wheeler, D.A.4    Newman, M.J.5    Coughlin, R.T.6    Kensil, C.R.7
  • 51
    • 0026520265 scopus 로고
    • Inhibition of specific T-cell activation by monosaccharides is through their reactivity as aldehydes
    • Rhodes J, Zheng B, and Lifely MR. Inhibition of specific T-cell activation by monosaccharides is through their reactivity as aldehydes. Immunology 1992;75:626-631.
    • (1992) Immunology , vol.75 , pp. 626-631
    • Rhodes, J.1    Zheng, B.2    Lifely, M.R.3
  • 54
    • 34247539566 scopus 로고    scopus 로고
    • Specific immune response to HBsAg is enhanced by beta-glucan oligosaccharide containing an alpha-(1-3)-linked bond and biased toward M2/Th2
    • Dong SF, Chen JM, Zhang W, Sun SH, Wang J, Gu JX, Boraschi D, and Qu D. Specific immune response to HBsAg is enhanced by beta-glucan oligosaccharide containing an alpha-(1-3)-linked bond and biased toward M2/Th2. Int. Immunol. 2007;7:725-733.
    • (2007) Int. Immunol. , vol.7 , pp. 725-733
    • Dong, S.F.1    Chen, J.M.2    Zhang, W.3    Sun, S.H.4    Wang, J.5    Gu, J.X.6    Boraschi, D.7    Qu, D.8
  • 55
    • 34547700637 scopus 로고    scopus 로고
    • New TB vaccines: Is there a requirement for CD8+ T cells?
    • Boom WH. New TB vaccines: Is there a requirement for CD8+ T cells? J. Clin. Invest . 2007;117(8):2092-2094.
    • (2007) J. Clin. Invest. , vol.117 , Issue.8 , pp. 2092-2094
    • Boom, W.H.1
  • 56
    • 0037673252 scopus 로고    scopus 로고
    • SecA2 functions in the secretion of superoxide dismutase A in the virulence of Mycobacterium tuberculosis
    • Braunstein M, Espinosa BJ, Chan J, Belisle JT, and Jacobs WR. SecA2 functions in the secretion of superoxide dismutase A in the virulence of Mycobacterium tuberculosis. Mol. Microbiol . 2003;48:453-464.
    • (2003) Mol. Microbiol. , vol.48 , pp. 453-464
    • Braunstein, M.1    Espinosa, B.J.2    Chan, J.3    Belisle, J.T.4    Jacobs, W.R.5
  • 57
    • 24944581330 scopus 로고    scopus 로고
    • Why is arginine effective in suppressing aggregation?
    • Tsumoto K, Ejima D, Kita Y, and Arakawa T. Why is arginine effective in suppressing aggregation? Protein Peptide Lett . 2005;12(7):613-619.
    • (2005) Protein Peptide Lett . , vol.12 , Issue.7 , pp. 613-619
    • Tsumoto, K.1    Ejima, D.2    Kita, Y.3    Arakawa, T.4
  • 58
    • 0033767368 scopus 로고    scopus 로고
    • Role of nitric oxide in central regulation of humoral immune response in rats
    • Roy S, Roy G, Mishra SC, and Prakash VR. Role of nitric oxide in central regulation of humoral immune response in rats. Indian J. Pharmacol. 2000;32:318-320.
    • (2000) Indian J. Pharmacol. , vol.32 , pp. 318-320
    • Roy, S.1    Roy, G.2    Mishra, S.C.3    Prakash, V.R.4
  • 59
    • 33744783686 scopus 로고    scopus 로고
    • L-arginine stimulates intestinal intraepithelial lymphocyte functions and immune response in chickens orally immunized with live intermediate plus strain of infectious bursal disease vaccine
    • Tayade C, Koti M, and Mishra SC. L-arginine stimulates intestinal intraepithelial lymphocyte functions and immune response in chickens orally immunized with live intermediate plus strain of infectious bursal disease vaccine. Vaccine 2006;24:5473-5480.
    • (2006) Vaccine , vol.24 , pp. 5473-5480
    • Tayade, C.1    Koti, M.2    Mishra, S.C.3
  • 62
    • 8644242379 scopus 로고    scopus 로고
    • Poly-guanosine strings improve cellular uptake and stimulatory activity of phosphodiester CpG oligonucleotides in human leukocytes
    • Bartz H, Mendoza Y, Gebker M, Fischborn T, Heeg K, and Dalpke A. Poly-guanosine strings improve cellular uptake and stimulatory activity of phosphodiester CpG oligonucleotides in human leukocytes. Vaccine 2004;23:148-155.
    • (2004) Vaccine , vol.23 , pp. 148-155
    • Bartz, H.1    Mendoza, Y.2    Gebker, M.3    Fischborn, T.4    Heeg, K.5    Dalpke, A.6
  • 63
    • 0038651180 scopus 로고    scopus 로고
    • Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: Activation of Toll-like-receptor 7
    • Lee J, Chuang TH, Redecke V, She L, Pitha PM, Carson DA, Raz E, and Cottam HB. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: Activation of Toll-like-receptor 7. Proc. Natl. Acad. Sci . 2003;100(11):6646-6651.
    • (2003) Proc. Natl. Acad. Sci. , vol.100 , Issue.11 , pp. 6646-6651
    • Lee, J.1    Chuang, T.H.2    Redecke, V.3    She, L.4    Pitha, P.M.5    Carson, D.A.6    Raz, E.7    Cottam, H.B.8
  • 65
    • 0035961464 scopus 로고    scopus 로고
    • Capsid and RNA stabilization of the oral polio vaccine
    • Verheyden B, Andries K, and Rombaut B. Capsid and RNA stabilization of the oral polio vaccine. Vaccine 2001;19:1899-1905.
    • (2001) Vaccine , vol.19 , pp. 1899-1905
    • Verheyden, B.1    Andries, K.2    Rombaut, B.3
  • 67
    • 84886183044 scopus 로고    scopus 로고
    • Patent No. WO 2007/026180 assigned to Cambridge Biostability Ltd., Cambridge, GB, Improvements in the stabilization of biological materials
    • Patent No. WO 2007/026180 assigned to Cambridge Biostability Ltd., Cambridge, GB, Improvements in the stabilization of biological materials, 2007.
    • (2007)
  • 69
    • 0034898470 scopus 로고    scopus 로고
    • Conjugation of a self-antigen to papillomaviruslike particles allows for efficient induction of protective autoantibodies
    • Chackerian B, Lowy DR, and Schiller JT. Conjugation of a self-antigen to papillomaviruslike particles allows for efficient induction of protective autoantibodies. J. Clin. Invest . 2001;108(3):415-423.
    • (2001) J. Clin. Invest. , vol.108 , Issue.3 , pp. 415-423
    • Chackerian, B.1    Lowy, D.R.2    Schiller, J.T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.