Promoter- and strain-selective enhancement of gene expression in a mouse skeletal muscle by a polymer excipient Pluronic P85

Journal of Controlled Release

Volumn 108, Issue 2-3, 2005, Pages 496-512

  Yang, Zhihui ^a   Zhu, Jian ^a,d   Sriadibhatla, Srikanth ^a   Gebhart, Catherine ^a,e   Alakhov, Valery ^b   Kabanov, Alexander ^a,c  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b Supratek Pharma Inc   (Canada)

^c NEBRASKA MEDICAL CENTER   (United States)

^d JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e Molecular Diagnostics Laboratory   (United States)

Author keywords

Block copolymer; Gene expression; Inflammation; NF B; p53; Plasmid DNA; Skeletal muscle; Transcription

Indexed keywords

BLOCK COPOLYMERS; DNA; GENE TRANSFER; GENETIC ENGINEERING; MUSCLE;

GENE EXPRESSION; INFLAMMATION; NFΚB; P53; PLASMID DNA; SKELETAL MUSCLE; TRANSCRIPTION;

GENES;

CRE RECOMBINASE; EXCIPIENT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LUCIFERASE; NAKED DNA; PLASMID DNA; PLURONIC P85; POLOXAMER; POLYMER; PROTEIN P53; RECOMBINANT PROTEIN; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOMEGALOVIRUS; DNA RESPONSIVE ELEMENT; FEMALE; GENE EXPRESSION; GENE TRANSFER; IMMUNOCOMPETENCE; MOUSE; MOUSE STRAIN; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PRIORITY JOURNAL; PROMOTER REGION; SIGNAL TRANSDUCTION; SIMIAN VIRUS 40; SKELETAL MUSCLE; TRANSCRIPTION INITIATION; VIRAL GENE DELIVERY SYSTEM;

ANIMALS; BETA-GALACTOSIDASE; BLOTTING, WESTERN; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, GEL; DNA; DRUG DELIVERY SYSTEMS; ETHIDIUM; EXCIPIENTS; FEMALE; FLUORESCENT DYES; GENE EXPRESSION; GENE THERAPY; I-KAPPA B PROTEINS; INDICATORS AND REAGENTS; INJECTIONS, INTRAMUSCULAR; LUCIFERASES; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, NUDE; MUSCLE, SKELETAL; NF-KAPPA B; NUCLEASE PROTECTION ASSAYS; PLASMIDS; POLOXALENE; PROMOTER REGIONS (GENETICS); REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SPECIES SPECIFICITY;

EID: 27744574546     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2005.08.015     Document Type: Article

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