Evaluation of molecular chaperons Hsp72 and neuropeptide y as characteristic markers of adaptogenic activity of plant extracts

Phytomedicine

Volumn 20, Issue 14, 2013, Pages 1323-1329

  Asea, Alexzander ^b   Kaur, Punit ^b   Panossian, Alexander ^a   Wikman, Karl Georg ^a  

^a Swedish Herbal Institute   (Sweden)

^b MOREHOUSE SCHOOL OF MEDICINE   (United States)

Author keywords

Adaptogen; Chaperon Hsp72; Neuroglia cells; Neuropeptide Y; Primary human neurons

Indexed keywords

ASTRAGALUS MEMBRANACEUS EXTRACT; BIOLOGICAL MARKER; BRYONIA ALBA EXTRACT; CHAPERONE; CODONOPSIS PILOSULA EXTRACT; ELEUTHEROCOCCUS SENTICOSUS EXTRACT; GINKGO BILOBA EXTRACT; GINSENG EXTRACT; GLYCYRRHIZA GLABRA EXTRACT; GRAPEFRUIT EXTRACT; HEAT SHOCK PROTEIN 72; HEDELIX; HIPPOPHAE RHAMNOIDES EXTRACT; LEPIDIUM MEYENII EXTRACT; MATRICARIA CHAMOMILLA EXTRACT; NEUROPEPTIDE Y; OCIMUM SANCTUM EXTRACT; OPHIOCORDYCEPS SINENSIS EXTRACT; PAULLINA CUNAPA EXTRACT; PELARGONIUM SIDOIDES EXTRACT; PLANT EXTRACT; POLYGONUM MULTIFLORUM EXTRACT; RHAPONTICUM CARTAMOIDES EXTRACT; RHODIOLA ROSEA EXTRACT; SCHISANDRA CHINENSIS EXTRACT; SUTHERLANDIA FRUTESENCE EXTRACT; UNCLASSIFIED DRUG; VALERIAN;

ADAPTOGENIC ACTIVITY; ADULT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTRAGALUS MEMBRANACEUS; BRYONIA ALBA; CELL VIABILITY; CIRCULATION; CODONOPSIS PILOSULA; DRUG ACTIVITY; DRUG CYTOTOXICITY; ELEUTHEROCOCCUS SENTICOSUS; ENZYME LINKED IMMUNOSORBENT ASSAY; FALLOPIA MULTIFLORA; FEMALE; GINKGO BILOBA; GINSENG; GLIA CELL; GLYCYRRHIZA GLABRA; GRAPE; HIGH THROUGHPUT SCREENING; HIPPOPHAE RHAMNOIDES; HUMAN; HUMAN CELL; IN VITRO STUDY; IVY; MATRICARIA; NEUROBLASTOMA CELL; OCIMUM TENUIFLORUM; PRIORITY JOURNAL; RHAPONTICUM CARTAMOIDES; RHODIOLA; RHODIOLA ROSEA; SCHISANDRA CHINENSIS; STATISTICAL SIGNIFICANCE; VALERIANA OFFICINALIS; WITHANIA SOMNIFERA;

BRYONIA ALBA; ELEUTHEROCOCCUS SENTICOSUS; HEDERA HELIX; MATRICARIA RECUTITA; PANAX GINSENG; PELARGONIUM SIDOIDES; RHAPONTICUM; RHODIOLA ROSEA; SCHISANDRA CHINENSIS; VITIS VINIFERA; WITHANIA SOMNIFERA;

ADAPTOGEN; CHAPERON HSP72; NEUROGLIA CELLS; NEUROPEPTIDE Y; PRIMARY HUMAN NEURONS.;

ADAPTATION, PHYSIOLOGICAL; BIOLOGICAL MARKERS; CELL LINE; ELEUTHEROCOCCUS; FRUIT; HSP70 HEAT-SHOCK PROTEINS; HSP72 HEAT-SHOCK PROTEINS; HUMANS; NEUROPEPTIDE Y; PHYTOTHERAPY; PLANT EXTRACTS; PLANT ROOTS; RHODIOLA; SCHISANDRA; STRESS, PHYSIOLOGICAL;

EID: 84886101086     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2013.07.001     Document Type: Article

References (47)

1. A. Asea Stress proteins and initiation of immune response: chaperokine activity of hsp72 Exercise Immunology Review 11 2005 34 45
2. A. Asea Release of heat shock proteins: passive vs active release mechanisms A. Asea, S.K. Calderwood, Potent Mediators of Inflammation and Immunity, 2007 Springer Dordrecht, the Netherlands 3 20
3. G. Aslanyan, E. Amroyan, E. Gabrielyan, M. Nylander, G. Wikman, and A. Panossian Double-blind, placebo-controlled, randomised study of single dose effects of ADAPT-232 on cognitive functions Phytomedicine 17 2010 494 499
4. I.I. Brekhman Eleutherococc (Bibliographic index) 1958-1981 1st ed 1982 USSR Academy of Sciences, Far East Scientific Center, Institute of Marine Biology Vladivostok, USSR 1 14
5. I.I. Brekhman, and I.V. Dardymov New substances of plant origin, which increase non-specific resistance Annual Review of Pharmacology 8 1968 419 430
6. G.P. Chrousos, and P.W. Gold The concept of stress system disorders: overview of behavioral and physical homeostasis JAMA 267 1992 1244 1252
7. M. Davydov, and A.D. Krikorian Eleutherococcus senticosus (Rupr.& Maxim.) Maxim. (Araliaceae) as an adaptogen: a closer look Journal of Ethnopharmacology 72 2000 345 393
8. EFSA Consolidated list of Article 13 health claims Database Consolidated list of Article 13 health claim list of references received by EFSA European Food Safety Authority (EFSA) Parma, 21 September 2009 1 235 http://www.efsa. europa.eu/en/ndaclaims/ndaclaims13.htm
9. EMEA/HMPC/102655/2007 Reflection Paper On The Adaptogenic Concept 2008 European Medicines Agency London, 8 May
10. N. Farnsworth, A.D. Kinghorn, D.D. Soejarto, and D.P. Waller Siberian Ginseng (Eleutherococcus senticosus): current status as an adaptogen H. Wagner, H. Hikino, N.R. Farnsworth, Economic and Medicinal Plant Research. 1985 Academic Press London, UK 156 209 Vol. 1
11. M.A. Febbraio, and I. Koukoulas HSP72 gene expression progressively increases in human skeletal muscle during prolonged, exhaustive exercise Journal of Applied Physiology 89 2000 1055 1060
12. M. Fleshner, and J.D. Johnson Endogenous extra-cellular heat shock protein 72: releasing signal(s) and function International Journal of Hyperthermia 21 2005 457 471
13. B. González, and R. Manso Induction, modification and accumulation of HSP70s in the rat liver after acute exercise: early and late responses Journal of Physiology 556 2004 369 385
14. I. Guzhova, K. Kislyakova, O. Moskaliova, I. Fridlanskaya, M. Tytell, M. Cheetham, and B. Margulis In vitro studies show that Hsp70 can be released by glia and that exogenous Hsp70 can enhance neuronal stress tolerance Brain Research 914 2001 66 73
15. D.A. Haas, and S.R. George Neuropeptide Y-induced effects on hypothalamic corticotropin-releasing factor content and release are dependent on noradrenergic/adrenergic neurotransmission Brain Research 498 2 1989 333 338 10.1016/0006-8993(89)91112-8 PMID 2551461
16. L. Huang, H. Zhao, B. Huang, C. Zheng, W. Peng, and L. Qin Acanthopanax senticosus: review of botany, chemistry and pharmacology Pharmazie 66 2011 83 97
17. M. Hauwel, E. Furon, C. Canova, M. Griffiths, J. Neal, and P. Gasque Innate (inherent) control of brain infection, brain inflammation and brain repair: the role of microglia, astrocytes, "protective" glial stem cells and stromal ependymal cells Brain Research Reviews 48 2005 220 223
18. P.G. Haydon Glia: listening and talking to the synapse Nature Reviews Neuroscience 2 2001 185 193
19. F.A. Henn, and A. Hamberger Glial cell function: uptake of transmitter substances Proceedings of the National Academy of Sciences USA 68 1971 2686 2690
20. J.D. Johnson, and M. Fleshner Endogenous extra-cellular heat shock protein 72: releasing signal(s) and function International Journal of Hyperthermia 21 2005 457 471
21. G.I. Lancaster, and M.A. Febbraio Mechanisms of stress-induced cellular HSP72 release: implications for exercise-induced increases in extracellular HSP72 Exercise Immunology Review 11 2005 46 52
22. N.V. Lazarev General and specific in action of pharmacological agents Pharmacology and Toxicology 21 1958 81 86
23. M.D. Mashkovskij Medicines (Manual on Pharmaco-therapy for Doctors). Part I 8th ed 1977 Meditsina Moscow 133
24. M.D. Nguyen, J.-P. Julien, and S. Rivest Innate immunity: the missing link in neuroprotection and neurodegeneration? Nature Reviews Neuroscience 3 2002 216 227
25. E.M.G. Olsson, B. von Schéele, and A.G. Panossian A randomized double-blind placebo controlled parallell group study of SHR-5 extract of Rhodiola rosea roots as treatment for patients with stress related fatigue Planta medica 75 2009 105 112
26. A. Panossian Adaptogens: tonic herbs for fatigue and stress Alternative and Complimentary Therapy 9 2003 327 332
27. A.G. Panossian Adaptogens in mental and behavioral disorders Psychiatric Clinics of North America 36 1 2013 49 64 10.1016/j.psc.2012.12.005
28. A. Panossian, E. Gabrielian, and H. Wagner On the mechanism of action of plant adaptogens with particular references on cucurbitacin R diglucoside Phytomedicine 6 1999 147 155
29. A. Panossian, M. Hambartsumyan, A. Hovanissian, E. Gabrielyan, and G. Wilkman The adaptogens rhodiola and schizandra modify the response to immobilization stress in rabbits by suppressing the increase of phosphorylated stress-activated protein kinase, nitric oxide and cortisol Drug Targets Insights 1 2007 39 54 Available at: www.la-press.com/the-adaptogens-rhodiola-and- schizandra-modifythe-response-to-immobili-a260. (Accessed 10.16.12)
30. A. Panossian, R. Hamm, G. Wikman, and T. Efferth Synergy and antagonism of active ingredients of complex herbal preparation ADAPT-232 on transcriptional level of metabolic regulation in isolated neuroglia cells Frontiers in Neuroscience 7 2013 16 10.3389/fnins.2013.00016 http://www.frontiersin.org/ Journal/Abstract.aspx?s=744&name=neuroendocrine-science
31. A. Panossian, and H. Wagner Stimulating effects of adaptogens: an overview of clinical trials of adaptogens with particular reference to their efficacy on single dose administration Phytotherapy Research 19 2005 819 838
32. A. Panossian, and H. Wagner A review of their history, biological activity, and clinical benefits HerbalGram 90 2011 52 63
33. A. Panossian, and G. Wikman Pharmacology of Schisandra chinensis Bail: an overview of Russian research and uses in medicine Journal of Ethnopharmacology 118 2008 183 212
34. A. Panossian, and G. Wikman Evidence-based efficacy of adaptogens in fatigue, and molecular mechanisms related to their stress-protective activity Current Clinical Pharmacology 4 2009 198 219
35. A. Panossian, and G. Wikman Effects of adaptogens on the central nervous system and the molecular mechanisms associated with their stress - protective activity Pharmaceuticals 3 2010 188 224
36. A. Panossian, G. Wikman, P. Kaur, and A. Asea Adaptogens exert a stress-protective effect by modulation of expression of molecular chaperones Phytomedicine 16 2009 617 622
37. A. Panossian, G. Wikman, P. Kaur, and A. Asea Adaptogens stimulate neuropeptide Y and Hsp72 expression and release in neuroglia cells Frontiers in Neuroscience 6 2012 6 10.3389/fnins.2012.00006 http://www.frontiersin.org/ neuroendocrine-science/10.3389/fnins.2012.00006/full
38. A. Panossian, G. Wikman, and J. Sarris Rosenroot (Rhodiolarosea): traditional use, chemical composition, pharmacology and clinical efficacy Phytomedicine 17 2010 481 493
39. A. Panossian, G. Wikman, and H. Wagner Plant adaptogens III: earlier and more recent aspects and concepts on their modes of action Phytomedicine 6 1999 287 300
40. S. Saggu, and R. Kumar V.K. Singh, J.N. Govil, Stress management and herbal adaptogens 25 2009 Recent Progress in Medicinal Plants 253 271
41. G. Samuelsson, and L. Bohlin Drugs of Natural Origin: A Treatise of Pharmacognosy 6 ed 2009 Swedish Academy of Phramaceutical Sciences Stockholm, Sweden
42. H. Selye Stress 1950 Acta Medical Publisher Montreal, Canada
43. E.M. Ullian, S.K. Sapperstein, K.S. Christopherson, and B.A. Barres Control of synapse 1087 number by glia Science 291 2001 657 661
44. H. Wagner, H. Norr, and H. Winterhoff Plant adaptogens Phytomedicine 1 1994 63 76
45. M. Whitham, and M.B. Fortes Heat shock protein 72: release and biological significance during exercise Frontiers in Bioscience 13 2008 1328 1339
46. F.A. Wiegant, S. Surinova, E. Ytsma, M. Langelaar-Makkinje, G. Wikman, and J.A. Post Plant adaptogens increase lifespan and stress resistance in C. elegans Biogerontology 10 2009 27 42
47. D. Winston, and S. Maims Adaptogens: Herbs for Strength, Stamina, and Stress Relief Inner Traditions /Bear & Co, Mar 22, 2007 - Health & Fitness 2007 324