Adaptogens exert a stress-protective effect by modulation of expression of molecular chaperones

Phytomedicine

Volumn 16, Issue 6-7, 2009, Pages 617-622

  Panossian, Alexander ^a   Wikman, Georg ^a   Kaur, Punit ^b   Asea, Alexzander ^b  

^a SHI Research and Development   (Sweden)

^b TEXAS A M COLLEGE OF MEDICINE   (United States)

Author keywords

Adaptogen; Chaperon Hsp72; Eleutherococcus senticocus; Exhaustion; Rhodiola rosea; Schisandra chinensis

Indexed keywords

ADAPT 232 FORTE; CHAPERONE; ELEUTHEROCOCCUS SENTICOSUS EXTRACT; HEAT SHOCK PROTEIN 72; RHODIOLA ROSEA EXTRACT; ROSAVIN; SALIDROSIDE; SCHISANDRA CHINENSIS EXTRACT; SCHIZANDRIN; SITOGLUSIDE; TYROSOL; UNCLASSIFIED DRUG;

ADAPTOGEN; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG ISOLATION; DRUG MECHANISM; ELEUTHEROCOCCUS SENTICOSUS; EMOTIONAL STRESS; ENDURANCE; ENZYME IMMUNOASSAY; ENZYME LINKED IMMUNOSORBENT ASSAY; EXHAUSTION; FATIGUE; FEMALE; MEDIATOR; MEDICINAL PLANT; MOUSE; NERVE STIMULATION; NONHUMAN; PHYSICAL ACTIVITY; PHYSICAL STRESS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; RHODIOLA; RHODIOLOA ROSEA; SCHISANDRA CHINENSIS; SCHISANDRACEAE; STRESS; SWIMMING; SYSTEMIC CIRCULATION;

ANIMALS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HSP70 HEAT-SHOCK PROTEINS; MICE; MICE, INBRED BALB C; MOLECULAR CHAPERONES; PHYSICAL ENDURANCE; PLANT EXTRACTS; PLANTS, MEDICINAL;

ANIMALIA; ELEUTHEROCOCCUS; MUS; RHODIOLA ROSEA; SCHISANDRA CHINENSIS;

EID: 67349132352     PISSN: 09447113     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phymed.2008.12.003     Document Type: Article

References (33)

1. Asea A. Release of heat shock proteins: passive vs active release mechanisms. In: Asea A., and DeMaio A. (Eds). Heat Shock Proteins: Potent Mediators of Inflammation and Immunity vol. 1 (2007), Springer, Dordrecht, The Netherlands 3-20
2. Asea A. Hsp70: a chaperokine. Novartis Found. Symp. 291 (2008) 173-179 discussion 179-183, 221-224
3. Asea A., and De Maio A. Heat Shock Proteins: Potent Mediators of Inflammation and Immunity vol. 1 (2007), Springer, Dordrecht, The Netherlands
4. Asea A. Stress proteins and initiation of immune response: chaperokine activity of hsp72. Exerc. Immunol. Rev. 11 (2005) 34-45
5. Bausero M.A., Gastpar R., Multhoff G., and Asea A. Alternative mechanism by which IFN-gamma enhances tumor recognition: active release of heat shock protein 72. J. Immunol. 175 (2005) 2900-2912
6. Brekhman I.I., and Dardymov I.V. New substances of plant origin which increase non-specific resistance. Ann. Rev. Pharmacol. 8 (1968) 419-430
7. Chiu P.Y., and Ko K.M. Schisandrin B protects myocardial ischemia-reperfusion injury partly by inducing Hsp25 and Hsp70 expression in rats. Mol. Cell. Biochem. 266 (2004) 139-144
8. Febbraio M.A., and Koukoulas I. HSP72 gene expression progressively increases in human skeletal muscle during prolonged, exhaustive exercise. J. Appl. Physiol. 89 (2000) 1055-1060
9. Fleshner M., and Johnson J.D. Endogenous extra-cellular heat shock protein 72: releasing signal(s) and function. Int. J. Hyperthermia 21 (2005) 457-471
10. Gabai V.L., Meriin A.B., Mosser D.D., Caron A.W., Rits S., Shifrin V.I., and Sherman M.Y. Hsp70 prevents activation of stress kinases. A novel pathway of cellular thermotolerance. J. Biol. Chem. 272 (1997) 18033-18037
11. Gabai V.L., Meriin A.B., Yaglom J.A., Volloch V.Z., and Sherman M.Y. Role of Hsp70 in regulation of stress-kinase JNK: implications in apoptosis and aging. FEBS Lett. 438 (1998) 1-4
12. Gallucci S., and Matzinger P. Danger signals: SOS to the immune system. Curr. Opin. Immunol. 13 (2001) 114-119
13. González B., and Manso R. Induction, modification and accumulation of HSP70s in the rat liver after acute exercise: early and late responses. J. Physiol. 556 (2004) 369-385
14. Harkness J.E., and Wagner J.E. The Biology and Medicine of Rabbits and Rodents. third ed (1989), Lea and Febiger, Philadelphia
15. International Conference on Harmonisation, 1996. ICH topic Q2B validation of analytical procedures: methodology, step 4, consensus guidelines. 6 November, 1996. 〈www.emea.eu.int/pdfs/human/ich/028195en.pdf〉.
16. International Organisation for Standardisation, 2001. EN ISO/IEC 17 025:2001 standard accreditation requirements for QC laboratories operating under the GxP Compliance Requirements 2001. 〈http://www.effichem.com〉.
17. Ip S.P., Che C.T., Kong Y.C., and Ko K.M. Effects of schisandrin B pretreatment on tumor necrosis factor-alpha induced apoptosis and Hsp70 expression in mouse liver. Cell Stress Chaperones 6 (2001) 44-48
18. Johnson J.D., and Fleshner M. Endogenous extra-cellular heat shock protein 72: releasing signal(s) and function. Int. J. Hyperthermia 21 (2005) 457-471
19. Lancaster G.I., and Febbraio M.A. Mechanisms of stress-induced cellular HSP72 release: implications for exercise-induced increases in extracellular HSP72. Exerc. Immunol. Rev. 11 (2005) 46-52
20. Matzinger P. An innate sense of danger. Semin. Immunol. 10 (1998) 399-415
21. Olsson, E.M.G., von Schéele, B., Panossian, A.G., 2008. A randomized double-blind placebo controlled parallell group study of SHR-5 extract of Rhodiola rosea roots as treatment for patients with stress related fatigue. Planta Med. November 18. 〈http://www.thieme-connect.de/ejournals/full DOI/10.1055/s-0028-1088346〉.
22. Panossian A. Adaptogens: tonic herbs for fatigue and stress. Alt. Comp. Ther. 9 (2003) 327-332
23. Panossian A., and Wagner H. Stimulating effects of adaptogens: an overview of clinical trials of adaptogens with particular reference to their efficacy on single dose administration. Phytother. Res. 19 (2005) 819-838
24. Panossian A., and Wikman G. Effect of adaptogens on the central nervous system. Arq. Bras. Fitomed Cient. 2 (2005) 108-130
25. Panossian A., Wikman G., and Wagner H. Plant adaptogens III. Earlier and more recent aspects and concepts on their mode of action. Phytomedicine 6 (1999) 287-300
26. Panossian A., Hambartsumyan M., Hovanissian A., Gabrielyan E., and Wikman G. The adaptogens rhodiola and schizandra modify the response to immobilization stress in rabbits by suppressing the increase of phosphorylated stress-activated protein kinase, nitric oxide and cortisol. Drug Targets Insights 1 (2007) 39-54. 〈http://la-press.com/cr_data/files/f_DTI-2-Panossian-et-al_296.pdf〉
27. Panossian A., Gabrielian E., and Wagner H. On the mechanism of action of plant adaptogens with particular references on cucurbitacin R diglucoside. Phytomedicine 6 (1999) 147-155
28. Panossian A., Oganessian A., Ambartsumian M., Gabrielian E., Wagner H., and Wikman G. Effects of heavy physical exercise and adaptogens on nitric oxide content in human saliva. Phytomedicine 6 (1999) 17-26
29. Roberts R.A., Soames A.R., James N.H., Gill J.H., and Wheeldon E.B. Dosing-induced stress causes hepatocyte apoptosis in rats primed by the rodent nongenotoxic hepatocarcinogen cyproterone acetate. Toxicol. Appl. Pharmacol. 135 (1995) 192-199
30. Westerheide S.D., and Morimoto R.I. Heat shock response modulators as therapeutic tools for deseases of protein conformation. J. Biol. Chem. 280 (2005) 33097-33100
31. Whitham M., and Fortes M.B. Heat shock protein 72: release and biological significance during exercise. Front. Biosci. 13 (2008) 1328-1339
32. Wiegant F.A.C., Limandjaja G., de Poot S.A.H., Bayda L.A., Vorontsova O.N., and Zenina T.A. Plant adaptogens activate cellular adaptive mechanisms by causing mild damage. In: Lukyanova L., Takeda N., and Singal P.K. (Eds). Adaptation Biology and Medicine: Health Potentials vol. 5 (2008), Narosa Publishers, New Delhi, India 319-332
33. Wiegant F.A.C., Surinova S., Ytsma E., Langelaar-Makkinje M., Wikman G., and Post J.A. Plant adaptogens increase life span and stress resistance in C. elegans. Biogerontology (2008) 10.1007/s10522-008-9151-9