Stress proteins and initiation of immune response: Chaperokine activity of Hsp72

Exercise Immunology Review

Volumn 11, Issue , 2005, Pages 34-45

  Asea, Alexzander ^a  

^a TEXAS A M COLLEGE OF MEDICINE   (United States)

Author keywords

Chaperokine; Exercise, heat shock proteins; Exosomes; Inflammation; Lipid rafts; Protein transport

Indexed keywords

CELL SURFACE RECEPTOR; CHAPERONE; ENDOTOXIN; HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN 70;

ANIMAL; BIOLOGICAL MODEL; HUMAN; IMMUNITY; METABOLISM; PHYSIOLOGY; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; ENDOTOXINS; HEAT-SHOCK PROTEINS; HSP70 HEAT-SHOCK PROTEINS; HUMANS; IMMUNITY; MODELS, BIOLOGICAL; MOLECULAR CHAPERONES; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION;

EID: 33646336921     PISSN: 10775552     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (72)

1. Adewoye AH, Klings ES, Farber HW, Palaima E, Bausero MA, McMahon L, Odhiambo A, Surinder S, Yoder M, Steinberg MH, and Asea A. Sickle cell vaso-occlusive crisis induces the release of circulating serum heat shock protein-70. Am J Hematol 78: 240-242, 2005. (Pubitemid 40316505)
2. Arnold-Schild D, Hanau D, Spehner D, Schmid C, Rammensee H-G, de la Salle H, and Schild H. Receptor-mediated endocytosis of heat shock proteins by professional antigen-presenting cells. J Immunol 162: 3757-3760, 1999. (Pubitemid 29314749)
3. Asea A. Chaperokine-induced signal transduction pathways. Exerc Immunol Rev 9: 25-33, 2003.
4. Asea A, Kabingu E, Stevenson MA, and Calderwood SK. HSP70 peptide-bearing and peptide-negative preparations act as chaperokines. Cell Stress Chaperones 5: 425-431, 2000. (Pubitemid 32057493)
5. Asea A, Kraeft SK, Kurt-Jones EA, Stevenson MA, Chen LB, Finberg RW, Koo GC, and Calderwood SK. HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine. Nat Med 6: 435-442, 2000. (Pubitemid 30208161)
6. Asea A, Rehli M, Kabingu E, Boch JA, Bare O, Auron PE, Stevenson MA, and Calderwood SK. Novel signal transduction pathway utilized by extracellular HSP70: role of toll-like receptor (TLR) 2 and TLR4. J Biol Chem 277: 15028- 15034., 2002.
7. Barreto A, Gonzalez JM, Kabingu E, Asea A, and Fiorentino S. Stress-induced release of HSC70 from human tumors. Cell Immunol 222: 97-104, 2003. (Pubitemid 36765431)
8. Basu S, Binder RJ, Suto R, Anderson KM, and Srivastava PK. Necrotic but not apoptotic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and activate the NF-kappa B pathway. Int Immunol 12: 1539-1546., 2000.
9. Bausero MA, Gastpar R, Multhoff G, and Asea A. Alternative Mechanism by which IFN-{gamma} Enhances Tumor Recognition: Active Release of Heat Shock Protein 72. J Immunol 175: 2900-2912, 2005. (Pubitemid 41170507)
10. Becker T, Hartl FU, and Wieland F. CD40, an extracellular receptor for binding and uptake of Hsp70-peptide complexes. J Cell Biol 158: 1277-1285, 2002.
11. Berwin B, Hart JP, Rice S, Gass C, Pizzo SV, Post SR, and Nicchitta CV. Scavenger receptor-A mediates gp96/GRP94 and calreticulin internalization by antigen-presenting cells. EMBO J 22: 6127-6136, 2003. (Pubitemid 37463255)
12. Berwin B, Reed RC, and Nicchitta CV. Virally induced lytic cell death elicits the release of immunogenic GRP94/gp96. J Biol Chem 276: 21083-21088, 2001.
13. Binder RJ, Anderson KM, Basu S, and Srivastava PK. Cutting edge: heat shock protein gp96 induces maturation and migration of CD11c+ cells in vivo. J Immunol 165: 6029-6035., 2000.
14. Binder RJ, Han DK, and Srivastava PK. CD91: a receptor for heat shock protein gp96. Nat Immunol 1: 151-155, 2000.
15. Binder RJ, Karimeddini D, and Srivastava PK. Adjuvanticity of alpha 2-macroglobulin, an independent ligand for the heat shock protein receptor CD91. J Immunol 166: 4968-4972, 2001. (Pubitemid 32280707)
16. Binder RJ and Srivastava PK. Essential role of CD91 in re-presentation of gp96- chaperoned peptides. Proc Natl Acad Sci U S A 101: 6128-6133, 2004. (Pubitemid 38520539)
17. Binder RJ, Vatner R, and Srivastava P. The heat-shock protein receptors: some answers and more questions. Tissue Antigens 64: 442-451, 2004. (Pubitemid 39312725)
18. Bukau B and Horwich AL. The Hsp70 and Hsp60 chaperone machines. Cell 92: 351-366, 1998. (Pubitemid 28093013)
19. Clayton A, Turkes A, Navabi H, Mason MD, and Tabi Z. Induction of heat shock proteins in B-cell exosomes. J Cell Sci 118: 3631-3638, 2005. (Pubitemid 41309410)
20. Delneste Y, Magistrelli G, Gauchat J, Haeuw J, Aubry J, Nakamura K, Kawakami- Honda N, Goetsch L, Sawamura T, Bonnefoy J, and Jeannin P. Involvement of LOX-1 in dendritic cell-mediated antigen cross-presentation. Immunity 17: 353- 362, 2002.
21. Dunn GP, Bruce AT, Ikeda H, Old LJ, and Schreiber RD. Cancer immunoediting: from immunosurveillance to tumor escape. Nat Immunol 3: 991-998, 2002. (Pubitemid 35363648)
22. Escola JM, Kleijmeer MJ, Stoorvogel W, Griffith JM, Yoshie O, and Geuze HJ. Selective enrichment of tetraspan proteins on the internal vesicles of multivesicular endosomes and on exosomes secreted by human B-lymphocytes. J Biol Chem 273: 20121-20127, 1998. (Pubitemid 28377568)
23. Fehrenbach E, Niess AM, Voelker K, Northoff H, and Mooren FC. Exercise intensity and duration affect blood soluble HSP72. Int J Sports Med 26: 552-557, 2005. (Pubitemid 41291177)
24. Fleshner M, Campisi J, Amiri L, and Diamond DM. Cat exposure induces both intra-and extracellular Hsp72: the role of adrenal hormones. Psychoneuroendocrinology 29: 1142-1152, 2004. (Pubitemid 38829176)
25. Gallucci S, Lolkema M, and Matzinger P. Natural adjuvants: endogenous activators of dendritic cells. Nat Med 5: 1249-1255, 1999. (Pubitemid 29535601)
26. Gao B and Tsan MF. Endotoxin contamination in recombinant human heat shock protein 70 (Hsp70) preparation is responsible for the induction of tumor necrosis factor alpha release by murine macrophages. J Biol Chem 278: 174-179, 2003. (Pubitemid 36043559)
27. Gao B and Tsan MF. Recombinant human heat shock protein 60 does not induce the release of tumor necrosis factor alpha from murine macrophages. J Biol Chem 278: 22523-22529, 2003. (Pubitemid 36830307)
28. Gastpar R, Gehrmann M, Bausero MA, Asea A, Gross C, Schroeder JA, and Multhoff G. Heat shock protein 70 surface-positive tumor exosomes stimulate migratory and cytolytic activity of natural killer cells. Cancer Res 65: 5238-5247, 2005. (Pubitemid 40827334)
29. Gleeson M, Nieman DC, and Pedersen BK. Exercise, nutrition and immune function. J Sports Sci 22: 115-125, 2004. (Pubitemid 38173094)
30. Gross C, Hansch D, Gastpar R, and Multhoff G. Interaction of heat shock protein 70 peptide with NK cells involves the NK receptor CD94. Biol Chem 384: 267-279, 2003. (Pubitemid 36348327)
31. Guzhova I, Kislyakova K, Moskaliova O, Fridlanskaya I, Tytell M, Cheetham M, and Margulis B. In vitro studies show that Hsp70 can be released by glia and that exogenous Hsp70 can enhance neuronal stress tolerance. Brain Res 914: 66-73, 2001. (Pubitemid 32905432)
32. Haworth R, Platt N, Keshav S, Hughes D, Darley E, Suzuki H, Kurihara Y, Kodama T, and Gordon S. The macrophage scavenger receptor type Ais expressed by activated macrophages and protects the host against lethal endotoxic shock. J Exp Med 186: 1431-1439, 1997. (Pubitemid 27479802)
33. Hunter-Lavin C, Davies EL, Bacelar MM, Marshall MJ, Andrew SM, and Williams JH. Hsp70 release from peripheral blood mononuclear cells. Biochem Biophys Res Commun 324: 511-517, 2004. (Pubitemid 39345547)
34. Lancaster GI and Febbraio MA. Exosome-dependent trafficking of HSP70: a novel secretory pathway for cellular stress proteins. J Biol Chem 280: 23349-23355, 2005. (Pubitemid 40853248)
35. Lancaster GI, Moller K, Nielsen B, Secher NH, Febbraio MA, and Nybo L. Exercise induces the release of heat shock protein 72 from the human brain in vivo. Cell Stress Chaperones 9: 276-280, 2004. (Pubitemid 39457431)
36. Lehner T, Bergmeier LA, Wang Y, Tao L, Sing M, Spallek R, and van der Zee R. Heat shock proteins generate beta-chemokines which function as innate adjuvants enhancing adaptive immunity. Eur J Immunol 30: 594-603, 2000. (Pubitemid 30098853)
37. Lehner T, Wang Y, Whittall T, McGowan E, Kelly CG, and Singh M. Functional domains of HSP70 stimulate generation of cytokines and chemokines, maturation of dendritic cells and adjuvanticity. Biochem Soc Trans 32: 629-632, 2004. (Pubitemid 39120401)
38. Lindquist S. The heat-shock response. Annu Rev Biochem 55: 1151-1191, 1986. (Pubitemid 16070798)
39. Lindquist S and Craig EA. The heat-shock proteins. Annu Rev Genet 22: 631-677, 1988. (Pubitemid 19156675)
40. MacAry PA, Javid B, Floto RA, Smith KG, Oehlmann W, Singh M, and Lehner PJ. HSP70 peptide binding mutants separate antigen delivery from dendritic cell stimulation. Immunity 20: 95-106, 2004. (Pubitemid 38134297)
41. Mayer MP and Bukau B. Hsp70 chaperone systems: diversity of cellular functions and mechanism of action. Biol Chem 379: 261-268, 1998. (Pubitemid 28152088)
42. Millar DG, Garza KM, Odermatt B, Elford AR, Ono N, Li Z, and Ohashi PS. Hsp70 promotes antigen-presenting cell function and converts T-cell tolerance to autoimmunity in vivo. Nat Med 9: 1469-1476, 2003. (Pubitemid 38004773)
43. Minota S, Cameron B, Welch WJ, and Winfield JB. Autoantibodies to the constitutive 73-kD member of the hsp70 family of heat shock proteins in systemic lupus erythematosus. J Exp Med 168: 1475-1480, 1988. (Pubitemid 18264879)
44. Mommersteeg PM, Heijnen CJ, Verbraak MJ, and van Doornen LJ. Clinical burnout is not reflected in the cortisol awakening response, the day-curve or the response to a low-dose dexamethasone suppression test. Psychoneuroendocrinology, 2005.
45. Multhoff G, Botzler C, Jennen L, Schmidt J, Ellwart J, and Issels R. Heat shock protein 72 on tumor cells: a recognition structure for natural killer cells. J Immunol 158: 4341-4350, 1997. (Pubitemid 127483936)
46. Multhoff G, Botzler C, Wiesnet M, Eissner G, and Issels R. CD3- large granular lymphocytes recognize a heat-inducible immunogenic determinant associated with the 72-kD heat shock protein on human sarcoma cells. Blood 86: 1374-1382, 1995.
47. Nakamura T, Hinagata J, Tanaka T, Imanishi T, Wada Y, Kodama T, and Doi T. HSP90, HSP70, and GAPDH directly interact with the cytoplasmic domain of macrophage scavenger receptors. Biochem Biophys Res Commun 290: 858-864, 2002. (Pubitemid 34687522)
48. Noessner E, Gastpar R, Milani V, Brandl A, Hutzler PJ, Kuppner MC, Roos M, Kremmer E, Asea A, Calderwood SK, and Issels RD. Tumor-derived heat shock protein 70 peptide complexes are cross- presented by human dendritic cells. J Immunol 169: 5424-5432., 2002. (Pubitemid 35291639)
49. Panjwani NN, Popova L, and Srivastava PK. Heat shock proteins gp96 and hsp70 activate the release of nitric oxide by APCs. J Immunol 168: 2997-3003, 2002. (Pubitemid 34211681)
50. Pockley AG, De Faire U, Kiessling R, Lemne C, Thulin T, and Frostegard J. Circulating heat shock protein and heat shock protein antibody levels in established hypertension. J Hypertens 20: 1815-1820, 2002.
51. Pockley AG, Georgiades A, Thulin T, de Faire U, and Frostegard J. Serum heat shock protein 70 levels predict the development of atherosclerosis in subjects with established hypertension. Hypertension 42: 235-238, 2003. (Pubitemid 37093466)
52. Pockley AG, Shepherd J, and Corton JM. Detection of heat shock protein 70 (Hsp70) and anti-Hsp70 antibodies in the serum of normal individuals. Immunol Invest 27: 367-377, 1998. (Pubitemid 28531057)
53. Raposo G, Nijman HW, Stoorvogel W, Liejendekker R, Harding CV, Melief CJ, and Geuze HJ. B lymphocytes secrete antigen-presenting vesicles. J Exp Med 183: 1161- 1172, 1996.
54. Reed RC and Nicchitta CV. Chaperone-mediated cross-priming: a hitchhiker's guide to vesicle transport (review). Int J Mol Med 6: 259-264, 2000.
55. Sauter B, Albert ML, Francisco L, Larsson M, Somersan S, and Bhardwaj N. Consequences of cell death: exposure to necrotic tumor cells, but not primary tissue cells or apoptotic cells, induces the maturation of immunostimulatory dendritic cells. J Exp Med 191: 423-434, 2000.
56. Schneider EM, Niess AM, Lorenz I, Northoff H, and Fehrenbach E. Inducible hsp70 expression analysis after heat and physical exercise: transcriptional, protein expression, and subcellular localization. Ann N YAcad Sci 973: 8-12, 2002. (Pubitemid 36124970)
57. Singh-Jasuja H, Scherer HU, Hilf N, Arnold-Schild D, Rammensee HG, Toes RE, and Schild H. The heat shock protein gp96 induces maturation of dendritic cells and down-regulation of its receptor. Eur J Immunol 30: 2211-2215, 2000. (Pubitemid 30655760)
58. Srivastava P. Interaction of heat shock proteins with peptides and antigen presenting cells: chaperoning of the innate and adaptive immune responses. Annu Rev Immunol 20: 395-425, 2002. (Pubitemid 34293430)
59. Srivastava PK. Heat shock protein-based novel immunotherapies. Drug News Perspect 13: 517-522, 2000. (Pubitemid 32120907)
60. Srivastava PK. Hypothesis: controlled necrosis as a tool for immunotherapy of human cancer. Cancer Immun 3: 4, 2003.
61. Srivastava PK. Immunotherapy for human cancer using heat shock protein-Peptide complexes. Curr Oncol Rep 7: 104-108, 2005. (Pubitemid 40485465)
62. Srivastava PK and Amato RJ. Heat shock proteins: the 'Swiss Army Knife' vaccines against cancers and infectious agents. Vaccine 19: 2590-2597, 2001. (Pubitemid 32234277)
63. Terry DF, McCormick M, Andersen S, Pennington J, Schoenhofen E, Palaima E, Bausero M, Ogawa K, Perls TT, and Asea A. Cardiovascular disease delay in centenarian offspring: role of heat shock proteins. Ann N YAcad Sci 1019: 502-505, 2004. (Pubitemid 38951365)
64. Theriault JR, Mambula SS, Sawamura T, Stevenson MA, and Calderwood SK. Extracellular HSP70 binding to surface receptors present on antigen presenting cells and endothelial/epithelial cells. FEBS Lett 579: 1951-1960, 2005. (Pubitemid 40404037)
65. Tsan MF and Gao B. Cytokine function of heat shock proteins. Am J Physiol Cell Physiol 286: C739-744, 2004. (Pubitemid 38543800)
66. Vabulas RM, Ahmad-Nejad P, Ghose S, Kirschning CJ, Issels RD, and Wagner H. HSP70 as endogenous stimulus of the Toll/interleukin-1 receptor signal pathway. J Biol Chem 277: 15107-15112., 2002. (Pubitemid 34952589)
67. Velin AK, Ericson AC, Braaf Y, Wallon C, and Soderholm JD. Increased antigen and bacterial uptake in follicle associated epithelium induced by chronic psychological stress in rats. Gut 53: 494-500, 2004. (Pubitemid 38372972)
68. Walsh RC, Koukoulas I, Garnham A, Moseley PL, Hargreaves M, and Febbraio MA. Exercise increases serum Hsp72 in humans. Cell Stress Chaperones 6: 386-393, 2001. (Pubitemid 33123492)
69. Wang Y, Whittall T, McGowan E, Younson J, Kelly C, Bergmeier LA, Singh M, and Lehner T. Identification of stimulating and inhibitory epitopes within the heat shock protein 70 molecule that modulate cytokine production and maturation of dendritic cells. J Immunol 174: 3306-3316, 2005. (Pubitemid 40354034)
70. Wright BH, Corton JM, El-Nahas AM, Wood RF, and Pockley AG. Elevated levels of circulating heat shock protein 70 (Hsp70) in peripheral and renal vascular disease. Heart Vessels 15: 18-22, 2000.
71. Zitvogel L, Fernandez N, Lozier A, Wolfers J, Regnault A, Raposo G, and Amigorena S. Dendritic cells or their exosomes are effective biotherapies of cancer. Eur J Cancer 35 Suppl 3: S36-38., 1999.
72. Zitvogel L, Regnault A, Lozier A, Wolfers J, Flament C, Tenza D, Ricciardi-Castagnoli P, Raposo G, and Amigorena S. Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell-derived exosomes. Nat Med 4: 594-600., 1998. (Pubitemid 28237359)