Mechanisms of stress-induced cellular HSP72 release: Implications for exercise-induced increases in extracellular HSP72

Exercise Immunology Review

Volumn 11, Issue , 2005, Pages 46-52

  Lancaster, Graeme I ^a   Febbraio, Mark A ^b  

^a Division of Biosciences   (Australia)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 72;

ANIMAL; EXERCISE; HUMAN; METABOLISM; PHYSIOLOGY; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; EXERCISE; HSP70 HEAT-SHOCK PROTEINS; HSP72 HEAT-SHOCK PROTEINS; HUMANS; SIGNAL TRANSDUCTION;

EID: 33646348746     PISSN: 10775552     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (27)

1. Asea A, Kraeft SK, Kurt-Jones EA, Stevenson MA, Chen LB, Finberg RW, Koo GC, and Calderwood SK. HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine. Nat Med 6: 435-442, 2000. (Pubitemid 30208161)
2. Asea A, Rehli M, Kabingu E, Boch JA, Bare O, Auron PE, Stevenson MA, and Calderwood SK. Novel signal transduction pathway utilized by extracellular HSP70: role of toll-like receptor (TLR) 2 and TLR4. J Biol Chem 277: 15028-15034, 2002. (Pubitemid 34952579)
3. Broquet AH, Thomas G, Masliah J, Trugnan G, and Bachelet M. Expression of the molecular chaperone Hsp70 in detergent-resistant microdomains correlates with its membrane delivery and release. J Biol Chem 278: 21601-21606, 2003. (Pubitemid 36792559)
4. Campisi JL, TH; Fleshner, M. Stress-induced extracellular Hsp72 is a functionally significant danger signal to the immune system. Cell Stress Chaperones 8: 272-286, 2003.
5. Clayton A, Turkes A, Navabi H, Mason MD, and Tabi Z. Induction of heat shock proteins in B-cell exosomes. J Cell Sci 118: 3631-3638, 2005. (Pubitemid 41309410)
6. Denzer K, Kleijmeer MJ, Heijnen HF, Stoorvogel W, and Geuze HJ. Exosome: from internal vesicle of the multivesicular body to intercellular signaling device. J Cell Sci 113 Pt 19: 3365-3374, 2000.
7. Febbraio MA, Ott P, Nielsen HB, Steensberg A, Keller C, Krustrup P, Secher NH, and Pedersen BK. Exercise induces hepatosplanchnic release of heat shock protein 72 in humans. J Physiol 544: 957-962, 2002. (Pubitemid 35355972)
8. Fehrenbach E, Niess AM, Voelker K, Northoff H, and Mooren FC. Exercise intensity and duration affect blood soluble HSP72. Int J Sports Med 26: 552-557, 2005. (Pubitemid 41291177)
9. Fevrier B and Raposo G. Exosomes: endosomal-derived vesicles shipping extracellular messages. Curr Opin Cell Biol 16: 415-421, 2004. (Pubitemid 38903148)
10. Fleshner M, Campisi J, Amiri L, and Diamond DM. Cat exposure induces both intraand extracellular Hsp72: the role of adrenal hormones. Psychoneuroendocrinology 29: 1142-1152, 2004. (Pubitemid 38829176)
11. Gething MJ and Sambrook J. Protein folding in the cell. Nature 355: 33-45, 1992.
12. Guzhova I, Kislyakova K, Moskaliova O, Fridlanskaya I, Tytell M, Cheetham M, and Margulis B. In vitro studies show that Hsp70 can be released by glia and that exogenous Hsp70 can enhance neuronal stress tolerance. Brain Res 914: 66-73, 2001. (Pubitemid 32905432)
13. Hegmans JP, Bard MP, Hemmes A, Luider TM, Kleijmeer MJ, Prins JB, Zitvogel L, Burgers SA, Hoogsteden HC, and Lambrecht BN. Proteomic analysis of exosomes secreted by human mesothelioma cells. Am J Pathol 164: 1807-1815, 2004. (Pubitemid 38529783)
14. Hightower LE and Guidon PT, Jr. Selective release from cultured mammalian cells of heat-shock (stress) proteins that resemble glia-axon transfer proteins. J Cell Physiol 138: 257-266, 1989. (Pubitemid 19061205)
15. Johnson JD, Campisi J, Sharkey CM, Kennedy SL, Nickerson M, and Fleshner M. Adrenergic receptors mediate stress-induced elevations in extracellular Hsp72. J Appl Physiol 99: 1789-1795, 2005. (Pubitemid 41547176)
16. Kjaer M. Regulation of hormonal and metabolic responses during exercise in humans. Exerc Sport Sci Rev 20: 161-184, 1992.
17. Kregel KC and Moseley PL. Differential effects of exercise and heat stress on liver HSP70 accumulation with aging. J Appl Physiol 80: 547-551, 1996. (Pubitemid 26061460)
18. Lancaster GI and Febbraio MA. Exosome-dependent trafficking of HSP70: a novel secretory pathway for cellular stress proteins. J Biol Chem 280: 23349-23355, 2005. (Pubitemid 40853248)
19. Mathew A, Bell A, and Johnstone RM. Hsp-70 is closely associated with the trans-ferrin receptor in exosomes from maturing reticulocytes. Biochem J 308 (Pt 3): 823- 830, 1995.
20. Multhoff G and Hightower LE. Cell surface expression of heat shock proteins and the immune response. Cell Stress Chaperones 1: 167-176, 1996.
21. Nickel W. Unconventional secretory routes: direct protein export across the plasma membrane of mammalian cells. Traffic 6: 607-614, 2005. (Pubitemid 40959689)
22. Pockley AG. Heat shock proteins in health and disease: therapeutic targets or therapeutic agents? Expert Rev Mol Med 2001: 1-21, 2001.
23. Salo DC, Donovan CM, and Davies KJ. HSP70 and other possible heat shock or oxidative stress proteins are induced in skeletal muscle, heart, and liver during exercise. Free Radic Biol Med 11: 239-246, 1991. (Pubitemid 121003919)
24. Savina A, Furlan M, Vidal M, and Colombo MI. Exosome release is regulated by a calcium-dependent mechanism in K562 cells. J Biol Chem 278: 20083-20090, 2003. (Pubitemid 36799202)
25. Vabulas RM, Ahmad-Nejad P, da Costa C, Miethke T, Kirschning CJ, Hacker H, and Wagner H. Endocytosed HSP60s use toll-like receptor 2 (TLR2) and TLR4 to activate the toll/interleukin-1 receptor signaling pathway in innate immune cells. J Biol Chem 276: 31332-31339, 2001. (Pubitemid 37385004)
26. Vabulas RM, Ahmad-Nejad P, Ghose S, Kirschning CJ, Issels RD, and Wagner H. HSP70 as endogenous stimulus of the Toll/interleukin-1 receptor signal pathway. J Biol Chem 277: 15107-15112, 2002. (Pubitemid 34952589)
27. Walsh RC, Koukoulas I, Garnham A, Moseley PL, Hargreaves M, and Febbraio MA. Exercise increases serum Hsp72 in humans. Cell Stress Chaperones 6: 386-393, 2001. (Pubitemid 33123492)