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Volumn 23, Issue 6, 2013, Pages 237-242

Effects of isolated GH deficiency on adipose tissue, feeding and adipokines in mice

Author keywords

Adiponectin; Food intake; Growth hormone releasing hormone knockout; Intra abdominal fat; Leptin; Subcutaneous fat; Visfatin

Indexed keywords

ADIPOCYTOKINE; ADIPONECTIN; GROWTH HORMONE; GROWTH HORMONE RELEASING FACTOR; LEPTIN; MESSENGER RNA; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE;

EID: 84886098345     PISSN: 10966374     EISSN: 15322238     Source Type: Journal    
DOI: 10.1016/j.ghir.2013.08.004     Document Type: Article
Times cited : (18)

References (60)
  • 2
    • 0025177911 scopus 로고
    • Actions of growth hormone on adipose tissue: possible involvement of autocrine or paracrine factors
    • Goodman H.M., Schwartz Y., Tai L.R., Gorin E. Actions of growth hormone on adipose tissue: possible involvement of autocrine or paracrine factors. Acta Paediatr. Scand. Suppl. 1990, 367:132-136.
    • (1990) Acta Paediatr. Scand. Suppl. , vol.367 , pp. 132-136
    • Goodman, H.M.1    Schwartz, Y.2    Tai, L.R.3    Gorin, E.4
  • 4
    • 0030830566 scopus 로고    scopus 로고
    • Action of growth hormone in adipose tissue
    • Richelsen B. Action of growth hormone in adipose tissue. Horm. Res. 1997, 48(Suppl. 5):105-110.
    • (1997) Horm. Res. , vol.48 , Issue.SUPPL. 5 , pp. 105-110
    • Richelsen, B.1
  • 7
    • 0032434881 scopus 로고    scopus 로고
    • Effects of zinc ion concentration on growth, fat content and reproduction in oMT1a-oGH transgenic mice
    • Eisen E.J., Peterson C.B., Parker I.J., Murray J.D. Effects of zinc ion concentration on growth, fat content and reproduction in oMT1a-oGH transgenic mice. Growth Dev. Aging 1998, 62:173-186.
    • (1998) Growth Dev. Aging , vol.62 , pp. 173-186
    • Eisen, E.J.1    Peterson, C.B.2    Parker, I.J.3    Murray, J.D.4
  • 8
    • 0035658776 scopus 로고    scopus 로고
    • Long-term growth hormone excess induces marked alterations in lipoprotein metabolism in mice
    • Frick F., Bohlooly-Y M., Lindén D., et al. Long-term growth hormone excess induces marked alterations in lipoprotein metabolism in mice. Am. J. Physiol. Endocrinol. Metab. 2001, 281:E1230-E1239.
    • (2001) Am. J. Physiol. Endocrinol. Metab. , vol.281
    • Frick, F.1    Bohlooly-Y, M.2    Lindén, D.3
  • 9
    • 0028836575 scopus 로고
    • Adults with growth hormone deficiency have abnormal body composition but normal energy metabolism
    • Hoffman D.M., O'Sullivan A.J., Freund J., Ho K.K. Adults with growth hormone deficiency have abnormal body composition but normal energy metabolism. J. Clin. Endocrinol. Metab. 1995, 80:72-77.
    • (1995) J. Clin. Endocrinol. Metab. , vol.80 , pp. 72-77
    • Hoffman, D.M.1    O'Sullivan, A.J.2    Freund, J.3    Ho, K.K.4
  • 10
    • 0028274615 scopus 로고
    • Magnetic resonance imaging evaluation of adipose tissue and muscle tissue mass in children with growth hormone (GH) deficiency, Turner's syndrome, and intrauterine growth retardation during the first year of treatment with GH
    • Leger J., Carel C., Legrand I., Paulsen A., Hassan M., Czernichow P. Magnetic resonance imaging evaluation of adipose tissue and muscle tissue mass in children with growth hormone (GH) deficiency, Turner's syndrome, and intrauterine growth retardation during the first year of treatment with GH. J. Clin. Endocrinol. Metab. 1994, 78:904-909.
    • (1994) J. Clin. Endocrinol. Metab. , vol.78 , pp. 904-909
    • Leger, J.1    Carel, C.2    Legrand, I.3    Paulsen, A.4    Hassan, M.5    Czernichow, P.6
  • 11
    • 2442505516 scopus 로고    scopus 로고
    • Growth hormone (GH) replacement therapy in adult-onset gh deficiency: effects on body composition in men and women in a double-blind, randomized, placebo-controlled trial
    • Hoffman A.R., Kuntze J.E., Baptista J., et al. Growth hormone (GH) replacement therapy in adult-onset gh deficiency: effects on body composition in men and women in a double-blind, randomized, placebo-controlled trial. J. Clin. Endocrinol. Metab. 2004, 89:2048-2056.
    • (2004) J. Clin. Endocrinol. Metab. , vol.89 , pp. 2048-2056
    • Hoffman, A.R.1    Kuntze, J.E.2    Baptista, J.3
  • 12
    • 0027455584 scopus 로고
    • Growth hormone deficiency in 'little' mice results in aberrant body composition, reduced insulin-like growth factor-I and insulin-like growth factor-binding protein-3 (IGFBP-3), but does not affect IGFBP-2, -1 or -4
    • Donahue L.R., Beamer W.G. Growth hormone deficiency in 'little' mice results in aberrant body composition, reduced insulin-like growth factor-I and insulin-like growth factor-binding protein-3 (IGFBP-3), but does not affect IGFBP-2, -1 or -4. J. Endocrinol. 1993, 136:91-104.
    • (1993) J. Endocrinol. , vol.136 , pp. 91-104
    • Donahue, L.R.1    Beamer, W.G.2
  • 13
    • 11144354485 scopus 로고    scopus 로고
    • A novel missense mutation in the mouse growth hormone gene causes semidominant dwarfism, hyperghrelinemia, and obesity
    • Meyer C.W., Korthaus D., Jagla W., et al. A novel missense mutation in the mouse growth hormone gene causes semidominant dwarfism, hyperghrelinemia, and obesity. Endocrinology 2004, 145:2531-2541.
    • (2004) Endocrinology , vol.145 , pp. 2531-2541
    • Meyer, C.W.1    Korthaus, D.2    Jagla, W.3
  • 14
    • 67650649523 scopus 로고    scopus 로고
    • Growth hormone improves body composition, fasting blood glucose, glucose tolerance and liver triacylglycerol in a mouse model of diet-induced obesity and type 2 diabetes
    • List E.O., Palmer A.J., Berryman D.E., Bower B., Kelder B., Kopchick J.J. Growth hormone improves body composition, fasting blood glucose, glucose tolerance and liver triacylglycerol in a mouse model of diet-induced obesity and type 2 diabetes. Diabetologia 2009, 52:1647-1655.
    • (2009) Diabetologia , vol.52 , pp. 1647-1655
    • List, E.O.1    Palmer, A.J.2    Berryman, D.E.3    Bower, B.4    Kelder, B.5    Kopchick, J.J.6
  • 15
    • 0028318660 scopus 로고
    • Energy expenditure and body composition in growth hormone deficient adults on exogenous growth hormone
    • Chong P.K., Jung R.T., Scrimgeour C.M., Rennie M.J., Paterson C.R. Energy expenditure and body composition in growth hormone deficient adults on exogenous growth hormone. Clin. Endocrinol. (Oxf.) 1994, 40:103-110.
    • (1994) Clin. Endocrinol. (Oxf.) , vol.40 , pp. 103-110
    • Chong, P.K.1    Jung, R.T.2    Scrimgeour, C.M.3    Rennie, M.J.4    Paterson, C.R.5
  • 16
    • 0036163905 scopus 로고    scopus 로고
    • Growth hormone affects both adiposity and voluntary food intake in old and obese female rats
    • Malmlöf K., Din N., Johansen T., Pedersen S.B. Growth hormone affects both adiposity and voluntary food intake in old and obese female rats. Eur. J. Endocrinol. 2002, 146:121-128.
    • (2002) Eur. J. Endocrinol. , vol.146 , pp. 121-128
    • Malmlöf, K.1    Din, N.2    Johansen, T.3    Pedersen, S.B.4
  • 17
    • 0030801317 scopus 로고    scopus 로고
    • Somatotropin treatment reduces energy intake without altering protein intake in pigs selecting between high and low protein diets
    • Roberts T.J., Azain M.J. Somatotropin treatment reduces energy intake without altering protein intake in pigs selecting between high and low protein diets. J. Nutr. 1997, 127:2047-2053.
    • (1997) J. Nutr. , vol.127 , pp. 2047-2053
    • Roberts, T.J.1    Azain, M.J.2
  • 18
    • 0032153298 scopus 로고    scopus 로고
    • Growth, body composition, and endocrine responses to chronic administration of insulin-like growth factor I and(or) porcine growth hormone in pigs
    • Klindt J., Yen J.T., Buonomo F.C., Roberts A.J., Wise T. Growth, body composition, and endocrine responses to chronic administration of insulin-like growth factor I and(or) porcine growth hormone in pigs. J. Anim. Sci. 1998, 76:2368-2381.
    • (1998) J. Anim. Sci. , vol.76 , pp. 2368-2381
    • Klindt, J.1    Yen, J.T.2    Buonomo, F.C.3    Roberts, A.J.4    Wise, T.5
  • 19
    • 0029285631 scopus 로고
    • Comparison of daily versus continuous administration of somatotropin on growth rate, feed intake, and body composition in intact female rats
    • Azain M.J., Roberts T.J., Martin R.J., Kasser T.R. Comparison of daily versus continuous administration of somatotropin on growth rate, feed intake, and body composition in intact female rats. J. Anim. Sci. 1995, 73:1019-1029.
    • (1995) J. Anim. Sci. , vol.73 , pp. 1019-1029
    • Azain, M.J.1    Roberts, T.J.2    Martin, R.J.3    Kasser, T.R.4
  • 20
    • 19944426672 scopus 로고    scopus 로고
    • Growth hormone overexpression in the central nervous system results in hyperphagia-induced obesity associated with insulin resistance and dyslipidemia
    • Bohlooly-Y M., Olsson B., Bruder C.E., et al. Growth hormone overexpression in the central nervous system results in hyperphagia-induced obesity associated with insulin resistance and dyslipidemia. Diabetes 2005, 54:51-62.
    • (2005) Diabetes , vol.54 , pp. 51-62
    • Bohlooly-Y, M.1    Olsson, B.2    Bruder, C.E.3
  • 22
    • 0034901778 scopus 로고    scopus 로고
    • Low-dose growth hormone treatment combined with diet restriction decreases insulin resistance by reducing visceral fat and increasing muscle mass in obese type 2 diabetic patients
    • Nam S.Y., Kim K.R., Cha B.S., et al. Low-dose growth hormone treatment combined with diet restriction decreases insulin resistance by reducing visceral fat and increasing muscle mass in obese type 2 diabetic patients. Int. J. Obes. Relat. Metab. Disord. 2001, 25:1101-1107.
    • (2001) Int. J. Obes. Relat. Metab. Disord. , vol.25 , pp. 1101-1107
    • Nam, S.Y.1    Kim, K.R.2    Cha, B.S.3
  • 23
    • 35948976925 scopus 로고    scopus 로고
    • Effect of growth hormone on body composition and visceral adiposity in middle-aged men with visceral obesity
    • Pasarica M., Zachwieja J.J., Dejonge L., Redman S., Smith S.R. Effect of growth hormone on body composition and visceral adiposity in middle-aged men with visceral obesity. J. Clin. Endocrinol. Metab. 2007, 92:4265-4270.
    • (2007) J. Clin. Endocrinol. Metab. , vol.92 , pp. 4265-4270
    • Pasarica, M.1    Zachwieja, J.J.2    Dejonge, L.3    Redman, S.4    Smith, S.R.5
  • 24
    • 0027301824 scopus 로고
    • Influence of growth hormone deficiency on growth and body composition in rats: site-specific effects upon adipose tissue development
    • Flint D.J., Gardner M.J. Influence of growth hormone deficiency on growth and body composition in rats: site-specific effects upon adipose tissue development. J. Endocrinol. 1993, 137:203-211.
    • (1993) J. Endocrinol. , vol.137 , pp. 203-211
    • Flint, D.J.1    Gardner, M.J.2
  • 25
    • 4344649944 scopus 로고    scopus 로고
    • A mouse with targeted ablation of the growth hormone-releasing hormone gene: a new model of isolated growth hormone deficiency
    • Alba M., Salvatori R. A mouse with targeted ablation of the growth hormone-releasing hormone gene: a new model of isolated growth hormone deficiency. Endocrinology 2004, 145:4134-4143.
    • (2004) Endocrinology , vol.145 , pp. 4134-4143
    • Alba, M.1    Salvatori, R.2
  • 26
    • 23244451417 scopus 로고    scopus 로고
    • Effects of recombinant mouse growth hormone treatment on growth and body composition in GHRH knock out mice
    • Alba M., Fintini D., Salvatori R. Effects of recombinant mouse growth hormone treatment on growth and body composition in GHRH knock out mice. Growth Horm. IGF Res. 2005, 15:275-282.
    • (2005) Growth Horm. IGF Res. , vol.15 , pp. 275-282
    • Alba, M.1    Fintini, D.2    Salvatori, R.3
  • 28
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
    • Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001, 25:402-408.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 29
    • 0031830864 scopus 로고    scopus 로고
    • Plasma growth hormone secretion is impaired in obesity-prone rats before onset of diet-induced obesity
    • Lauterio T.J., Barkan A., DeAngelo M., DeMott-Friberg R., Ramirez R. Plasma growth hormone secretion is impaired in obesity-prone rats before onset of diet-induced obesity. Am. J. Physiol. 1998, 275:E6-E11.
    • (1998) Am. J. Physiol. , vol.275
    • Lauterio, T.J.1    Barkan, A.2    DeAngelo, M.3    DeMott-Friberg, R.4    Ramirez, R.5
  • 30
    • 0036767579 scopus 로고    scopus 로고
    • Growth and development of male "little" mice assessed with Parks' theory of feeding and growth
    • Puche R.C., Alloatti R., Chapo G. Growth and development of male "little" mice assessed with Parks' theory of feeding and growth. Growth Dev. Aging 2002, 66:71-78.
    • (2002) Growth Dev. Aging , vol.66 , pp. 71-78
    • Puche, R.C.1    Alloatti, R.2    Chapo, G.3
  • 31
    • 33751044208 scopus 로고    scopus 로고
    • Developmental aspects of adipose tissue in GH receptor and prolactin receptor gene disrupted mice: site-specific effects upon proliferation, differentiation and hormone sensitivity
    • Flint D.J., Binart N., Boumard S., Kopchick J.J., Kelly P. Developmental aspects of adipose tissue in GH receptor and prolactin receptor gene disrupted mice: site-specific effects upon proliferation, differentiation and hormone sensitivity. J. Endocrinol. 2006, 191:101-111.
    • (2006) J. Endocrinol. , vol.191 , pp. 101-111
    • Flint, D.J.1    Binart, N.2    Boumard, S.3    Kopchick, J.J.4    Kelly, P.5
  • 33
    • 33644855561 scopus 로고    scopus 로고
    • Growth hormone receptor deficiency results in blunted ghrelin feeding response, obesity, and hypolipidemia in mice
    • Egecioglu E., Bjursell M., Ljungberg A., et al. Growth hormone receptor deficiency results in blunted ghrelin feeding response, obesity, and hypolipidemia in mice. Am. J. Physiol. Endocrinol. Metab. 2006, 290:E317-E325.
    • (2006) Am. J. Physiol. Endocrinol. Metab. , vol.290
    • Egecioglu, E.1    Bjursell, M.2    Ljungberg, A.3
  • 34
    • 0041419437 scopus 로고    scopus 로고
    • Deletion, but not antagonism, of the mouse growth hormone receptor results in severely decreased body weights, insulin, and insulin-like growth factor I levels and increased life span
    • Coschigano K.T., Holland A.N., Riders M.E., List E.O., Flyvbjerg A., Kopchick J.J. Deletion, but not antagonism, of the mouse growth hormone receptor results in severely decreased body weights, insulin, and insulin-like growth factor I levels and increased life span. Endocrinology 2003, 144:3799-3810.
    • (2003) Endocrinology , vol.144 , pp. 3799-3810
    • Coschigano, K.T.1    Holland, A.N.2    Riders, M.E.3    List, E.O.4    Flyvbjerg, A.5    Kopchick, J.J.6
  • 35
    • 0021930910 scopus 로고
    • Comparison of growth hormone binding and metabolic response in rat adipocytes of epididymal, subcutaneous, and retroperitoneal origin
    • LaFranchi S., Hanna C.E., Torresani T., Schoenle E., Illig R. Comparison of growth hormone binding and metabolic response in rat adipocytes of epididymal, subcutaneous, and retroperitoneal origin. Acta Endocrinol. (Copenh.) 1985, 110:50-55.
    • (1985) Acta Endocrinol. (Copenh.) , vol.110 , pp. 50-55
    • LaFranchi, S.1    Hanna, C.E.2    Torresani, T.3    Schoenle, E.4    Illig, R.5
  • 36
    • 34547186534 scopus 로고    scopus 로고
    • CIDE-A gene expression is decreased in white adipose tissue of growth hormone receptor/binding protein gene disrupted mice and with high-fat feeding of normal mice
    • Kelder B., Berryman D.E., Clark R., Li A., List E.O., Kopchick J.J. CIDE-A gene expression is decreased in white adipose tissue of growth hormone receptor/binding protein gene disrupted mice and with high-fat feeding of normal mice. Growth Horm. IGF Res. 2007, 17:346-351.
    • (2007) Growth Horm. IGF Res. , vol.17 , pp. 346-351
    • Kelder, B.1    Berryman, D.E.2    Clark, R.3    Li, A.4    List, E.O.5    Kopchick, J.J.6
  • 37
    • 0037315784 scopus 로고    scopus 로고
    • Enlargement of interscapular brown adipose tissue in growth hormone antagonist transgenic and in growth hormone receptor gene-disrupted dwarf mice
    • Li Y., Knapp J.R., Kopchick J.J. Enlargement of interscapular brown adipose tissue in growth hormone antagonist transgenic and in growth hormone receptor gene-disrupted dwarf mice. Exp. Biol. Med. (Maywood) 2003, 228:207-215.
    • (2003) Exp. Biol. Med. (Maywood) , vol.228 , pp. 207-215
    • Li, Y.1    Knapp, J.R.2    Kopchick, J.J.3
  • 39
    • 0034457292 scopus 로고    scopus 로고
    • Serum leptin levels in patients with acromegaly before and after correction of hypersomatotropism by trans-sphenoidal surgery
    • Damjanović S.S., Petakov M.S., Raicević S., et al. Serum leptin levels in patients with acromegaly before and after correction of hypersomatotropism by trans-sphenoidal surgery. J. Clin. Endocrinol. Metab. 2000, 85:147-154.
    • (2000) J. Clin. Endocrinol. Metab. , vol.85 , pp. 147-154
    • Damjanović, S.S.1    Petakov, M.S.2    Raicević, S.3
  • 40
    • 0038807882 scopus 로고    scopus 로고
    • Perturbations in adiponectin, leptin and resistin levels in acromegaly: lack of correlation with insulin resistance
    • Silha J.V., Krsek M., Hana V., et al. Perturbations in adiponectin, leptin and resistin levels in acromegaly: lack of correlation with insulin resistance. Clin. Endocrinol. (Oxf.) 2003, 58:736-742.
    • (2003) Clin. Endocrinol. (Oxf.) , vol.58 , pp. 736-742
    • Silha, J.V.1    Krsek, M.2    Hana, V.3
  • 41
    • 72949118657 scopus 로고    scopus 로고
    • Total and high molecular weight adiponectin are elevated in patients with Laron syndrome despite marked obesity
    • Kanety H., Hemi R., Ginsberg S., et al. Total and high molecular weight adiponectin are elevated in patients with Laron syndrome despite marked obesity. Eur. J. Endocrinol. 2009, 161:837-844.
    • (2009) Eur. J. Endocrinol. , vol.161 , pp. 837-844
    • Kanety, H.1    Hemi, R.2    Ginsberg, S.3
  • 42
    • 76149129354 scopus 로고    scopus 로고
    • Adipokine profile and urinary albumin excretion in isolated growth hormone deficiency
    • Oliveira C.R., Salvatori R., Meneguz-Moreno R.A., et al. Adipokine profile and urinary albumin excretion in isolated growth hormone deficiency. J. Clin. Endocrinol. Metab. 2010, 95:693-698.
    • (2010) J. Clin. Endocrinol. Metab. , vol.95 , pp. 693-698
    • Oliveira, C.R.1    Salvatori, R.2    Meneguz-Moreno, R.A.3
  • 43
    • 0141992268 scopus 로고    scopus 로고
    • A fat-enriched, glucose-enriched diet markedly attenuates adiponectin mRNA levels in rat epididymal adipose tissue
    • Naderali E.K., Estadella D., Rocha M., et al. A fat-enriched, glucose-enriched diet markedly attenuates adiponectin mRNA levels in rat epididymal adipose tissue. Clin. Sci. (Lond.) 2003, 105:403-408.
    • (2003) Clin. Sci. (Lond.) , vol.105 , pp. 403-408
    • Naderali, E.K.1    Estadella, D.2    Rocha, M.3
  • 45
    • 84859524069 scopus 로고    scopus 로고
    • Adipocytes as a source of increased circulating levels of nicotinamide phosphoribosyltransferase/visfatin in active acromegaly
    • Olarescu N.C., Ueland T., Lekva T., et al. Adipocytes as a source of increased circulating levels of nicotinamide phosphoribosyltransferase/visfatin in active acromegaly. J. Clin. Endocrinol. Metab. 2012, 97:1355-1362.
    • (2012) J. Clin. Endocrinol. Metab. , vol.97 , pp. 1355-1362
    • Olarescu, N.C.1    Ueland, T.2    Lekva, T.3
  • 46
    • 70349902771 scopus 로고    scopus 로고
    • A link between bone mineral density and serum adiponectin and visfatin levels in acromegaly
    • Sucunza N., Barahona M.J., Resmini E., et al. A link between bone mineral density and serum adiponectin and visfatin levels in acromegaly. J. Clin. Endocrinol. Metab. 2009, 94:3889-3896.
    • (2009) J. Clin. Endocrinol. Metab. , vol.94 , pp. 3889-3896
    • Sucunza, N.1    Barahona, M.J.2    Resmini, E.3
  • 47
    • 79954634068 scopus 로고    scopus 로고
    • Leucocytes are a major source of circulating nicotinamide phosphoribosyltransferase (NAMPT)/pre-B cell colony (PBEF)/visfatin linking obesity and inflammation in humans
    • Friebe D., Neef M., Kratzsch J., et al. Leucocytes are a major source of circulating nicotinamide phosphoribosyltransferase (NAMPT)/pre-B cell colony (PBEF)/visfatin linking obesity and inflammation in humans. Diabetologia 2011, 54:1200-1211.
    • (2011) Diabetologia , vol.54 , pp. 1200-1211
    • Friebe, D.1    Neef, M.2    Kratzsch, J.3
  • 48
    • 0027958452 scopus 로고
    • Cloning and characterization of the cDNA encoding a novel human pre-B-cell colony-enhancing factor
    • Samal B., Sun Y., Stearns G., Xie C., Suggs S., McNiece I. Cloning and characterization of the cDNA encoding a novel human pre-B-cell colony-enhancing factor. Mol. Cell. Biol. 1994, 14:1431-1437.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 1431-1437
    • Samal, B.1    Sun, Y.2    Stearns, G.3    Xie, C.4    Suggs, S.5    McNiece, I.6
  • 49
    • 72949097428 scopus 로고    scopus 로고
    • Nicotinamide phosphoribosyltransferase (NAMPT/PBEF/visfatin) is constitutively released from human hepatocytes
    • Garten A., Petzold S., Barnikol-Oettler A., et al. Nicotinamide phosphoribosyltransferase (NAMPT/PBEF/visfatin) is constitutively released from human hepatocytes. Biochem. Biophys. Res. Commun. 2010, 391:376-381.
    • (2010) Biochem. Biophys. Res. Commun. , vol.391 , pp. 376-381
    • Garten, A.1    Petzold, S.2    Barnikol-Oettler, A.3
  • 51
    • 13344295079 scopus 로고    scopus 로고
    • Serum immunoreactive-leptin concentrations in normal-weight and obese humans
    • Considine R.V., Sinha M.K., Heiman M.L., et al. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N. Engl. J. Med. 1996, 334:292-295.
    • (1996) N. Engl. J. Med. , vol.334 , pp. 292-295
    • Considine, R.V.1    Sinha, M.K.2    Heiman, M.L.3
  • 52
    • 0029131574 scopus 로고
    • Expression of ob mRNA and its encoded protein in rodents. Impact of nutrition and obesity
    • Frederich R.C., Löllmann B., Hamann A., et al. Expression of ob mRNA and its encoded protein in rodents. Impact of nutrition and obesity. J. Clin. Invest. 1995, 96:1658-1663.
    • (1995) J. Clin. Invest. , vol.96 , pp. 1658-1663
    • Frederich, R.C.1    Löllmann, B.2    Hamann, A.3
  • 53
    • 0031954415 scopus 로고    scopus 로고
    • Physiological insulinemia acutely modulates plasma leptin
    • Saad M.F., Khan A., Sharma A., et al. Physiological insulinemia acutely modulates plasma leptin. Diabetes 1998, 47:544-549.
    • (1998) Diabetes , vol.47 , pp. 544-549
    • Saad, M.F.1    Khan, A.2    Sharma, A.3
  • 54
    • 0031941683 scopus 로고    scopus 로고
    • Changes of serum leptin and endocrine and metabolic parameters after 7days of energy restriction in men and women
    • Dubuc G.R., Phinney S.D., Stern J.S., Havel P.J. Changes of serum leptin and endocrine and metabolic parameters after 7days of energy restriction in men and women. Metabolism 1998, 47:429-434.
    • (1998) Metabolism , vol.47 , pp. 429-434
    • Dubuc, G.R.1    Phinney, S.D.2    Stern, J.S.3    Havel, P.J.4
  • 55
    • 4143085927 scopus 로고    scopus 로고
    • Disruption of growth hormone receptor gene causes diminished pancreatic islet size and increased insulin sensitivity in mice
    • Liu J.L., Coschigano K.T., Robertson K., et al. Disruption of growth hormone receptor gene causes diminished pancreatic islet size and increased insulin sensitivity in mice. Am. J. Physiol. Endocrinol. Metab. 2004, 287:E405-E413.
    • (2004) Am. J. Physiol. Endocrinol. Metab. , vol.287
    • Liu, J.L.1    Coschigano, K.T.2    Robertson, K.3
  • 56
    • 70350435108 scopus 로고    scopus 로고
    • Is altered expression of hepatic insulin-related genes in growth hormone receptor knockout mice due to GH resistance or a difference in biological life spans?
    • Panici J.A., Wang F., Bonkowski M.S., et al. Is altered expression of hepatic insulin-related genes in growth hormone receptor knockout mice due to GH resistance or a difference in biological life spans?. J. Gerontol. A Biol. Sci. Med. Sci. 2009, 64:1126-1133.
    • (2009) J. Gerontol. A Biol. Sci. Med. Sci. , vol.64 , pp. 1126-1133
    • Panici, J.A.1    Wang, F.2    Bonkowski, M.S.3
  • 57
    • 12644257576 scopus 로고    scopus 로고
    • A mammalian model for Laron syndrome produced by targeted disruption of the mouse growth hormone receptor/binding protein gene (the Laron mouse)
    • Zhou Y., Xu B.C., Maheshwari H.G., et al. A mammalian model for Laron syndrome produced by targeted disruption of the mouse growth hormone receptor/binding protein gene (the Laron mouse). Proc. Natl. Acad. Sci. U. S. A. 1997, 94:13215-13220.
    • (1997) Proc. Natl. Acad. Sci. U. S. A. , vol.94 , pp. 13215-13220
    • Zhou, Y.1    Xu, B.C.2    Maheshwari, H.G.3
  • 58
    • 84858031213 scopus 로고    scopus 로고
    • Insulin sensitivity and β-cell function in adults with lifetime, untreated isolated growth hormone deficiency
    • Oliveira C.R., Salvatori R., Barreto-Filho J.A., et al. Insulin sensitivity and β-cell function in adults with lifetime, untreated isolated growth hormone deficiency. J. Clin. Endocrinol. Metab. 2012, 97:1013-1019.
    • (2012) J. Clin. Endocrinol. Metab. , vol.97 , pp. 1013-1019
    • Oliveira, C.R.1    Salvatori, R.2    Barreto-Filho, J.A.3
  • 59
    • 18944407852 scopus 로고    scopus 로고
    • Pancreatic islet-specific expression of an insulin-like growth factor-I transgene compensates islet cell growth in growth hormone receptor gene-deficient mice
    • Guo Y., Lu Y., Houle D., et al. Pancreatic islet-specific expression of an insulin-like growth factor-I transgene compensates islet cell growth in growth hormone receptor gene-deficient mice. Endocrinology 2005, 146:2602-2609.
    • (2005) Endocrinology , vol.146 , pp. 2602-2609
    • Guo, Y.1    Lu, Y.2    Houle, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.