Differential effects of genetic susceptibility factors in males and females with multiple sclerosis

Clinical Immunology

Volumn 149, Issue 2, 2013, Pages 170-175

  Sadovnick, A Dessa ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Gender; HLA DRB1; Maternal effect; Multiple sclerosis; Sex ratio; Susceptibility

Indexed keywords

HLA DRB1 ANTIGEN;

EPIGENETICS; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENOTYPE; GENOTYPE ENVIRONMENT INTERACTION; HUMAN; MULTIPLE SCLEROSIS; NETHERLANDS; PREVALENCE; PRIORITY JOURNAL; RECURRENCE RISK; REVIEW; RISK FACTOR; SEX DIFFERENCE; X CHROMOSOME; X CHROMOSOME INACTIVATION;

GENDER; HLA DRB1; MATERNAL EFFECT; MULTIPLE SCLEROSIS; SEX RATIO; SUSCEPTIBILITY;

FEMALE; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION TO DISEASE; HLA-DRB1 CHAINS; HUMANS; MALE; MULTIPLE SCLEROSIS;

EID: 84886094450     PISSN: 15216616     EISSN: 15217035     Source Type: Journal    
DOI: 10.1016/j.clim.2013.05.002     Document Type: Review

References (59)

1. Rose A.M., Bell L.C. Epistasis and immunity: the role of genetic interactions in autoimmune diseases. Immunology 2012, 137:131-138.
2. Gourraud P.A., Harbo H.F., Hauser S.L., Baranzini S.E. The genetics of multiple sclerosis: an up-to-date review. Immunol. Rev. 2012, 248:87-103.
3. Weschler I.S. Statistics of multiple sclerosis including a study of the infantile, congenital, familial and hereditary forms and the mental and psychic symptoms. Arch. Neurol. Psychol. 1922, 8:59-75.
4. Buckley O.E. The status of multiple sclerosis. Ann. N. Y. Acad. Sci. 1954, 58:541-720.
5. Acheson E.D. Epidemiology of multiple sclerosis. Br. Med. Bull. 1977, 33:9-14.
6. Confavreux C., Aimard G., Devic M. Course and prognosis of multiple sclerosis assessed by the computerized data processing of 349 patients. Brain 1980, 103:281-300.
7. Steinman L. Autoimmune disease. Sci. Am. 1993, 269:106-114.
8. McDonald W.I., Compston A., Edan G., Goodkin D., Hartung H>P., Lublin F.D., McFarland H.F., Paty D.W., Polman C.H., Reingold S.C., Sandberg-Wollheim M., Sibley W., Thompson A., van den Noort S., Weinshenker B.G., Wolinsky J.S. Recommended diagnostic criteria for multiple sclerosis: guidelines from the international panel on the diagnosis of multiple sclerosis. Ann. Neurol. 2001, 50:121-127.
9. Polman C.H., Reingold S.C., Edan G., Filippi M., Hartung H.P., Kappos L., Lublin F.D., Metz L.M., McFarland H.F., O'Connor P.W., Sandberg-Wollheim M., Thompson A.J., Weinshenker B.G., Wolinsky J.S. Diagnostic criteria for multiple sclerosis: 2005 revisions to the McDonald Criteria. Ann. Neurol. 2005, 58:840-846.
10. Polman C.H., Reingold S.C., Banwell B., Clanet M., Cohen J.A., Filippi M., Fujihara K., Havrdova E., Hutchinson M., Kappos L., Lublin F.D., Montalban X., O'Connor P., Sandberg-Wollheim M., Thompson A.J., Waubant E., Weinshenker B., Wolinsky J.S. Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald Criteria. Ann. Neurol. 2011, 69:292-302.
11. Sadovnick A.D., Risch N.J., G.C.Ebers, Canadian Collaborative Project on Genetic Susceptibility to MS phase 2: rationale and method. Can. J. Neurol. Sci. 1998, 25:216-221.
12. Orton S.M., Herrrera B.M., Yee I.M., Valdar W., Ramagopalan S.V., Sadovnick A.D., Ebers G.C., for the Canadian Collaborative Study Group Sex ratio of multiple sclerosis in Canada: a longitudinal study. Lancet Neurol. 2006, 5:932-936.
13. Maghzi A.H., Ghazavi H., Ahsan M. Increasing female preponderance of multiple sclerosis in Isfahan, Iran: a population-based study. Mult. Scler. 2010, 16:359-361.
14. Trojano M., Lucchese G., Graziano G., Taylor B.V., Simpson S., Lepore V., Grand'maison F., Duquette P., Izquierdo G., Grammond P., Amato M.P., Bergamaschi R., Giuliani G., Boz C., Hupperts R., Van Pesch V., Lechner-Scott J., Cristiano E., Fiol M., Oreja-Guevara C., Saladino M.L., Verheul F., Slee M., Paolicelli D., Tortorella C., D'Onghia M., Iaffaldano P., Direnzo V., Butzkueven H., MSBase Study Group and the New Zealand MS Prevalence Study Group Geographical variations in sex ratio trends over time in multiple sclerosis. PLoS One 2012, 7:e48078.
15. Alonso A., Hernán M.A. Temporal trends in the incidence of multiple sclerosis: a systematic review. Neurology 2008, 71:129-135.
16. Boström I., Stawiarz L., Landtblom A.M. Sex ratio of multiple sclerosis in the National Swedish MS Register (SMSreg). Mult. Scler. Jan 2013, 19(1):46-52.
17. Ebers G.C., Sadovnick A.D., Risch N.J., the Canadian Collaborative Study Group A genetic basis for familial aggregation in multiple sclerosis. Nature 1995, 377:150-151.
18. Sadovnick A.D., Ebers G.C., Dyment D., Risch N.J., the Canadian Collaborative Study Group Evidence for genetic basis of multiple sclerosis. Lancet 1996, 347:1728-1730.
19. Ebers G.C., Sadovnick A.D., Dyment D.A., Yee I.M.L., Willer C.J., Risch N. Parent of origin effect in multiple sclerosis: observations in half siblings. Lancet 2004, 363:1773-1774.
20. Dyment D.A., Yee I.M., Ebers GC G.C., Sadovnick A.D., for the Canadian Collaborative Study Group Multiple sclerosis in stepsiblings: recurrence risk and ascertainment. J. Neurol. Neurosurg. Psychiatry 2006, 77:258-259.
21. Handel A.D., Giovannoni G., Ebers G.C., Ramagopalan S.V. Environmental factors and their timing in adult-onset multiple sclerosis. Nat. Rev. Neurol. 2010, 6:156-166.
22. Munger K.L., Levin L.I., O'Reilly J., Falk K.I., Ascherio A. Anti-Epstein-Barr virus antibodies as serological markers of multiple sclerosis: a prospective study among United States military personnel. Mult. Scler. 2011, 17:1185-1193.
23. Ascherio A., Munger K.L., Simon K.C. Vitamin D and multiple sclerosis. Lancet Neurol. 2010, 9:599-612.
24. Ramagopalan S.V., Maugeri N.J., Handunnetthi L., Lincoln M.R., Orton S.M., Dyment D.A., Deluca G.C., Herrera B.M., Chao M.J., Sadovnick A.D., Ebers G.C., Knigh J.C. Expression of the multiple sclerosis-associated MHC class II Allele HLA-DRB1*1501 is regulated by vitamin D. PLoS Genet. 2009, 5:e1000369.
25. Orton S.M., Ramagopalan SV S.V., Para AE A.E., Lincoln M.R., Handunnetthi L., Chao M.J., MorahaJ J., Morrison K.M., Sadovnick AD A.D., Ebers G.C. Vitamin D metabolic pathway genes and risk of multiple sclerosis in Canadians. J. Neurol. Sci. 2011, 305:116-120.
26. Salzer J., Hallmans G., Nyström M., Stenlund H., Wadell G., Sundström P. Vitamin D as a protective factor in multiple sclerosis. Neurology 2012, 29:2140-2145.
27. Dobson R., Giovannoni G., Ramagopalan S. The month of birth effect in multiple sclerosis: systematic review, meta-analysis and effect of latitude. J. Neurol. Neurosurg. Psychiatry 2013, 84:427-432.
28. Hedstrom A.K., Baarnhielm M., Olsson T., Alfredsson L. Tobacco smoking, but not Swedish snuff use, increases the risk of multiple sclerosis. Neurology 2009, 73:696-701.
29. Sundstrom P., Nystrom L., Hallmans G. Smoke exposure increases the risk for multiple sclerosis. Eur. J. Neurol. 2008, 15:579-583.
30. World Health Organization Obesity: preventing and managing the global epidemic: report of a WHO consultation. WHO Technical Report Series 894 2000, World Health Organization, Geneva.
31. Munger K.L., Chitnis T., Ascherio A. Body size and risk of MS in two cohorts of US women. Neurology 2009, 73:1543-1550.
32. Hedström A.K., Olsson T., Alfredsson L. High body mass index before age 20 is associated with increased risk for multiple sclerosis in both men and women. Mult. Scler. J. 2012, 18:1334-1336.
33. Langer-Gould A., Zhang J.L., Chung J., Yeung Y., Wauban E., Yao J. Incidence of acquired CNS demyelinating syndromes in a multiethnic cohort of children. Neurology 2011, 77:1143-1148.
34. Langer-Gould A., Brara S.M., Beaber B.E., Koebnick C. Childhood obesity and risk of pediatric multiple sclerosis and clinically isolated syndrome. Neurology 2013, 80:548-552.
35. Munger K.L., Bentzen J., Laursen B., Stenager E., Koch-Henriksen N., Sørensen T.I.A., Baker J.L. Childhood body mass index and multiple sclerosis risk: a long-term cohort study. Mult. Scler. 2013, (published online 2 April).
36. McLeod J.G., Hammond S.R., Kurtzke J.F. Migration and multiple sclerosis in immigrants to Australia from United Kingdom and Ireland: a reassessment. I. Risk of MS by age at immigration. J. Neurol. 2011, 258:1140-1149.
37. McLeod M.G., Hammond S.R., Kurtzke J.F. Migration and multiple sclerosis in United Kingdom and Ireland immigrants to Australia: a reassessment. II. Characteristics of early (pre-1947) compared to later migrants. J. Neurol. 2012, 259:684-693.
38. Herrera B.M., Ramagopalan S.V., Lincoln M.R., Orton S.M., Chao M.J., Sadovnick A.D., Ebers G.C. Parent-of-origin effects in MS: observations from avuncular pairs. Neurology 2008, 71:799-803.
39. Willer C.J., Dyment D.A., Risch N.J., Sadovnick A.D., Ebers G.C. Twin concordance and sibling recurrence rates in multiple sclerosis. PNAS 2003, 100:12877-12882.
40. Hoppenbrouwers I.A., Liu F., Aulchenko Y.S., Ebers G.C., Oostra B.A., Oostra C.M., vanDuijn, B.A., Hintzen R.Q. Maternal transmission of multiple sclerosis in a Dutch population. Arch. Neurol. 2008, 65:345-348.
41. Ramagopalan S.V., Yee I.M., Dyment D.A., Yee I.M., Willer C.J., Risch N. Parent-of-origin effect in multiple sclerosis: observations from interracial matings. Neurology 2004, 273:602-605.
42. Knudson G.P. Gender bias in autoimmune diseases: X chromosome inactivation in women with multiple sclerosis. J. Neurol. 2009, 286:43-46.
43. Herrera B.M., Cader M.Z., Dyment D.A., Bell J.T., DeLuca G.C., Willer C.J., Lincoln M.R., Ramagopalan S.V., Chao M., Orton S.M., Sadovnick A.D., Ebers G.C. Multiple sclerosis and the X chromosome. Mult. Scler. 2007, 13:856-864.
44. The International Multiple Sclerosis Genetics Consortium (IMSGC) Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature 2011, 476:214-219.
45. Van Lambalgen R., Sanders E.A., D'Amaro J. Sex distribution, age of onset and HLA profiles in two types of multiple sclerosis. A role for sex hormones and microbial infections in the development of autoimmunity. J. Neurol. Sci. 1986, 76:13-21.
46. Celius E.G., Harbo H.F., Egeland T., Vartdal F., Vandvik B., Spurkiand A. Sex and age at diagnosis are correlated with the HLA-DR2, DQ6 haplotype in multiple sclerosis. J. Neurol. Sci. 2000, 178:132-135.
47. Ramagopalan S.V., Herrera B.M., Bell J.T., Dyment D.A., Deluca G.C., Lincoln M.R., Orton S.M., Chao M.J., Sadovnick A.D., Ebers G.C. Parental transmission of HLA-DRB1*15 in multiple sclerosis. Hum. Genet. 2008, 122:661-663.
48. Chao M.J., Ramagopalan S.V., Herrera BM B.M., et al. Epigenetics in multiple sclerosis susceptibility: difference in transgenerational risk localizes to the major histocompatibility complex. Hum. Mol. Genet. 2009, 18:261-266.
49. Chao M.J., Ramagopalan S.V., Herrera B.M., Lincoln M.R., Dyment BM D.A., Sadovnick A.D., Ebers G.C. MHC transmission: insights into gender bias in MS susceptibility. Neurology 2011, 76:242-246.
50. Burrell A.M., Handel A.E., Ramagopalan S.V., Ebers G.C., Morahan J.M. Epigenetic mechanisms in multiple sclerosis and the major histocompatibility complex (MHC). Discov. Med. 2011, 11:187-196.
51. Ramagopalan S.V., Valdar W., Dyment D.A., DeLuca G.C., Yee I.M., Giovannoni G., Ebers G.C., Sadovnick A.D., for the Canadian Collaborative Study Group Association of infectious mononucleosis with multiple sclerosis: a population-based study. Neuroepidemiology 2009, 32:257-262.
52. Rapagopalan S.V., Valdar W., Dyment D.A., DeLuca G.C., Orton S.M., Yee I.M., Ciscuoli M., Ebers G.C., Sadovnick A.D. No effect of preterm birth on the risk of multiple sclerosis: a population based study. BMC Neurol. 2008, 8:30.
53. Ramagopalan S.V., Herrer B.M., Valder W W., Dyment D.A., Orton S.M., Yee I.M., Criscuoli M., Atkins K., Ebers GC G.C., Sadovnick A.D., Canadian Collaborative Study Group No effect of birth weight on the risk of multiple sclerosis: a population based study. Neuroepidemiology 2008, 31:181-184.
54. Ramagopalan S.V., Dyment D.A., Herrera B.M., Criscuoli M., Yee I.M., Sadovnick A.D., Ebers G.C. Clustering of autoimmune disease in families at high risk for multiple sclerosis. Lancet Neurol. 2007, 6:206-207.
55. Sadovnick A.D. Genetic background of autoimmune diseases. Autoimmun. Rev. 2012, 11:163-166.
56. Ebers G.C., Yee I.M., Sadovnick A.D., Duquette P P., for the Canadian Collaborative Study Group Conjugal multiple sclerosis: population-based prevalence and recurrence risks in offspring. Ann. Neurol. 2000, 48:927-931.
57. Sadovnick A.D., Yee I.M.L., Ebers G.C., for the Canadian Collaborative Study Group Recurrence risks to sibs of MS index cases: impact of consanguineous mating. Neurology 2001, 56:784-785.
58. Kantarci O.H., Barcellos L.F., Atkinson E.J., Ramsay P.P., Lincoln R., Achenbach S.J., DeSndrade M., Hauser S.L., Weinshenker B.G. Men transmit MS more often to their children vs. women: the Carter effect. Neurology 2006, 67:305-310.
59. Herrera B.M., Ramagopalan S.V., Orton S., Chao M.J., Yee I.M., Sadoovnick A.D., Ebers G.C. Parental transmission of MS in a population-based Canadian cohort. Neurology 2007, 69:1208-1212.