Intestinal transport of 3,6′-disinapoylsucrose, a major active component of polygala tenuifolia, using caco-2 cell monolayer and in situ rat intestinal perfusion models

Planta Medica

Volumn 79, Issue 15, 2013, Pages 1434-1439

  Chen, Ying ^a,b   Liu, Xinmin ^a   Pan, Ruile ^a   Zhu, Xiaoxin ^b   Steinmetz, André ^c   Liao, Yonghong ^a   Wang, Ning ^c   Peng, Bo ^b   Chang, Qi ^a  

^a INSTITUTE OF MEDICINAL PLANT DEVELOPMENT   (China)

^b INSTITUTE OF CHINESE MATERIA MEDICA   (China)

^c Public Research Centre for Health   (Luxembourg)

Author keywords

3,6 disinapoylsucrose; absorption enhancer; Caco 2 cell; intestinal perfusion; Polygala tenuifolia; Polygalaceae

Indexed keywords

3,6' DISINAPOYLSUCROSE; CYCLOSPORIN A; EDETIC ACID; PLANT EXTRACT; SODIUM AZIDE; UNCLASSIFIED DRUG; VERAPAMIL;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL STRAIN CACO 2; CELL TRANSPORT; COLON; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG PENETRATION; DRUG SCREENING; DRUG STABILITY; DRUG TRANSPORT; IN VITRO STUDY; INTESTINE ABSORPTION; INTESTINE MUCOSA; INTESTINE PERFUSION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; POLYGALA TENUIFOLIA; RAT; SMALL INTESTINE; STOMACH;

POLYGALA TENUIFOLIA; POLYGALACEAE; RATTUS;

ANIMALS; BIOLOGICAL AVAILABILITY; BIOLOGICAL TRANSPORT; CACO-2 CELLS; COUMARIC ACIDS; DECANOIC ACIDS; EDETIC ACID; HUMANS; INTESTINAL ABSORPTION; INTESTINAL MUCOSA; INTESTINES; MALE; PERFUSION; PERMEABILITY; POLYGALA; RATS, SPRAGUE-DAWLEY; STOMACH; SUCROSE;

EID: 84886086533     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0033-1350794     Document Type: Article

References (29)

1. Hügel H. M., Jackson N., May B. H., Xue C. C. Chinese herbs for dementia diseases. Mini Rev Med Chem: 2012; 12 371 379
2. Wu T. Y., Chen C. P., Jinn T. R. Traditional Chinese medicines and Alzheimers disease. Taiwan J Obstet Gynecol: 2011; 50 131 135
3. Jesky R., Hailong C. Are herbal compounds the next frontier for alleviating learning and memory impairments? An integrative look at memory, dementia and the promising therapeutics of traditional Chinese medicines. Phytother Res: 2011; 25 1105 1118
4. Zhang Y. C., Wang L. W. Effect of extracts from Polygala tenuifolia on learning and memory abilities of mice. Chin J New Drugs: 2006; 15 1254 1257
5. Guan S. J., Yan X. P., Lin J. K., Li L. Study on acute toxicity test of different processed products of Radix Polygalae. Chin J Integr Med: 2012; 32 398 401
6. James T. M., Peter F. KE. Acute and sub-chronic oral toxicity profiles of the aqueous extract of Polygala fruticosa in female mice and rats. J Ethnopharmacol: 2010; 128 236 240
7. Ikeya Y., Takeda S., Tunakawa M., Karakida H., Toda K., Yamaguchi T., Aburada M. Cognitive improving and cerebral protective effects of acylated oligosaccharides in Polygala tenuifolia. Biol Pharm Bull: 2004; 27 1081 1085 (Pubitemid 41701763)
8. Liu P., Hu Y., Guo D. H., Wang D. X., Tu H. H., Ma L., Xie T. T., Kong L. Y. Potential antidepressant properties of Radix Polygalae (Yuan Zhi). Phytomedicine: 2010; 17 794 799
9. Liu P., Wang D. X., Guo D. H., Tu H. H., Ma L., Xie T. T., Kong L. Y. Antidepressant effect of 3,6′-disinapoyl sucrose from Polygala tenuifolia Willd in pharmacological depression model. J Chin Pharm: 2008; 43 1391 1395
10. Hu Y., Liao H. B., Dai H. G., Liu P., Wang Y. Y., Rahman K. Antidepressant-like effects of 3,6′-disinapoyl sucrose on hippocampal neuronal plasticity and neurotrophic signal pathway in chronically mild stressed rats. Neurochem Int: 2012; 56 461 465
11. Yukinobu I., Shigefumi T., Mitsuo T., Humito K., Kouin T., Takuji Y., Masaki A. Cognitive improving and cerebral protective effects of acylated oligosaccharides in Polygala tenuifolia. Biol Pharm Bull: 2004; 27 1081 1085
12. Hu Y., Li J., Liu P., Chen X., Guo D. H., Li Q. S., Rahman K. Protection of SH-SY5Y neuronal cells from glutamate-induced apoptosis by 3,6′-disinapoyl sucrose, a bioactive compound isolated from Radix Polygala. J Biomed Biotechnol: 2012; 34 1 5
13. Chen Y., Liu X. M., Pan R. L., Wang G. N., Fu Y., Chang Q. An LC-MS/MS method for determination of 3,6′-disinapoylsucrose in rat plasma and its application to a pharmacokinetic study. Biomed Chromatogr: 2009; 23 1326 1332
14. Abraham D. J. Burgers medicinal chemistry and drug discovery, Volume 2. Drug discovery and drug development. New Zealand John Wiley & Sons Inc.: 2003; 253 257
15. Batrakova E. V., Li S., Li Y., Alakhov V. Y., Kabanov A. V. Effect of pluronic P85 on ATPase activity of drug efflux transporters. Pharm Res: 2004; 21 2226 2233 (Pubitemid 40575635)
16. Brunet J. L., Maresca M., Fantini J., Belzunces L. P. Human intestinal absorption of imidacloprid with Caco-2 cells as enterocyte model. Toxicol Appl Pharmacol: 2004; 194 1 9 (Pubitemid 38064436)
17. Song J., Kwon O., Chen S., Daruwala R., Eck P., Park J. B., Levine M. Flavonoid inhibition of sodium-dependent vitamin C transporter 1 (SVCT1) and glucose transporter isoform 2 (GLUT2), intestinal transporters for vitamin C and glucose. J Biol Chem: 2002; 277 15252 15260 (Pubitemid 34967785)
18. Teng Z. H., Zhou S. Y., Ran Y. H. Cellular absorption of anthraquinones emodin and chrysophanol in human intestinal Caco-2 cells. Biosci Biotechnol Biochem: 2007; 71 1636 1643
19. Yu Q., Wang Z., Li P., Yang Q. The effect of various absorption enhancers on tight junction in the human intestinal Caco-2 cell line. Drug Dev Ind Pharm: 2013; 39 587 592
20. Murakami T., Kawakita M., Kishimoto M., Higashi Y., Amagase H., Hayashi T., Nojima N., Fuwa T., Yata N. Intravenous and subcutaneous pharmacokinetics and rectal bioavailability of human epidermal growth factor in the presence of absorption promoter in rats. Int J Pharm: 1988; 46 9 17
21. Lindmark T., Soderholm J. D., Olaison G., Alvan G., Ocklind G., Artursson P. Mechanism of absorption enhancement in humans after rectal administration of ampicillin in suppositories containing sodium caprate. Pharm Res: 1997; 14 930 935 (Pubitemid 27326990)
22. Takahashi K., Murakami T., Yumoto R., Hattori T., Higashi Y., Yata N. Decanoic acid induced enhancement of rectal absorption of hydrophilic compounds in rats. Pharm Res: 1994; 11 1401 1404 (Pubitemid 24339645)
23. Anilkumar P., Badarinath A. V., Naveen N., Prasad K., Ravi Shankar Reddy B., Hyndhavi M., Nirosha M. A rationalized description on study of intestinal barrier, drug permeability and permeation enhancers. J Global Trends Pharm Sci: 2011; 4 431 449
24. Cano-Cebrián M. J., Zornoza T., Granero L., Polache A. Intestinal absorption enhancement via the paracellular route by fatty acids, chitosans and others: a target for drug delivery. Curr Drug Deliv: 2005; 2 9 22 (Pubitemid 40590917)
25. Lindmark T., Schipper N., Lazorova L., Boer A. G., Artursson P. Absorption enhancement in intestinal epithelial Caco-2 monolayers by sodium caprate: assessment of molecular weight dependence and demonstration of transport routes. J Drug Target: 1998; 5 215 223 (Pubitemid 28176793)
26. Schipper N. GM, Vrum K. M., Stenberg P., Ocklind G. L., Artursson H. Chitosans as absorption enhancers of poorly absorbable drugs. 3: Influence of mucus on absorption enhancement. Eur J Pharm Sci: 1999; 8 335 343 (Pubitemid 29325026)
27. Barthe L., Woodley J., Houin G. Gastrointestinal absorption of drugs: methods and studies. Fundam Clin Pharmacol: 1999; 2 154 168 (Pubitemid 32324243)
28. Zhang L., Zheng Y., Chow M. S., Zuo Z. Investigation of intestinal absorption and disposition of green tea catechins by Caco-2 monolayer model. Int J Pharm: 2004; 287 1 12 (Pubitemid 39487237)
29. Chang Q., Zuo Z., Chow M. S., Ho W. K. Difference in absorption and bioavailability of the two structurally similar flavonoid glycosides, hyperoside and isoquercitrin, in rats. Eur J Pharm Biopharma: 2005; 59 549 555 (Pubitemid 40347294)