Acute and sub-chronic oral toxicity profiles of the aqueous extract of Polygala fruticosa in female mice and rats

Journal of Ethnopharmacology

Volumn 128, Issue 1, 2010, Pages 236-240

  Mukinda, James T ^a   Eagles, Peter F K ^a  

^a UNIVERSITY OF THE WESTERN CAPE   (South Africa)

Author keywords

Acute toxicity; Aqueous extract; Blood analysis; Mice; Polygala fruticosa; Rats; Sub chronic toxicity

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CREATININE; PLANT EXTRACT; POLYGALA FRUTICOSA EXTRACT; UNCLASSIFIED DRUG;

ABNORMAL FECES; ACUTE TOXICITY; AGGRESSIVENESS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CHRONIC DRUG ADMINISTRATION; CONTROLLED STUDY; CONVULSION; CREATININE BLOOD LEVEL; DIARRHEA; DISORIENTATION; DOSE RESPONSE; DRUG DOSE INCREASE; DRUG MEGADOSE; DRUG TOLERABILITY; FEMALE; HEMATOPOIESIS; HYPERVENTILATION; KIDNEY FUNCTION; LD 50; LIVER FUNCTION; LIVER TOXICITY; LOW DRUG DOSE; MEDICINAL PLANT; MOUSE; NEPHROTOXICITY; NONHUMAN; ORGAN WEIGHT; PLANT LEAF; POLYGALA FRUTICOSA; POLYGALACEAE; RAT; REFLEX; SALIVATION; SHORT COURSE THERAPY; SINGLE DRUG DOSE; THROMBOCYTE COUNT; TOXICITY TESTING; TREATMENT DURATION;

ANIMALS; BEHAVIOR, ANIMAL; FEMALE; HUMANS; LETHAL DOSE 50; LIVER FUNCTION TESTS; MALE; MICE; MICE, INBRED BALB C; ORGAN SIZE; PLANT EXTRACTS; POLYGALA; RATS; RATS, WISTAR;

MUS; POLYGALA; RATTUS;

EID: 76749111451     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2010.01.022     Document Type: Article

References (18)

1. Hilaly J.E., Israili Z.H., Lyouss B. Acute and chronic toxicological studies of Ajuva Iva in experimental animals. Journal of Ethnopharmacology 2004, 91:43-50.
2. Iwalewa E.O., McGaw L.J., Naidoo V., Eloff J.N. Inflammation: the foundation of diseases and disorders. A review of phytomedicines of South African origin used to treat pain and inflammatory conditions. African Journal of Biotechnology 2007, 25:2868-2885.
3. Kaplan A., Jack R., Opheim K.E., Toivola B., Lyon A.W. Clinical Chemistry Interpretation and Techniques 1995, Williams & Wilkins, USA, pp. 155-333. 4th ed.
4. Lameire N., Van Biesen W., Vanholder R. Acute renal failure. The Lancet 2005, 365:417-430.
5. Litchfield J.T.J.R., Wilcoxon F. A simplified method of evaluating dose-effect experiments. Journal of Pharmacology and Experimental Therapeutics 1949, 96:99-113.
6. Loomis T.A., Hayes A.W. Loomis's Essentials of Toxicology 1996, Academic Press, California, pp. 208-245. 4th ed.
7. Mukinda J.T., Syce J.A. Acute and chronic toxicity of the aqueous extract of Artemisia afra in rodents. Journal of Ethnopharmacology 2007, 112:138-144.
8. Mdhluli, M., 2003. Toxicological and antifertility investigations of oleanolic acid in male vervet monkeys (Chlorocebus aethiops). PhD Thesis. Discipline of Physiological Sciences, University of the Western Cape, Cape Town, South Africa.
9. PathCare, 2009. Laboratory Manual. Parow, Cape Town, South Africa.
10. Rahman M.F., Siddiqui M.K., Jamil K. Effects of Vepacide (Azadirachta indica) on aspartate and alanine aminotransferase profiles in a subchronic study with rats. Human and Experimental Toxicology 2001, 20:243-249.
11. Saad B., Azaizeh H., Abu-Hijleh G., Said S. Safety of traditional Arab herbal medicine. Evidence-based Complementary and Alternative Medicine 2006, 3:433-439.
12. San Marcos Growers, 2008. Polygala Fruticosa, Habit and cultural information. http://www.smgrowers.com/products/plants/plantdisplay.asp?plant_id=2689.
13. Slichter S.J. Relationship between platelet count and bleeding risk in thrombocytopenic patients. Transfusion Medicine Reviews 2004, 18:153-167.
14. Springfield E.P., Eagles P.K.F., Scott G. Quality assessment of South African herbal medicines by means of HPLC fingerprinting. Journal of Ethnopharmacology 2005, 101:75-83.
15. Van Wyk B., van Oudshoorn B., Gericke N. Medicinal Plants of South Africa 1997, Briza Publications, Pretaria, pp. 196-197. 1st ed.
16. Watt J.M., Breyer-Brandwijk B.N. The Medicinal and Poisonous Plants of Southern and Eastern Africa 1962, Livingstone, London. 2nd ed.
17. WHO, 2007. WHO Guidelines for Assessing Quality of Herbal Medicines With Reference to Contaminants and Residues. World Health Organization, Geneva.
18. Wolf P.L., Williams D., Tsudaka T., Acosta L. Methods and Techniques in Clinical Chemistry 1972, John Wiley & Sons, USA, pp. 132-196, 375-383.