Chinese herbs for dementia diseases

Mini-Reviews in Medicinal Chemistry

Volumn 12, Issue 5, 2012, Pages 371-379

  Hugel H M ^a   Jackson, N ^a   May, B H ^a   Xue, C C I ^a  

^a RMIT UNIVERSITY   (Australia)

Author keywords

Acoris gramineus; Alzheimer disease; P. ginseng; P. tenuifolia; Poria cocos

Indexed keywords

3' ,6 DI O SINAPOYLSUCROSE; ACORIS GRAMINEUS RHIZOME EXTRACT; ALPHA ASARONE; BETA ASARONE; CHINESE DRUG; CHOLINESTERASE INHIBITOR; ESSENTIAL OIL; GINSENG EXTRACT; GINSENOSIDE RE; GINSENOSIDE RG 1; GINSENOSIDE RG 3; HERBACEOUS AGENT; HUMULENE; NOOTROPIC AGENT; PINENE; POLYGALA TENUIFOLIA EXTRACT; PORIA COCOS EXTRACT; SALVIA LAVANDULAEFOLIA EXTRACT; SALVIA OFFICINALIS EXTRACT; SAPONIN DERIVATIVE; SESQUITERPENE DERIVATIVE; UNCLASSIFIED DRUG;

ACORIS GRAMINEUS RHIZOME; ANTIDEPRESSANT ACTIVITY; CHINESE HERB; CHINESE MEDICINE; DEMENTIA; DRUG BIOAVAILABILITY; DRUG METABOLISM; DRUG SCREENING; DRUG STRUCTURE; GINSENG; HERBAL MEDICINE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MASS FRAGMENTOGRAPHY; NEUROPROTECTION; NONHUMAN; OXIDATION; OXIDATIVE STRESS; PLANT ROOT; POLYGALA TENUIFOLIA; POLYGALACEAE; PORIA COCOS; REVIEW; SALVIA; SALVIA FRUTICOSA; SALVIA LAVANDULAEFOLIA; SALVIA OFFICINALIS; SEDATION; SINGLE DRUG DOSE; SLEEP TIME;

EID: 84860309287     PISSN: 13895575     EISSN: 18755607     Source Type: Journal    
DOI: 10.2174/138955712800493951     Document Type: Review

References (60)

1. May, B.H.; Xue, C.C.I.; Yang, A.W.H.; Zhang, A.L.; Owens, M.D.; Head, R.; Coblac, L.; Li, C.-G.; Hügel, H.; Storey, D.F., Herbal Medicine for Dementia: A Systematic Review, Phytother. Res., 2009, 23, 447-459.
2. May, B.H.; Yang, A.W.H.; Zhang, A.L.; Owens, M.D.; Bennett, L.; Head, R.; Coblac, L.; Li, C.-G.; Hügel, H.; Storey, D.F.; Xue, C.C.I., Chinese herbal medicine for Mild Cognitive Impairment and Age Associated Memory Impairment: a review of randomized controlled trials, Biogerontology, 2009, 10, 109-123.
3. Dai, J.; Ha, C.; Shen, M., Systematic study of β -asarone rich volatile oil from Acori graminei rhizoma by off-line supercritical CO2 extraction-gas chromatography-mass spectrometry, J. Sep. Sci., 2008, 31, 714-720.
4. Cho, J.; Kim, Y.H.; Kong, J.-Y.; Yang, C.H.; Park, C.G., Protection of cultured rat cortical neurons from excitotoxcity by asarone, a major essential oil component in the rhizomes of Acorus gramineus, Life Sciences, 2002, 71, 591-599.
5. Liao, J.-F.; Huang, S.-Y.; Jan, Y.-M.; Yu, L.-L.; Chen, C.-F., Central Inhibitory effects of water extract of Acori graminei rhizoma in mice, J. Ethnopharmacol., 1998, 61, 185-193.
6. Perry, N.S.L.; Houghton, P.G.; Sampson, J.; Theolad, A.E.; Hart, S.; Lis-balchin, M.; Hoult, J.R.S.; Evans, P.; Jenner, P.; Milligan, S.; Perry, E.K., In vitro activities of Salvia lavandulaefolia (Spanish Sage) relevant to treatment of Alzheimer's disease, J. Pharm. Pharmacol., 2001, 53, 1347-1356.
7. Savelev, S.U.; Okello, E.J.; Perry, E.K.; Butyryl- and acetyl- cholinesterase inhibitory ativities in essential oils of Salvia species and their constituents, Phytother. Res., 2004, 18, 315-324.
8. Elmann, A.; Mordechay, S.; Rindner, M.; Larkov, O.; Elkabetz, M.; Ravid, U., Protective Effects of the Essential Oil of Salivia Fruticosa and Its Constituents on Astrocytic Susceptibility to Hydrogen Peroxide-Induced Cell Death, J. Agric. Food Chem., 2009, 57, 6636-6664.
9. Woitiski, C.B.; Kozlov, Y.N.; Mandelli, D.; Nizova, G.V.; Schuchardt, U.; Shul'pin, G.B., Oxidations by the system "hydrogen peroxide-dinuclear manganese(IV) complex-carboxylic acid": Part 5. Epoxidation of olefins including natural terpenes, Journal of Molecular Catalysis A: Chemical, 2004, 222, 103-119.
10. Gill, K.J.; Hites, R.A., Rate Constants for the Gas-Phase Reactions of the Hydroxyl Radical with Isoprene, α - and β -Pinene, and Limonene as a Function of Temperature, J. Phys. Chem. A, 2002, 106, 2538-2544.
11. Ka, M.-H.; Choi, E.H.; Chun, H.-S.; Lee, K.-G., Antioxidative Activity of Volatile Extracts Isolated from Angelica tenuissimae Roots, Peppermint Leaves, Pine Needles, and Sweet Flag Leaves, J. Agric. Food Chem., 2005, 53, 4124-4129.
12. Irie, Y.; Keung, W.M., Rhizoma acori graminei and its active principles protect PC-12 cells from the toxic effect of amyloid-β peptide, Brain Research, 2003, 963, 282-289.
13. Park, S.-Y.; Kim, H.-S.; Hong, S.U.; Sul, D.; Hwang, K.W.; Lee, D., The neuroprotective effects of traditional oriental herbal medicines against β -amyloid-induced toxicity, Pharmaceutical Biology, 2009, 47, 976-981.
14. Li, C.; Xing, G.; Dong, M.; Zhou, L.; Li, J.; Wang, G.; Zou, D.; Wang, R.; Liu, J.; Niu, Y., Beta-asarone protection against beta-amyloid-induced neurotoxcity in PC12 cells via JNK signaling and modulation of Bcl-2 family proteins, European Journal of Pharmacology, 2010, 635, 96-102.
15. Yao, Y.; Jia, M.; Wu, J.-G.; Zhang, H.; Sun, L.-N.; Chen, W.-S.; Rahman, K., Anxiolytic and sedative-hypnotic activities of polygalasaponins from Polygala tenuifolian mice, Pharmaceutical Biology, 2010, 48, 801-807.
16. Chung, I.W.; Kim, S.R.; Kim, E.G., Dopamine-2 and Serotonin-2 receptor bindings in antipsychotic medicines from natural plants, J. Korean Neuropsychiatr. Assoc., 1992, 31, 857-867.
17. Chung, I.W.; Moore, N.A.; Oh, W.-K.; O'Neill, M.F.; Ahn, J.S.; Park, J.B.; Kang, U.G.; Kim, Y.S., Behavioral pharmacology of polygalasaponins indicates potential antipsychotic efficacy, Pharmacol. Biochem. Behav., 2002, 71, 191-195.
18. Yabe, T.; Tuchida, H.; Kiyohara, H.; Takeda, T.; Yamada, H., Induction of NGF synthesis in astrocytes by onjisaponins of Polygala tenuifolia, constituents of Kampo (Japanese herbal) medicine, Ninjin-Yoel-To, Phytomedicine, 2003, 10, 106-114.
19. Li, J.; Do G.X; Jiang, Y.; Gao, Q.; Jiang, Z.; Cheung, A.W.H.; Duan, R.; Dong, T.T.X.; Tu, P.; Sim, K.W.K., Simultaneous determination of phenols in Radix Polygalae by high performance liquid chromatography: Quality assurance of herbs from different regions and seasons, J. Sep. Sci., 2007, 30, 2583-2589.
20. Liu, P.; Hu, Y.; Guo, D.-H.; Wang, D.-X.; Tu, H.-H.; Ma, L.; Xie, T.-T.; Komng, L.-Y., Potential antidepressant properties of Radix Polygalae (Yuan Zhi), Phytomedicine, 2010, 17, 794-799.
21. Cheng, M.-C.; Li, C.-Y.; Ko, H.-C.; Ko, F.-N.; Lin, Y.-L.; Wu, T.-S.; Antidepressant Principles of the Roots of Polygala tenuifolia, J. Nat. Prod., 2006, 69, 1305-1309.
22. Liu, J.; Yang, X.; He, J.; Xia, M.; Xu, L.; Yang, S., Structure analysis of triterpene saponins in Polygala tenuifolia by electrospray ionization ion trap multiple-stage mass spectrometry J. Mass Spectrom., 2007, 42, 861-873.
23. Jia, H.; Jiang, Y.; Ruan, Y.; Zhang, Y.; Ma, X.; Zhang, J.; Beyreuther, K.; Tu, P.; Zhang, D., Tenuigenin treatment decreases secretion of the Alzheimer's disease amyloid β-protein in cultured cells, J. Neurosci. Lett., 2004, 367, 123-128.
24. Sun, X.-L.; Ito, H.; Masuoka, T.; Kamei, C.; Hatano, T., Effect of Polygala tenuifolia root Extract on Scopolamine-Induced Impairment of Rat spatial Cognition in an Eight-Arm Radical Maze Task, Biol. Pharm. Bull., 2007, 30, 1727-1731.
25. Lee, M.-R.; Yun, B.-S.; Park, S.-Y.; Ly, S.-Y.; Kim, S.-N.; Han, B.-H.; Sung, C.-K.; Anti-amnesic effect of Chong-Myung-Tang on scopolamine induced memory impairments in mice, J. Ethnopharmacology, 2010, 132, 70-74.
26. Chen, Y.L.; Hsieh, C.L.; Wu, P.H.; Lin, J.G., Effect of Polygala tenuifolia root on behavioral disorders by lesioning nucleus basalis magnocellularis in rat., J. Ethnopharmacology, 2004, 95, 47-55.
27. Chung, I.W.; Moore, N.A.; Oh, W.K.; O'Neill, M.E.; Ahn, J.S.; Park, J.B.; Kang, U.G.; Kim, Y.S. Behavioural pharmacology of polygalasaponins indicates potential antipsychotic efficacy, Pharmacol. Biochem. Behav., 2002, 71, 191-195.
28. Kim, H.M.; Lee, E.H.; Na, H.J.; Lee, S.B.; Shin, T.Y.; Lyu, Y.S.; Kim, N.S.; Nomura, S., Effect of Polygala tenuifolia root extract on the tumor necrosis factor-a secretion from mouse astrocytes, J. Ethnopharmacology, 1998, 61, 201-208.
29. Kwon, Y.S.; Nabeshima, T.; Shin, E.J.; Chun, W.; Jhoo, J.H.; Jhoo, W.K.; Wie, M.B.; Jang, C.G.; Chung, H.; Sung, Y.E.; Kim, H.C., PAP 9704, a Korean Herbal Medicine Attenuates Methamphetamine-Induced Hyperlocomotion via Adenosine A2A Receptor Stimulation in Mice, Biol. Pharm. Bull., 2004, 27, 906-909.
30. Smirga, M.; Saito, H.; Nishiyama, N., Hoelen (poria cocos Wolf) and Ginseng (Panax Ginseng C.A. Meyer), the Ingredients of a Chinese Prescription DX-9386, Individually Promote Hippocampal Long-Term Potentiation in vivo, Biol. Pharm. Bull., 1995, 18, 518-522.
31. Naito, R.; Tohda, C., Characterization of Anti-neurodegenerative Effects of Polygala tenuifolia in Ab (25-35)Treated Cortical Neurons., Biol. Pharm. Bull., 2006, 29, 1892-1896.
32. Park, J.-H.; Kim, J.S.; Jang, D.S.; Lee, S.-M., Effect of Polygala tenuifolia Root Extract on Cerebral Ischemia and Reperfusion, Am. J. Chinese Medicine, 2006, 34, 115-123.
33. Ikeya, Y.; Takeda, S.; Tunakawa, M.; Karakida, H.; Toda, K.; Yamaguchi, T.; Aburada, M., Cognitive Improving and cerebral Protective effects of Acylated Oligosaccharides in Polygala tenuifolia, Biol. Pharm. Bull., 2004, 27, 1081-1085.
34. Lv, J.; Jia, H.; Jiang, Y.; Ruan, Y.; Liu, Z.; Yue, W.; Beyreuther, K.; Tu, P.; Zhang, D., Tenuifolin, an extract derived from tenuigenin, inhibits amyloid-b secretion in vitro, Acta Physiologica, 2009, 196, 419-425.
35. Lee, H.J.; Ban, J.Y.; Koh, S.B.; Seong, N.S.; Song, K.S.; Bae, K.W.; Seong, K.W., Polygalae Radix Extract Protects Cultured Rat Granule Cells Against Damage Induced by NMDA, Am. J. Chinese Medicine, 2004, 32, 599-610.
36. Chen, Y.-J.; Huang, X.-B.; Li, Z.-X.; Yin, L.-L.; Chen, W.-Q.; Li, L., Tenuigenin protects cultured hippocampal neurons against methylglyoxal-induced neurotoxicity, Eur. J. Pharmacol., 2010, 645, 1-8.
37. Zhou, J.; Xie, G.; Yan, X. Traditional Chinese Medicines. Ashgate: Hampshire GU11 3HR, England., 2003.
38. Kim, T. W.; Chung, S. Dammarane and Ginsenoside Compounds for Treating Alzheimer's Disease and for Inhibiting β-Amyloid Peptide Production. US 2005245465, 2005.
39. Chen, F.; Eckman, E. A.; Eckman, C. B. Reductions in levels of the Alzheimer's amyloid beta peptide after oral administration of ginsenosides. FASEB J. 2006, 20, 1269-1271.
40. M. Synthesis of Steroid Glycosides Useful as Modulators of Amyloid-Beta Production. Satori Pharmaceuticals Nov. 13 2008: WO 2008/136863, 2008.
41. Findeis, M.; Creaser, S. P. Preparation of Steroids as Modulators of Amyloid-Beta Production. Satori Pharmaceuticals Oct. 30 2008: WO 2008/130449, 2008.
42. Yang, L.; Hao, J.; Zhang, J.; Xia, W.; Dong, X.; Hu, X.; Kong, F.; Ginsenoside Rg3 promotes β-amyloid peptide degradation by enhancing gene expression of neprilysin, J. Pharm. & Pharmacol., 2009, 61, 375-380.
43. Bae, E.A.; Hyun, Y.J.; Choo, M.K.; Oh, J.K.; Ryu, J.H.; Kim, D.H., Protective effect of fermented Red ginseng on a transient focal ischemic rats, Arch. Pharm. Res., 2004, 27, 1136-1140.
44. Kim, Y.C.; Kim, S.R.; Markelonis, G.J.; Oh, T.H.,Ginsenosides Rb1 and Rg3 Protect Cultured Rat Cortical Cells From Glutamate-Induced Neurodegeneration, J. Neurosci. Res., 1998, 53, 426-432.
45. Kim, D.H.; Jung, J.S.; Suh, H.W.; Huh, S.O.; Min, S.K.; Son, B.K.; Park, J.H.; Kim, N.D.; Kim, Y.H.; Song, D.K., Inhibition of stress-induced plasma corticosterone levels by ginsenosides in mice: involvement of nitric oxide, Neuroreport 9, 1998, 2261-2264.
46. Lee, S.H.; Jung, B.H.; Choi, S.Y.; Kim, S.Y.; Lee, E.H.; Chung, B.C., Influence of Ginsenoside Rb1 on Brain Neurosteroid during Acute Immobilization Stress, Pharmacol. Arch. Pharm. Res., 2006, 29, 566-569.
47. Lee, S.H.; Jung, B.H.; Kim, S.Y.; Lee, E.H.; Chung, B.C., The anti stress effect of ginseng total saponin and ginsenoside Rg3 and Rb1 evaluated by brain polyamine level under immobilization stress, Pharmacol. Res., 2006, 54, 46-49.
48. Kim, S.-O.; You, J.-M.; Yun, S.-J.; Son, M.-S.; Nam, K.N.; Hong, J.-W.; Kim, S.Y.; Choi, S.Y.; Lee, E.H., Ginsenoside Rb1 and Rg3 attenuate glucocorticoid-induced Neurotoxicity, Cell Mol Neurobiol., 2010, 30, 857-862.
49. Lim, J.H.; Wen, T.C.; Matsuda, S.; Tanaka, J.; Maeda, N.; Peng, H.; Aburaya, J.; Shihara, K.; Sakanaka, M., Protection of ischemic hippocampal neurons by ginsenoside Rb1, a main ingredient of ginseng root, J. Neurosci. Res., 1997, 28, 191-200.
50. Lian, X.Y.; Zhang, Z.; Stringer, J.L., Anticonvulsant and neuroprotective effects of ginsenosides in rats, Epilepsy Res., 2006, 70, 244-256.
51. Salim, K.N.; McEwen, B.S.; Chao, H.M., Ginsenoside Rb1 regulates ChAT, NGF and trkA mRNA expression in the rat brain, Mol. Brain Res., 1997, 47, 177-182.
52. Lee, B.; Park, J.; Kwon, S.; Park, M.-W.; Oh, S.-M.; Yeom, M.-J.; Shim, I.; Lee, H.-J.; Hahm, D.-H., Effect of wild ginseng on scopolamine-induced acetylcholine depletion in the rat hippocampus, J Pharm. & Pharmacol., 2010, 62, 263-271.
53. Adams, M.; Gmunder, F.; Hamburger, M., Plants traditionally used in age related brain disorders-Asurvey of ethnobotanical literature, J. Ethnopharmacol., 2007, 113, 363-368.
54. Ukiya, M.; Akihisa, T.; Tokuda, H.; Hirano, M.; Oshikubo, M.; Nobukuni, Y.; Kimura, Y.; Tai, T.; Kondo, S.; Nishino, H.;, Inhibition of Tumor-Promoting Effects by Poricoic Acids g and H and other Lanostane-type Triterpenes and cytotoxic Activity of Porioic acids A and G from Poria cocos, J. Nat. Prod., 2002, 65, 462-465.
55. Akihisa, T.; Nakamura, Y.; Tokuda, H.; Uchiyama, E.; Suzuki, T.; Kimura, Y.; Uchikura, K.; Nishino, H.,Triterpene Acids from Poria cocos and Their anti-Tumor-Promoting effects., J. Nat. Prod., 2007, 70, 948-953.
56. Lu, M.-K.; Cheng, J.-J.; Lin, C.-Y.; Chang, C.-C., Purification, structural elucidation, and anti-inflammatory effect of a water-soluble 1,6-branched 1,3-a-D-galactan from cultured mycelia of Poria cocos, Food Chemistry, 2010, 118, 349-356.
57. RuiDian, K.; ShunFa, L.; Yi, C.; ChuRong, J.; QiaGuang, S., Analysis of chemical composition of polysaccharides from Poria cocos Wolf and its anti-tumor activity by NMR spectroscopy, Carbohydrate Polymers, 2010, 80, 31-34.
58. Siegel, S.J.; Bieschke, J.; Powers, E.T.; Kelly, J.W., The Oxidative Stress Metabolite 4-Hydroxynonenal Promotes Alzheimer Proto fibril Formation, Biochemistry, 2007, 46, 1503-1510.
59. Lin, Z.; Zhu, D.; Yan, Y.; Yu, B.; Wang, Q.; Shen, P.; Ruan, K., An Antioxidant Phytotherapy to Rescue Neuronal Oxidative Stress, Evidence-Based Complementary and Alternative Medicine, 2011, 2011 Article ID 519517,7 pages, 2011. doi:10.1093/ecam/nen053.
60. Howes, M.R.; Perry, N.S.L.; Houghton, P.J., Plants with traditional uses and activities, relevant to the management of Alzheimer's disease and other cognitive disorders, Phytother. Res., 2003, 17, 1-18.