메뉴 건너뛰기




Volumn 8, Issue 10, 2013, Pages

Development and Histopathological Characterization of Tumorgraft Models of Pancreatic Ductal Adenocarcinoma

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL; CANCER GRAFT; CANCER STAGING; CANCER TRANSPLANTATION; CELL COUNT; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE MODEL; FEMALE; GENE MUTATION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; LYMPH NODE METASTASIS; LYMPH VESSEL METASTASIS; MORPHOLOGY; MOUSE; NONHUMAN; ONCOGENE K RAS; PANCREAS ADENOCARCINOMA; TUMOR VOLUME; ANIMAL; METABOLISM; NUCLEOTIDE SEQUENCE; PANCREAS CARCINOMA; PANCREAS TUMOR; PATHOPHYSIOLOGY; XENOGRAFT;

EID: 84886036947     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0078183     Document Type: Article
Times cited : (24)

References (49)
  • 1
    • 74949144690 scopus 로고    scopus 로고
    • Epidemiology of pancreatic cancer: an overview
    • doi: 10.1038/nrgastro.2009.177
    • Raimondi S, Maisonneuve P, Lowenfels AB, (2009) Epidemiology of pancreatic cancer: an overview. Nat. Rev Gastroenterol Hepatol 6: 699-708. doi:10.1038/nrgastro.2009.177.
    • (2009) Nat Rev Gastroenterol Hepatol , vol.6 , pp. 699-708
    • Raimondi, S.1    Maisonneuve, P.2    Lowenfels, A.B.3
  • 2
    • 84855792427 scopus 로고    scopus 로고
    • Cancer statistics, 2012
    • doi: 10.3322/caac.20138
    • Siegel R, Naishadham D, Jemal A, (2012) Cancer statistics, 2012. CA Cancer J Clin 62: 10-29. doi:10.3322/caac.20138. PubMed: 22237781.
    • (2012) CA Cancer J Clin , vol.62 , pp. 10-29
    • Siegel, R.1    Naishadham, D.2    Jemal, A.3
  • 3
    • 41149161849 scopus 로고    scopus 로고
    • Molecular genetics of pancreatic ductal adenocarcinomas and recent implications for translational efforts
    • doi: 10.2353/jmoldx.2008.070115
    • Feldmann G, Maitra A, (2008) Molecular genetics of pancreatic ductal adenocarcinomas and recent implications for translational efforts. J Mol Diagn 10: 111-122. doi:10.2353/jmoldx.2008.070115. PubMed: 18258927.
    • (2008) J Mol Diagn , vol.10 , pp. 111-122
    • Feldmann, G.1    Maitra, A.2
  • 4
    • 77951709577 scopus 로고    scopus 로고
    • Preoperative/neoadjuvant therapy in pancreatic cancer: a systematic review and meta-analysis of response and resection percentages
    • PubMed: 20422030
    • Gillen S, Schuster T, Meyer Zum Büschenfelde C, Friess H, Kleeff J, (2010) Preoperative/neoadjuvant therapy in pancreatic cancer: a systematic review and meta-analysis of response and resection percentages. PLOS Med 7: e1000267. PubMed: 20422030.
    • (2010) PLOS Med , vol.7
    • Gillen, S.1    Schuster, T.2    Meyer, Z.B.C.3    Friess, H.4    Kleeff, J.5
  • 5
    • 0036142720 scopus 로고    scopus 로고
    • Exploring the host desmoplastic response to pancreatic carcinoma: gene expression of stromal and neoplastic cells at the site of primary invasion
    • doi: 10.1016/S0002-9440(10)64353-2
    • Iacobuzio-Donahue CA, Ryu B, Hruban RH, Kern SE, (2002) Exploring the host desmoplastic response to pancreatic carcinoma: gene expression of stromal and neoplastic cells at the site of primary invasion. Am J Pathol 160: 91-99. doi:10.1016/S0002-9440(10)64353-2. PubMed: 11786403.
    • (2002) Am J Pathol , vol.160 , pp. 91-99
    • Iacobuzio-Donahue, C.A.1    Ryu, B.2    Hruban, R.H.3    Kern, S.E.4
  • 6
    • 58549118535 scopus 로고    scopus 로고
    • Direct in vivo xenograft tumor model for predicting chemotherapeutic drug response in cancer patients
    • doi: 10.1038/clpt.2008.200
    • Rubio-Viqueira B, Hidalgo M, (2009) Direct in vivo xenograft tumor model for predicting chemotherapeutic drug response in cancer patients. Clin Pharmacol Ther 85: 217-221. doi:10.1038/clpt.2008.200. PubMed: 19005462.
    • (2009) Clin Pharmacol Ther , vol.85 , pp. 217-221
    • Rubio-Viqueira, B.1    Hidalgo, M.2
  • 7
    • 0037899253 scopus 로고    scopus 로고
    • Role of tissue stroma in cancer cell invasion
    • doi: 10.1002/path.1398
    • De Wever O, Mareel M, (2003) Role of tissue stroma in cancer cell invasion. J Pathol 200: 429-447. doi:10.1002/path.1398. PubMed: 12845611.
    • (2003) J Pathol , vol.200 , pp. 429-447
    • De Wever, O.1    Mareel, M.2
  • 8
    • 38649132916 scopus 로고    scopus 로고
    • The use of xenograft models for the selection of cancer treatments with the EGFR as an example
    • doi: 10.1016/j.critrevonc.2007.10.003
    • Troiani T, Schettino C, Martinelli E, Morgillo F, Tortora G, et al. (2008) The use of xenograft models for the selection of cancer treatments with the EGFR as an example. Crit Rev Oncol/Hematol 65: 200-211. doi:10.1016/j.critrevonc.2007.10.003. PubMed: 18389522.
    • (2008) Crit Rev Oncol/Hematol , vol.65 , pp. 200-211
    • Troiani, T.1    Schettino, C.2    Martinelli, E.3    Morgillo, F.4    Tortora, G.5
  • 9
    • 1942422743 scopus 로고    scopus 로고
    • Of mice and men: values and liabilities of the athymic nude mouse model in anticancer drug development
    • doi: 10.1016/j.ejca.2003.11.028
    • Kelland LR, (2004) Of mice and men: values and liabilities of the athymic nude mouse model in anticancer drug development. Eur J Cancer 40: 827-836. doi:10.1016/j.ejca.2003.11.028. PubMed: 15120038.
    • (2004) Eur J Cancer , vol.40 , pp. 827-836
    • Kelland, L.R.1
  • 10
    • 20444489533 scopus 로고    scopus 로고
    • Phenotypic instability of Saos-2 cells in long-term culture
    • doi: 10.1016/j.bbrc.2005.05.097
    • Hausser HJ, Brenner RE, (2005) Phenotypic instability of Saos-2 cells in long-term culture. Biochem Biophys Res Commun 333: 216-222. doi:10.1016/j.bbrc.2005.05.097. PubMed: 15939397.
    • (2005) Biochem Biophys Res Commun , vol.333 , pp. 216-222
    • Hausser, H.J.1    Brenner, R.E.2
  • 11
    • 41749100127 scopus 로고    scopus 로고
    • Pancreatic cancer
    • doi: 10.1146/annurev.pathmechdis.3.121806.154305
    • Maitra A, Hruban RH, (2008) Pancreatic cancer. Annu Rev Pathol 3: 157-188. doi:10.1146/annurev.pathmechdis.3.121806.154305. PubMed: 18039136.
    • (2008) Annu Rev Pathol , vol.3 , pp. 157-188
    • Maitra, A.1    Hruban, R.H.2
  • 12
    • 9144266295 scopus 로고    scopus 로고
    • Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse
    • doi: 10.1016/S1535-6108(03)00309-X
    • Hingorani SR, Petricoin EF, Maitra A, Rajapakse V, King C, et al. (2003) Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. Cancer Cell 4: 437-450. doi:10.1016/S1535-6108(03)00309-X. PubMed: 14706336.
    • (2003) Cancer Cell , vol.4 , pp. 437-450
    • Hingorani, S.R.1    Petricoin, E.F.2    Maitra, A.3    Rajapakse, V.4    King, C.5
  • 13
    • 0346455774 scopus 로고    scopus 로고
    • Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma
    • doi: 10.1101/gad.1158703
    • Aguirre AJ, Bardeesy N, Sinha M, Lopez L, Tuveson DA, et al. (2003) Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma. Genes Dev 17: 3112-3126. doi:10.1101/gad.1158703. PubMed: 14681207.
    • (2003) Genes Dev , vol.17 , pp. 3112-3126
    • Aguirre, A.J.1    Bardeesy, N.2    Sinha, M.3    Lopez, L.4    Tuveson, D.A.5
  • 14
    • 19344362405 scopus 로고    scopus 로고
    • Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice
    • doi: 10.1016/j.ccr.2005.04.023
    • Hingorani SR, Wang L, Multani AS, Combs C, Deramaudt TB, et al. (2005) Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice. Cancer Cell 7: 469-483. doi:10.1016/j.ccr.2005.04.023. PubMed: 15894267.
    • (2005) Cancer Cell , vol.7 , pp. 469-483
    • Hingorani, S.R.1    Wang, L.2    Multani, A.S.3    Combs, C.4    Deramaudt, T.B.5
  • 15
    • 33751251034 scopus 로고    scopus 로고
    • Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer
    • doi: 10.1101/gad.1478706
    • Bardeesy N, Cheng KH, Berger JH, Chu GC, Pahler J, et al. (2006) Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer. Genes Dev 20: 3130-3146. doi:10.1101/gad.1478706. PubMed: 17114584.
    • (2006) Genes Dev , vol.20 , pp. 3130-3146
    • Bardeesy, N.1    Cheng, K.H.2    Berger, J.H.3    Chu, G.C.4    Pahler, J.5
  • 16
    • 31544467540 scopus 로고    scopus 로고
    • Pathology of genetically engineered mouse models of pancreatic exocrine cancer: consensus report and recommendations
    • doi: 10.1158/0008-5472.CAN-05-2168
    • Hruban RH, Adsay NV, Albores-Saavedra J, Anver MR, Biankin AV, et al. (2006) Pathology of genetically engineered mouse models of pancreatic exocrine cancer: consensus report and recommendations. Cancer Res 66: 95-106. doi:10.1158/0008-5472.CAN-05-2168. PubMed: 16397221.
    • (2006) Cancer Res , vol.66 , pp. 95-106
    • Hruban, R.H.1    Adsay, N.V.2    Albores-Saavedra, J.3    Anver, M.R.4    Biankin, A.V.5
  • 17
    • 52149123619 scopus 로고    scopus 로고
    • Core signaling pathways in human pancreatic cancers revealed by global genomic analyses
    • doi: 10.1126/science.1164368
    • Jones S, Zhang X, Parsons DW, Lin JC, Leary RJ, et al. (2008) Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science 321: 1801-1806. doi:10.1126/science.1164368. PubMed: 18772397.
    • (2008) Science , vol.321 , pp. 1801-1806
    • Jones, S.1    Zhang, X.2    Parsons, D.W.3    Lin, J.C.4    Leary, R.J.5
  • 18
    • 68849085858 scopus 로고    scopus 로고
    • Models for prevention and treatment of cancer: problems vs promises
    • doi: 10.1016/j.bcp.2009.05.027
    • Aggarwal BB, Danda D, Gupta S, Gehlot P, (2009) Models for prevention and treatment of cancer: problems vs promises. Biochem Pharmacol 78: 1083-1094. doi:10.1016/j.bcp.2009.05.027. PubMed: 19481061.
    • (2009) Biochem Pharmacol , vol.78 , pp. 1083-1094
    • Aggarwal, B.B.1    Danda, D.2    Gupta, S.3    Gehlot, P.4
  • 19
    • 33645734205 scopus 로고    scopus 로고
    • Contributions of human tumor xenografts to anticancer drug development
    • doi: 10.1158/0008-5472.CAN-05-3627
    • Sausville EA, Burger AM, (2006) Contributions of human tumor xenografts to anticancer drug development. Cancer Res 66: 3351-3354, discussion: 10.1158/0008-5472.CAN-05-3627. PubMed: 16585151.
    • (2006) Cancer Res , vol.66 , pp. 3351-3354
    • Sausville, E.A.1    Burger, A.M.2
  • 20
    • 0014649888 scopus 로고
    • Heterotransplantation of a human malignant tumour to "Nude" mice
    • PubMed: 5383844
    • Rygaard J, Povlsen CO, (1969) Heterotransplantation of a human malignant tumour to "Nude" mice. Acta Pathol Microbiol Scand 77: 758-760. PubMed: 5383844.
    • (1969) Acta Pathol Microbiol Scand , vol.77 , pp. 758-760
    • Rygaard, J.1    Povlsen, C.O.2
  • 21
  • 22
    • 34447249881 scopus 로고    scopus 로고
    • The pediatric preclinical testing program: description of models and early testing results
    • doi: 10.1002/pbc.21078
    • Houghton PJ, Morton CL, Tucker C, Payne D, Favours E, et al. (2007) The pediatric preclinical testing program: description of models and early testing results. Pediatr Blood Cancer 49: 928-940. doi:10.1002/pbc.21078. PubMed: 17066459.
    • (2007) Pediatr Blood Cancer , vol.49 , pp. 928-940
    • Houghton, P.J.1    Morton, C.L.2    Tucker, C.3    Payne, D.4    Favours, E.5
  • 23
    • 1942518912 scopus 로고    scopus 로고
    • Clonogenic assay with established human tumour xenografts: correlation of in vitro to in vivo activity as a basis for anticancer drug discovery
    • doi: 10.1016/j.ejca.2004.01.009
    • Fiebig HH, Maier A, Burger AM, (2004) Clonogenic assay with established human tumour xenografts: correlation of in vitro to in vivo activity as a basis for anticancer drug discovery. Eur J Cancer 40: 802-820. doi:10.1016/j.ejca.2004.01.009. PubMed: 15120036.
    • (2004) Eur J Cancer , vol.40 , pp. 802-820
    • Fiebig, H.H.1    Maier, A.2    Burger, A.M.3
  • 24
    • 33748088524 scopus 로고    scopus 로고
    • An in vivo platform for translational drug development in pancreatic cancer
    • doi: 10.1158/1078-0432.CCR-06-0113
    • Rubio-Viqueira B, Jimeno A, Cusatis G, Zhang X, Iacobuzio-Donahue C, et al. (2006) An in vivo platform for translational drug development in pancreatic cancer. Clin Cancer Res 12: 4652-4661. doi:10.1158/1078-0432.CCR-06-0113. PubMed: 16899615.
    • (2006) Clin Cancer Res , vol.12 , pp. 4652-4661
    • Rubio-Viqueira, B.1    Jimeno, A.2    Cusatis, G.3    Zhang, X.4    Iacobuzio-Donahue, C.5
  • 25
    • 81255135837 scopus 로고    scopus 로고
    • Tumor grafts derived from women with breast cancer authentically reflect tumor pathology, growth, metastasis and disease outcomes
    • doi: 10.1038/nm.2454
    • DeRose YS, Wang G, Lin YC, Bernard PS, Buys SS, et al. (2011) Tumor grafts derived from women with breast cancer authentically reflect tumor pathology, growth, metastasis and disease outcomes. Nat Med 17: 1514-1520. doi:10.1038/nm.2454. PubMed: 22019887.
    • (2011) Nat Med , vol.17 , pp. 1514-1520
    • DeRose, Y.S.1    Wang, G.2    Lin, Y.C.3    Bernard, P.S.4    Buys, S.S.5
  • 26
    • 60849118097 scopus 로고    scopus 로고
    • A direct pancreatic cancer xenograft model as a platform for cancer stem cell therapeutic development
    • doi: 10.1158/1535-7163.MCT-08-0924
    • Jimeno A, Feldmann G, Suárez-Gauthier A, Rasheed Z, Solomon A, et al. (2009) A direct pancreatic cancer xenograft model as a platform for cancer stem cell therapeutic development. Mol Cancer Ther 8: 310-314. doi:10.1158/1535-7163.MCT-08-0924. PubMed: 19174553.
    • (2009) Mol Cancer Ther , vol.8 , pp. 310-314
    • Jimeno, A.1    Feldmann, G.2    Suárez-Gauthier, A.3    Rasheed, Z.4    Solomon, A.5
  • 27
    • 34249679184 scopus 로고    scopus 로고
    • Molecular analysis of xenograft models of human cancer cachexia--possibilities for therapeutic intervention
    • PubMed: 17878525
    • Baumgarten AJ, Fiebig HH, Burger AM, (2007) Molecular analysis of xenograft models of human cancer cachexia--possibilities for therapeutic intervention. Cancer Genomics Proteomics 4: 223-231. PubMed: 17878525.
    • (2007) Cancer Genomics Proteomics , vol.4 , pp. 223-231
    • Baumgarten, A.J.1    Fiebig, H.H.2    Burger, A.M.3
  • 28
    • 84864542307 scopus 로고    scopus 로고
    • Preclinical modeling of EGFR inhibitor resistance in head and neck cancer
    • doi: 10.4161/cbt.20846
    • Quesnelle KM, Wheeler SE, Ratay MK, Grandis JR, (2012) Preclinical modeling of EGFR inhibitor resistance in head and neck cancer. Cancer Biol Ther 13: 935-945. doi:10.4161/cbt.20846. PubMed: 22785204.
    • (2012) Cancer Biol Ther , vol.13 , pp. 935-945
    • Quesnelle, K.M.1    Wheeler, S.E.2    Ratay, M.K.3    Grandis, J.R.4
  • 29
    • 33846812600 scopus 로고    scopus 로고
    • Xenografts of human hepatocellular carcinoma: a useful model for testing drugs
    • doi: 10.1158/1078-0432.CCR-05-2568
    • Huynh H, Soo KC, Chow PK, Panasci L, Tran E, (2006) Xenografts of human hepatocellular carcinoma: a useful model for testing drugs. Clin Cancer Res 12: 4306-4314. doi:10.1158/1078-0432.CCR-05-2568. PubMed: 16857806.
    • (2006) Clin Cancer Res , vol.12 , pp. 4306-4314
    • Huynh, H.1    Soo, K.C.2    Chow, P.K.3    Panasci, L.4    Tran, E.5
  • 30
    • 84861842895 scopus 로고    scopus 로고
    • Histological and molecular evaluation of patient-derived colorectal cancer explants
    • doi: 10.1371/journal.pone.0038422
    • Uronis JM, Osada T, McCall S, Yang XY, Mantyh C, et al. (2012) Histological and molecular evaluation of patient-derived colorectal cancer explants. PLOS ONE 7: e38422. doi:10.1371/journal.pone.0038422. PubMed: 22675560.
    • (2012) PLOS ONE , vol.7
    • Uronis, J.M.1    Osada, T.2    McCall, S.3    Yang, X.Y.4    Mantyh, C.5
  • 31
    • 23844497341 scopus 로고    scopus 로고
    • Sensitive sequencing method for KRAS mutation detection by pyrosequencing
    • doi: 10.1016/S1525-1578(10)60571-5
    • Ogino S, Kawasaki T, Brahmandam M, Yan L, Cantor M, et al. (2005) Sensitive sequencing method for KRAS mutation detection by pyrosequencing. J Mol Diagn 7: 413-421. doi:10.1016/S1525-1578(10)60571-5. PubMed: 16049314.
    • (2005) J Mol Diagn , vol.7 , pp. 413-421
    • Ogino, S.1    Kawasaki, T.2    Brahmandam, M.3    Yan, L.4    Cantor, M.5
  • 32
    • 80054936061 scopus 로고    scopus 로고
    • Inhibition of Ras for cancer treatment: the search continues
    • Baines AT, Xu D, Der CJ, (2011) Inhibition of Ras for cancer treatment: the search continues. Future. J Med Chem 3: 1787-1808.
    • (2011) Future J Med Chem , vol.3 , pp. 1787-1808
    • Baines, A.T.1    Xu, D.2    Der, C.J.3
  • 33
    • 67650924582 scopus 로고    scopus 로고
    • Pancreatic cancer: molecular pathogenesis and new therapeutic targets
    • doi: 10.1038/nrgastro.2009.89
    • Wong HH, Lemoine NR, (2009) Pancreatic cancer: molecular pathogenesis and new therapeutic targets. Nat. Rev Gastroenterol Hepatol 6: 412-422. doi:10.1038/nrgastro.2009.89.
    • (2009) Nat Rev Gastroenterol Hepatol , vol.6 , pp. 412-422
    • Wong, H.H.1    Lemoine, N.R.2
  • 34
    • 0024292722 scopus 로고
    • Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes
    • doi: 10.1016/0092-8674(88)90571-5
    • Almoguera C, Shibata D, Forrester K, Martin J, Arnheim N, et al. (1988) Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes. Cell 53: 549-554. doi:10.1016/0092-8674(88)90571-5. PubMed: 2453289.
    • (1988) Cell , vol.53 , pp. 549-554
    • Almoguera, C.1    Shibata, D.2    Forrester, K.3    Martin, J.4    Arnheim, N.5
  • 35
    • 0023735997 scopus 로고
    • KRAS codon 12 mutations occur very frequently in pancreatic adenocarcinomas
    • doi: 10.1093/nar/16.16.7773
    • Smit VT, Boot AJ, Smits AM, Fleuren GJ, Cornelisse CJ, et al. (1988) KRAS codon 12 mutations occur very frequently in pancreatic adenocarcinomas. Nucleic Acids Res 16: 7773-7782. doi:10.1093/nar/16.16.7773. PubMed: 3047672.
    • (1988) Nucleic Acids Res , vol.16 , pp. 7773-7782
    • Smit, V.T.1    Boot, A.J.2    Smits, A.M.3    Fleuren, G.J.4    Cornelisse, C.J.5
  • 36
  • 37
  • 38
    • 84862240414 scopus 로고    scopus 로고
    • Genomic characterization of explant tumorgraft models derived from fresh patient tumor tissue
    • doi: 10.1186/1479-5876-10-125
    • Monsma DJ, Monks NR, Cherba DM, Dylewski D, Eugster E, et al. (2012) Genomic characterization of explant tumorgraft models derived from fresh patient tumor tissue. J Transl Med 10: 125. doi:10.1186/1479-5876-10-125. PubMed: 22709571.
    • (2012) J Transl Med , vol.10 , pp. 125
    • Monsma, D.J.1    Monks, N.R.2    Cherba, D.M.3    Dylewski, D.4    Eugster, E.5
  • 39
    • 27344456844 scopus 로고    scopus 로고
    • The anti-tumor effect of Apo2L/TRAIL on patient pancreatic adenocarcinomas grown as xenografts in SCID mice
    • doi: 10.1186/1479-5876-3-22
    • Hylander BL, Pitoniak R, Penetrante RB, Gibbs JF, Oktay D, et al. (2005) The anti-tumor effect of Apo2L/TRAIL on patient pancreatic adenocarcinomas grown as xenografts in SCID mice. J Transl Med 3: 22. doi:10.1186/1479-5876-3-22. PubMed: 15943879.
    • (2005) J Transl Med , vol.3 , pp. 22
    • Hylander, B.L.1    Pitoniak, R.2    Penetrante, R.B.3    Gibbs, J.F.4    Oktay, D.5
  • 40
    • 80052470635 scopus 로고    scopus 로고
    • Tumor engraftment in nude mice and enrichment in stroma- related gene pathways predict poor survival and resistance to gemcitabine in patients with pancreatic cancer
    • doi: 10.1158/1078-0432.CCR-11-0341
    • Garrido-Laguna I, Uson M, Rajeshkumar NV, Tan AC, de Oliveira E, et al. (2011) Tumor engraftment in nude mice and enrichment in stroma- related gene pathways predict poor survival and resistance to gemcitabine in patients with pancreatic cancer. Clin Cancer Res 17: 5793-5800. doi:10.1158/1078-0432.CCR-11-0341. PubMed: 21742805.
    • (2011) Clin Cancer Res , vol.17 , pp. 5793-5800
    • Garrido-Laguna, I.1    Uson, M.2    Rajeshkumar, N.V.3    Tan, A.C.4    de Oliveira, E.5
  • 41
    • 77955981869 scopus 로고    scopus 로고
    • Integrated preclinical and clinical development of mTOR inhibitors in pancreatic cancer
    • doi: 10.1038/sj.bjc.6605819
    • Garrido-Laguna I, Tan AC, Uson M, Angenendt M, Ma WW, et al. (2010) Integrated preclinical and clinical development of mTOR inhibitors in pancreatic cancer. Br J Cancer 103: 649-655. doi:10.1038/sj.bjc.6605819. PubMed: 20664591.
    • (2010) Br J Cancer , vol.103 , pp. 649-655
    • Garrido-Laguna, I.1    Tan, A.C.2    Uson, M.3    Angenendt, M.4    Ma, W.W.5
  • 42
    • 0026452172 scopus 로고
    • Phase II preclinical drug screening in human tumor xenografts: a first European multicenter collaborative study
    • PubMed: 1394220
    • Boven E, Winograd B, Berger DP, Dumont MP, Braakhuis BJ, et al. (1992) Phase II preclinical drug screening in human tumor xenografts: a first European multicenter collaborative study. Cancer Res 52: 5940-5947. PubMed: 1394220.
    • (1992) Cancer Res , vol.52 , pp. 5940-5947
    • Boven, E.1    Winograd, B.2    Berger, D.P.3    Dumont, M.P.4    Braakhuis, B.J.5
  • 43
    • 79955492036 scopus 로고    scopus 로고
    • MK-1775, a potent Wee1 inhibitor, synergizes with gemcitabine to achieve tumor regressions, selectively in p53-deficient pancreatic cancer xenografts
    • doi: 10.1158/1078-0432.CCR-10-2580
    • Rajeshkumar NV, De Oliveira E, Ottenhof N, Watters J, Brooks D, et al. (2011) MK-1775, a potent Wee1 inhibitor, synergizes with gemcitabine to achieve tumor regressions, selectively in p53-deficient pancreatic cancer xenografts. Clin Cancer Res 17: 2799-2806. doi:10.1158/1078-0432.CCR-10-2580. PubMed: 21389100.
    • (2011) Clin Cancer Res , vol.17 , pp. 2799-2806
    • Rajeshkumar, N.V.1    De Oliveira, E.2    Ottenhof, N.3    Watters, J.4    Brooks, D.5
  • 44
    • 78751559414 scopus 로고    scopus 로고
    • Personalizing cancer treatment in the age of global genomic analyses: PALB2 gene mutations and the response to DNA damaging agents in pancreatic cancer
    • doi: 10.1158/1535-7163.TARG-11-B3
    • Villarroel MC, Rajeshkumar NV, Garrido-Laguna I, De Jesus-Acosta A, Jones S, et al. (2011) Personalizing cancer treatment in the age of global genomic analyses: PALB2 gene mutations and the response to DNA damaging agents in pancreatic cancer. Mol Cancer Ther 10: 3-8. doi:10.1158/1535-7163.TARG-11-B3. PubMed: 21135251.
    • (2011) Mol Cancer Ther , vol.10 , pp. 3-8
    • Villarroel, M.C.1    Rajeshkumar, N.V.2    Garrido-Laguna, I.3    De Jesus-Acosta, A.4    Jones, S.5
  • 45
    • 80051588648 scopus 로고    scopus 로고
    • A pilot clinical study of treatment guided by personalized tumorgrafts in patients with advanced cancer
    • doi: 10.1158/1535-7163.MCT-11-0233
    • Hidalgo M, Bruckheimer E, Rajeshkumar NV, Garrido-Laguna I, De Oliveira E, et al. (2011) A pilot clinical study of treatment guided by personalized tumorgrafts in patients with advanced cancer. Mol Cancer Ther 10: 1311-1316. doi:10.1158/1535-7163.MCT-11-0233. PubMed: 21673092.
    • (2011) Mol Cancer Ther , vol.10 , pp. 1311-1316
    • Hidalgo, M.1    Bruckheimer, E.2    Rajeshkumar, N.V.3    Garrido-Laguna, I.4    De Oliveira, E.5
  • 46
    • 0028875562 scopus 로고
    • Allelotype of pancreatic adenocarcinoma using xenograft enrichment
    • PubMed: 7553647
    • Hahn SA, Seymour AB, Hoque AT, Schutte M, da Costa LT, et al. (1995) Allelotype of pancreatic adenocarcinoma using xenograft enrichment. Cancer Res 55: 4670-4675. PubMed: 7553647.
    • (1995) Cancer Res , vol.55 , pp. 4670-4675
    • Hahn, S.A.1    Seymour, A.B.2    Hoque, A.T.3    Schutte, M.4    da Costa, L.T.5
  • 47
    • 81855194258 scopus 로고    scopus 로고
    • c-Met is a marker of pancreatic cancer stem cells and therapeutic target
    • e2215 10.1053/j.gastro.2011.08.009
    • Li C, Wu JJ, Hynes M, Dosch J, Sarkar B, et al. (2011) c-Met is a marker of pancreatic cancer stem cells and therapeutic target. Gastroenterology 141: 2218-2227 e2215 doi:10.1053/j.gastro.2011.08.009. PubMed: 21864475.
    • (2011) Gastroenterology , vol.141 , pp. 2218-2227
    • Li, C.1    Wu, J.J.2    Hynes, M.3    Dosch, J.4    Sarkar, B.5
  • 48
    • 84865635727 scopus 로고    scopus 로고
    • Sensitization of pancreatic cancer stem cells to gemcitabine by Chk1 inhibition
    • PubMed: 22787433
    • Venkatesha VA, Parsels LA, Parsels JD, Zhao L, Zabludoff SD, et al. (2012) Sensitization of pancreatic cancer stem cells to gemcitabine by Chk1 inhibition. Neoplasia 14: 519-525. PubMed: 22787433.
    • (2012) Neoplasia , vol.14 , pp. 519-525
    • Venkatesha, V.A.1    Parsels, L.A.2    Parsels, J.D.3    Zhao, L.4    Zabludoff, S.D.5
  • 49
    • 34249303463 scopus 로고    scopus 로고
    • Gene signatures developed from patient tumor explants grown in nude mice to predict tumor response to 11 cytotoxic drugs
    • PubMed: 17878523
    • Fiebig HH, Schüler J, Bausch N, Hofmann M, Metz T, et al. (2007) Gene signatures developed from patient tumor explants grown in nude mice to predict tumor response to 11 cytotoxic drugs. Cancer Genomics Proteomics 4: 197-209. PubMed: 17878523.
    • (2007) Cancer Genomics Proteomics , vol.4 , pp. 197-209
    • Fiebig, H.H.1    Schüler, J.2    Bausch, N.3    Hofmann, M.4    Metz, T.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.