-
1
-
-
0037374498
-
The price of innovation: New estimates of drug development costs
-
DiMasi, J.A., Hansen, R.W. & Grabowski, H.G. The price of innovation: new estimates of drug development costs. J. Health Econ. 22, 151-185 (2003).
-
(2003)
J. Health Econ
, vol.22
, pp. 151-185
-
-
DiMasi, J.A.1
Hansen, R.W.2
Grabowski, H.G.3
-
2
-
-
0031896592
-
There are no bad anticancer agents, only bad clinical trial designs - twenty-first Richard and Hinda Rosenthal Foundation Award Lecture
-
Von Hoff, D.D. There are no bad anticancer agents, only bad clinical trial designs - twenty-first Richard and Hinda Rosenthal Foundation Award Lecture. Clin. Cancer Res. 4, 1079-1086 (1998).
-
(1998)
Clin. Cancer Res
, vol.4
, pp. 1079-1086
-
-
Von Hoff, D.D.1
-
3
-
-
0021272340
-
Current NCI preclinical antitumor screening in vivo: Results of tumor panel screening, 1976-1982, and future directions
-
Venditti, J.M., Wesley, R.A. & Plowman, J. Current NCI preclinical antitumor screening in vivo: results of tumor panel screening, 1976-1982, and future directions. Adv. Pharmacol. Chemother. 20, 1-20 (1984).
-
(1984)
Adv. Pharmacol. Chemother
, vol.20
, pp. 1-20
-
-
Venditti, J.M.1
Wesley, R.A.2
Plowman, J.3
-
4
-
-
58549107335
-
-
Boyd, M. The NCI in vitro anticancer drug discovery screen: concept, implementation, and operation, 1985-1995. In Anticancer Drug Development Guide: Preclinical Screening, Clinical Trials, and Approval (ed. Teicher, B.) 23 (Humana, Totowa, NJ, 1997).
-
Boyd, M. The NCI in vitro anticancer drug discovery screen: concept, implementation, and operation, 1985-1995. In Anticancer Drug Development Guide: Preclinical Screening, Clinical Trials, and Approval (ed. Teicher, B.) 23 (Humana, Totowa, NJ, 1997).
-
-
-
-
5
-
-
1942518907
-
The hollow fibre model in cancer drug screening: The NCI experience
-
Decker, S., Hollingshead, M., Bonomi, C.A., Carter, J.P. & Sausville, E.A. The hollow fibre model in cancer drug screening: the NCI experience. Eur. J. Cancer 40, 821-826 (2004).
-
(2004)
Eur. J. Cancer
, vol.40
, pp. 821-826
-
-
Decker, S.1
Hollingshead, M.2
Bonomi, C.A.3
Carter, J.P.4
Sausville, E.A.5
-
6
-
-
2042458747
-
Relationships between drug activity in NCI preclinical in vitro and in vivo models and early clinical trials
-
Johnson, J.I. et al. Relationships between drug activity in NCI preclinical in vitro and in vivo models and early clinical trials. Br. J. Cancer 84, 1424-1431 (2001).
-
(2001)
Br. J. Cancer
, vol.84
, pp. 1424-1431
-
-
Johnson, J.I.1
-
7
-
-
20444489533
-
Phenotypic instability of Saos-2 cells in long-term culture
-
Hausser, H.J. & Brenner, R.E. Phenotypic instability of Saos-2 cells in long-term culture. Biochem. Biophys. Res. Commun. 333, 216-222 (2005).
-
(2005)
Biochem. Biophys. Res. Commun
, vol.333
, pp. 216-222
-
-
Hausser, H.J.1
Brenner, R.E.2
-
8
-
-
0037899253
-
Role of tissue stroma in cancer cell invasion
-
De Wever, O. & Mareel, M. Role of tissue stroma in cancer cell invasion. J. Pathol. 200, 429-447 (2003).
-
(2003)
J. Pathol
, vol.200
, pp. 429-447
-
-
De Wever, O.1
Mareel, M.2
-
9
-
-
33748088524
-
An in vivo platform for translational drug development in pancreatic cancer
-
Rubio-Viqueira, B. et al. An in vivo platform for translational drug development in pancreatic cancer. Clin. Cancer Res. 12, 4652-4661 (2006).
-
(2006)
Clin. Cancer Res
, vol.12
, pp. 4652-4661
-
-
Rubio-Viqueira, B.1
-
10
-
-
0034922952
-
Human-SCID mouse chimeric models for the evaluation of anti-cancer therapies
-
Bankert, R.B., Egilmez, N.K. & Hess, S.D. Human-SCID mouse chimeric models for the evaluation of anti-cancer therapies. Trends Immunol. 22, 386-393 (2001).
-
(2001)
Trends Immunol
, vol.22
, pp. 386-393
-
-
Bankert, R.B.1
Egilmez, N.K.2
Hess, S.D.3
-
11
-
-
0034488466
-
Response and determinants of sensitivity to paclitaxel in human non-small cell lung cancer tumors heterotransplanted in nude mice
-
Perez-Soler, R. et al. Response and determinants of sensitivity to paclitaxel in human non-small cell lung cancer tumors heterotransplanted in nude mice. Clin. Cancer Res. 6, 4932-4938 (2000).
-
(2000)
Clin. Cancer Res
, vol.6
, pp. 4932-4938
-
-
Perez-Soler, R.1
-
12
-
-
13344279397
-
Engraftment of human tumor-infiltrating lymphocytes and the production of anti-tumor antibodies in SCID mice
-
Williams, S.S. et al. Engraftment of human tumor-infiltrating lymphocytes and the production of anti-tumor antibodies in SCID mice. J. Immunol. 156, 1908-1915 (1996).
-
(1996)
J. Immunol
, vol.156
, pp. 1908-1915
-
-
Williams, S.S.1
-
13
-
-
45549083809
-
Long-term engraftment and expansion of tumor-derived memory T cells following the implantation of non-disrupted pieces of human lung tumor into NOD-scid IL2Rgamma(null) mice
-
Simpson-Abelson, M.R. et al. Long-term engraftment and expansion of tumor-derived memory T cells following the implantation of non-disrupted pieces of human lung tumor into NOD-scid IL2Rgamma(null) mice. J. Immunol. 180, 7009-7018 (2008).
-
(2008)
J. Immunol
, vol.180
, pp. 7009-7018
-
-
Simpson-Abelson, M.R.1
-
14
-
-
0346023951
-
Anticancer drug response and expression of molecular markers in early-passage xenotransplanted colon carcinomas
-
Fichtner, I. et al. Anticancer drug response and expression of molecular markers in early-passage xenotransplanted colon carcinomas. Eur. J. Cancer 40, 298-307 (2004).
-
(2004)
Eur. J. Cancer
, vol.40
, pp. 298-307
-
-
Fichtner, I.1
-
15
-
-
1942518912
-
Clonogenic assay with established human tumour xenografts: Correlation of in vitro to in vivo activity as a basis for anticancer drug discovery
-
Fiebig, H.H., Maier, A. & Burger, A.M. Clonogenic assay with established human tumour xenografts: correlation of in vitro to in vivo activity as a basis for anticancer drug discovery. Eur. J. Cancer 40, 802-820 (2004).
-
(2004)
Eur. J. Cancer
, vol.40
, pp. 802-820
-
-
Fiebig, H.H.1
Maier, A.2
Burger, A.M.3
-
16
-
-
1842510883
-
Models for evaluation of targeted therapies of metastatic disease
-
ed. Teicher, B.A, Humana, Totowa, NJ
-
Eccles, S. Models for evaluation of targeted therapies of metastatic disease. In Tumor Models in Cancer Research (ed. Teicher, B.A.) 293-319 (Humana, Totowa, NJ, 2002).
-
(2002)
Tumor Models in Cancer Research
, pp. 293-319
-
-
Eccles, S.1
-
17
-
-
0028245129
-
Modulation of tumor cell response to chemotherapy by the organ environment
-
Fidler, I.J. et al. Modulation of tumor cell response to chemotherapy by the organ environment. Cancer Metastasis Rev. 13, 209-222 (1994).
-
(1994)
Cancer Metastasis Rev
, vol.13
, pp. 209-222
-
-
Fidler, I.J.1
-
18
-
-
0027409346
-
Importance of orthotopic implantation for human tumors as model systems: Relevance to metastasis and invasion
-
Manzotti, C., Audisio, R.A. & Pratesi, G. Importance of orthotopic implantation for human tumors as model systems: relevance to metastasis and invasion. Clin. Exp. Metastasis 11, 5-14 (1993).
-
(1993)
Clin. Exp. Metastasis
, vol.11
, pp. 5-14
-
-
Manzotti, C.1
Audisio, R.A.2
Pratesi, G.3
-
19
-
-
1542436704
-
Human tumor xenografts as predictive preclinical models for anticancer drug activity in humans: Better than commonly perceived-but they can be improved
-
Kerbel, R.S. Human tumor xenografts as predictive preclinical models for anticancer drug activity in humans: better than commonly perceived-but they can be improved. Cancer Biol. Ther. 2, S134-S139 (2003).
-
(2003)
Cancer Biol. Ther
, vol.2
-
-
Kerbel, R.S.1
-
20
-
-
0027994031
-
Matrix metalloproteinase inhibitor BB-94 (batimastat) inhibits human colon tumor growth and spread in a patient-like orthotopic model in nude mice
-
Wang, X., Fu, X., Brown, P.D., Crimmin, M.J. & Hoffman, R.M. Matrix metalloproteinase inhibitor BB-94 (batimastat) inhibits human colon tumor growth and spread in a patient-like orthotopic model in nude mice. Cancer Res. 54, 4726-4728 (1994).
-
(1994)
Cancer Res
, vol.54
, pp. 4726-4728
-
-
Wang, X.1
Fu, X.2
Brown, P.D.3
Crimmin, M.J.4
Hoffman, R.M.5
-
21
-
-
1942454409
-
Orthotopic models of cancer for preclinical drug evaluation: Advantages and disadvantages
-
Bibby, M.C. Orthotopic models of cancer for preclinical drug evaluation: advantages and disadvantages. Eur. J. Cancer 40, 852-857 (2004).
-
(2004)
Eur. J. Cancer
, vol.40
, pp. 852-857
-
-
Bibby, M.C.1
-
22
-
-
0031110087
-
Chemotherapeutic profiles of human tumors implanted in SCID mice showing appreciable inconsistencies with those in nude mice
-
Yoshimura, M., Endo, S., Hioki, K., Ueyama, Y. & Ohnishi, Y. Chemotherapeutic profiles of human tumors implanted in SCID mice showing appreciable inconsistencies with those in nude mice. Exp. Anim. 46, 153-156 (1997).
-
(1997)
Exp. Anim
, vol.46
, pp. 153-156
-
-
Yoshimura, M.1
Endo, S.2
Hioki, K.3
Ueyama, Y.4
Ohnishi, Y.5
-
23
-
-
1942422737
-
Integrating pharmacology and in vivo cancer models in preclinical and clinical drug development
-
Peterson, J.K. & Houghton, P.J. Integrating pharmacology and in vivo cancer models in preclinical and clinical drug development. Eur. J. Cancer 40, 837-844 (2004).
-
(2004)
Eur. J. Cancer
, vol.40
, pp. 837-844
-
-
Peterson, J.K.1
Houghton, P.J.2
-
24
-
-
0024451424
-
Evaluation of antitumor activity in a human breast tumor/ nude mouse model with a special emphasis on treatment dose
-
Inaba, M. et al. Evaluation of antitumor activity in a human breast tumor/ nude mouse model with a special emphasis on treatment dose. Cancer 64, 1577-1582 (1989).
-
(1989)
Cancer
, vol.64
, pp. 1577-1582
-
-
Inaba, M.1
-
25
-
-
0024363349
-
Responsiveness of human lung cancer/nude mouse to antitumor agents in a model using clinically equivalent doses
-
Tashiro, T. et al. Responsiveness of human lung cancer/nude mouse to antitumor agents in a model using clinically equivalent doses. Cancer Chemother. Pharmacol. 24, 187-192 (1989).
-
(1989)
Cancer Chemother. Pharmacol
, vol.24
, pp. 187-192
-
-
Tashiro, T.1
-
26
-
-
0036359767
-
Scaling down imaging: Molecular mapping of cancer in mice
-
Weissleder, R. Scaling down imaging: molecular mapping of cancer in mice. Nat. Rev. Cancer 2, 11-18 (2002).
-
(2002)
Nat. Rev. Cancer
, vol.2
, pp. 11-18
-
-
Weissleder, R.1
-
27
-
-
0032764062
-
Evolving approaches to cancer drug discovery and development at the National Cancer Institute, USA
-
Sausville, E.A. & Feigal, E. Evolving approaches to cancer drug discovery and development at the National Cancer Institute, USA. Ann. Oncol. 10, 1287-1291 (1999).
-
(1999)
Ann. Oncol
, vol.10
, pp. 1287-1291
-
-
Sausville, E.A.1
Feigal, E.2
-
28
-
-
58549101075
-
A prospective validation of a direct tumor xenograft model in pancreatic ductal adenocarcinoma (PDA)
-
Chicago, IL, Abstract 4500
-
Jimeno, A. et al. A prospective validation of a direct tumor xenograft model in pancreatic ductal adenocarcinoma (PDA). ASCO Annual Meeting, Chicago, IL, 2008. Abstract 4500.
-
(2008)
ASCO Annual Meeting
-
-
Jimeno, A.1
-
29
-
-
33749335282
-
The Connectivity Map: Using gene-expression signatures to connect small molecules, genes, and disease
-
Lamb, J. et al. The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease. Science 313, 1929-1935 (2006).
-
(2006)
Science
, vol.313
, pp. 1929-1935
-
-
Lamb, J.1
-
30
-
-
58549085729
-
NCI-60 gene set connectivity map (GS-CMAP): Connecting pathway-based gene expression profiles for therapeutic efficacy determination
-
Chicago, IL, Abstract 3588
-
Tan, A., Jimeno, A., Rubio-Viqueira, B. & Hidalgo, M. NCI-60 gene set connectivity map (GS-CMAP): connecting pathway-based gene expression profiles for therapeutic efficacy determination. ASCO Annual Meeting, Chicago, IL, 2008. Abstract 3588.
-
(2008)
ASCO Annual Meeting
-
-
Tan, A.1
Jimeno, A.2
Rubio-Viqueira, B.3
Hidalgo, M.4
-
31
-
-
0032748041
-
Evaluation of rodent-only toxicology for early clinical trials with novel cancer therapeutics
-
Newell, D.R., Burtles, S.S., Fox, B.W., Jodrell, D.I. & Connors, T.A. Evaluation of rodent-only toxicology for early clinical trials with novel cancer therapeutics. Br. J. Cancer 81, 760-768 (1999).
-
(1999)
Br. J. Cancer
, vol.81
, pp. 760-768
-
-
Newell, D.R.1
Burtles, S.S.2
Fox, B.W.3
Jodrell, D.I.4
Connors, T.A.5
|