Discovery of pyrazolo[1,5-a]pyrimidine-based CHK1 inhibitors: A template-based approach - Part 2

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 1, 2011, Pages 467-470

  Labroli, Marc ^a   Paruch, Kamil ^a,b   Dwyer, Michael P ^a   Alvarez, Carmen ^a   Keertikar, Kartik ^a   Poker, Cory ^a   Rossman, Randall ^a   Duca, Jose S ^a,c   Fischmann, Thierry O ^a   Madison, Vincent ^a   Parry, David ^a   Davis, Nicole ^a   Seghezzi, Wolfgang ^a   Wiswell, Derek ^a   Guzi, Timothy J ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b MASARYK UNIVERSITY   (Czech Republic)

^c NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

CDK; Cell cycle; CHK1; Inhibitors; Kinase; Pyrazolo 1,5 a pyrimidine

Indexed keywords

CHECKPOINT KINASE 1; CHECKPOINT KINASE 1 INHIBITOR; PROTEIN SERINE THREONINE KINASE INHIBITOR; PYRAZOLO[1,5 A]PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; DRUG POTENCY; ENZYME INHIBITION; IC 50; STRUCTURE ACTIVITY RELATION;

EID: 78650510557     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.10.113     Document Type: Article

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