Hydroxysafflor yellow A enhances survival of vascular endothelial cells under hypoxia via upregulation of the HIF-1α-VEGF pathway and regulation of Bcl-2/Bax

Journal of Cardiovascular Pharmacology

Volumn 52, Issue 2, 2008, Pages 191-202

  Ji, Deng Bo ^a,b   Zhu, Mei Cai ^c   Zhu, Bing ^d   Zhu, Yi Zhun ^e,f   Li, Chang Ling ^a   Ye, Jia ^a   Zhu, Hai Bo ^b,g  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^c GENERAL HOSPITAL OF NORTHERN THEATER COMMAND   (China)

^d UNIVERSITY OF SOUTH ALABAMA COLLEGE OF MEDICINE   (United States)

^e NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^f FUDAN UNIVERSITY   (China)

^g INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Apoptosis; Bcl 2 Bax; Endothelial cell; HIF 1a; Hydroxysafflor yellow A; VEGF

Indexed keywords

HYDROXYSAFFLOR YELLOW A; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MESSENGER RNA; PLANT EXTRACT; PROTEIN BAX; PROTEIN BCL 2; SAFFLOWER EXTRACT; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; VASCULOTROPIN; CHALCONE; DRUG DERIVATIVE; HIF1A PROTEIN, HUMAN; QUINONE DERIVATIVE;

APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL SURVIVAL; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG STRUCTURE; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GENE CONTROL; GENE EXPRESSION; GENE SILENCING; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HYPOXIA; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SAFFLOWER; VASCULAR ENDOTHELIUM; WESTERN BLOTTING; CELL HYPOXIA; CYTOLOGY; DRUG EFFECT; ENDOTHELIUM CELL; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; TUMOR CELL LINE;

APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BLOTTING, WESTERN; CELL HYPOXIA; CELL LINE, TUMOR; CELL SURVIVAL; CHALCONE; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; PROTO-ONCOGENE PROTEINS C-BCL-2; QUINONES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSCRIPTION, GENETIC; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 56149108015     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/FJC.0b013e318181fb02     Document Type: Article

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