Screening of actinobacillus pleuropneumoniae LuxS inhibitors

Current Microbiology

Volumn 67, Issue 5, 2013, Pages 564-571

  Li, Lu ^a   Sun, Lili ^a   Song, Yunfeng ^a   Wu, Xinjuan ^a   Zhou, Xuan ^a   Liu, Ziduo ^a   Zhou, Rui ^a  

^a HUAZHONG AGRICULTURAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITOR; RECOMBINANT ENZYME; S RIBOSYLHOMOCYSTEINASE;

ACTINOBACILLUS PLEUROPNEUMONIAE; ANIMAL CELL; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY TEST; DRUG SCREENING; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; GROWTH INHIBITION; HAEMOPHILUS PARASUIS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; STREPTOCOCCUS SUIS;

ACTINOBACILLUS PLEUROPNEUMONIAE; BACTERIA (MICROORGANISMS); STREPTOCOCCUS SUIS; SUIDAE; SUS;

ACTINOBACILLUS PLEUROPNEUMONIAE; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; CARBON-SULFUR LYASES; CLONING, MOLECULAR; DRUG DISCOVERY; ENZYME ACTIVATION; ENZYME INHIBITORS; GENE EXPRESSION; INHIBITORY CONCENTRATION 50; KINETICS; MICROBIAL SENSITIVITY TESTS; RECOMBINANT PROTEINS; SMALL MOLECULE LIBRARIES;

EID: 84885870762     PISSN: 03438651     EISSN: 14320991     Source Type: Journal    
DOI: 10.1007/s00284-013-0403-9     Document Type: Article

References (29)

1. Alfaro JF, Zhang T, Wynn DP (2004) Synthesis of luxS inhibitors targeting bacterial cell-cell communication. Org Lett 6(18):3043-3046. doi: 10.1021/ol049182i
2. Bjarnsholt T, Givskov M (2008) Quorum sensing inhibitory drugs as next generation antimicrobials: worth the effort? Curr Infect Dis Rep 10(1):22-28
3. Blackall PJ, Klaasen HL, van den Bosch H, Kuhnert P, Frey J (2002) Proposal of a new serovar of Actinobacillus pleuropneumoniae: serovar 15. Vet Microbiol 84(1-2):47-52. doi: S037811350100428X
4. Cornell KA, Primus S, Martinez JA, Parveen N (2009) Assessment of methylthioadenosine/S-adenosylhomocysteine nucleosidases of Borrelia burgdorferi as targets for novel antimicrobials using a novel high-throughput method. J Antimicrob Chemother 63(6):1163-1172. doi: 10.1093/jac/dkp129
5. Federle MJ, Bassler BL (2003) Interspecies communication in bacteria. J Clin Invest 112(9):1291-1299. doi: 10.1172/JCI20195
6. Fong KP, Gao L, Demuth DR (2003) luxS and arcB control aerobic growth of Actinobacillus actinomycetemcomitans under iron limitation. Infect Immun 71(1):298-308. doi: 10.1128/IAI.71.1.298-308.2003
7. Gopishetty B, Zhu J, Rajan R, Sobczak AJ, Wnuk SF, Bell CE, Pei D (2009) Probing the catalytic mechanism of S-ribosylhomocysteinase (luxS) with catalytic intermediates and substrate analogues. J Am Chem Soc 131(3):1243-1250. doi: 10.1021/ja808206w
8. Han X, Lu C (2009) Biological activity and identification of a peptide inhibitor of luxS from Streptococcus suis serotype 2. FEMS Microbiol Lett 294(1):16-23. doi: 10.1111/j.1574-6968.2009.01534.x
9. Kang M, Zhou R, Liu L, Langford PR, Chen H (2009) Analysis of an Actinobacillus pleuropneumoniae multi-resistance plasmid, pHB0503. Plasmid 61(2):135-139. doi: 10.1016/j.plasmid.2008.11.001
10. Lebeer S, De Keersmaecker SC, Verhoeven TL, Fadda AA, Marchal K, Vanderleyden J (2007) Functional analysis of luxS in the probiotic strain Lactobacillus rhamnosus GG reveals a central metabolic role important for growth and biofilm formation. J Bacteriol 189(3):860-871. doi: 10.1128/JB.01394-06
11. Li L, Zhou R, Li T, Kang M, Wan Y, Xu Z, Chen H (2008) Enhanced biofilm formation and reduced virulence of Actinobacillus pleuropneumoniae luxS mutant. Microb Pathog 45(3):192-200. doi: 10.1016/j.micpath.2008.05.008
12. Li L, Xu Z, Zhou Y, Li T, Sun L, Chen H, Zhou R (2011) Analysis on Actinobacillus pleuropneumoniae luxS regulated genes reveals pleiotropic roles of LuxS/AI-2 on biofilm formation, adhesion ability and iron metabolism. Microb Pathog 50(6):293-302. doi: 10.1016/j.micpath.2011.02.002
13. Malladi VL, Sobczak AJ, Meyer TM, Pei D, Wnuk SF (2011) Inhibition of luxS by S-ribosylhomocysteine analogues containing a [4-aza]ribose ring. Bioorg Med Chem 19(18):5507-5519. doi: 10.1016/j.bmc.2011.07.043
14. Roy V, Adams BL, Bentley WE (2011) Developing next generation antimicrobials by intercepting AI-2 mediated quorum sensing. Enzyme Microb Technol 49(2):113-123. doi: 10.1016/j.enzmictec.2011.06.001
15. Schauder S, Bassler BL (2001) The languages of bacteria. Genes Dev 15(12):1468-1480. doi: 10.1101/gad.899601
16. Schauder S, Shokat K, Surette MG, Bassler BL (2001) The luxS family of bacterial autoinducers: biosynthesis of a novel quorum-sensing signal molecule. Mol Microbiol 41(2):463-476. doi: 10.1046/j.1365-2958.2001.02532.x
17. Sheehan BJ, Bosse JT, Beddek AJ, Rycroft AN, Kroll JS, Langford PR (2003) Identification of Actinobacillus pleuropneumoniae genes important for survival during infection in its natural host. Infect Immun 71(7):3960-3970. doi: 10.1128/iai.71.7.3960-3970.2003
18. Shen G, Rajan R, Zhu J, Bell CE, Pei D (2006) Design and synthesis of substrate and intermediate analogue inhibitors of S-ribosylhomocysteinase. J Med Chem 49(10):3003-3011. doi: 10.1021/jm060047g
19. Siller M, Janapatla RP, Pirzada ZA, Hassler C, Zinkl D, Charpentier E (2008) Functional analysis of the group A streptococcal luxS/AI-2 system in metabolism, adaptation to stress and interaction with host cells. BMC Microbiol 8:188. doi: 10.1186/1471-2180-8-188
20. Singh V, Shi W, Almo SC, Evans GB, Furneaux RH, Tyler PC, Painter GF, Lenz DH, Mee S, Zheng R, Schramm VL (2006) Structure and inhibition of a quorum sensing target from Streptococcus pneumoniae. Biochemistry 45(43):12929-12941. doi: 10.1021/bi061184i
21. Sperandio V (2007) Novel approaches to bacterial infection therapy by interfering with bacteria-to-bacteria signaling. Expert Rev Anti Infect Ther 5(2):271-276. doi: 10.1586/14787210.5.2.271
22. Vendeville A, Winzer K, Heurlier K, Tang CM, Hardie KR (2005) Making 'sense' of metabolism: autoinducer-2, luxS and pathogenic bacteria. Nat Rev Microbiol 3(5):383-396. doi: 10.1038/nrmicro1146
23. Waters CM, Bassler BL (2005) Quorum sensing: cell-to-cell communication in bacteria. Annu Rev Cell Dev Biol 21:319-346. doi: 10.1146/annurev.cellbio.21. 012704.131001
24. Winzer K, Hardie KR, Burgess N, Doherty N, Kirke D, Holden MT, Linforth R, Cornell KA, Taylor AJ, Hill PJ, Williams P (2002) LuxS: its role in central metabolism and the in vitro synthesis of 4-hydroxy-5-methyl-3(2H)-furanone. Microbiology 148(Pt 4):909-922
25. Wnuk SF, Lalama J, Garmendia CA, Robert J, Zhu J, Pei D (2008) S-Ribosylhomocysteine analogues with the carbon-5 and sulfur atoms replaced by a vinyl or (fluoro) vinyl unit. Bioorg Med Chem 16(9):5090-5102. doi: 10.1016/j.bmc.2008.03.028
26. Wnuk SF, Robert J, Sobczak AJ, Meyers BP, Malladi VL, Zhu J, Gopishetty B, Pei D (2009) Inhibition of S-ribosylhomocysteinase (luxS) by substrate analogues modified at the ribosyl C-3 position. Bioorg Med Chem 17(18):6699-6706. doi: 10.1016/j.bmc.2009.07.057
27. Xavier KB, Bassler BL (2003) LuxS quorum sensing: more than just a numbers game. Curr Opin Microbiol 6(2):191-197. doi: S1369527403000286
28. Xavier KB, Bassler BL (2005) Interference with AI-2-mediated bacterial cell-cell communication. Nature 437(7059):750-753. doi: 10.1038/nature03960
29. Zang T, Lee BW, Cannon LM, Ritter KA, Dai S, Ren D, Wood TK, Zhou ZS (2009) A naturally occurring brominated furanone covalently modifies and inactivates luxS. Bioorg Med Chem Lett 19(21):6200-6204. doi: 10.1016/j.bmcl.2009.08.095