Synthesis, antimicrobial, anticancer evaluation and QSAR studies of 6-methyl-4-[1-(2-substituted-phenylamino-acetyl)-1H-indol-3-yl]-2-oxo/thioxo-1, 2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl esters

European Journal of Medicinal Chemistry

Volumn 48, Issue , 2012, Pages 16-25

  Sharma, Sandeep Kumar ^a   Kumar, Pradeep ^a   Narasimhan, Balasubramanian ^a   Ramasamy, Kalavathy ^b   Mani, Vasudevan ^b   Mishra, Rakesh Kumar ^b   Majeed, Abu Bakar Abdul ^b  

^a MAHARSHI DAYANAND UNIVERSITY   (India)

^b UNIVERSITI TEKNOLOGI MARA   (Malaysia)

Author keywords

Antibacterial; Anticancer; Antifungal; Indoles; QSAR

Indexed keywords

1 (2 CHLORO ACETYL) 1H INDOLE 3 CARBALDEHYDE; 4 [1 [2 (2 CHLORO 4 NITRO PHENYLAMINO)ACETYL] 1H INDOL 3 YL] 6 METHYL 2 OXO 1,2,3,4 TETRAHYDROPYRIMIDINE 5 CARBOXYLIC ACID ETHYL ESTER; 6 METHYL 4 [1 [2 (4 NITRO PHENYLAMINO)ACETYL] 1H INDOL 3 YL] 2 THIOXO 1,2,3,4 TETRAHYDROPYRIMIDINE 5 CARBOXYLIC ACID ETHYL ESTER; ANTIFUNGAL AGENT; ANTIINFECTIVE AGENT; ANTINEOPLASTIC AGENT; FLUCONAZOLE; FLUOROURACIL; NORFLOXACIN; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; ASPERGILLUS NIGER; BACILLUS SUBTILIS; CANCER CELL; CANDIDA ALBICANS; COLON CANCER; CONTROLLED STUDY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ESCHERICHIA COLI; HUMAN; HUMAN CELL; LIPOPHILICITY; NONHUMAN; QUANTITATIVE STRUCTURE ACTIVITY RELATION; STAPHYLOCOCCUS AUREUS;

ANTI-BACTERIAL AGENTS; ANTINEOPLASTIC AGENTS; CELL SURVIVAL; HCT116 CELLS; HUMANS; INDOLES; INHIBITORY CONCENTRATION 50; MAGNETIC RESONANCE SPECTROSCOPY; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; PYRIMIDINES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; SPECTROSCOPY, FOURIER TRANSFORM INFRARED;

EID: 84856006196     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.11.028     Document Type: Article

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