Involvement of multiple cell cycle aberrations in early preneoplastic liver cell lesions by tumor promotion with thioacetamide in a two-stage rat hepatocarcinogenesis model

Experimental and Toxicologic Pathology

Volumn 65, Issue 7-8, 2013, Pages 979-988

  Kimura, Masayuki ^a   Fujii, Yuta ^a   Yamamoto, Ryuichi ^a   Yafune, Atsunori ^a,b   Hayashi, Shim mo ^c   Suzuki, Kazuhiko ^a   Shibutani, Makoto ^a  

^a TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY   (Japan)

^b GIFU UNIVERSITY   (Japan)

^c SAN EI GEN F F I INC   (Japan)

Author keywords

Cell cycle; Checkpoint; Hepatocarcinogenesis; Rat; Thioacetamide (TAA); Tumor promotion

Indexed keywords

ANTIOXIDANT; CELL MARKER; CHECKPOINT KINASE 1; CYCLIN DEPENDENT KINASE 1; DIETHYLNITROSAMINE; DNA TOPOISOMERASE (ATP HYDROLYSING); GLUTATHIONE TRANSFERASE; HISTONE H2AX; HISTONE H3; ISOQUERCITRIN; KI 67 ANTIGEN; PROTEIN MAD2; THIOACETAMIDE; THIOCTIC ACID; TOPOISOMERASE 2 ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL CYCLE CHECKPOINT; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DISEASE ASSOCIATION; DNA DAMAGE; DOWN REGULATION; ENZYME MODIFICATION; G2 PHASE CELL CYCLE CHECKPOINT; GENE CONTROL; IMMUNOREACTIVITY; LIVER CARCINOGENESIS; LIVER CELL DAMAGE; M PHASE CELL CYCLE CHECKPOINT; MALE; NONHUMAN; PROTEIN PHOSPHORYLATION; RAT; TUMOR PROMOTION;

RATTUS;

CELL CYCLE; CHECKPOINT; HEPATOCARCINOGENESIS; RAT; THIOACETAMIDE (TAA); TUMOR PROMOTION;

ANIMALS; CARCINOGENESIS; CARCINOGENS; CELL CYCLE; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; DISEASE MODELS, ANIMAL; IMMUNOHISTOCHEMISTRY; LIVER NEOPLASMS, EXPERIMENTAL; MALE; OXIDATIVE STRESS; PRECANCEROUS CONDITIONS; RATS; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; THIOACETAMIDE;

EID: 84885840772     PISSN: 09402993     EISSN: 16181433     Source Type: Journal    
DOI: 10.1016/j.etp.2013.01.012     Document Type: Article

References (37)

1. Adler M., Müller K., Rached E., Dekant W., Mally A. Modulation of key regulators of mitosis linked to chromosomal instability is an early event in ochratoxin A carcinogenicity. Carcinogenesis 2009, 30:711-719.
2. Akiyama T., Washino T., Yamada T., Koda T., Maitani T. Constituents of enzymatically modified isoquercitrin and enzymatically modified rutin (extract). Journal of the Food Hygienic Society of Japan 2000, 41:54-60.
3. Amudha G., Josephine A., Mythili Y., Sundarapandiyan R., Varalakshmi P. Therapeutic efficacy of dl-α-lipoic acid on cyclosporine A induced renal alterations. European Journal of Pharmacology 2007, 571:209-214.
4. Amudha G., Josephine A., Sudhahar V., Varalakshmi P. Protective effect of lipoic acid on oxidative and peroxidative damage in cyclosporine A-induced renal toxicity. International Immunopharmacology 2007, 7:1442-1449.
5. Bruno S., Darzynkiewicz Z. Cell cycle dependent expression and stability of the nuclear protein detected by Ki-67 antibody in HL-60 cells. Cell Proliferation 1992, 25:31-40.
6. Burma S., Chen B.P., Murphy M., Kurimasa A., Chen D.J. ATM phosphorylates histone H2AX in response to DNA double-strand breaks. Journal of Biological Chemistry 2001, 276:42462-42467.
7. Chan T.A., Hermeking H., Lengauer C., Kinzler K.W., Vogelstein B. 14-3-3σ is required to prevent mitotic catastrophe after DNA damage. Nature 1999, 401:616-620.
8. Gervasi P.G., Longo V., Marzano M., Saviozzi M., Malvaldi G. Chronic liver injury by thioacetamide and promotion of hepatic carcinogenesis. Journal of Cancer Research and Clinical Oncology 1989, 115:29-35.
9. Graves P.R., Lovly C.M., Uy G.L., Piwnica-Worms H. Localization of human Cdc25C is regulated both by nuclear export and 14-3-3 protein binding. Oncogene 2001, 20:1839-1851.
10. Hajovsky H., Hu G., Koen Y., Sarma D., Cui W., Moore D.S., et al. Metabolism and toxicity of thioacetamide and thioacetamide s-oxide in rat hepatocytes. Chemical Research in Toxicology 2012, 25:1955-1963.
11. Hirota T., Lipp J.L., Tof B.H., Peters J.M. Histone H3 serine 10 phosphorylation by Aurora B causes HP1 dissociation from heterochromatin. Nature 2005, 438:1176-1180.
12. Ichijima Y., Yoshioka K., Yoshioka Y., Shinohe K., Fujimori H., Unno J., et al. DNA lesions induced by replication stress trigger mitotic aberration and tetraploidy development. PLoS One 2010, 5:e8821.
13. Jia Z., Zhu H., Vitto M.J., Misra B.R., Li Y., Misra H.P. Alpha-lipoic acid potently inhibits peroxynitrite-mediated DNA strand breakage and hydroxyl radical formation: implications for the neuroprotective effects of alpha-lipoic acid. Molecular and Cellular Biochemistry 2009, 323:131-138.
14. Kim K.T., Han S.Y., Jeong J.S. Expression of G1 cell cycle regulators in rat liver upon repeated exposure to thioacetamide. Korean Journal of Hepatology 2007, 13:81-90.
15. Kops G.J., Foltz D.R., Cleveland D.W. Lethality to human cancer cells through massive chromosome loss by inhibition of the mitotic checkpoint. Proceedings of the National Academy of Sciences of the United States of America 2004, 101:8699-8704.
16. Kono Y., Inomata M., Hagiwara S., Hiratsuka T., Suzuki K., Koga H., et al. Antiproliferative effects of a new α-lipoic acid derivative, DHL-HisZnNa, in HT29 human colon cancer cells in vitro. Expert Opinion on Therapeutic Targets 2012, 16(Suppl 1):S103-S109.
17. 6+-induced DNA damage by alpha-lipoic acid: implications in reducing occupational cancer risk. Mutagenesis 2009, 24:495-500.
18. Kuwata K., Shibutani M., Hayashi H., Shimamoto K., Hayashi S., Suzuki K., et al. Concomitant apoptosis and regeneration of liver cells as a mechanism of liver-tumor promotion by β-naphthoflavone involving TNFα-signaling due to oxidative cellular stress in rats. Toxicology 2011, 283:8-17.
19. Lam M.H., Rosen J.M. Chk1 versus Cdc25: chking one's levels of cellular proliferation. Cell Cycle 2004, 3:1355-1357.
20. Mangipudy R.S., Chanda S., Mehendale H.M. Tissue repair response as a function of dose in thioacetamide hepatotoxicity. Environmental Health Perspectives 1995, 103:260-267.
21. Mattila R., Alanen K., Syrjänen S. Immunohistochemical study on topoisomerase IIα, Ki-67 and cytokeratin-19 in oral lichen planus lesions. Archives for Dermatological Research 2007, 298:381-388.
22. Mitrea D.M., Yoon M.K., Ou L., Kriwacki R.W. Disorder-function relationships for the cell cycle regulatory proteins p21 and p27. Biological Chemistry 2012, 393:259-274.
23. Molinari M. Cell cycle checkpoints and their inactivation in human cancer. Cell Proliferation 2000, 33:261-274.
24. Morita R., Shimamoto K., Ishii Y., Kuwata K., Ogawa B., Imaoka M., et al. Suppressive effect of enzymatically modified isoquercitrin on phenobarbital-induced liver tumor promotion in rats. Archives of Toxicology 2011, 85:1475-1484.
25. Niida H., Katsuno Y., Banerjee B., Hande M.P., Nakanishi M. Specific role of Chk1 phosphorylations in cell survival and checkpoint activation. Molecular and Cellular Biology 2007, 27:2572-2581.
26. Nishimura J., Saegusa Y., Dewa Y., Jin M., Kawai M., Kemmochi S., et al. Antioxidant enzymatically modified isoquercitrin or melatonin supplementation reduces oxidative stress-mediated hepatocellular tumor promotion of oxfendazole in rats. Archives of Toxicology 2010, 84:143-153.
27. Nozu F., Takeyama N., Tanaka T. Changes of hepatic fatty acid metabolism produced by chronic thioacetamide administration in rats. Hepatology 1992, 15:1099-1106.
28. Packer L., Witt E.H., Tritschler H.J. Alpha-lipoic acid as a biological antioxidant. Free Radical Biology and Medicine 1995, 19:227-250.
29. Shimada Y., Dewa Y., Ichimura R., Suzuki T., Mizukami S., Hayashi S.M., et al. Antioxidant enzymatically modified isoquercitrin suppresses the development of liver preneoplastic lesions in rats induced by β-naphthoflavone. Toxicology 2010, 268:213-218.
30. Shirai T. A medium-term rat liver bioassay as a rapid in vivo test for carcinogenic potential: a historical review of model development and summary of results from 291 tests. Toxicologic Pathology 1997, 25:453-460.
31. Sotillo R., Hernando E., Díaz-Rodríguez E., Teruya-Feldstein J., Cordón-Cardo C., Lowe S., et al. Mad2 overexpression promotes aneuploidy and tumorigenesis in mice. Cancer Cell 2007, 11:9-23.
32. Takaoka M., Ohkita M., Kobayashi Y., Yuba M., Matsumura Y. Protective effect of α-lipoic acid against ischaemic acute renal failure in rats. Clinical and Experimental Pharmacology and Physiology 2002, 29:189-194.
33. Taniai E., Kawai M., Dewa Y., Nishimura J., Harada T., Saegusa Y., et al. Crosstalk between PTEN/Akt2 and TGFβ signaling involving EGF receptor downregulation during the tumor promotion process from the early stage in a rat two-stage hepatocarcinogenesis model. Cancer Science 2009, 100:813-820.
34. Tong W., Cortes U., Hande M., Ohgaki H., Cavalli L., Lansdorp P., et al. Synergistic role of Ku80 and Poly (ADP-ribose) polymerase in suppressing chromosomal aberrations and liver cancer formation. Cancer Research 2002, 62:6990-6996.
35. Ink4a) in early-stage liver tumor-promotion facilitating liver cell regeneration in rats. Toxicology 2012, 299:146-154.
36. Uehara T., Hirode M., Ono A., Kiyosawa N., Omura K., Shimizu T., et al. A toxicogenomics approach for early assessment of potential non-genotoxic hepatocarcinogenicity of chemicals in rats. Toxicology 2008, 250:15-26.
37. Winiarska K., Malinska D., Szymanski K., Dudziak M., Bryla J. Lipoic acid ameliorates oxidative stress and renal injury in alloxan diabetic rabbits. Biochimie 2008, 90:450-459.