Culture promotes transfer of thyroid epithelial cell hyperplasia and proliferation by reducing regulatory T cell numbers

Cellular Immunology

Volumn 285, Issue 1-2, 2013, Pages 84-91

  Kayes, Timothy D ^a   Braley Mullen, Helen ^a  

^a University of Missouri   (United States)

Author keywords

Autoimmunity; IL 2; NOD.H 2h4; T regulatory Cells; TEC H P; Thyroid

Indexed keywords

INTERLEUKIN 2; TRANSCRIPTION FACTOR FOXP3;

ADOPTIVE TRANSFER; ANIMAL CELL; ARTICLE; CD4+ T LYMPHOCYTE; CELL COUNT; CELL CULTURE; CELL HYPERPLASIA; CELL PROLIFERATION; COMPARATIVE STUDY; EPITHELIUM CELL; FEMALE; FLOW CYTOMETRY; LYMPHOCYTE SUBPOPULATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECIPIENT; REGULATORY T LYMPHOCYTE; SPLEEN CELL; THYROID GLAND;

AUTOIMMUNITY; IHC; IL-2; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-2; NOD.H-2H4; SAT; SCID; SEVERE COMBINED IMMUNODEFICIENT; SPONTANEOUS AUTOIMMUNE THYROIDITIS; T CELL RECEPTOR; T REGULATORY CELLS; TCR; TEC; TEC H/P; THYROID; THYROID EPITHELIAL CELL; THYROID EPITHELIAL CELL HYPERPLASIA/PROLIFERATION;

ANIMALS; CD4 LYMPHOCYTE COUNT; CELL PROLIFERATION; CELLS, CULTURED; EPITHELIAL CELLS; FORKHEAD TRANSCRIPTION FACTORS; HYPERPLASIA; INTERFERON-GAMMA; INTERLEUKIN-2; LYMPHOCYTE COUNT; MICE; MICE, INBRED NOD; MICE, KNOCKOUT; MICE, SCID; SODIUM IODIDE; SPLEEN; T-LYMPHOCYTES, REGULATORY; THYROID GLAND; THYROIDITIS, AUTOIMMUNE;

EID: 84885821290     PISSN: 00088749     EISSN: 10902163     Source Type: Journal    
DOI: 10.1016/j.cellimm.2013.09.003     Document Type: Article

References (47)

1. Tunbridge W.M., Vanderpump M.P. Population screening for autoimmune thyroid disease. Endocrinol. Metab. Clin. North Am. 2000, 29:239-253.
2. Braley-Mullen H., Sharp G.C., Medling B., Tang H. Spontaneous autoimmune thyroiditis in NOD.H-2h4 mice. J. Autoimmun. 1999, 12:157-165.
3. Rose N.R., Bonita R., Burek C.L. Iodine: an environmental trigger of thyroiditis. Autoimmun. Rev. 2002, 1:97-103.
4. Yu S., Medling B., Yagita H., Braley-Mullen H. Characteristics of inflammatory cells in spontaneous autoimmune thyroiditis of NOD.H-2h4 mice. J. Autoimmun. 2001, 16:37-46.
5. Yu S., Sharp G.C., Braley-Mullen H. Thyroid epithelial cell hyperplasia in IFN-gamma deficient NOD.H-2h4 mice. Clin. Immunol. 2006, 118:92-100.
6. Yu S., Sharp G.C., Braley-Mullen H. Thyrocytes responding to IFN-gamma are essential for development of lymphocytic spontaneous autoimmune thyroiditis and inhibition of thyrocyte hyperplasia. J. Immunol. 2006, 176:1259-1265.
7. Fang Y., Yu S., Braley-Mullen H. TGF-beta promotes proliferation of thyroid epithelial cells in IFN-gamma(-/-) mice by down-regulation of p21 and p27 via AKT pathway. Am. J. Pathol. 2012, 180:650-660.
8. DeMay R.M. Follicular lesions of the thyroid. W(h)ither follicular carcinoma?. Am. J. Clin. Pathol. 2000, 114:681-683.
9. Singh R.R. SLE: translating lessons from model systems to human disease. Trends Immunol. 2005, 26:572-579.
10. Gabrielli A., Avvedimento E.V., Krieg T. Scleroderma. N. Engl. J. Med. 2009, 360:1989-2003.
11. Asa S.L. My approach to oncocytic tumours of the thyroid. J. Clin. Pathol. 2004, 57:225-232.
12. Derwahl M., Studer H. Hyperplasia versus adenoma in endocrine tissues: are they different?. Trends Endocrinol. Metab. 2002, 13:23-28.
13. Powell D.J., Russell J.P., Li G., Kuo B.A., Fidanza V., Huebner K., Rothstein J.L. Altered gene expression in immunogenic poorly differentiated thyroid carcinomas from RET/PTC3p53-/- mice. Oncogene 2001, 20:3235-3246.
14. Yu S., Fang Y., Sharav T., Sharp G.C., Braley-Mullen H. CD8+ T cells induce thyroid epithelial cell hyperplasia and fibrosis. J. Immunol. 2011, 186:2655-2662.
15. Yu S., Sharp G.C., Braley-Mullen H. Dual roles for IFN-gamma, but not for IL-4, in spontaneous autoimmune thyroiditis in NOD.H-2h4 mice. J. Immunol. 2002, 169:3999-4007.
16. Yu S., Ellis J.S., Dunn R., Kehry M.R., Braley-Mullen H. Transient depletion of B cells in young mice results in activation of regulatory T cells that inhibit development of autoimmune disease in adults. Int. Immunol. 2012, 24:233-242.
17. Braley-Mullen H., Johnson M., Sharp G.C., Kyriakos M. Induction of experimental autoimmune thyroiditis in mice with in vitro activated splenic T cells. Cell. Immunol. 1985, 93:132-143.
18. Fontenot J.D., Rasmussen J.P., Gavin M.A., Rudensky A.Y. A function for interleukin 2 in Foxp3-expressing regulatory T cells. Nat. Immunol. 2005, 6:1142-1151.
19. D'Alise A.M., Auyeung V., Feuerer M., Nishio J., Fontenot J., Benoist C., Mathis D. The defect in T-cell regulation in NOD mice is an effect on the T-cell effectors. Proc. Natl. Acad. Sci. USA 2008, 105:19857-19862.
20. Tang Q., Adams J.Y., Tooley A.J., Bi M., Fife B.T., Serra P., Santamaria P., Locksley R.M., Krummel M.F., Bluestone J.A. Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice. Nat. Immunol. 2006, 7:83-92.
21. Malek T.R., Yu A., Zhu L., Matsutani T., Adeegbe D., Bayer A.L. IL-2 family of cytokines in T regulatory cell development and homeostasis. J. Clin. Immunol. 2008, 28:635-639.
22. Gregg R., Smith C.M., Clark F.J., Dunnion D., Khan N., Chakraverty R., Nayak L., Moss P.A. The number of human peripheral blood CD4+ CD25high regulatory T cells increases with age. Clin. Exp. Immunol. 2005, 140:540-546.
23. Lages C.S., Suffia I., Velilla P.A., Huang B., Warshaw G., Hildeman D.A., Belkaid Y., Chougnet C. Functional regulatory T cells accumulate in aged hosts and promote chronic infectious disease reactivation. J. Immunol. 2008, 181:1835-1848.
24. Zhao L., Sun L., Wang H., Ma H., Liu G., Zhao Y. Changes of CD4+CD25+Foxp3+ regulatory T cells in aged Balb/c mice. J. Leukoc. Biol. 2007, 81:1386-1394.
25. Sharma S., Dominguez A.L., Lustgarten J. High accumulation of T regulatory cells prevents the activation of immune responses in aged animals. J. Immunol. 2006, 177:8348-8355.
26. Nishioka T., Shimizu J., Iida R., Yamazaki S., Sakaguchi S. CD4+CD25+Foxp3+ T cells and CD4+CD25-Foxp3+ T cells in aged mice. J. Immunol. 2006, 176:6586-6593.
27. Trzonkowski P., Szmit E., Mysliwska J., Mysliwski A. CD4+CD25+ T regulatory cells inhibit cytotoxic activity of CTL and NK cells in humans-impact of immunosenescence. Clin. Immunol. 2006, 119:307-316.
28. Tsaknaridis L., Spencer L., Culbertson N., Hicks K., LaTocha D., Chou Y.K., Whitham R.H., Bakke A., Jones R.E., Offner H., Bourdette D.N., Vandenbark A.A. Functional assay for human CD4+CD25+ Treg cells reveals an age-dependent loss of suppressive activity. J. Neurosci. Res. 2003, 74:296-308.
29. Tritt M., Sgouroudis E., d'Hennezel E., Albanese A., Piccirillo C.A. Functional waning of naturally occurring CD4+ regulatory T-cells contributes to the onset of autoimmune diabetes. Diabetes 2008, 57:113-123.
30. You S., Belghith M., Cobbold S., Alyanakian M.A., Gouarin C., Barriot S., Garcia C., Waldmann H., Bach J.F., Chatenoud L. Autoimmune diabetes onset results from qualitative rather than quantitative age-dependent changes in pathogenic T-cells. Diabetes 2005, 54:1415-1422.
31. Tartar D.M., VanMorlan A.M., Wan X., Guloglu F.B., Jain R., Haymaker C.L., Ellis J.S., Hoeman C.M., Cascio J.A., Dhakal M., Oukka M., Zaghouani H. FoxP3+RORgammat+ T helper intermediates display suppressive function against autoimmune diabetes. J. Immunol. 2010, 184:3377-3385.
32. Wu A.J., Hua H., Munson S.H., McDevitt H.O. Tumor necrosis factor-alpha regulation of CD4+CD25+ T cell levels in NOD mice. Proc. Natl. Acad. Sci. USA 2002, 99:12287-12292.
33. Salomon B., Lenschow D.J., Rhee L., Ashourian N., Singh B., Sharpe A., Bluestone J.A. B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes. Immunity 2000, 12:431-440.
34. Alard P., Manirarora J.N., Parnell S.A., Hudkins J.L., Clark S.L., Kosiewicz M.M. Deficiency in NOD antigen-presenting cell function may be responsible for suboptimal CD4+CD25+ T-cell-mediated regulation and type 1 diabetes development in NOD mice. Diabetes 2006, 55:2098-2105.
35. Tang Q., Adams J.Y., Penaranda C., Melli K., Piaggio E., Sgouroudis E., Piccirillo C.A., Salomon B.L., Bluestone J.A. Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction. Immunity 2008, 28:687-697.
36. Ferber I.A., Brocke S., Taylor-Edwards C., Ridgway W., Dinisco C., Steinman L., Dalton D., Fathman C.G. Mice with a disrupted IFN-gamma gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE). J. Immunol. 1996, 156:5-7.
37. Willenborg D.O., Fordham S., Bernard C.C., Cowden W.B., Ramshaw I.A. IFN-gamma plays a critical down-regulatory role in the induction and effector phase of myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis. J. Immunol. 1996, 157:3223-3227.
38. Krakowski M., Owens T. Interferon-gamma confers resistance to experimental allergic encephalomyelitis. Eur. J. Immunol. 1996, 26:1641-1646.
39. Caspi R.R., Chan C.C., Grubbs B.G., Silver P.B., Wiggert B., Parsa C.F., Bahmanyar S., Billiau A., Heremans H. Endogenous systemic IFN-gamma has a protective role against ocular autoimmunity in mice. J. Immunol. 1994, 152:890-899.
40. Vermeire K., Heremans H., Vandeputte M., Huang S., Billiau A., Matthys P. Accelerated collagen-induced arthritis in IFN-gamma receptor-deficient mice. J. Immunol. 1997, 158:5507-5513.
41. Guedez Y.B., Whittington K.B., Clayton J.L., Joosten L.A., van de Loo F.A., van den Berg W.B., Rosloniec E.F. Genetic ablation of interferon-gamma up-regulates interleukin-1beta expression and enables the elicitation of collagen-induced arthritis in a nonsusceptible mouse strain. Arthritis Rheum. 2001, 44:2413-2424.
42. Esposito M., Ruffini F., Bergami A., Garzetti L., Borsellino G., Battistini L., Martino G., Furlan R. IL-17- and IFN-gamma-secreting Foxp3+ T cells infiltrate the target tissue in experimental autoimmunity. J. Immunol. 2010, 185:7467-7473.
43. Fujimoto M., Nakano M., Terabe F., Kawahata H., Ohkawara T., Han Y., Ripley B., Serada S., Nishikawa T., Kimura A., Nomura S., Kishimoto T., Naka T. The influence of excessive IL-6 production in vivo on the development and function of Foxp3+ regulatory T cells. J. Immunol. 2011, 186:32-40.
44. Koch M.A., Tucker-Heard G., Perdue N.R., Killebrew J.R., Urdahl K.B., Campbell D.J. The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation. Nat. Immunol. 2009, 10:595-602.
45. Hall A.O., Beiting D.P., Tato C., John B., Oldenhove G., Lombana C.G., Pritchard G.H., Silver J.S., Bouladoux N., Stumhofer J.S., Harris T.H., Grainger J., Wojno E.D., Wagage S., Roos D.S., Scott P., Turka L.A., Cherry S., Reiner S.L., Cua D., Belkaid Y., Elloso M.M., Hunter C.A. The cytokines interleukin 27 and interferon-gamma promote distinct Treg cell populations required to limit infection-induced pathology. Immunity 2012, 37:511-523.
46. Chang J.H., Kim Y.J., Han S.H., Kang C.Y. IFN-gamma-STAT1 signal regulates the differentiation of inducible Treg: potential role for ROS-mediated apoptosis. Eur. J. Immunol. 2009, 39:1241-1251.
47. Wang Z., Hong J., Sun W., Xu G., Li N., Chen X., Liu A., Xu L., Sun B., Zhang J.Z. Role of IFN-gamma in induction of Foxp3 and conversion of CD4+ CD25- T cells to CD4+ Tregs. J. Clin. Invest. 2006, 116:2434-2441.