Persistent STAT5 Phosphorylation and Epigenetic Dysregulation of GM-CSF and PGS2/COX2 Expression in Type 1 Diabetic Human Monocytes

PLoS ONE

Volumn 8, Issue 10, 2013, Pages

  Garrigan, Erin ^a   Belkin, Nicole S ^a,c   Alexander, John J ^a,d   Han, Zhao ^a   Seydel, Federica ^a,e   Carter, Jamal ^a   Atkinson, Mark ^a   Wasserfall, Clive ^a   Clare Salzler, Michael J ^a   Amick, Matthew A ^b   Litherland, Sally A ^a,b  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b BURNHAM INSTITUTE   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOOXYGENASE 2; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HISTONE ACETYLTRANSFERASE PCAF; HISTONE H3; INTERLEUKIN 10; INTERLEUKIN 4; NUCLEAR RECEPTOR COREPRESSOR; PROSTAGLANDIN SYNTHASE; PROSTAGLANDIN SYNTHASE 2; RNA POLYMERASE II; SILENCING MEDIATOR OF RETINOID AND THYROID HORMONE RECEPTOR; STAT5 PROTEIN; TYROSINE; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; AGED; ARTICLE; BINDING SITE; CHILD; CHROMATIN IMMUNOPRECIPITATION; CHROMOSOME 1; CONTROLLED STUDY; CSF2 GENE; DISEASE DURATION; EPIGENETIC DYSREGULATION; FEMALE; FLOW CYTOMETRY; GENE; GENE CONTROL; GENE EXPRESSION; GENETIC DISORDER; HISTONE ACETYLATION; HUMAN; HUMAN CELL; INFLAMMATION; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; MALE; MONOCYTE; PRESCHOOL CHILD; PROMOTER REGION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PTGS2 GENE; REGULATORY SEQUENCE; SCHOOL CHILD; SEQUENCE ANALYSIS; TRANSCRIPTION REGULATION;

ACETYLATION; ADOLESCENT; ADULT; AGED; BASE SEQUENCE; CELLS, CULTURED; CHILD; CYCLOOXYGENASE 2; DIABETES MELLITUS, TYPE 1; EPIGENESIS, GENETIC; FEMALE; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HISTONES; HUMANS; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; MONOCYTES; PHOSPHORYLATION; PROTEIN BINDING; REGULATORY SEQUENCES, NUCLEIC ACID; SEQUENCE HOMOLOGY, NUCLEIC ACID; STAT5 TRANSCRIPTION FACTOR; TYROSINE; YOUNG ADULT;

EID: 84885798811     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0076919     Document Type: Article

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