IL10 resistant PGS2 expression in at-risk/Type 1 diabetic human monocytes

Journal of Autoimmunity

Volumn 22, Issue 3, 2004, Pages 227-233

  Litherland, S A ^a   Xie, T X ^a   Grebe, K M ^a,b   Li, Y ^a   Moldawer, L L ^a   Clare Salzler, M J ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

Autoimmunity; Cytokines; Diabetes; Lipid mediators; Monocyte macrophage

Indexed keywords

GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 10; PROSTAGLANDIN SYNTHASE;

ADULT; AGED; ANTIGEN PRESENTING CELL; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE ACTIVATION; GENE CONTROL; GENE FUNCTION; GENE REPRESSION; GENE TARGETING; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MALE; MONOCYTE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; RISK ASSESSMENT;

ADOLESCENT; ADULT; AGED; CHILD; CHILD, PRESCHOOL; CYCLOOXYGENASE 2; DIABETES MELLITUS, TYPE 1; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; INTERLEUKIN-10; ISOENZYMES; MEMBRANE PROTEINS; MIDDLE AGED; MONOCYTES; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES;

EID: 1642393304     PISSN: 08968411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaut.2003.12.006     Document Type: Article

References (22)

1. DeWitt D., Smith W.L. Yes but do they still get headaches? Cell. 83:1995;345-348.
2. Sweet M.J., Hume D.A. Endotoxin signal transduction in macrophages. J Leukoc Biol. 60:1996;8-26.
3. Paliogianni F., Kincaid R.L., Boumpas D.T. Prostaglandin E2 and other cyclic AMP elevating agents inhibit interleukin 2 gene transcription by counteracting calcineurin-dependent pathways. J Exp Med. 178:1993;1813-1817.
4. Foegh M.L. Immune regulation by eicosanoids. Transplant Proc. 20:(6):1988;1151-1161.
5. Narumiya S. Prostanoid receptors and signal transduction. Prog Brain Res. 113:1996;231-241.
6. Snijdewint F.G.M., Kalinski P., Wierenga E.A., Bos J.D., Kapenberg M.L. Prostaglandin E2 differentially modulates cytokine secretion profiles of human T helper lymphocytes. J Immunol. 150:1993;5321-5329.
7. Chase H.P., Williams R.L., Dupont J. Increased prostaglandin synthesis in childhood diabetes mellitus. J Pediatr. 94:(2):1979;185-189.
8. Litherland S.A., Xie X.T., Hutson A.D., Wasserfall C., Whittaker D.S., She J.-X., et al. Aberrant prostaglandin synthase 2 expression defines an antigen presenting cell defect in humans at risk for insulin dependent diabetes mellitus (IDDM). J Clin Invest. 104:1999;515-523.
9. Litherland S.A., She J.-X., Schatz D., Fuller K., Hutson A.D., Peng R.H., et al. Aberrant monocyte prostaglandin synthase 2 (PGS2) expression in Type 1 diabetes before and after disease onset. Ped Diabetes. 4:2003;10-18.
10. Lety M.A., Coulaud J., Bens M., Dardenne M., Homo-Delarche F. Enhanced metabolism of arachidonic acid by macrophages from nonobese diabetic (NOD) mice. Clin Immunol Immunopathol. 64:(3):1992;188-196.
11. Clare-Salzler M.J. The immunopathogenic roles of antigen presenting cells in the NOD mouse. Leiter E.H., Atkinson M.A. NOD mice and related strains: research applications in diabetes AIDS cancer and other diseases. 1998;101-120 Landes Bioscience Publishers, Austin (TX).
12. Prud'Homme G.J., Fuks A., Colle E., Seemayer T.A., Guttmann R.D. Immune dysfunction in diabetes-prone BB rats. J Exp Med. 159:1984;463-478.
13. Riese J., Hoff T., Nordhoff A., DeWitt D.L., Reach K., Kaever W. Transient expression of prostaglandin endoperoxide synthase-2 during mouse macrophage activation. J Leukoc Biol. 55:1994;476-482.
14. Mertz P.M., DeWitt D.L., Stetler-Stevenson W.G., Wahl L.M. Interleukin 10 suppression of monocyte prostaglandin H synthase-2. J Biol Chem. 269:(33):1994;21322-21329.
15. Strassmann G., Patil-Koota V., Finkelman F., Fong M., Kambayshi T. Evidence for the involvement of interleukin 1 in the differential deactivation of murine peritoneal macrophages by prostaglandin E2. J Exp Med. 180:1994;2365-2370.
16. Niiro H., Otsuka T., Tanabe T., Hara S., Kug S., Nemoto Y., et al. Inhibition by interleukin-10 of inducible cyclooxygenase expression in lipopolysaccharide-stimulated monocytes: its underlying mechanism in comparison with interleukin-4. Blood. 85:(12):1995;3736-3745.
17. Parry S.L., Sebbag M., Feldmann M., Brennan F.M. Contact with T cells modulates monocyte IL10 production. J Immunol. 158:1997;3673-3681.
18. Yamaoka K., Otsuka T., Niiro H., Arinobu Y., Niho Y., Hamasaki M., et al. Activation of STAT5 by lipopolysaccharide through granulocyte-macrophage colony-stimulating factor production in human monocytes. J Immunol. 160:1998;838-845.
19. de Waal Malefyt R., Abrams J., Bennett B., Figdor C.G., de Vries J.E. Interleukin 10(IL10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL10 produced by monocytes. J Exp Med. 174:1991;1209-1220.
20. Berger S., Ballo H., Stutte H.J. Immune complex-induced interleukin-6, interleukin-10 and prostaglandin secretion by human monocytes: a network of pro- and anti-inflammatory cytokines dependent on the antigen:antibody ratio. J Immunol. 26:1996;1297-1301.
21. Hart P.H., Jones C.A., Finlay-Jones J.J. Monocytes cultured in cytokine-defined environments differ from freshly isolated monocytes in their responses to IL-4 and IL10. J Leukoc Biol. 57:1995;909-918.
22. Daftarian P.M., Kumar A., Kryworuchko M., Diaz-Mitoma F. IL10 production is enhanced in human T cells by IL-12 and IL-6 and in monocytes by tumor necrosis factor-α J Immunol. 157:1996;12-20.