Antiparasitic effect of a fraction enriched in tight-binding protease inhibitors isolated from the Caribbean coral Plexaura homomalla

Experimental Parasitology

Volumn 135, Issue 3, 2013, Pages 611-622

  Salas Sarduy, Emir ^a,e   Cabrera Muñoz, Aymara ^a   Cauerhff, Ana ^b   González González, Yamile ^a,e,f   Trejo, Sebastián A ^c,e   Chidichimo, Agustina ^d   Chávez Planes, Maria de los Angeles ^a,e   Cazzulo, Juan José ^d,e  

^a UNIVERSITY OF HAVANA   (Cuba)

^b FUNDACIÓN INSTITUTO LELOIR   (Argentina)

^c UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^d INSTITUTO DE INVESTIGACIONES BIOTECNOLÓGICAS   (Argentina)

^e UNIVERSIDAD NACIONAL DE LA PLATA   (Argentina)

^f FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Antiparasitic agents; Cysteine peptidases; Plasmodium falciparum; Plexaura homomalla; Tight binding inhibitor; Trypanosoma cruzi

Indexed keywords

CHLOROQUINE; CRUZIPAIN; CYSTEINE PEPTIDASE; FALCIPAIN 2; HEMOGLOBIN; NATURAL PRODUCT; PAPAIN LIKE CYSTEINE PEPTIDASE; PEPSIN LIKE ASPARTYL PEPTIDASE; PEPTIDASE; PLEXAURA HOMOMALLA EXTRACT; PROTEINASE INHIBITOR; TISSUE EXTRACT; UNCLASSIFIED DRUG;

ANTIPARASITIC ACTIVITY; ARTICLE; CARIBBEAN CORAL; CELL DIFFERENTIATION; CELL DIVISION; CONTROLLED STUDY; CORAL; DRUG ACTIVITY; GENETIC STRAIN; HUMAN; HUMAN CELL; ISOLATION PROCEDURE; NONHUMAN; PLASMODIUM FALCIPARUM; PLEXAURA HOMOMALLA; PRIORITY JOURNAL; PROTEIN DEGRADATION; TROPHOZOITE; TRYPANOSOMA CRUZI; TRYPOMASTIGOTE; VERO CELL;

7-AMINO-4-METHYL COUMARIN; AAFP; ABSORBANCE UNITS; ACETONITRILE; ACN; AMC; ANTIPARASITIC AGENTS; AU; BAPA; BENZOYL-ARGINYL-P-NITRO-ANILIDE-HCL; BENZYLOXYCARBONYL-PHENYL-ARGINYL-7-AMINO-4-METHYL COUMARIN; CARBOXYMETHYL DEXTRAN; CMD; CYSTEINE PEPTIDASES; E-64; IF; INTENSITY FADING; N-(4-METOXIPHENYLAZOFORMYL)-L-PHENYLALANINE; NAAC; PLASMODIUM FALCIPARUM; PLEXAURA HOMOMALLA; REVERSE-PHASE; ROOM TEMPERATURE; RP; RT; SODIUM ACETATE BUFFER; TFA; TIGHT-BINDING INHIBITOR; TRANS-EPOXYSUCCINYL-L-LEUCYLAMIDO-(4-GUANIDINO)BUTANE; TRIFLUORACETIC ACID; TRYPANOSOMA CRUZI; Z-FR-AMC;

ANIMALS; ANTHOZOA; ANTIPROTOZOAL AGENTS; CATTLE; CERCOPITHECUS AETHIOPS; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; ERYTHROCYTES; HUMANS; INHIBITORY CONCENTRATION 50; PAPAIN; PLASMODIUM FALCIPARUM; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SWINE; TRYPANOSOMA CRUZI; VERO CELLS;

EID: 84885791425     PISSN: 00144894     EISSN: 10902449     Source Type: Journal    
DOI: 10.1016/j.exppara.2013.09.013     Document Type: Article

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