Peptide transporter DtpA has two alternate conformations, one of which is promoted by inhibitor binding

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 42, 2013, Pages

  Bippes, Christian A ^a   Ge, Lin ^a   Meury, Marcel ^b,c   Harder, Daniel ^b,c   Ucurum, Zöhre ^b,c   Daniel, Hannelore ^d   Fotiadis, Dimitrios ^b,c   Müller, Daniel J ^a  

^a ETH ZURICH   (Switzerland)

^b Institute of Biochemistry and Molecular Medicine   (Switzerland)

^c UNIVERSITY OF BERN   (Switzerland)

^d TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Atomic force microscopy; Major facilitator superfamily; Membrane transporter; Molecular interactions; Proton dependent oligopeptide transporter

Indexed keywords

CARRIER PROTEINS AND BINDING PROTEINS; DIPEPTIDE; PEPTIDE TRANSPORTER DTPA; PERMEASE; PROTEIN INHIBITOR; TRIPEPTIDE; UNCLASSIFIED DRUG;

ARTICLE; ATOMIC FORCE MICROSCOPY; BINDING AFFINITY; CONTROLLED STUDY; ENZYME SPECIFICITY; ESCHERICHIA COLI; LIGAND BINDING; LIPID MEMBRANE; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN SECONDARY STRUCTURE; PROTEIN STRUCTURE; PROTEIN UNFOLDING;

ATOMIC FORCE MICROSCOPY; MAJOR FACILITATOR SUPERFAMILY; MEMBRANE TRANSPORTER; MOLECULAR INTERACTIONS; PROTON-DEPENDENT OLIGOPEPTIDE TRANSPORTER;

BACTERIAL PROTEINS; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; HUMANS; MEMBRANE TRANSPORT PROTEINS; OLIGOPEPTIDES; PROTEIN STABILITY; PROTEIN STRUCTURE, SECONDARY; PROTEIN TRANSPORT; STRUCTURAL HOMOLOGY, PROTEIN; SYMPORTERS;

EID: 84885765846     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1312959110     Document Type: Article

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