Functional analysis of a chimeric mammalian peptide transporter derived from the intestinal and renal isoforms

Journal of Physiology

Volumn 497, Issue 3, 1996, Pages 773-779

  Döring, Frank ^a   Dorn, Daniela ^a   Bachfischer, Ulla ^a   Amasheh, Salah ^a   Herget, Martina ^a   Daniel, Hannelore ^a  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; ISOPROTEIN; PEPTIDE;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME SPECIFICITY; GENETIC TRANSFECTION; HUMAN; KIDNEY; NONHUMAN; OOCYTE; PH; PRIORITY JOURNAL; PROTEIN ANALYSIS; RABBIT; SMALL INTESTINE; STRUCTURE ACTIVITY RELATION; XENOPUS;

EID: 0030463324     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1113/jphysiol.1996.sp021808     Document Type: Article

References (19)

1. BERTRAN, J., WERNER, A., STANGE, G., MARKOVICH, D., BIBER, J., TESTAR, X., ZORZANO, A., PALACIN, M. & MURER, H. (1992). Expression of Na(+)-independent amino acid transport in Xtnopus laevia oocytes by injection of rabbit kidney cortex mRNA. Biochemical Journal 281, 717-723.
2. BOLL, M., HERGET, M., WAGENER, M., WEBER, W. M., MARKOVICH, D., BIBER, J., CLAUSS, W., MURER, H. & DANIEL, H. (1996). Expression cloning and functional characterization of the kidney cortex high-affinity proton-coupled peptide transporter. Proceedings of the National Acadamy of Scifnces of the USA 93, 284-289.
3. BOLL, M., MARKOVICH, D., WEBER, W.-M., KORTE, H., DANIEL, H. & MURER, H. (1994). Expression cloning of a cDNA from rabbit small intestine related to proton-coupled transport of peptides, β-lactam antibiotics and ACE-inhibitors. Pflügers Archiv 429, 146-149.
4. CLOSS, E. I., LYONS, G, KELLY, C. & CUNNINGHAM, J. M. (1993). Characterization of the third member of the MCAT family of cationic amino acid transporters. Identification of a domain that determines the transport properties of the MCAT proteins. Journal of Biological Chemistry 268, 20796-20800.
5. + symporter. Journal of Clinical Investigation 92, 2215-2223.
6. DANIEL, H., MOBSE, E. L. & ADIBI, S. A. (1991). The high and low affinity transport systems for dipeptides in kidney brush border membrane respond differently to alterations in pH gradient and membrane potential. Journal of Biological Chemistry 266, 19917-19924.
7. FEI, Y.-J., KANAI, Y., NUSSBERGER, S., GANAPATHY, V., LEIBACH, F. H., ROMERO, M. F., SINGH, S. K., BORON, W. F. & HEDIGER, M. A. (1994). Expression cloning of a mammalian proton-coupled oligopeptide transporter. Nature 368, 563-566.
8. GANAPATHY, M. E., BRANDSCH, M., PRASAD, P. D., GANAPATHY, V. & LEIBACH, F. H. (1995). Differential recognition of beta-lactam antibiotics by intestinal and renal peptide transporters, PEFF1 and PEPT2. Journal of Biological Chemistry 270, 25672-25677.
9. GANAPATHY, V., BURCKHARDT, C. & LEIBACH, F. H. (1984). Characteristics of glycylsarcosine transport in rabbit intestinal brush-border membrane vesicles. Journal of Biological Chemistry 259, 8954-8959.
10. + coupled transport of cephradine via dipeptide carriers in rabbit intestinal brush-border membranes: Role of histidine residues. Journal of Pharmacology and Experimental Therapeutics 251, 745-749.
11. +/peptide cotransporter. Journal of Biological Chemistry 270, 6456-6463.
12. +/peptide cotransporter family, from human kidney. Biothimica et Biophysica Acta 1235, 461-466.
13. +-coupled oligopeptide transporter hPepT1. Journal of Biological Chemistry 271, 5430-5437.
14. MIYAMOTO, K. L, SHIRAGA, T., MURITA, K., YAMAMOTO, H., HAGA, H., TAKETANI, Y, TAMAI, L, SAI, Y, TSUJI, A. & TAKEDA, E. (1996). Sequence, tissue distribution and developmental changes in rat intestinal oligopeptide transporter. Biochimica et Biophysica Acta 1305, 34-38.
15. MIYAMOTO, Y, GANAPATHY, V. & LEIBACH, K. H. (1986). Identification of histidyl and thiol groups at the active site of rabbit renal dipeptide transporter. Journal of Biological Chemistry 261, 16133-16140.
16. +/peptide cotransporter mediating absorption of β-lastam antibiotics in the intestine and kidney. Journal of Pharmacology and Experimental Therapeutics 275, 1631-1637
17. SAMBROOK, J., FRITSCH, K. F. & MANIATIS, T. (1989). Molecular Cloning. A Laboratory Manual. Cold Spring Harbor Press, New York.
18. TIRUPPATHI, C, GANAPATHY, V. & LEIBACH, F. H. (1990). Evidence for tripeptide-proton symport in renal brush border membrane vesicles. Journal of Biological Chemistry 265, 2048-2053.
19. WENZEL, U, GEBERT, I., WEINTRAUT, H., WEBER, W.-M., CLAUSS, W. & DANIEL, H. (1996). Transport characteristics of differently charged cephalosporin antibiotics in oocytes expressing the cloned intestinal peptide transporter PepT1 and in human intestinal Caco-2 cells. Journal of Pharmacology and Experimental Theraputics 277, 831-839.