Probing the Interactions of Carboxy-atractyloside and Atractyloside with the Yeast Mitochondrial ADP/ATP Carrier

Structure

Volumn 18, Issue 1, 2010, Pages 39-46

  Kedrov, Alexej ^a   Hellawell, Alex M ^b   Klosin, Adam ^a   Broadhurst, R Bill ^c   Kunji, Edmund R S ^b   Müller, Daniel J ^a,d  

^a DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^b MEDICAL RESEARCH COUNCIL   (United Kingdom)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d ETH ZURICH   (Switzerland)

Author keywords

PROTEINS

Indexed keywords

ADENINE NUCLEOTIDE TRANSLOCASE; ATRACTYLOSIDE; CARBOXYATRACTYLOSIDE;

ALPHA HELIX; ARTICLE; ATOMIC FORCE MICROSCOPY; BINDING KINETICS; CHEMICAL STRUCTURE; MOLECULAR INTERACTION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PURIFICATION; SACCHAROMYCES CEREVISIAE; STEREOCHEMISTRY;

ATRACTYLOSIDE; MICROSCOPY, ATOMIC FORCE; MICROSCOPY, ELECTRON; MITOCHONDRIAL ADP, ATP TRANSLOCASES; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

EID: 73449133713     PISSN: 09692126     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.str.2009.11.009     Document Type: Article

References (33)

1. Bamber L., Harding M., Butler P.J., and Kunji E.R.S. Yeast mitochondrial ADP/ATP carriers are monomeric in detergents. Proc. Natl. Acad. Sci. USA 103 (2006) 16224-16229
2. Bippes C.A., Zeltina A., Casagrande F., Ratera M., Palacin M., Muller D.J., and Fotiadis D. Substrate binding tunes conformational flexibility and kinetic stability of an amino acid antiporter. J. Biol. Chem. 284 (2009) 18651-18663
3. Bruni A., Luciani S., and Contessa A.R. Inhibition by atractyloside of the binding of adenine-nucleotides to rat-liver mitochondria. Nature 201 (1964) 1219-1220
4. Butt H., and Jaschke M. Calculation of thermal noise in atomic-force microscopy. Nanotechnology 6 (1995) 1-7
5. Cavanagh J., Fairbrother W.J., Palmer A.G., Skelton N.J., and Rance M. Protein NMR Spectroscopy: Principles and Practice. Second Edition (2006), Academic Press
6. Cisneros D.A., Oberbarnscheidt L., Pannier A., Klare J.P., Helenius J., Engelhard M., Oesterhelt F., and Muller D.J. Transducer binding establishes localized interactions to tune sensory rhodopsin II. Structure 16 (2008) 1206-1213
7. Crowther R.A., Henderson R., and Smith J.M. MRC image processing programs. J. Struct. Biol. 116 (1996) 9-16
8. Dehez F., Pebay-Peyroula E., and Chipot C. Binding of ADP in the mitochondrial ADP/ATP carrier is driven by an electrostatic funnel. J. Am. Chem. Soc. 130 (2008) 12725-12733
9. Evans E., and Ritchie K. Dynamic strength of molecular adhesion bonds. Biophys. J. 72 (1997) 1541-1555
10. Evans E., and Ludwig F. Dynamic strengths of molecular anchoring and material cohesion in fluid biomembranes. J. Phys. Condens. Matter 12 (2000) A315-A320
11. Florin E., Rief M., Lehmann H., Ludwig M., Dornmair C., Moy V., and Gaub H. Sensing specific molecular interactions with the atomic force microscopy. Biosens. Bioelectron. 10 (1995) 895-901
12. Janovjak H., Struckmeier J., Hubain M., Kedrov A., Kessler M., and Müller D.J. Probing the energy landscape of the membrane protein bacteriorhodopsin. Structure 12 (2004) 871-879
13. Janovjak H., Sapra K.T., Kedrov A., and Muller D.J. From valleys to ridges: exploring the dynamic energy landscape of single membrane proteins. ChemPhysChem 9 (2008) 954-966
14. Johnston J.M., Khalid S., and Sansom M.S. Conformational dynamics of the mitochondrial ADP/ATP carrier: a simulation study. Mol. Membr. Biol. 25 (2008) 506-517
15. Kedrov A., Ziegler C., Janovjak H., Kuhlbrandt W., and Muller D.J. Controlled unfolding and refolding of a single sodium-proton antiporter using atomic force microscopy. J. Mol. Biol. 340 (2004) 1143-1152
16. Kedrov A., Ziegler C., and Muller D.J. Differentiating ligand and inhibitor interactions of a single antiporter. J. Mol. Biol. 362 (2006) 925-932
17. Kedrov A., Janovjak H., Sapra K.T., and Muller D.J. Deciphering molecular interactions of native membrane proteins by single-molecule force spectroscopy. Annu. Rev. Biophys. Biomol. Struct. 36 (2007) 233-260
18. Klingenberg M. Molecular aspects of the adenine nucleotide carrier from mitochondria. Arch. Biochem. Biophys. 270 (1989) 1-14
19. Klingenberg M. The ADP and ATP transport in mitochondria and its carrier. Biochim. Biophys. Acta 1778 (2008) 1978-2021
20. Kunji E.R.S., and Harding M. Projection structure of the atractyloside-inhibited mitochondrial ADP/ATP carrier of Saccharomyces cerevisiae. J. Biol. Chem. 278 (2003) 36985-36988
21. Kunji E.R.S., and Robinson A.J. The conserved substrate binding site of mitochondrial carriers. Biochim. Biophys. Acta 1757 (2006) 1237-1248
22. Luciani S., Martini N., and Santi R. Effects of carboxyatractyloside a structural analogue of atractyloside on mitochondrial oxidative phosphorylation. Life Sci. II. 10 (1971) 961-968
23. MacLeod J.K., Gaul K.L., and Oelrichs P.B. Bifloratoxin, a toxic aminoglycoside of carboxyatractyligenin, from Melanthera biflora. Aust. J. Chem. 43 (1990) 1533-1539
24. Muller D.J. AFM: a nanotool in membrane biology. Biochemistry 47 (2008) 7986-7998
25. Oesterhelt F., Oesterhelt D., Pfeiffer M., Engel A., Gaub H.E., and Muller D.J. Unfolding pathways of individual bacteriorhodopsins. Science 288 (2000) 143-146
26. Pebay-Peyroula E., Dahout-Gonzalez C., Kahn R., Trezeguet V., Lauquin G.J., and Brandolin G. Structure of mitochondrial ADP/ATP carrier in complex with carboxyatractyloside. Nature 426 (2003) 39-44
27. Pfaff E., Klingenberg M., and Heldt H.W. Unspecific permeation and specific exchange of adenine nucleotides in liver mitochondria. Biochim. Biophys. Acta 104 (1965) 312-315
28. Piozzi F., Quilico A., Mondelli R., Ajello T., Sprio V., and Melera A. The structure and stereochemistry of atractyligenin. Tetrahedron 8 (1966) 515-529
29. Robinson A.J., and Kunji E.R.S. Mitochondrial carriers in the cytoplasmic state have a common substrate binding site. Proc. Natl. Acad. Sci. USA 103 (2006) 2617-2622
30. Robinson A.J., Overy C., and Kunji E.R.S. The mechanism of transport by mitochondrial carriers based on analysis of symmetry. Proc. Natl. Acad. Sci. USA 105 (2008) 17766-17771
31. Saraste M., and Walker J.E. Internal sequence repeats and the path of polypeptide in mitochondrial ADP/ATP translocase. FEBS Lett. 144 (1982) 250-254
32. Vignais P.V., Vignais P.M., and Defaye G. Gummiferin, an inhibitor of the adenine-nucleotide translocation. Study of its binding properties to mitochondria. FEBS Lett. 17 (1971) 281-288
33. Wang Y., and Tajkhorshid E. Electrostatic funneling of substrate in mitochondrial inner membrane carriers. Proc. Natl. Acad. Sci. USA 105 (2008) 9598-9603