The Suppressive Role and Aberrent Promoter Methylation of BTG3 in the Progression of Hepatocellular Carcinoma

PLoS ONE

Volumn 8, Issue 10, 2013, Pages

  Lv, Zhenbing ^a,b   Zou, Huichun ^a   Peng, Kaiwen ^a   Wang, Jianmei ^a   Ding, Yi ^a   Li, Yuling ^a   Ren, Xiaoli ^a   Wang, Feifei ^a   Chang, Rui ^a   Liang, Li ^a   Ding, Yanqing ^a  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

^b Central Hospital of Nanchong   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; B CELL TRANSLOCATION GENE 3; BTG3 GENE; CANCER CELL CULTURE; CANCER INHIBITION; CANCER PROGNOSIS; CANCER SURVIVAL; CANCER TISSUE; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE REGULATION; CELL CYCLE S PHASE; CELL DIFFERENTIATION; CELL INVASION; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DISEASE COURSE; DISTANT METASTASIS; DNA METHYLATION; DOWN REGULATION; FEMALE; GENE EXPRESSION; GENE FUNCTION; GENE IDENTIFICATION; GENE LOCATION; GENETIC CORRELATION; GENETIC MARKER; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; LIVER CELL; LIVER CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; OVERALL SURVIVAL; PROMOTER REGION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TISSUE DISTRIBUTION; TUMOR SUPPRESSOR GENE; UPREGULATION; WESTERN BLOTTING;

ADULT; AGED; CARCINOMA, HEPATOCELLULAR; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; DISEASE PROGRESSION; DNA METHYLATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE KNOCKDOWN TECHNIQUES; GENE SILENCING; HUMANS; IMMUNOHISTOCHEMISTRY; LIVER NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM METASTASIS; PROGNOSIS; PROMOTER REGIONS, GENETIC; PROTEINS; TRANSCRIPTION, GENETIC; TUMOR BURDEN;

EID: 84885694404     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0077473     Document Type: Article

References (33)

1. Chen JG, Zhang SW, (2011) Liver cancer epidemic in China: past, present and future. Semin Cancer Biol 21: 59-69. doi:10.1016/j.semcancer.2010.11.002. PubMed: 21144900.
2. Macheiner D, Heller G, Kappel S, Bichler C, Stättner S, et al. (2006) NORE1B, a candidate tumor suppressor, is epigenetically silenced in human hepatocellular carcinoma. J Hepatol 45: 81-89. doi:10.1016/j.jhep.2005.12.017. PubMed: 16516329.
3. Matsuda S, Rouault J, Magaud J, Berthet C, (2001) In search of a function for the TIS21/PC3/BTG1/TOB family. FEBS Lett 497: 67-72. doi:10.1016/S0014-5793(01)02436-X. PubMed: 11377414.
4. Guéhenneux F, Duret L, Callanan MB, Bouhas R, Hayette S, et al. (1997) Cloning of the mouse BTG3 gene and definition of a new gene family (the BTG family) involved in the negative control of the cell cycle. Leukemia 11: 370-375. doi:10.1038/sj.leu.2400599. PubMed: 9067576.
5. Winkler GS, (2010) The mammalian anti-proliferative BTG/Tob protein family. J Cell Physiol 222: 66-72. doi:10.1002/jcp.21919. PubMed: 19746446.
6. Lim IK, (2006) TIS21 (/BTG2/PC3) as a link between ageing and cancer: cell cycle regulator and endogenous cell death molecule. J Cancer Res Clin Oncol 132: 417-426. doi:10.1007/s00432-006-0080-1. PubMed: 16456675.
7. Toyota M, Suzuki H, Sasaki Y, Maruyama R, Imai K, et al. (2008) Epigenetic silencing of microRNA-34b/c and B-cell translocation gene 4 is associated with CpG island methylation in colorectal cancer. Cancer Res 68: 4123-4132. doi:10.1158/0008-5472.CAN-08-0325. PubMed: 18519671.
8. Dong W, Tu S, Xie J, Sun P, Wu Y, et al. (2009) Frequent promoter hypermethylation and transcriptional downregulation of BTG4 gene in gastric cancer. Biochem Biophys Res Commun 387: 132-138. doi:10.1016/j.bbrc.2009.06.140. PubMed: 19576178.
9. Zhang ZM, Wang G, Chen C, Yang ZX, Jin F, et al. (2009) Rapid induction of PC3/BTG2 gene by hepatopoietin or partial hepatectomy and its mRNA expression in hepatocellular carcinoma. Hepatobiliary Pancreat Dis Int 8: 288-293. PubMed: 19502170.
10. O'Malley S, Su H, Zhang T, Ng C, Ge H, et al. (2009) TOB suppresses breast cancer tumorigenesis. Int J Cancer 125: 1805-1813. doi:10.1002/ijc.24490. PubMed: 19569230.
11. Yoneda M, Suzuki T, Nakamura T, Ajima R, Yoshida Y, et al. (2009) Deficiency of antiproliferative family protein Ana correlates with development of lung adenocarcinoma. Cancer Sci 100: 225-232. doi:10.1111/j.1349-7006.2008.01030.x. PubMed: 19068083.
12. Yamamoto N, Uzawa K, Yakushiji T, Shibahara T, Noma H, et al. (2001) Analysis of the ANA gene as a candidate for the chromosome 21q oral cancer susceptibility locus. Br J Cancer 84: 754-759. doi:10.1054/bjoc.2000.1656. PubMed: 11259088.
13. Lin TY, Cheng YC, Yang HC, Lin WC, Wang CC, et al. (2012) Loss of the candidate tumor suppressor BTG3 triggers acute cellular senescence via the ERK-JMJD3-p16(INK4a) signaling axis. Oncogene 31: 3287-3297. doi:10.1038/onc.2011.491. PubMed: 22020331.
14. Majid S, Dar AA, Ahmad AE, Hirata H, Kawakami K, et al. (2009) BTG3 tumor suppressor gene promoter demethylation, histone modification and cell cycle arrest by genistein in renal cancer. Carcinogenesis 30: 662-670. doi:10.1093/carcin/bgp042. PubMed: 19221000.
15. Majid S, Dar AA, Shahryari V, Hirata H, Ahmad A, et al. (2010) Genistein reverses hypermethylation and induces active histone modifications in tumor suppressor gene B-Cell translocation gene 3 in prostate cancer. Cancer 116: 66-76. PubMed: 19885928.
16. Yu J, Zhang Y, Qi Z, Kurtycz D, Vacano G, et al. (2008) Methylation-mediated downregulation of the B-cell translocation gene 3 (BTG3) in breast cancer cells. Gene Expr 14: 173-182. PubMed: 18590053.
17. Putnik M, Zhao C, Gustafsson JÅ, Dahlman-Wright K, (2012) Global identification of genes regulated by estrogen signaling and demethylation in MCF-7 breast cancer cells. Biochem Biophys Res Commun 14: 26-32. PubMed: 22902638.
18. Ou YH, Chung PH, Hsu FF, Sun TP, Chang WY, et al. (2007) The candidate tumor suppressor BTG3 is a transcriptional target of p53 that inhibits E2F1. EMBO J 26: 3968-3980. doi:10.1038/sj.emboj.7601825. PubMed: 17690688.
19. Wang F, Qiao Y, Yu J, Ren X, Wang J, et al. (2013) FBX8 Acts as an Invasion and Metastasis Suppressor and Correlates with Poor Survival in Hepatocellular Carcinoma. PLOS ONE 8(6):: e65495. doi:10.1371/journal.pone.0065495. PubMed: 23826080.
20. Zhang X, Li N, Li X, Zhao W, Qiao Y, et al. (2012) Low expression of DAB2IP contributes to malignant development and poor prognosis in hepatocellular carcinoma. J Gastroenterol Hepatol 27(6):: 1117-1125. doi:10.1111/j.1440-1746.2011.07049.x. PubMed: 22168621.
21. Liang L, Guan J, Zeng Y, Wang J, Li X, (2011) Down-regulation of formin-like 2 predicts poor prognosis in hepatocellular carcinoma. Hum Pathol 42(11):: 1603-1612. doi:10.1016/j.humpath.2010.08.025. PubMed: 21496865.
22. Sakata J, Shirai Y, Wakai T, Kaneko K, Nagahashi M, et al. (2008) Preoperative predictors of vascular invasion in hepatocellular carcinoma. Eur J Surg Oncol 34: 900-905. doi:10.1016/j.ejso.2008.01.031. PubMed: 18343084.
23. Ke-Wei L, Tian-Fu W, Xi L, Lü-Nan Y, Bo L, et al. (2012) The effect of postoperative TACE on prognosis of HCC with microscopic venous invasion. Hepatogastroenterology 59: 1944-1946. PubMed: 22246191.
24. Jiang YF, Yang ZH, Hu JQ, (2000) Recurrence or metastasis of HCC: predictors, early detection and experimental antiangiogenic therapy. World J Gastroenterol 6: 61-65. PubMed: 11819524.
25. Arimura E, Kotoh K, Nakamuta M, Morizono S, Enjoji M, et al. (2005) Local recurrence is an important prognostic factor of hepatocellular carcinoma. World J Gastroenterol 28: 5601-5606. PubMed: 16237751.
26. Du J, Qian X, Liu B, (2013) Long-term progression-free survival in a case of hepatocellular carcinoma with vertebral metastasis treated with a reduced dose of sorafenib: Case report and review of the literature. Oncol Lett 5: 381-385. PubMed: 23255954.
27. Lin S, Zhu Q, Xu Y, Liu H, Zhang J, et al. (2012) The role of the TOB1 gene in growth suppression of hepatocellular carcinoma. Oncol Lett 4: 981-987. PubMed: 23162636.
28. Matsubara N, (2012) Epigenetic regulation and colorectal cancer. Dis Colon Rectum 55: 96-104. doi:10.1097/DCR.0b013e318233a1ef. PubMed: 22156874.
29. Bender CM, Pao MM, Jones PA, (1998) Inhibition of DNA methylation by 5-aza-2'-deoxycytidine suppresses the growth of human tumor cell lines. Cancer Res 58: 95-101. PubMed: 9426064.
30. Cheng YC, Lin TY, Shieh SY, (2013) Candidate tumor suppressor BTG3 maintains genomic stability by promoting Lys63-linked ubiquitination and activation of the checkpoint kinase CHK1. Proc Natl Acad Sci U_S_A 110: 5993-5998. doi:10.1073/pnas.1220635110. PubMed: 23533280.
31. Feng M, Li Z, Aau M, Wong CH, Yang X, et al. (2011) Myc/miR-378/TOB2/cyclin D1 functional module regulates oncogenic transformation. Oncogene 30: 2242-2251. doi:10.1038/onc.2010.602. PubMed: 21242960.
32. Kawakubo H, Brachtel E, Hayashida T, Yeo G, Kish J, et al. (2006) Loss of B-cell translocation gene-2 in estrogen receptor-positive breast carcinoma is associated with tumor grade and overexpression of cyclin d1 protein. Cancer Res 66: 7075-7082. doi:10.1158/0008-5472.CAN-06-0379. PubMed: 16849553.
33. Deng B, Zhao Y, Gou W, Chen S, Mao X, et al. (May 9(2013) Decreased expression of BTG3 was linked to carcinogenesis, aggressiveness, and prognosis of ovarian carcinoma. Tumour Biol May 9. [Epub ahead of print]. PubMed: 23657964.