Global identification of genes regulated by estrogen signaling and demethylation in MCF-7 breast cancer cells

Biochemical and Biophysical Research Communications

Volumn 426, Issue 1, 2012, Pages 26-32

  Putnik, Milica ^a   Zhao, Chunyan ^a   Gustafsson, Jan Åke ^a,b   Dahlman Wright, Karin ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UNIVERSITY OF HOUSTON   (United States)

Author keywords

5 Aza 2' deoxycytidine; Breast cancer; DNA methylation; Estrogen; Estrogen receptor; Microarray

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; BTG FAMILY MEMBER 3; CYCLIN DEPENDENT KINASE INHIBITOR 1A; ESTRADIOL; ESTROGEN; ESTROGEN RECEPTOR; ESTROGEN RECEPTOR ALPHA; FOUR AND A HALF LIM DOMAIN 2; PROTEIN; PROTEIN NOXA; TRANSFORMING GROWTH FACTOR BETA2; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL; CELL MIGRATION; CELL MOTION; CELL PROLIFERATION; CONTROLLED STUDY; CPG ISLAND; DEMETHYLATION; DNA METHYLATION; EPIGENETICS; GENE CONTROL; GENE EXPRESSION; GENE IDENTIFICATION; GENE REPRESSION; HUMAN; HUMAN CELL; MOLECULAR INTERACTION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION;

AZACITIDINE; BREAST NEOPLASMS; CELL LINE, TUMOR; DNA METHYLATION; DNA MODIFICATION METHYLASES; EPIGENESIS, GENETIC; ESTRADIOL; ESTROGENS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIM DOMAIN PROTEINS; PROMOTER REGIONS, GENETIC; PROTEINS; SIGNAL TRANSDUCTION; TRANSCRIPTOME;

EID: 84866320302     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.08.007     Document Type: Article

References (36)

1. Dahlman-Wright K., Cavailles V., Fuqua S.A., Jordan V.C., Katzenellenbogen J.A., et al. International union of pharmacology. LXIV. Estrogen receptors. Pharmacol. Rev. 2006, 58:773-781.
2. Sharma S., Kelly T.K., Jones P.A. Epigenetics in cancer. Carcinogenesis 2010, 31:27-36.
3. Platet N., Cathiard A.M., Gleizes M., Garcia M. Estrogens and their receptors in breast cancer progression: a dual role in cancer proliferation and invasion. Crit. Rev. Oncol. Hematol. 2004, 51:55-67.
4. Thomas C., Gustafsson J.A. The different roles of ER subtypes in cancer biology and therapy. Nat. Rev. Cancer 2011, 11:597-608.
5. Jovanovic J., Ronneberg J.A., Tost J., Kristensen V. The epigenetics of breast cancer. Mol. Oncol. 2010, 4:242-254.
6. Nilsson S., Gustafsson J.A. Estrogen receptor action. Crit. Rev. Eukaryot. Gene Expr. 2002, 12:237-257.
7. Sommer S., Fuqua S.A. Estrogen receptor and breast cancer. Semin. Cancer Biol. 2001, 11:339-352.
8. Kato S. Estrogen receptor-mediated cross-talk with growth factor signaling pathways. Breast Cancer 2001, 8:3-9.
9. Jemal A., Bray F., Center M.M., Ferlay J., Ward E., et al. Global cancer statistics. CA Cancer J. Clin. 2011, 61:69-90.
10. Early Breast Cancer Trialists' Collaborative Group (EBCTCG), Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials. Lancet 365 (2005) 1687-717.
11. Ali S., Buluwela L., Coombes R.C. Antiestrogens and their therapeutic applications in breast cancer and other diseases. Annu. Rev. Med. 2011, 62:217-232.
12. Garinis G.A., Patrinos G.P., Spanakis N.E., Menounos P.G. DNA hypermethylation: when tumour suppressor genes go silent. Hum. Genet. 2002, 111:115-127.
13. Rodenhiser D., Mann M. Epigenetics and human disease: translating basic biology into clinical applications. CMAJ 2006, 174:341-348.
14. Egger G., Liang G., Aparicio A., Jones P.A. Epigenetics in human disease and prospects for epigenetic therapy. Nature 2004, 429:457-463.
15. Yang X., Lay F., Han H., Jones P.A. Targeting DNA methylation for epigenetic therapy. Trends Pharmacol. Sci. 2010, 31:536-546.
16. Das P.M., Singal R. DNA methylation and cancer. J. Clin. Oncol. 2004, 22:4632-4642.
17. Yager J.D., Davidson N.E. Estrogen carcinogenesis in breast cancer. N. Engl. J. Med. 2006, 354:270-282.
18. Fan M., Yan P.S., Hartman-Frey C., Chen L., Paik H., et al. Diverse gene expression and DNA methylation profiles correlate with differential adaptation of breast cancer cells to the antiestrogens tamoxifen and fulvestrant. Cancer Res. 2006, 66:11954-11966.
19. Hsu P.Y., Hsu H.K., Singer G.A., Yan P.S., Rodriguez B.A., et al. Estrogen-mediated epigenetic repression of large chromosomal regions through DNA looping. Genome Res. 2010, 20:733-744.
20. Leu Y.W., Yan P.S., Fan M., Jin V.X., Liu J.C., et al. Loss of estrogen receptor signaling triggers epigenetic silencing of downstream targets in breast cancer. Cancer Res. 2004, 64:8184-8192.
21. Metivier R., Gallais R., Tiffoche C., Le Peron C., Jurkowska R.Z., et al. Cyclical DNA methylation of a transcriptionally active promoter. Nature 2008, 452:45-50.
22. Ramaswamy B., Majumder S., Roy S., Ghoshal K., Kutay H., et al. Estrogen-mediated suppression of the gene encoding protein tyrosine phosphatase PTPRO in human breast cancer: mechanism and role in tamoxifen sensitivity. Mol. Endocrinol. 2009, 23:176-187.
23. Widschwendter M., Siegmund K.D., Muller H.M., Fiegl H., Marth C., et al. Association of breast cancer DNA methylation profiles with hormone receptor status and response to tamoxifen. Cancer Res. 2004, 64:3807-3813.
24. Huang da W., Sherman B.T., Lempicki R.A. Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res. 2009, 37:1-13.
25. Huang da W., Sherman B.T., Lempicki R.A. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat. Protoc. 2009, 4:44-57.
26. Li L.C., Dahiya R. MethPrimer: designing primers for methylation PCRs. Bioinformatics 2002, 18:1427-1431.
27. Akamine R., Yamamoto T., Watanabe M., Yamazaki N., Kataoka M., et al. Usefulness of the 5' region of the cDNA encoding acidic ribosomal phosphoprotein P0 conserved among rats, mice, and humans as a standard probe for gene expression analysis in different tissues and animal species. J. Biochem. Bioph. Methods 2007, 70:481-486.
28. Matthews J., Wihlen B., Tujague M., Wan J., Strom A., et al. Estrogen receptor (ER) beta modulates ERalpha-mediated transcriptional activation by altering the recruitment of c-Fos and c-Jun to estrogen-responsive promoters. Mol. Endocrinol. 2006, 20:534-543.
29. Edgar R., Domrachev M., Lash A.E. Gene expression omnibus: NCBI gene expression and hybridization array data repository. Nucleic Acids Res. 2002, 30:207-210.
30. Pryzbylkowski P., Obajimi O., Keen J.C. Trichostatin A and 5 Aza-2' deoxycytidine decrease estrogen receptor mRNA stability in ER positive MCF7 cells through modulation of HuR. Breast Cancer Res. Treat. 2008, 111:15-25.
31. Fujikane T., Nishikawa N., Toyota M., Suzuki H., Nojima M., et al. Genomic screening for genes upregulated by demethylation revealed novel targets of epigenetic silencing in breast cancer. Breast Cancer Res. Treat. 2010, 122:699-710.
32. Irizarry R.A., Ladd-Acosta C., Wen B., Wu Z., Montano C., et al. The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores. Nat. Genet. 2009, 41:178-186.
33. Sandoval J., Heyn H., Moran S., Serra-Musach J., Pujana M.A., et al. Validation of a DNA methylation microarray for 450,000 CpG sites in the human genome. Epigenetics 2011, 6:692-702.
34. Yu J., Zhang Y., Qi Z., Kurtycz D., Vacano G., et al. Methylation-mediated downregulation of the B-cell translocation gene 3 (BTG3) in breast cancer cells. Gene Expr. 2008, 14:173-182.
35. Majid S., Dar A.A., Ahmad A.E., Hirata H., Kawakami K., et al. BTG3 tumor suppressor gene promoter demethylation, histone modification and cell cycle arrest by genistein in renal cancer. Carcinogenesis 2009, 30:662-670.
36. Majid S., Dar A.A., Shahryari V., Hirata H., Ahmad A., et al. Genistein reverses hypermethylation and induces active histone modifications in tumor suppressor gene B-Cell translocation gene 3 in prostate cancer. Cancer 2010, 116:66-76.