Down-regulation of formin-like 2 predicts poor prognosis in hepatocellular carcinoma

Human Pathology

Volumn 42, Issue 11, 2011, Pages 1603-1612

  Liang, Li ^a   Guan, Jian ^a   Zeng, Yuanfeng ^a   Wang, Jianmei ^a   Li, Xianzheng ^a   Zhang, Xiaojing ^a   Ding, Yanqing ^a  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

Author keywords

FMNL2; Hepatocellular carcinoma; Prognostic marker

Indexed keywords

FORMIN LIKE 2 PROTEIN; METHENAMINE; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CANCER CELL CULTURE; CANCER INVASION; CANCER SURGERY; CANCER SURVIVAL; CANCER TISSUE; CELL MOTILITY; CONTROLLED STUDY; DOWN REGULATION; EPITHELIUM CELL; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; LIVER CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; OVERALL SURVIVAL; PREDICTION; PROGNOSIS; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SURVIVAL TIME; TRANSIENT TRANSFECTION; WESTERN BLOTTING;

ADULT; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CELL MOVEMENT; DISEASE PROGRESSION; DOWN-REGULATION; FEMALE; HEP G2 CELLS; HUMANS; KAPLAN-MEIER ESTIMATE; LIVER; LIVER CIRRHOSIS; LIVER NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM INVASIVENESS; PROGNOSIS; PROTEINS; REAL-TIME POLYMERASE CHAIN REACTION; TUMOR MARKERS, BIOLOGICAL;

EID: 80054705810     PISSN: 00468177     EISSN: 15328392     Source Type: Journal    
DOI: 10.1016/j.humpath.2010.08.025     Document Type: Article

References (33)

1. Bosch F.X., Ribes J., Cleries R., and Diaz M. Epidemiology of hepatocellular carcinoma Clin Liver Dis 9 2005 191 211
2. Llovet J.M., Burroughs A., and Bruix J. Hepatocellular carcinoma Lancet 362 2003 1907 1917 (Pubitemid 37518510)
3. Tung-Ping Poon R., Fan S.T., and Wong J. Risk factors, prevention, and management of postoperative recurrence after resection of hepatocellular carcinoma Ann Surg 232 2000 10 24 (Pubitemid 30456545)
4. Thomas M.B., and Zhu A.X. Hepatocellular carcinoma: the need for progress J Clin Oncol 23 2005 2892 2899 (Pubitemid 46224106)
5. Cha C.H., Saif M.W., Yamane B.H., and Weber S.M. Hepatocellular carcinoma: current management Curr Probl Surg 47 2010 10 67
6. Thorgeirsson S.S., and Grisham J.W. Molecular pathogenesis of human hepatocellular carcinoma Nat Genet 31 2002 339 346 (Pubitemid 35154440)
7. Yam J.W., Wong C.M., and Ng I.O. Molecular and functional genetics of hepatocellular carcinoma Front Biosci 2 2010 117 134
8. Farazi P.A., and DePinho R.A. Hepatocellular carcinoma pathogenesis: from genes to environment Nat Rev Cancer 6 2006 674 687 (Pubitemid 44286000)
9. Teufel A., Staib F., Kanzler S., Weinmann A., Schulze-Berkamen H., and Galle P.R. Genetics of hepatocellular carcinoma World J Gastroenterol 23 2007 2271 2282 (Pubitemid 46860727)
10. Faix J., and Grosse R. Staying in shape with formins Dev Cell 10 2006 693 706 (Pubitemid 43779105)
11. Young K.G., and Copeland J.W. Formins in cell signaling Biochim Biophys Acta 1803 2010 183 190
12. Goode B.L., and Eck M.J. Mechanism and function of formins in the control of actin assembly Annu Rev Biochem 76 2007 593 627
13. Higgs H.N. Formin proteins: a domain-based approach Trends Biochem Sci 30 2005 342 353 (Pubitemid 40799053)
14. Sahai E. Mechanisms of cancer cell invasion Curr Opin Genet Dev 15 2005 87 96 (Pubitemid 40127636)
15. Eisenmann K.M., Harris E.S., Kitchen S.M., Holman H.A., Higgs H.N., and Alberts A.S. Dia-interacting protein modulates formin-mediated actin assembly at the cell cortex Curr Biol 17 2007 579 591 (Pubitemid 46497803)
16. Katoh M., and Katoh M. Identification and characterization of human FMNL1, FMNL2 and FMNL3 genes in silico Int J Oncol 22 2003 1161 1168
17. Zhang Y.F., Liu L., and Ding Y.Q. Isolation and characterization of human colorectal cancer cell subline with unique metastatic potential in the liver Nan Fang Yi Ke Da Xue Xue Bao 27 2007 126 130
18. Wang S., Zhou J., and Wang X.Y. Down-regulated expression of SATB2 is associated with metastasis and poor prognosis in colorectal cancer J Pathol 219 2009 114 122
19. Zhu X.L., Liang L., and Ding Y.Q. Overexpression of FMNL2 is closely related to metastasis of colorectal cancer Int J Colorectal Dis 23 2008 1041 1047
20. Zhu X.L., Liang L., and Ding Y.Q. Expression of FMNL2 and its relation to the metastatic potential of human colorectal cancer cells Nan Fang Yi Ke Da Xue Xue Bao 28 2008 1775 1778
21. Zhou J., Wang S., Lu J., Li J., and Ding Y. Over-expression of phosphatase of regenerating liver-3 correlates with tumor progression and poor prognosis in nasopharyngeal carcinoma Int J Cancer 124 2009 1879 1886
22. Soumaoro L.T., Uetake H., Higuchi T., Takagi Y., Enomoto M., and Sugihara K. Cyclooxygenase-2 expression: a significant prognostic indicator for patients with colorectal cancer Clin Cancer Res 10 2004 8465 8471 (Pubitemid 40053411)
23. Schwartzberg P.L. Formin the way Immunity 26 2007 139 141 (Pubitemid 46329445)
24. Seth A., Otomo C., and Rosen M.K. Autoinhibition regulates cellular localization and actin assembly activity of the diaphanous-related formins FRLalpha and mDia1 J Cell Biol 174 2006 701 713 (Pubitemid 44306726)
25. Lu J., Meng W., Poy F., Maiti S., Goode B.L., and Eck M.J. Structure of the FH2 domain of Daam1: implications for formin regulation of actin assembly J Mol Biol 369 2007 1258 1269 (Pubitemid 46770768)
26. Higashi T., Ikeda T., and Shirakawa R. Biochemical characterization of the Rho GTPase-regulated actin assembly by diaphanous-related formins, mDia1 and Daam1, in platelets J Biol Chem 283 2008 8746 8755
27. Lizárraga F., Poincloux R., and Romao M. Diaphanous-related formins are required for invadopodia formation and invasion of breast tumor cells Cancer Res 69 2009 2792 2800
28. Carreira S., Goodall J., and Denat L. Mitf regulation of Dia1 controls melanoma proliferation and invasiveness Genes Dev 20 2006 3426 3439 (Pubitemid 44969160)
29. Kitzing T.M., Sahadevan A.S., and Brandt D.T. Positive feedback between Dia1, LARG, and RhoA regulates cell morphology and invasion Genes Dev 21 2007 1478 1483 (Pubitemid 46955720)
30. Kitzing T.M., Wang Y., Pertz O., Copeland J.W., and Grosse R. Formin-like 2 drives amoeboid invasive cell motility downstream of RhoC Oncogene 29 2010 2441 2448
31. Ding Y., Chen B., and Wang S. Overexpression of Tiam1 in hepatocellular carcinomas predicts poor prognosis of HCC patients Int J Cancer 124 2009 653 658
32. Sakata J., Shirai Y., Wakai T., Kaneko K., Nagahashi M., and Hatakeyama K. Preoperative predictors of vascular invasion in hepatocellular carcinoma Eur J Surg Oncol 34 2008 900 905
33. Miralles F., Posern G., Zaromytidou A.I., and Treisman R. Actin dynamics control SRF activity by regulation of its coactivator MAL Cell 113 2003 329 342 (Pubitemid 36556115)