Hypoxia-induced invadopodia formation: A role for β-PIX

Open Biology

Volumn 3, Issue JUN, 2013, Pages

  Md Hashim, Nur Fariesha ^a,c   Nicholas, Nicole S ^a   Dart, Anna E ^a   Kiriakidis, Serafim ^b   Paleolog, Ewa ^b   Wells, Claire M ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY PUTRA MALAYSIA   (Malaysia)

Author keywords

PIX; Hypoxia; Invadopodia

Indexed keywords

ARHGEF7 PROTEIN, HUMAN; DICARBOXYLIC AMINO ACID; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MESSENGER RNA; OXALYLGLYCINE; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR; SMALL INTERFERING RNA;

Β-PIX; ARTICLE; CELL HYPOXIA; CELL STRAIN HEK293; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; HUMAN; HYPOXIA; INVADOPODIA; METABOLISM; RNA INTERFERENCE; TUMOR CELL LINE; UPREGULATION; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; HEK293 CELL LINE;

Β-PIX; HYPOXIA; INVADOPODIA;

AMINO ACIDS, DICARBOXYLIC; CELL HYPOXIA; CELL LINE, TUMOR; HEK293 CELLS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; RHO GUANINE NUCLEOTIDE EXCHANGE FACTORS; RNA INTERFERENCE; RNA, MESSENGER; RNA, SMALL INTERFERING; UP-REGULATION;

EID: 84885636373     PISSN: None     EISSN: 20462441     Source Type: Journal    
DOI: 10.1098/rsob.120159     Document Type: Article

References (35)

1. DeSantis C, Siegel R, Bandi P, Jemal A. 2011 Breast cancer statistics, 2011. CA Cancer J. Clin. 61, 409-418. (doi:10.3322/caac.20134)
2. Boyle RG, Travers S. 2006 Hypoxia: targeting the tumour. Anticancer Agents Med. Chem. 6, 281-286. (doi:10.2174/187152006777698169)
3. Brown JM, Wilson WR. 2004 Exploiting tumour hypoxia in cancer treatment. Nat. Rev. Cancer 4, 437-447. (doi:10.1038/nrc1367)
4. Semenza GL, Wang GL. 1992 A nuclear factor induced by hypoxia via denovo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol. Cell. Biol. 12, 5447-5454. (doi:10.1128/MCB.12.12.5447)
5. Sullivan R, Graham CH. 2007 Hypoxia-driven selection of the metastatic phenotype. Cancer Metastasis Rev. 26, 319-331. (doi:10.1007/s10555-007-9062-2)
6. Goonewardene TI, Sowter HM, Harris AL. 2002 Hypoxia-induced pathways in breast cancer. Microsc. Res. Tech. 59, 41-48. (doi:10.1002/jemt.10175)
7. Harris AL. 2002 Hypoxia - a key regulatory factor in tumour growth. Nat. Rev. Cancer 2, 38-47. (doi:10.1038/nrc704)
8. Schindl M et al. 2002 Overexpression of hypoxiainducible factor 1 alpha is associated with an unfavorable prognosis in lymph node-positive breast cancer. Clin. Cancer Res. 8, 1831-1837.
9. Sahlgren C, Gustafsson MV, Jin S, Poellinger L, Lendahl U. 2008 Notch signaling mediates hypoxiainduced tumor cell migration and invasion. Proc. Natl Acad. Sci. USA 105, 6392-6397. (doi:10.1073/pnas.0802047105)
10. Fujiwara S et al. 2007 Silencing hypoxia-inducible factor-1alpha inhibits cell migration and invasion under hypoxic environment in malignant gliomas. Int. J. Oncol. 30, 793-802.
11. Krishnamachary B et al. 2003 Regulation of colon carcinoma cell invasion by hypoxia-inducible factor 1. Cancer Res. 63, 1138-1143.
12. Victor N, Ivy A, Jiang B-H, Agani FH. 2006 Involvement of HIF-1 in invasion of Mum2B uveal melanoma cells. Clin. Exp. Metastasis 23, 87-96. (doi:10.1007/s10585-006-9024-z)
13. Coutts AS, Pires IM, Weston L, Buffa FM, Milani M, Li J-L, Harris AL, Hammond EM, La Thangue NB. 2011 Hypoxia-driven cell motility reflects the interplay between JMY and HIF-1 alpha. Oncogene 30, 4835-4842. (doi:10.1038/onc.2011.188)
14. Hara S, Nakashiro K, Klosek SK, Ishikawa T, Shintani S, Hamakawa H. 2006 Hypoxia enhances c-Met/HGF receptor expression and signaling by activating HIF- 1 alpha in human salivary gland cancer cells. Oral Oncol. 42, 593-598. (doi:10.1016/j.oraloncology.2005.10.016)
15. Zhou J, Li K, Gu Y, Feng B, Ren G, Zhang L, Wang Y, Nie Y, Fan D. 2011 Transcriptional up-regulation of RhoE by hypoxia-inducible factor (HIF)-1 promotes epithelial to mesenchymal transition of gastric cancer cells during hypoxia. Biochem. Biophys. Res. Commun. 415, 348-354. (doi:10.1016/j.bbrc.2011. 10.065)
16. Buccione R, Caldieri G, Ayala I. 2009 Invadopodia: specialized tumor cell structures for the focal degradation of the extracellular matrix. Cancer Metastasis Rev. 28, 137-149. (doi:10.1007/s10555-008-9176-1)
17. Linder S. 2007 The matrix corroded: podosomes and invadopodia in extracellular matrix degradation. Trends Cell Biol. 17, 107-117. (doi:10.1016/j.tcb.2007.01.002)
18. Bowden ET, Onikoyi E, Slack R, Myoui A, Yoneda T, Yamada K, Mueller S. 2006 Co-localization of cortactin and phosphotyrosine identifies active invadopodia in human breast cancer cells. Exp. Cell Res. 312, 1240-1253. (doi:10.1016/j.yexcr.2005.12.012)
19. Saltel F, Daubon T, Juin A, Ganuza IE, Veillat V, Elisabeth G. 2011 Invadosomes: intriguing structures with promise. Eur. J. Cell Biol. 90, 100-107. (doi:10.1016/j.ejcb.2010.05.011)
20. Nakahara H, Otani T, Sasaki T, Miura Y, Takai Y, Kogo M. 2003 Involvement of Cdc42 and Rac small G proteins in invadopodia formation of RPMI7951 cells. Genes Cells 8, 1019-1027. (doi:10.1111/j.1365-2443.2003.00695.x)
21. Ayala I, Baldassarre M, Giacchetti G, Caldieri G, Tete S, Luini A, Buccione R. 2008 Multiple regulatory inputs converge on cortactin to control invadopodia biogenesis and extracellular matrix degradation. J. Cell Sci. 121(Pt 3), 369-378. (doi:10.1242/jcs.008037)
22. Badowski C, Pawlak G, Grichine A, Chabadel A, Oddou C, Jurdic P, Pfaff M, Albiges-Rizo C, Block MR. 2008 Paxillin phosphorylation controls invadopodia/podosomes spatiotemporal organization. Mol. Biol. Cell 19, 633-645. (doi:10.1091/mbc.E06-01-0088)
23. Yamaguchi H et al. 2005 Molecular mechanisms of invadopodium formation: the role of the N-WASPArp2/ 3 complex pathway and cofilin. J. Cell Biol. 168, 441-452. (doi:10.1083/jcb.200407076)
24. Lucien F, Brochu-Gaudreau K, Arsenault D, Harper K, Dubois CM, Welm AL. 2011 Hypoxia-induced invadopodia formation involves activation of NHE-1 by the p90 ribosomal S6 kinase (p90RSK). PLoS ONE 6, e28851. (doi:10.1371/journal.pone. 0028851)
25. Milkiewicz M, Pugh CW, Egginton S. 2004 Inhibition of endogenous HIF inactivation induces angiogenesis in ischaemic skeletal muscles of mice. J. Physiol. 560(Pt 1), 21-26. (doi:10.1113/jphysiol.2004.069757)
26. Hudecova S, Lencesova L, Csaderova L, Sirova M, Cholujova D, Cagala M. 2011 Chemically mimicked hypoxia modulates gene expression and protein levels of the sodium calcium exchanger in HEK 293 cell line via HIF-1 alpha. Gen. Physiol. Biophys. 30, 196-206. (doi:10.4149/gpb-2011-02-196)
27. Elvidge GP, Glenny L, Appelhoff RJ, Ratcliffe PJ, Ragoussiss J, Gleadle JM. 2006 Concordant regulation of gene expression by hypoxia and 2-oxoglutarate-dependent dioxygenase inhibition: the role of HIF-1alpha, HIF-2alpha, and other pathways. J. Biol. Chem. 281, 15 215-15 226.
28. Kuo JC, Han X, Hsiao C-T, Yates III JR, Waterman CM. 2011 Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for beta-PIX in negative regulation of focal adhesion maturation. Nat. Cell Biol. 13, 383-393. (doi:10.1038/ncb2216)
29. Ten Klooster JP, Jaffer ZM, Chernoff J, Hordijk PL. 2006 Targeting and activation of Rac1 are mediated by the exchange factor beta-PIX. J. Cell Biol. 172, 759-769. (doi:10.1083/jcb.200509096)
30. Webb BA, Eves R, Crawley SW, Zhou S, Cote GP, Mak AS. 2005 PAK1 induces podosome formation in A7r5 vascular smooth muscle cells in a PAK-interacting exchange factor-dependent manner. Am. J. Physiol. Cell Physiol. 289, C898-C907. (doi:10.1152/ajpcell.00095.2005)
31. Gringel A, Walz D, Rosenberger G, Minden A, Kutsche K, Kopp P, Linder S. 2006 PAK4 and alphaPIX determine podosome size and number in macrophages through localized actin regulation. J. Cell Physiol. 209, 568-579. (doi:10.1002/jcp. 20777)
32. Zhao ZS, Manser E, Loo T-H, Lim L. 2000 Coupling of PAK-interacting exchange factor PIX to GIT1 promotes focal complex disassembly. Mol. Cell. Biol. 20, 6354-6363. (doi:10.1128/MCB.20.17.6354-6363.2000)
33. Vitale N, Patton WA, Moss J, Vaughan M, Lefkowitz RJ, Premont RT. 2000 GIT proteins, a novel family of phosphatidylinositol 3,4, 5-trisphosphate- stimulated GTPase-activating proteins for ARF6. J. Biol. Chem. 275, 13 901-13 906. (doi:10.1074/jbc.275.18.13901)
34. Tague SE, Muralidharan V, D'Souza-Schorey C. 2004 ADP-ribosylation factor 6 regulates tumor cell invasion through the activation of the MEK/ERK signaling pathway. Proc. Natl Acad. Sci. USA 101, 9671-9676. (doi:10.1073/pnas. 0403531101)
35. Wells CM, Abo A, Ridley AJ. 2002 PAK4 is activated via PI3K in HGF-stimulated epithelial cells. J. Cell Sci. 115(Pt 20), 3947-3956. (doi:10.1242/jcs.00080)