Type II toxin-antitoxin loci, hipBA and persisters

Prokaryotic Toxin-Antitoxins

Volumn , Issue , 2013, Pages 189-203

  Lewis, Kim ^a   Hansen, Sonja ^a  

^a NORTHEASTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84885593411     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-3-642-33253-1_11     Document Type: Chapter

References (63)

1. Alexander, C., Bilgin, N., Lindschau, C., Mesters, J. R., Kraal, B., Hilgenfeld, R., et al. (1995). Phosphorylation of elongation factor Tu prevents ternary complex formation. Journal of Biological Chemistry, 270(24), 14541-14547
2. Bayles, K. W. (2007). The biological role of death and lysis in biofilm development. Nature Reviews, 5(9), 721-726
3. Bigger, J.W. (1944). Treatment of staphylococcal infections with penicillin. Lancet ii: 497-500
4. Black, D. S., Irwin, B., & Moyed, H. S. (1994). Autoregulation of hip, an operon that affects lethality due to inhibition of peptidoglycan or DNA synthesis. Journal of Bacteriology, 176(13), 4081-4091
5. Black, D. S., Kelly, A. J., Mardis, M. J., & Moyed, H. S. (1991). Structure and organization of hip, an operon that affects lethality due to inhibition of peptidoglycan or DNA synthesis. Journal of Bacteriology, 173(18), 5732-5739
6. Brooun, A., Liu, S., & Lewis, K. (2000). A dose-response study of antibiotic resistance in Pseudomonas aeruginosa biofilms. Antimicrobial Agents and Chemotherapy, 44(3), 640-646
7. Chen, C. R., Malik, M., Snyder, M., & Drlica, K. (1996). DNA gyrase and topoisomerase IV on the bacterial chromosome: quinolone-induced DNA cleavage. Journal of Molecular Biology, 258(4), 627-637. doi:10.1006/jmbi.1996.0274
8. Christensen, S. K., Pedersen, K., Hansen, F. G., & Gerdes, K. (2003). Toxin-antitoxin loci as stressresponse-elements: ChpAK/MazF and ChpBK cleave translated RNAs and are counteracted by tmRNA. Journal of Molecular Biology, 332(4), 809-819. doi:S0022283603009227. [pii]
9. Correia, F. F., D'Onofrio, A., Rejtar, T., Li, L., Karger, B. L., Makarova, K., et al. (2006). Kinase activity of overexpressed HipA is required for growth arrest and multidrug tolerance in Escherichia coli. Journal of Bacteriology, 188(24), 8360-8367
10. Costerton, J. W., Stewart, P. S., & Greenberg, E. P. (1999). Bacterial biofilms: A common cause of persistent infections. Science, 284(5418), 1318-1322
11. Courcelle, J., Khodursky, A., Peter, B., Brown, P. O., & Hanawalt, P. C. (2001). Comparative gene expression profiles following UV exposure in wild-type and SOS-deficient Escherichia coli. Genetics, 158(1), 41-64
12. Davis, B. D., Chen, L. L., & Tai, P. C. (1986). Misread protein creates membrane channels: an essential step in the bactericidal action of aminoglycosides. Proceedings of the National academy of Sciences of the United States of America, 83(16), 6164-6168
13. Dorr, T., Lewis, K., & Vulic, M. (2009). SOS response induces persistence to fluoroquinolones in Escherichia coli. PLoS Genetics, 5(12), e1000760. doi:10.1371/journal.pgen.1000760
14. Dorr,T.,Vulic,M.,&Lewis, K. (2010).Ciprofloxacin causes persister formation by inducing the TisB toxin in Escherichia coli. PLoS Biology, 8(2), e1000317. doi:10.1371/journal.pbio.1000317
15. Drlica, K., Malik, M., Kerns, R. J., & Zhao, X. (2008). Quinolone-mediated bacterial death. Antimicrobial Agents and Chemotherapy, 52(2), 385-392. doi:10.1128/AAC.01617-06
16. Evdokimov, A., Voznesensky, I., Fennell, K., Anderson, M., Smith, J. F., & Fisher, D. A. (2009). New kinase regulation mechanism found in HipBA: a bacterial persistence switch. Acta Crystallographica Section D Biological Crystallography, 65(Pt 8), 875-879
17. Falla, T. J., & Chopra, I. (1998). Joint tolerance to beta-lactam and fluoroquinolone antibiotics in Escherichia coli results from overexpression of hipA. Antimicrobial Agents and Chemotherapy, 42(12), 3282-3284
18. Falla, T. J., & Chopra, I. (1999). Stabilization of Rhizobium symbiosis plasmids. Microbiology, 145(Pt 3), 515-516
19. Fernandez De Henestrosa, A. R., Ogi, T., Aoyagi, S., Chafin, D., Hayes, J. J., Ohmori, H., et al. (2000). Identification of additional genes belonging to the LexA regulon in Escherichia coli. Molecular Microbiology, 35(6), 1560-1572
20. Garcia-Olmedo, F., Molina, A., Alamillo, J. M., & Rodriguez-Palenzuela, P. (1998). Plant defense peptides. Biopolymers, 47(6), 479-491. doi:10.1002/(SICI)1097-0282(1998)47:6 \479:AID-BIP6[3.0.CO;2-K
21. Garton, N. J., Waddell, S. J., Sherratt, A. L., Lee, S. M., Smith, R. J., Senner, C., et al. (2008). Cytological and transcript analyses reveal fat and lazy persister-like bacilli in tuberculous sputum. PLoS Med, 5(4), e75. doi:10.1371/journal.pmed.0050075
22. Gerdes, K., Bech, F. W., Jorgensen, S. T., Lobner-Olesen, A., Rasmussen, P. B., Atlung, T., et al. (1986). Mechanism of postsegregational killing by the hok gene product of the parB system of plasmid R1 and its homology with the relF gene product of the E. coli relB operon. EMBO Journal, 5(8), 2023-2029
23. Gotfredsen, M., & Gerdes, K. (1998). The Escherichia coli relBE genes belong to a new toxinantitoxin gene family. Molecular Microbiology, 29(4), 1065-1076
24. Gurnev, P. A., Ortenberg, R., Dorr, T., Lewis, K., Bezrukov, S. M. (2012). Persister-promoting bacterialtoxin TisB produces anion-selective pores in planar lipid bilayers. FEBS letters 586(16), 2529-2534. doi:10.1016/j.febslet.2012.06.021
25. Hansen, S., Lewis, K., & Vulic, M. (2008). Role of global regulators and nucleotide metabolism in antibiotic tolerance in Escherichia coli. Antimicrobial Agents and Chemotherapy, 52(8), 2718-2726. doi:AAC.00144-0810.1128/AAC.00144-08. [pii]
26. Hansen, S., Vulic, M., Min, J., Yen, T. J., Schumacher, M. A., Brennan, R. G., Lewis, K. (2012). Regulation of the Escherichia coli HipBA toxin-antitoxin system by proteolysis. PLoS ONE 7(6), e39185.doi:10.1371/journal.pone.0039185
27. Harrison, J. J., Wade, W. D., Akierman, S., Vacchi-Suzzi, C., Stremick, C. A., Turner, R. J., et al. (2009). The chromosomal toxin gene yafQ is a determinant of multidrug tolerance for Escherichia coli growing in a biofilm. Antimicrobial Agents and Chemotherapy, 53(6), 2253-2258. doi:10.1128/AAC.00043-09
28. Hooper, D. (2001). Mechanism of action of antimicrobials: Focus on fluoroquinolones. Clinical Infectious Diseases, 32, S9-S15
29. Jensen, R. B., & Gerdes, K. (1995). Programmed cell death in bacteria: proteic plasmid stabilization systems. Molecular Microbiology, 17(2), 205-210
30. Kawano, M., Aravind, L., & Storz, G. (2007). An antisense RNA controls synthesis of an SOSinduced toxin evolved from an antitoxin. Molecular Microbiology, 64(3), 738-754. doi:10.1111/j.1365-2958.2007.05688.x
31. Keren, I., Minami, S., Rubin, E., & Lewis, K. (2011). Characterization and transcriptome analysis of mycobacterium tuberculosis persisters. mBio, 2(3), e00100-e00111. doi:10.1128/mBio. 00100-11
32. Keren, I., Shah, D., Spoering, A., Kaldalu, N., & Lewis, K. (2004). Specialized persister cells and the mechanism of multidrug tolerance in Escherichia coli. Journal of Bacteriology, 186(24), 8172-8180
33. Kim, Y., & Wood, T. K. (2010). Toxins Hha and CspD and small RNA regulator Hfq are involved in persister cell formation through MqsR in Escherichia coli. Biochemical and Biophysical Research Communications, 391(1), 209-213. doi:10.1016/j.bbrc.2009.11.033
34. Korch, S. B., Henderson, T. A., & Hill, T. M. (2003). Characterization of the hipA7 allele of Escherichia coli and evidence that high persistence is governed by (p)ppGpp synthesis. Molecular Microbiology, 50(4), 1199-1213
35. Korch, S. B., & Hill, T. M. (2006). Ectopic overexpression of wild-type and mutant hipA genes in Escherichia coli: Effects on macromolecular synthesis and persister formation. Journal of Bacteriology, 188(11), 3826-3836
36. Lafleur, M. D., Qi, Q., & Lewis, K. (2010). Patients with long-term oral carriage harbor highpersister mutants of Candida albicans. Antimicrobial Agents and Chemotherapy, 54(1), 39-44. doi:10.1128/AAC.00860-09
37. Lewis, K. (2007). Persister cells, dormancy and infectious disease. Nature Reviews, 5(1), 48-56. doi:10.1038/nrmicro1557
38. Lewis, K. (2010). Persister cells. Annual Review of Microbiology, 64, 357-372. doi:10.1146/ annurev.micro.112408.134306
39. Lippmann, C., Lindschau, C., Vijgenboom, E., Schroder, W., Bosch, L., & Erdmann, V. A. (1993). Prokaryotic elongation factor Tu is phosphorylated in vivo. Journal of Biological Chemistry, 268(1), 601-607
40. Maisonneuve, E., Shakespeare, L. J., Jorgensen, M. G., & Gerdes, K. (2011). Bacterial persistence by RNA endonucleases. Proceedings of the National academy of Sciences of the USA, 108(32), 13206-13211. doi:10.1073/pnas.1100186108
41. Masuda, Y., Miyakawa, K., Nishimura, Y., & Ohtsubo, E. (1993). chpA and chpB, Escherichia coli chromosomal homologs of the pem locus responsible for stable maintenance of plasmid R100. Journal of Bacteriology, 175(21), 6850-6856
42. McKenzie, G. J., Magner, D. B., Lee, P. L., & Rosenberg, S. M. (2003). The dinB operon and spontaneous mutation in Escherichia coli. Journal of Bacteriology, 185(13), 3972-3977
43. Motiejunaite, R., Armalyte, J., Markuckas, A., & Suziedeliene, E. (2007). Escherichia coli dinJyafQ genes act as a toxin-antitoxin module. FEMS Microbiology Letters, 268(1), 112-119. doi:10.1111/j.1574-6968.2006.00563.x
44. Moyed, H. S., & Bertrand, K. P. (1983). hipA, a newly recognized gene of Escherichia coli K-12 that affects frequency of persistence after inhibition of murein synthesis. Journal of Bacteriology, 155(2), 768-775
45. Mulcahy, L. R., Burns, J. L., Lory, S., & Lewis, K. (2010). Emergence of Pseudomonas aeruginosa strains producing high levels of persister cells in patients with cystic fibrosis. Journal of Bacteriology, 192(23), 6191-6199. doi:10.1128/JB.01651-09
46. Pedersen, K., Christensen, S. K., & Gerdes, K. (2002). Rapid induction and reversal of a bacteriostatic condition by controlled expression of toxins and antitoxins. Molecular Microbiology, 45(2), 501-510
47. Pedersen, K., & Gerdes, K. (1999). Multiple hok genes on the chromosome of Escherichia coli. Molecular Microbiology, 32(5), 1090-1102
48. Phillips, I., Culebras, E., Moreno, F., & Baquero, F. (1987). Induction of the SOS response by new 4-quinolones. Journal of Antimicrobial Chemotherapy, 20(5), 631-638
49. Ramage, H. R., Connolly, L. E., & Cox, J. S. (2009). Comprehensive functional analysis of mycobacterium tuberculosis toxin-antitoxin systems: implications for pathogenesis, stress responses, and evolution. PLoS Genetics, 5(12), e1000767. doi:10.1371/journal.pgen.1000767
50. Rotem, E., Loinger, A., Ronin, I., Levin-Reisman, I., Gabay, C., Shoresh, N., et al. (2010). Regulation of phenotypic variability by a threshold-based mechanism underlies bacterial persistence. Proceedings of the National academy of Sciences of the United States of America, 107(28), 12541-12546
51. Sahl, H. G., & Bierbaum, G. (1998). Lantibiotics: Biosynthesis and biological activities of uniquely modified peptides from gram-positive bacteria. Annual Review of Microbiology, 52, 41-79. doi:10.1146/annurev.micro.52.1.41
52. Scherrer, R., & Moyed, H. S. (1988). Conditional impairment of cell division and altered lethality in hipA mutants of Escherichia coli K-12. Journal of Bacteriology, 170(8), 3321-3326
53. Schumacher, M. A., Piro, K. M., Xu, W., Hansen, S., Lewis, K., & Brennan, R. G. (2009). Molecular mechanisms of HipA-mediated multidrug tolerance and its neutralization by HipB. Science, 323(5912), 396-401
54. Shah, D., Zhang, Z., Khodursky, A., Kaldalu, N., Kurg, K., & Lewis, K. (2006). Persisters: A distinct physiological state of E. coli. BMC Microbiology, 6(1), 53-61
55. Singletary, L. A., Gibson, J. L., Tanner, E. J., McKenzie, G. J., Lee, P. L., Gonzalez, C., et al. (2009). An SOS-regulated type 2 toxin-antitoxin system. Journal of Bacteriology, 191(24), 7456-7465. doi:10.1128/JB.00963-09
56. Spoering, A. L.,& Lewis, K. (2001). Biofilms and planktonic cells of Pseudomonas aeruginosa have similar resistance to killing by antimicrobials. Journal of Bacteriology, 183(23), 6746-6751
57. Tian, Q. B., Hayashi, T., Murata, T., & Terawaki, Y. (1996). Gene product identification and promoter analysis of hig locus of plasmid Rts1. Biochemical and Biophysical Research Communications, 225(2), 679-684. doi:10.1006/bbrc.1996.1229
58. Unoson, C., & Wagner, E. G. (2008). A small SOS-induced toxin is targeted against the inner membrane in Escherichia coli. Molecular Microbiology, 70(1), 258-270. doi:10.1111/j.1365-2958.2008.06416.x
59. Vazquez-Laslop, N., Lee, H., & Neyfakh, A. A. (2006). Increased persistence in Escherichia coli caused by controlled expression of toxins or other unrelated proteins. Journal of Bacteriology, 188(10), 3494-3497
60. Vogel, J., Argaman, L., Wagner, E. G., & Altuvia, S. (2004). The small RNA IstR inhibits synthesis of an SOS-induced toxic peptide. Current Biology, 14(24), 2271-2276. doi:10.1016/ j.cub.2004.12.003
61. Wayne, L. G., & Hayes, L. G. (1996). An in vitro model for sequential study of shiftdown of mycobacterium tuberculosis through two stages of nonreplicating persistence. Infection and Immunity, 64(6), 2062-2069
62. Wayne, L. G.,& Sohaskey, C. D. (2001). Nonreplicating persistence ofmycobacterium tuberculosis. Annual Review of Microbiology, 55, 139-163. doi:10.1146/annurev.micro.55.1.139
63. Wolfson, J. S., Hooper, D. C., McHugh, G. L., Bozza, M. A., & Swartz, M. N. (1990). Mutants of Escherichia coli K-12 exhibiting reduced killing by both quinolone and beta-lactam antimicrobial agents. Antimicrobial Agents and Chemotherapy, 34(10), 1938-1943.