New kinase regulation mechanism found in HipBA: A bacterial persistence switch

Acta Crystallographica Section D: Biological Crystallography

Volumn 65, Issue 8, 2009, Pages 875-879

  Evdokimov, Artem ^a   Voznesensky, Igor ^a   Fennell, Kimberly ^a   Anderson, Marie ^a   Smith, James F ^a   Fisher, Douglas A ^a  

^a PFIZER INC   (United States)

Author keywords

Bacterial persistence; Heavy atom phasing; HipA; HipB; Kinase activation; Space group transition

Indexed keywords

ANTIINFECTIVE AGENT; DNA BINDING PROTEIN; ESCHERICHIA COLI PROTEIN; HIPA PROTEIN, E COLI; HIPB PROTEIN, E COLI; MERCURY; PROTEIN KINASE INHIBITOR; TRYPTOPHAN;

ANTIBIOTIC RESISTANCE; ARTICLE; BINDING SITE; CHEMISTRY; CRYSTALLIZATION; ENZYMOLOGY; ESCHERICHIA COLI; ESCHERICHIA COLI INFECTION; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; MICROBIOLOGY; OPERON; PROTEIN CONFORMATION; REGULATOR GENE; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

ANTI-BACTERIAL AGENTS; BINDING SITES; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; DNA-BINDING PROTEINS; DRUG RESISTANCE, BACTERIAL; ESCHERICHIA COLI; ESCHERICHIA COLI INFECTIONS; ESCHERICHIA COLI PROTEINS; GENE EXPRESSION REGULATION, BACTERIAL; GENES, SWITCH; HUMANS; MERCURY; OPERON; PROTEIN CONFORMATION; PROTEIN KINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPTOPHAN;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI;

EID: 68349152308     PISSN: 09074449     EISSN: 13990047     Source Type: Journal    
DOI: 10.1107/S0907444909018800     Document Type: Article

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